Protein Alignment Cftr and CG7627

DIOPT Version :10

• Sequence 1: NP_651269.1
• Gene: Cftr / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Sequence 2: NP_609215.3
• Gene: CG7627 / 34148
• FlyBaseID: FBgn0032026
• Length: 1355
• Species: Drosophila melanogaster
• Alignment Length: 1449
• Identity: 606/1449 - (41%)
• Similarity: 851/1449 - (58%)
• Gaps: 181/1449 - (12%)

  Fly    10 KNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSHRK 74
            :|||:|.|.||...|.:.:|...:|.:|.|:|.||.:.|||.:||.||::|...|..|||::
  Fly    11 ENPREHCNFISAACFWYTMPTFIKGRKRTLDTKDLYRALKEHKSETLGNKLCASWELELEKT--- 72

  Fly    75 KQKPHLRNALFRCFLGPTIINGLICFIY-IVIKTLIPAVLAQLLIQFQKTPVAQLRNIDVNDISI 138
            |.||:|..||.|.|.....:.||:.|:. :.::||.|..|.:|:..:
  Fly    73 KGKPNLLRALLRVFGWYFALLGLVLFLLELGLRTLQPIFLLKLIAYY------------------ 119

  Fly   139 SDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNATAVRSILDQ 203
                                  :.||..                    :|...:.|..|
  Fly   120 ----------------------THGSES--------------------IESAYYYAAGV------ 136

  Fly   204 TVEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRLMGARMRIACCSLIYRKTLRLSMKTAGQTP 268
                            :|.:.....::|...|....:|.:||:..||:||||.||||....|.|.
  Fly   137 ----------------ILCSALNVIIMHPYMLGTMHVGLKMRVGMCSMIYRKALRLSKSALGDTT 185

  Fly   269 AGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVPVQTAL 333
            ||:::||:||||.|||...||:|::|:.||:.:...||::..|||.|:.||..:|| .:|:|..|
  Fly   186 AGHVVNLMSNDVGRLDLATIFVHYLWVGPLETLFITYLMYREIGIAAVFGVAFMLL-FIPLQAYL 249

  Fly   334 SKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIRYASYLRGF 398
            .|.|||||:|.|.|||.||.:|||::.|||||||||||.||:.:||.||:.||..||:.||:||.
  Fly   250 GKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEINAIRHVSYIRGI 314

  Fly   399 YLSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNILQLVAAIWYPLAVSFGAEALVSLR 463
            .||.::|..|.:::::|....|:|..:|.:..|...:|||||:....:::|..:|..||.|||::
  Fly   315 LLSFIIFLTRVSIFLSLVGYVLLGTFLTPEVAFLITAYYNILRTTMTVFFPQGISQMAETLVSIK 379

  Fly   464 RIQDFL---------MLEGREERTQGLTHKRDQEGGDSR-------------------------A 494
            |:|.::         |.....|..||...:.....||..                         .
  Fly   380 RVQKYMQSDETNVMDMSVDLTEDFQGSNQETVHADGDEERDEAEDKLLGPPIATVNENAKLSEAG 444

  Fly   495 VTIKDINASWDIEKPQKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGD 559
            ::|..:.|.||:..|..:|..:||:::.|.:..::|..|:||||::|.:|||||...|.:.:.|.
  Fly   445 ISISGLMAKWDVNSPDYSLNGVNLRVQPGTMLGIVGRTGSGKSSLIQAILGELPAESGEIKVNGS 509

  Fly   560 LSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQ 624
            :|||:||||||:|:||.|||||:..||:||.:|.:.|||..||:.||..|||:||||||||||||
  Fly   510 MSYASQEPWLFSGTVRQNILFGQPMDRRRYAKVVKKCALERDFELLPFKDKTIVGERGASLSGGQ 574

  Fly   625 RARISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRILVTHQVHFLSEA 689
            :||||||||||:...|||:||||||||.||.||||::.:  ||.|.:  ...||.|||:.||..|
  Fly   575 KARISLARAVYRETSIYLLDDPLSAVDTHVARHLFEQCM--RGYLRE--RIVILATHQLQFLQHA 635

  Fly   690 DVIVIVDQGRILRQGTYQELINSDLDFARLLERPKEEEEGENSRNQTSPLSVNSLESDDEDIPFI 754
            |.|||:|:||:...|||:.|..|.||||.:|..|:.:|:.| .|:::...|.....||
  Fly   636 DQIVIMDKGRVSAVGTYESLRESGLDFASMLADPERDEQSE-ERSRSRSGSYTHSHSD------- 692

  Fly   755 DGVKDGYQQLRKQSSSVHGSKSLDSTQLDD-NVDEDDLAEAQASGGISPRVWYEYFHAGSTLLSF 818
                    |.|....|:   .|:..:.:|| ..::.:..|.|.:|.|..|::.:||.||....:|
  Fly   693 --------QRRNSEQSL---LSMADSCMDDLEAEQANNQERQEAGQIGLRLYSKYFKAGGGFFAF 746

  Fly   819 SFMVFVMVMSQVVCSSSDFFANIWT-----------QQEHQRSQG-EATFSTF----------EC 861
            ..|:...|:||.:.|..|:|.:.|.           ..:..||:. |...||:          |.
  Fly   747 FVMMGFCVLSQGLASLGDYFLSYWVTKKGNVAYRADNNDTTRSEELEPRLSTWLRDIGLSVDAEM 811

  Fly   862 M--YIYGALIIAVVIMTTFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSK 924
            :  ||:..:.:..:::|..|.||||.:.|.||..||:.||..|..|.|.||:|.|||||||||||
  Fly   812 LDTYIFTVITVLTILVTVARSFLFFNLAMKASIRLHNSMFRGITRAAMYFFNTNPSGRILNRFSK 876

  Fly   925 DMGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLVVAVVDVLILKLYLRPSQDLKRL 989
            |||.:||:||..|||.|||.|.:.||:|||.::||:.:...:|:.::...:...||:.|:|:||:
  Fly   877 DMGQVDEILPAVMMDVIQIFLALAGIVIVIAVVNPLFLIPTVVLGIIFYQLRTFYLKTSRDVKRM 941

  Fly   990 EGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCVSC 1054
            |.|.||||:|||:||||||:.||:...|.|:..|||..||:|||.:.:.::.:...|.||||...
  Fly   942 EAITRSPVYSHLAASLTGLSTIRAFGAQRVLEAEFDNYQDMHSSAFYMFISTSRAFGYWLDCFCV 1006

  Fly  1055 IFLTSVTFSFIISSETTYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTELEQE 1119
            |::..:|.||.|..... .|:|||||.|||.:|||||:|:||.||....||:||||::|.::|.|
  Fly  1007 IYIAIITLSFFIFPPAN-GGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDIEPE 1070

  Fly  1120 PAL---GEKTPPQQWPTRGQVEFRNMSCRY--DPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSS 1179
            .||   .:|.||:.||.:|::.|..:|.||  ||....||::|:..|:...||||||||||||||
  Fly  1071 GALEAPADKKPPKSWPEQGKIVFDELSLRYTPDPKSENVLKSLSFVIKPKEKVGIVGRTGAGKSS 1135

  Fly  1180 LIGALFRLAHIEGEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWS 1244
            ||.|||||::.:|.:.||..:|..:.|..||::||||||:|||||.|:|||||||:.|:|.:||.
  Fly  1136 LINALFRLSYNDGSVLIDKRDTSEMGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDDKLWR 1200

  Fly  1245 ALEDVELRKAI----PGLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDA 1305
            :||:|:|::.:    .||...:||.|.|||||||||:||||||||.|::||:||||||||||||.
  Fly  1201 SLEEVKLKEVVADLPSGLQSKITEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDG 1265

  Fly  1306 LIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHL-RQMVEATG 1369
            |||.|||.|||:|||||:||||||:||||:::|||||.||||..||.||..:...: ..||:.||
  Fly  1266 LIQTTIRNKFKECTVLTIAHRLHTIMDSDKVLVMDAGRAVEFGTPYELLTLADSKVFHGMVKQTG 1330

  Fly  1370 GES-EALKKTASDSHKRMQ 1387
            ..: |:|.|.|..:.:..|
  Fly  1331 HATYESLLKIAQKAFENRQ 1349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cftr	NP_651269.1	MRP_assoc_pro	12..1356	CDD:188098	596/1412 (42%)
CG7627	NP_609215.3	PLN03130	13..1348	CDD:215595	604/1444 (42%)