Protein Alignment Cftr and abcc3

DIOPT Version :10

• Sequence 1: NP_651269.1
• Gene: Cftr / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Sequence 2: XP_009304645.1
• Gene: abcc3 / 323301
• ZFINID: ZDB-GENE-050517-16
• Length: 1540
• Species: Danio rerio
• Alignment Length: 1454
• Identity: 468/1454 - (32%)
• Similarity: 727/1454 - (50%)
• Gaps: 240/1454 - (16%)

  Fly    12 PRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSH---- 72
            |...|..:|::.|.|...:..:|.:..|...||....|.|.||.:...|.:||..|..::|
Zfish   204 PETTAGFLSRMTFWWFTRMAIKGYKSPLENKDLWSLNKNDSSELVVPGLLNQWEVEKSKAHSSDD 268

  Fly    73 ------------------------------------RKKQKPHLRNALFRCFLGPTIINGLICFI 101
                                                :|.::|....||.|.| ||..:.|....:
Zfish   269 QNVKEQVTFTKPGSGAESNHVNESPEEAEVLLSKQQQKSRQPSFLWALLRAF-GPYFLIGSAFKL 332

  Fly   102 YIVIKTLIPAVLAQLLIQFQKTPVAQLRNIDVNDISISDSLNRTARAIPN---YVLSQAVANSSG 163
            ...:.|.|...|.::||.|.|.               ||        :|:   |.|:
Zfish   333 LQDLITFINPQLLRMLIAFTKQ---------------SD--------VPSWWGYALA-------- 366

  Fly   164 SPGDALFPKSLDKAGPLEPIQPPVEEVDHNATAVRSILDQTVEHMWNDMNSLGAVLVLSTLFCCF 228
               ..:|..||     |:.:                ||.|..::                   ||
Zfish   367 ---FLMFGTSL-----LQTL----------------ILHQHFQY-------------------CF 388

  Fly   229 LLHHVDLRQRLMGARMRIACCSLIYRKTLRLSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWI 293
                      :.|.|:|......||||.|.::.:....:..|.::||:|.|..|......|::.:
Zfish   389 ----------VTGMRLRTGIIGAIYRKALVITNEAKRSSTVGEVVNLMSVDAQRFMDLTTFLNML 443

  Fly   294 WIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNEL 358
            |..|||..|..:.:|.|:| |:::..|.:::..:|....::..|...::...:..|.|:.:|||:
Zfish   444 WSAPLQIFLALFFLWQNLG-PSVLAGVAVMVLLIPFNAFIAMKTRTYQVEQMKYKDDRIKLMNEI 507

  Fly   359 VQGIQVIKMYAWEKPFQAVVAEARRSEIKQIRYASYLRGFYLSTMVFTERSTLYITLAAAALMG- 422
            :.||:|:|:||||..|:..:.:.|:.|:..:|..:||..  ||||.:|....|....:.|..:.
Zfish   508 LNGIKVLKLYAWEPSFRDKILQIRQKELHVLRKTAYLSA--LSTMAWTSAPFLVALTSFAVFVNV 570

  Fly   423 ---QTITADFVFSAASYYNILQLVAAIWYPLAVSFGAEALVSLRRIQDFLMLEGREERTQGLTH- 483
               ..:.|:..|.:.|.:|||:....: .|..:|...:|.|||:|:|||            |.|
Zfish   571 DEKNVLDAEKAFVSLSLFNILRFPLNM-LPQVISSIVQASVSLKRLQDF------------LNHD 622

  Fly   484 KRDQEGGDSR------AVTIKDINASWDIEKPQKTLQSINLQIEKGQLCAVIGPVGAGKSSILQL 542
            :.|.|..|.:      ||::.:...|| .::.|..|.:||:.:.:|.|.||:|.||.||:|::..
Zfish   623 ELDPESVDRKSNTTEYAVSVVNGKFSW-AKRDQVILDNINVLVPQGSLLAVVGHVGCGKTSLISA 686

  Fly   543 LLGELPVIDGGVFIQGDLSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPN 607
            ||||:..:||.:.|:|.::|..|:.|:...::|:|||||..:..::|:.|...|||:.|.:.||.
Zfish   687 LLGEMEKLDGQISIRGSVAYVPQQAWIQNATLRDNILFGRPYVEQKYRCVLEACALTPDLEVLPG 751

  Fly   608 GDKTLVGERGASLSGGQRARISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQL 672
            ||.|.:||:|.:||||||.|:|||||:|..|.:||:|||||||||||.:|:||.||||.|.|.
Zfish   752 GDLTEIGEKGINLSGGQRQRVSLARALYSEADVYLLDDPLSAVDAHVAKHIFDHVIGPEGALK-- 814

  Fly   673 KATRILVTHQVHFLSEADVIVIVDQGRILRQGTYQELINSDLDFARLLERPKEEEEGENSRNQTS 737
            ..|||||||.:.||.:.:.|:::..||:...|:||:|:..:..||..|.....|:..|:..
Zfish   815 GKTRILVTHGISFLPQVNNILVLVDGRVSEMGSYQDLLRQNGAFAEFLRNYSLEDIIEDDE---- 875

  Fly   738 PLSVNSLESDDEDIP---------FIDG---VKDGYQQLRKQ----SSSVHGSKSLD-------- 778
             |:| |.:.::|:.|         .:|.   |.:..:|..:|    |:.|...|.:.
Zfish   876 -LTV-SFDEEEEEFPEDALSNHTDMVDNEPVVNEARRQFMRQMSIMSNDVENPKKMSRRRRCSER 938

  Fly   779 ------STQLDDNVDEDDLAEAQASGGISPRVWYEYFHAGSTLLSFSFMVFVMVMSQVVCSSSDF 837
                  :.:.:..|::...||...:|.:..:|::||..|...||:. |:.|:..........::|
Zfish   939 KHPETPTEKKEPKVEKLIQAETTETGRVKLQVYWEYVKAIGPLLAL-FICFLYGCQSAAAIGANF 1002

  Fly   838 FANIWTQQE-HQRSQGEATFSTFECMY----IYGALIIAVVIMTTFRGFLFFKIC--------MH 889
            :.:.||... |.|:|        |.:.    :|.||.|:       :|.|...||        :.
Zfish  1003 WLSEWTNDALHNRTQ--------EMLQTRVGVYAALGIS-------QGVLILSICLLCRAYSTLR 1052

  Fly   890 ASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMF----GI 950
            |::..|..|...:|.|...||:.|||||:|||||||:..||.|:|    |.|.|.:..|    .:
Zfish  1053 AARHTHQHMLNSVLRAPQAFFEATPSGRVLNRFSKDVDTIDSLIP----DNIDIWMRTFWYTVNV 1113

  Fly   951 LIVIGILNPVLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQ 1015
            |:|..:|.|:.:..::.:.:....:.:.|:..|:.|||||.:.|||::||.|.|:||.::||:..
Zfish  1114 LMVCSVLTPIFLIVIVPLMLFYWWVQRFYVATSRQLKRLESVSRSPIYSHFSESITGTSVIRAYG 1178

  Fly  1016 LQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCV-SCIFLTSVTFSFIISSETTYSGNVGLA 1079
            .........|...|.:...:...:..|..||:.::.: :||.|.:..|: :...:....|.|||:
Zfish  1179 RNAAFVLMSDNKVDENQKSYYPGIVSNRWLGVRIEFIGNCIVLFAALFA-VTGKDKLSPGLVGLS 1242

  Fly  1080 IAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTELEQEP--ALGEKTPPQQWPTRGQVEFRNM 1142
            ::.|:.:|..:.:.||..::....:.:||||.:|:|.:.|.  .:.||.||..||..|.|||.:.
Zfish  1243 VSYALQVTMSLNWMVRMTSDLESNIVAVERVKEYSETQTEAPWEVLEKKPPPDWPPLGNVEFVDY 1307

  Fly  1143 SCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAH-IEGEIFIDGIETGTISL 1206
            |.||......||:|::|.:..|.|:||||||||||||:...||||.. ..|||.||.::...|.|
Zfish  1308 SVRYREGLDLVLKNISLKVRGGEKIGIVGRTGAGKSSMTLCLFRLLEAAAGEIVIDDVKISEIGL 1372

  Fly  1207 EILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDVELRKAIPG----LDYMVTERGG 1267
            ..||::::||||:|||||.|:|.||||||||:|.|:|.|||...|:|.:..    |:...:|.|.
Zfish  1373 HDLRSKLTIIPQEPVLFSGTLRMNLDPFERYSDEEVWKALELSHLQKFVTNQAAKLELECSEGGE 1437

  Fly  1268 NFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMD 1332
            |.|||||||:|||||:||..::||||||||.||.:||.|||.|||.:|:.|||.|:||||:|:||
Zfish  1438 NLSVGQRQLVCLARALLRKTRILVLDEATAAVDLETDDLIQSTIRTEFQDCTVFTIAHRLNTIMD 1502

  Fly  1333 SDRIIVMDAGVAVEFDVPYLLLKK 1356
            ..|::|:|.|...|||.|..|:.:
Zfish  1503 YTRVLVLDKGQIAEFDTPTNLMNQ 1526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cftr	NP_651269.1	MRP_assoc_pro	12..1356	CDD:188098	468/1452 (32%)
abcc3	XP_009304645.1	MRP_assoc_pro	10..1539	CDD:188098	468/1454 (32%)