DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and Abcb5

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	XP_006240775.1	Gene:	Abcb5 / 314537	RGDID:	1566342	Length:	1255	Species:	Rattus norvegicus

Alignment Length:	1198	Identity:	268/1198 - (22%)
Similarity:	488/1198 - (40%)	Gaps:	294/1198 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   317 VGVVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEA 381
            :|:|..|:|:..:..|:.. ||.|.|       |...:.:.:|..:...::.|:.|  ...|||.
  Rat   195 IGLVISLIKSWKLSLAILS-TSPLIM-------AASALCSRMVISLTSKELDAYSK--AGAVAEE 249

  Fly   382 RRSEIKQI-----------RYASYLRGFYLSTMVFTERSTLYITLAAAALMGQTITADFVFSAAS 435
            ..|.|:.:           ||...|:          :.....|..|.|:.:  ::.|.:.|...:
  Rat   250 ALSSIRTVTAFGAQEKEIQRYTQNLK----------DAKDAGIKRAIASKL--SLGAVYFFMNGA 302

  Fly   436 YYNILQLVAAIWYPLAVSFGAEALVSLRRI---------------------QDFLMLEGREERTQ 479
            |      ..|.||..::.||.|...::..|                     :.|.:..|......
  Rat   303 Y------GLAFWYGTSLIFGGEPGYTVGTILAVFFSVIHSSYCIGSVAPHLETFTIARGAAFNIF 361

  Fly   480 GLTHKRDQEGGDSRA----------VTIKDINASWDIEKPQKTLQSINLQIEKGQLCAVIGPVGA 534
            .:..|:......|.|          :..|:::.|:......|.|:..||:|:.|:..|::||.|:
  Rat   362 HVIDKKPNIDNFSTAGYKPESIEGNIEFKNVSFSYPSRPSAKILKGFNLKIKSGETVALVGPSGS 426

  Fly   535 GKSSILQLLL-------GELPVIDGGVFIQG------DLSYAAQEPWLFTGSVRNNILFGEEFDR 586
            ||::.:|||.       |.:.|.:..:..|.      .:...:|||.||..::.|||.||.|...
  Rat   427 GKTTTVQLLQRLYDPEEGCITVDENDIRTQNVRHYREQIGVVSQEPVLFGTTIGNNIKFGREGVS 491

  Fly   587 KRYQEVTRCCALSTDF-QQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQIYLMDDPLSAV 650
            :...|.....|.:.|| ...|....|||||:||.:||||:.||::|||:.:..:|.::|:..||:
  Rat   492 EEEMEQAAREANAYDFIMAFPKKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSAL 556

  Fly   651 DAHVGRHLFDEVI--GPRGRLAQLKATRILVTHQVHFLSEADVIVIVDQGRILRQGTYQELINS- 712
            |.. ...|....:  ..:||      |.::|.|::..:..||:||.:..|.::.:|.:.||:..
  Rat   557 DTE-SESLVQAALEKASKGR------TTLVVAHRLSTIRGADLIVTMKDGEVVEKGIHAELMAKQ 614

  Fly   713 ----DLDFARLLERPKEEEEGE------NSRNQTSPLSVNSLESDDEDIPFIDGVKDGYQQLRKQ 767
                .|..|:.:::..|:.|..      |:.| .|..:|||.:|     |..|..::.   :..|
  Rat   615 GLYYSLAVAQDIKKVDEQMESRTCSAAGNASN-GSLCNVNSAKS-----PCTDQFEEA---VPHQ 670

  Fly   768 SSSVHGSKSLDSTQLDDN----VDEDDLAEAQASGGISPRVWYEYFHAGSTLLSFSFMVFVMVMS 828
            .:::.....|...:|..:    |....||.| .:|.:.|                   .|.::..
  Rat   671 KTTLPEVSLLKIFKLSKSEWPFVVLGTLASA-LNGSVHP-------------------AFSIIFG 715

  Fly   829 QVVCSSSDFFANIWTQQEHQRSQGEATFSTFECMYIYGALIIAVVIMTTF--RGFLFFKICMHAS 891
            ::|....|              :.:.|......:|....:::.:|.:.|:  :|..:.:    |.
  Rat   716 KLVTMFED--------------KNKTTLKQDAELYSMMLVVLGIVALVTYLMQGLFYGR----AE 762

  Fly   892 KVLHDRM----FACILHATMRFFD--TTPSGRILNRFSKDM----GA-----------IDELLPR 935
            ::|..|:    |..:|:..|.::|  ...:|.:....:.|:    ||           :..:...
  Rat   763 EILAMRLRHSAFKAMLYQDMAWYDEKDNSTGALTTTLAVDVAQIRGAATSRLGIITQDVTNMSLS 827

  Fly   936 AMMDFI---QIALVMFGILIVIGILNPVLVAAMLVVAVVDVLIL----KLYLRPSQDLKRLEGIC 993
            .::.|:   ::.|::.....::.:...:..|||...|..|...|    |:.....::::.:..:.
  Rat   828 ILISFVYGWEMTLLILSFAPILAVTGMIQTAAMAGFANKDKQELKRAGKIATEAVENIRTVVSLT 892

  Fly   994 RSPVFSHL--------------SASLTGLAIIRSRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTT 1044
            |...|.|:              .|.:||...        .|:..|     ||
  Rat   893 REKAFEHMYEETLRTQHRNALKRAHITGSCY--------AVSHAF-----VH------------- 931

  Fly  1045 LGLWLDCVSCIFLTSVTFSFIISSETTYSGNVGLAIAQAMILT--GM------VQYGVRQVAESL 1101
                       |..:..|.|            |..:.||..:|  ||      :.||...:.|:|
  Rat   932 -----------FAHAAGFRF------------GAYLIQAGRMTPEGMFIVFTAIAYGAMAIGETL 973

  Fly  1102 QQMTSVERVLQ-----YTELEQEPAL------GEKTPPQQWPTRGQVEFRNMS----CRYDPNGS 1151
            .......:...     :..|:.:|::      |||..    ...|.:|||.:|    ||.:   .
  Rat   974 VWAPEYSKAKAGAAHLFALLKNKPSIDSCSQNGEKPD----ACEGNLEFREVSFFYPCRPE---V 1031

  Fly  1152 PVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAH-IEGEIFIDGIETGTISLEILRTRISI 1215
            |||::::|:||.|..|..||.:|.|||:.:..|.|... ::|::.:||::...::::.||::.:|
  Rat  1032 PVLQDMSLSIEKGKTVAFVGSSGCGKSTCVQLLQRFYDPMKGQVLLDGVDVKELNVQWLRSQTAI 1096

  Fly  1216 IPQDPVLFSATIRYNLDPFERYTDAELWSALEDVE-------LRKAIPGL----DYMVTERGGNF 1269
            :.|:||||:.:|..|:    .|.|......||:::       :...|.||    ...|..||.:.
  Rat  1097 VSQEPVLFNCSIAENI----AYGDNSRMVPLEEIKEVADAANIHSFIEGLPGKYSTQVGLRGMHL 1157

  Fly  1270 SVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSD 1334
            |.||:|.|.:|||:||..|:|:|||||:.:|.:::.::|:.:....:..|.|.|||||.|:.::|
  Rat  1158 SGGQKQRLAIARALLRKPKILLLDEATSALDNESEKMVQQALDKARRGRTCLVVAHRLSTIQNAD 1222

  Fly  1335 RIIVMDAGVAVEFDVPYLLLKKSQGHLR 1362
            .|:|:..|...|......||:..:.:.:
  Rat  1223 MIVVLQNGRIKEQGTHQELLRNGETYFK 1250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	268/1198 (22%)
		ABC_membrane	214..441	CDD:294371	27/134 (20%)
		ABCC_MRP_domain1	495..699	CDD:213217	67/219 (31%)
		ABC_membrane	863..1088	CDD:294371	41/270 (15%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	78/230 (34%)
Abcb5	XP_006240775.1	PTZ00265	48..1252	CDD:240339	268/1198 (22%)
		ABC_membrane	53..334	CDD:279056	34/166 (20%)
		ABC_MTABC3_MDL1_MDL2	387..624	CDD:213216	72/243 (30%)
		ABC_membrane	697..963	CDD:279056	52/352 (15%)
		ABC_MTABC3_MDL1_MDL2	1017..1254	CDD:213216	79/241 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000