Protein Alignment Cftr and abcc5

DIOPT Version :10

• Sequence 1: NP_651269.1
• Gene: Cftr / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Sequence 2: NP_001182542.1
• Gene: abcc5 / 336147
• ZFINID: ZDB-GENE-050517-17
• Length: 1426
• Species: Danio rerio
• Alignment Length: 1473
• Identity: 436/1473 - (29%)
• Similarity: 692/1473 - (46%)
• Gaps: 250/1473 - (16%)

  Fly     6 KPTR-----KNPRQHANIISQLIFAWAIPLLYRGSRRG-LNTDDLTQCLKEDRSEQLGDRLEDQW 64
            ||.|     ::|..:|.:.|.:.|.|...|.....::| |..:|:....:.:..|....||...|
Zfish    84 KPIRSTSKYQHPVDNAGLFSFMTFNWLTSLAVLAHKKGQLFLEDIWAVSQFESCEINRRRLAGLW 148

  Fly    65 FKELERSHRKKQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLR 129
            .:|: ||  :.....||..::. |....::..::|.:                       |.||.
Zfish   149 EEEI-RS--RGNDASLRRVVWH-FCRTRLLLSILCLM-----------------------VTQLA 186

  Fly   130 NIDVNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNA 194
            ........:...|..|.|:.|                                      ::.:..
Zfish   187 GFSSPAFVVWRLLEYTQRSEP--------------------------------------DLPYGL 213

  Fly   195 TAVRSILDQTVEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRLMGARMRIACCSLIYRKTLRL 259
            ..|..:|...:...|:  ::|...|...|                 |.|:|.|..::.:.|.|||
Zfish   214 LLVLGLLATELIRSWS--HALTWALNYRT-----------------GTRLRGAILTMAFHKILRL 259

  Fly   260 SMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAML-TCYLIWLNIGIPAIVGVVGLL 323
              ::..:...|.|||:.|.|..|:.........:...||.|:| ..|.::: :|..:::|....:
Zfish   260 --RSLREKSMGELINMCSGDGQRMFEAAAVGSLLAGGPLVAVLGMAYNLFV-LGPTSLLGSAVFI 321

  Fly   324 LKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQ 388
            | ..|.....|::|:..|.:....||.||..|||::..|:.||||||.|.|...|...|..|.:.
Zfish   322 L-FYPTMMFSSRLTAYFRRKGVAVTDQRVQKMNEILNYIKFIKMYAWVKAFSQAVRRIRDEERQI 385

  Fly   389 IRYASYLRGFYLSTMVFTERSTLYITLAAAA------LMGQTITADFVFSAASYYNILQLVAAIW 447
            :....|.:...:..      :.:.:.:|:.|      |:|..:||...|:..:.:|.:.....:
Zfish   386 LERTGYFQSITVGV------APIVVVIASVATFSTHMLLGYDLTAAQAFTVVTVFNAMTFALKV- 443

  Fly   448 YPLAVSFGAEALVSLRRIQDFLMLE----------------------------GREER------- 477
            .|.:|...:||.|::.|.:..|::.                            |...:
Zfish   444 TPFSVKSLSEASVAIDRFKSLLLMAEVKMIRELPRNPSVAVEMSGASLAWETGGHSAQPSPRGTP 508

  Fly   478 ---TQGLTHKRDQEG---------GDSRAVTIKDINASWD-------------IEKPQKTLQSIN 517
               |:|...||.|..         .::....:.|::....             .::.|:||..|:
Zfish   509 HVGTRGCRKKRRQRDVPKHHAILEEETHGQLLNDVSGEMASSPKDQTLHVPTISQRLQRTLHCID 573

  Fly   518 LQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGDLSYAAQEPWLFTGSVRNNILFGE 582
            |.|:||:|..|.|.||:||:|::..:||::.:::|.|.:.||.:|.||:.|:...|.|:|||||:
Zfish   574 LSIQKGKLVGVCGSVGSGKTSLISAILGQMTLLEGTVAVDGDFAYVAQQAWILNASFRDNILFGK 638

  Fly   583 EFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQIYLMDDPL 647
            |.:.:|||.:...|.|..|...||:||.|.:|||||:||||||.|||||||:|....||::||||
Zfish   639 EMEEERYQAILSACCLRPDLAMLPSGDLTEIGERGANLSGGQRQRISLARALYSNRGIYILDDPL 703

  Fly   648 SAVDAHVGRHLFDEVIGP--RGRLAQLKATRILVTHQVHFLSEADVIVIVDQGRILRQGTYQELI 710
            ||:|||||.|:|:..|..  ||:      |.|.||||:.:|.:.|.::::..|.|..||::::|:
Zfish   704 SALDAHVGNHIFNNAIKKQLRGK------TVIFVTHQLQYLVDCDDVIVMRDGSIAEQGSHEDLM 762

  Fly   711 NSDLDFARLLERPKEEEEGENSRNQTSPLSVNSLESDDEDIPFIDGVKDGYQQLRKQSSSVHGS- 774
            |.:.|:|.:.                     |:|:..:..|..:...|.|....:....|..||
Zfish   763 NVNGDYAAMF---------------------NNLQLGETPIIEVPNKKSGSSLKKPLEKSKAGSV 806

  Fly   775 -KSLDSTQLDDNVDEDDLAEAQASGGISPRVWYEYFHA--GSTLLSFSFMVFVMVMSQVVCSSSD 836
             |...:||.|..:.:   .|.:..|.:...|:..|..|  |..:..|...:|::.:      .|.
Zfish   807 KKEKSTTQGDGQLMQ---VEERGKGSVPWAVYKVYIQALGGWPVFLFILALFILNV------GST 862

  Fly   837 FFANIWTQQEHQRSQGEATFST------FECM----------YIYGALIIAVVIMTTFRGFLFFK 885
            .|:|.|.....::..|..|...      .|.|          .:|...:..::::...||.:|.|
Zfish   863 AFSNWWLCYWIKQGSGNTTVQVGNSSVLSESMRDNPLMQHYAAVYTMSMGVMLLLKLLRGIVFVK 927

  Fly   886 ICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGI 950
            ..:.||..|||.:|..||.:.|:||||||:.||||||||||..:|..||.....|.|..:::...
Zfish   928 GTLRASSRLHDELFQKILRSPMKFFDTTPTARILNRFSKDMDEVDTRLPFQAEMFTQNVILVLFC 992

  Fly   951 LIVIGILNP---VLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIR 1012
            |.|||.:.|   |.|..::::..|..::.::::|   :||||:.:.:||..||:::|:.||..:.
Zfish   993 LAVIGSVFPWFLVAVGPLVLLFTVLHVVSRVFIR---ELKRLDNVTQSPFLSHIASSIQGLTTVH 1054

  Fly  1013 SRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCVSCIFLTSVTFSFIISSETTYSGNV- 1076
            :...:|.....:..|.|.:.:.:.|.......|.:.||.:| :.|.|:|...|:    ...|.:
Zfish  1055 AYGKEDEFLHRYQELLDQNQAPFYLFSCAMRWLAVRLDVIS-VALISITALMIV----LMHGQIP 1114

  Fly  1077 ----GLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTE---LEQEPALGEKTPPQQWPTR 1134
                ||||:.|:.|||:.|:.||..:|:..:.|||||:..|.:   ||....:..|.||..||..
Zfish  1115 PAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVERIHHYIKSLSLEAPARVKNKAPPSDWPQE 1179

  Fly  1135 GQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAH-IEGEIFIDG 1198
            |::.|.....:|..|...:|:..:.|:....|:|||||||:|||||...|:||.. ..|.|.|||
Zfish  1180 GEIVFDQTEMKYRDNLPLILKKASFTVRPKEKIGIVGRTGSGKSSLGVVLYRLVEPCGGSIKIDG 1244

  Fly  1199 IETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDVELRKAIP----GLD 1259
            :....|.|..:|:::|||||:|||||.|:|.|||||.:|::|::|.|||...:::.:.    .|:
Zfish  1245 VNICDIGLADVRSKLSIIPQEPVLFSGTVRSNLDPFSQYSEAQIWDALERTHMKECVSQLPLKLE 1309

  Fly  1260 YMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVA 1324
            ..|.|.|.|||||:|||||:||.:||..|:|:||||||.:..:||.|||.|||..|:.||.||:|
Zfish  1310 SEVVENGENFSVGERQLLCVARVLLRQCKILILDEATAAMGTETDCLIQETIRNAFQDCTTLTIA 1374

  Fly  1325 HRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEA 1367
            ||:|||:..|||:|::.|..||||.|..||.........|:.|
Zfish  1375 HRVHTVLSCDRIMVLNQGQVVEFDEPSKLLANENSRFCAMLAA 1417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cftr	NP_651269.1	MRP_assoc_pro	12..1356	CDD:188098	431/1449 (30%)
abcc5	NP_001182542.1	intraplasmic N-terminal	1..59
		transmembrane domain 1	59..149		15/64 (23%)
		MRP_assoc_pro	95..1405	CDD:188098	430/1448 (30%)
		nucleotide binding domain 1	188..248		13/116 (11%)
		transmembrane domain 2	279..379		30/101 (30%)
		nucleotide binding domain 2	403..450		10/47 (21%)