DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and Abcc10

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_001101671.1	Gene:	Abcc10 / 316231	RGDID:	1306696	Length:	1494	Species:	Rattus norvegicus

Alignment Length:	1420	Identity:	436/1420 - (30%)
Similarity:	696/1420 - (49%)	Gaps:	228/1420 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSHRKKQKPHLRNA 83
            :|:..:||..|||.||.|..|.....| |       :|..||...:.....::| .|:...|..|
  Rat   222 LSRFSYAWLAPLLARGVRGELRQPQDT-C-------RLPRRLHPAYLARAFQAH-WKEGAQLWRA 277

  Fly    84 LFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNIDVNDISISDSLNRTARA 148
            |:..|....|..||:..:..::....|.:|: ||:.|          ::.....:|..|
  Rat   278 LYGAFGCCYIALGLLKMVGTMLGFSGPLLLS-LLVGF----------LEEGQEPLSHGL------ 325

  Fly   149 IPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNATAVRSILDQTVEHMWNDMN 213
              .|||..|    |||                               .:.::|          .|
  Rat   326 --LYVLGLA----SGS-------------------------------VISAVL----------QN 343

  Fly   214 SLGAVLVLSTLFCCFLLHHVDLRQRLMGARMRIACCSLIYRKTLRLSMKTAGQTPAGYLINLLSN 278
            ..|..:...||                  :.|:|..|::|||||:|.   ..:.|.|.::|||..
  Rat   344 QYGYEVRKVTL------------------QARVAVLSILYRKTLKLG---PSRPPTGEVLNLLGT 387

  Fly   279 DVNR-LDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVPVQTALSKVTSVLRM 342
            |..| |::...| |..|.:|||..:|.||::..:|:..:.|:| |.|..|||...::........
  Rat   388 DSERLLNFAGSF-HEAWGLPLQLAITLYLLYEQVGVAFLAGLV-LALLLVPVNKVIATRIMANNQ 450

  Fly   343 RIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIRYASYLRG--FYL-STMV 404
            .:....||||.:|.||:.||:|:|.:.||:.....|...|..|:.::|...||..  .|| :.:.
  Rat   451 EMLRHKDARVKLMTELLSGIRVLKFFRWEQALGDRVKACRTQELGRLRVIKYLDAACVYLWAALP 515

  Fly   405 FTERSTLYITLAAAALMGQTITADFVFSAASYYNILQLVAAIWYPLAVSFGAEALVSLRRIQDFL 469
            ......::||.   .|:|..:||..||:|.:..::| ::....:|..::...|:.|||.|||.||
  Rat   516 VVICIVIFITY---VLLGHQLTATKVFTALALVHML-ILPLNNFPWVINGLLESKVSLDRIQRFL 576

  Fly   470 MLEGREERTQGLTHKRDQEGGDSRAVTIKDINASWD-IEKPQKTLQSINLQIEKGQLCAVIGPVG 533
            .|........   :..|.....|..:.:.:...||| ....|||..| :||::||.|..::|.||
  Rat   577 DLPSYSPEAY---YSPDPPTEPSTVLELHEALFSWDPTGTSQKTFIS-HLQVKKGMLVGIVGKVG 637

  Fly   534 AGKSSILQLLLGELPVIDGGVFIQGDLS----YAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTR 594
            .||||:|..:.|||..:.|.|.: .|||    .|.||||:...::|:|:|||:.||.:.|:||..
  Rat   638 CGKSSLLAAITGELHRLCGWVAV-SDLSKGFGLATQEPWIQCATIRDNVLFGKTFDAQLYREVLE 701

  Fly   595 CCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQIYLMDDPLSAVDAHVGRHLF 659
            .|||:.|...||.||:|.|||:|.:|||||||||:||||||:...:||:||||:||||.|..||.
  Rat   702 ACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKTLYLLDDPLAAVDADVANHLL 766

  Fly   660 DE-VIGPRGRLAQLKATRILVTHQVHFLSEADVIVIVDQGRILRQGTYQELINSDLDFARLLERP 723
            .. ::|..|.     .||:|.||:..:|..||::::::.||::|.|...|::
  Rat   767 HRCILGVLGH-----TTRLLCTHRTEYLERADLVLLMEAGRLVRAGPPSEIL------------- 813

  Fly   724 KEEEEGENSRNQTSPLSVNSLESDDEDIPFIDGVKDGYQQLRKQSSSVHGSKSLDSTQLDDNVDE 788
                    ...|.:|.::    :|.|.:     ...|      ||.|||        .|:...:|
  Rat   814 --------PLVQAAPTAL----ADKEQV-----TDSG------QSPSVH--------NLEKTTEE 847

  Fly   789 DDLA----------EAQASGGISPRVWYEYFHAGSTLLSFSFMVFVMVMSQVVCSSSDFFANIWT 843
            .|:|          |:::.|.::..|:..|:.|..:.|:.:.::.:::| |...:.:|::...|.
  Rat   848 LDVAQNTSGRLVQEESKSEGAVALHVYRAYWRAMGSGLATAILISLLLM-QATRNGADWWLAHWL 911

  Fly   844 QQ--------------EHQRSQG-------------------EATFSTFECMYIYGALIIAVV-- 873
            .|              ...||.|                   :||.:....::.|..:...:.
  Rat   912 SQLKAGRNSSEERPASSSPRSMGFFSPRLLLFSPGNLYIPLHKATSNGSSDVHFYLTVYATIAGV 976

  Fly   874 --IMTTFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRA 936
              :.|..|..||....:.|:..||.|:...:|.|.:.|:|:|||||:|||||.|:..:|:.||..
  Rat   977 NSLCTLLRAVLFAAGALQAAASLHHRLLHRLLMAPVTFYDSTPSGRVLNRFSSDVACVDDSLPFL 1041

  Fly   937 MMDFIQIALVMFGILIVIGILNPVLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHL 1001
            :...:..::.:.|:|.|:|...|.|:..:..::.:...:.:.|....::|:||..:..||::|||
  Rat  1042 LNILLANSVGLLGLLAVLGSGLPWLLLLLPPLSFIYYGVQRRYRASFRELRRLGSLTLSPLYSHL 1106

  Fly  1002 SASLTGLAIIRSRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCVSCIFLTSVTFSFII 1066
            :.:|.||.::|:........:|...|.:::......:.|....|.:.|..:....::::....::
  Rat  1107 ADTLAGLPVLRAAGATYRFEEENQRLLELNQRCQFASYATMQWLDIRLQLMGAAVVSAIAGIALV 1171

  Fly  1067 SSETTYS--GNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYT-ELEQEPALGEKTPP 1128
            ..:...:  |.|||.::.|:.|||::...|....::...|.||||:.:|: ::.|||   ...||
  Rat  1172 QHQQGLANPGLVGLVLSYALSLTGLLSGLVSSFTQTEAMMVSVERLEEYSCDIPQEP---HGQPP 1233

  Fly  1129 Q------QWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRL 1187
            |      .|.|:|.|||:::...|.|.....|..:...:|.|.|:|||||||:|||||...||||
  Rat  1234 QSPHQRVSWLTQGSVEFQDVVLVYRPGLPNALDGVTFRVEPGEKLGIVGRTGSGKSSLFLVLFRL 1298

  Fly  1188 AH-IEGEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDV-- 1249
            .. ..|::.:||::|..:.|..||:::::|||:|.|||.|:|.||||...:.|..||.|||..
  Rat  1299 LEPSAGQVLLDGVDTSQLELAELRSQLAVIPQEPFLFSGTVRENLDPQGLHEDRALWQALEQCHL 1363

  Fly  1250 -ELRKAIPGLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRI 1313
             |:..||.|||..:.|||.:.|:|||||||||||:|.:.|:|.:|||||:||.:||.|:|:||..
  Rat  1364 SEVAMAIGGLDGELGERGRDLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICR 1428

  Fly  1314 KFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEAT 1368
            :|...||||:||||:|:::|||::|:.||..||.|.|..|..:.....||:::::
  Rat  1429 RFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPSALRNQPHSLFRQLLQSS 1483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	436/1417 (31%)
		ABC_membrane	214..441	CDD:294371	67/230 (29%)
		ABCC_MRP_domain1	495..699	CDD:213217	94/209 (45%)
		ABC_membrane	863..1088	CDD:294371	57/230 (25%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	108/218 (50%)
Abcc10	NP_001101671.1	CFTR_protein	211..1485	CDD:273530	436/1420 (31%)
		ABC_membrane	290..552	CDD:294371	86/352 (24%)
		ABCC_MRP_domain1	599..802	CDD:213217	94/209 (45%)
		ABC_membrane	957..1190	CDD:294371	55/232 (24%)
		PBP2_NikA_DppA_OppA_like	<1201..>1274	CDD:294989	22/75 (29%)
		ABCC_MRP_domain2	1246..1465	CDD:213211	108/218 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810