DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG5789 and Abcc12

DIOPT Version :9

Sequence 1:NP_001247286.1 Gene:CG5789 / 42928 FlyBaseID:FBgn0039207 Length:1402 Species:Drosophila melanogaster
Sequence 2:XP_008770597.1 Gene:Abcc12 / 291923 RGDID:735100 Length:1378 Species:Rattus norvegicus


Alignment Length:1489 Identity:475/1489 - (31%)
Similarity:739/1489 - (49%) Gaps:284/1489 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 NPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSHRKK 75
            ||...|.::|...|:|..|::.|..:..|..|.|......|.|:....||:..|.:|:||     
  Rat    44 NPVDDAGLLSFATFSWLTPVMIRSYKHTLTVDTLPPLSPYDSSDVNAKRLQILWDEEIER----- 103

  Fly    76 QKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNIDVNDISISD 140
                         :||.                 .|.|.:::.:||:|                 
  Rat   104 -------------VGPE-----------------RASLGRVVWKFQRT----------------- 121

  Fly   141 SLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNATAVRSILDQTV 205
                       .||...|||.......||.|..|                          :.|.:
  Rat   122 -----------RVLMDVVANILCIIMAALGPTVL--------------------------IHQIL 149

  Fly   206 EHMWN-DMNSLGAVLVLSTLFCCFLLHHVDLRQRLMGA-----------RMRIACCSLIYRKTLR 258
            :|:.| ....:|..:.|     |..|...:..:.|..|           |:::|..:||::..  
  Rat   150 QHVTNISSGHIGISICL-----CLALFATEFTKVLFWALAWAINYRTAIRLKVALSTLIFKNL-- 207

  Fly   259 LSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQA-----MLTC--YLIWLNIGIPAI 316
            ||.||.....||.::|:||:|...|....:|      .||.|     |:.|  |..:: :|..|:
  Rat   208 LSFKTLTHISAGEVLNVLSSDSYSLFEAALF------CPLPATIPILMVVCAVYAFFI-LGSTAL 265

  Fly   317 VGVVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEA 381
            ||:...|: .:|:|..::|:.|..|......||.||..|||.:..|::||||||||.|...:.:.
  Rat   266 VGICVYLI-FIPIQMFMAKLNSAFRRSAISVTDKRVQTMNEFLTCIKLIKMYAWEKSFMNTIHDI 329

  Fly   382 RRSEIKQIRYASYLRGF------YLSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNIL 440
            |:.|.|.:..|.|::..      .:||:......|.:|.|.      :|:||...||..:.:|::
  Rat   330 RKREKKLLEKAGYVQSGNSALAPIVSTIAIVSTFTCHIFLK------RTLTAPVAFSVIAMFNVM 388

  Fly   441 QLVAAIWYPLAVSFGAEALVSLRRIQ------------------DFLMLEGREERT--QGLTHKR 485
            :...|| .|.:|...|||.|||||::                  |.::|......|  |.:..||
  Rat   389 KFSIAI-LPFSVKAVAEASVSLRRMKKILVAKSPPSYITQPEDPDTILLLANATLTWEQEINRKR 452

  Fly   486 DQ-EGGDSRAVTIKDINASWDIEK----------------PQKTLQSINLQIEKGQLCAVIGPVG 533
            .. :..|.|....|...|....|:                |:..|.:|:..:.||::..:.|.||
  Rat   453 GPLKTQDQRRHVFKKQRAELYSEQSLSDQGVASPERQSGSPKSVLHNISFVVRKGKVLGICGNVG 517

  Fly   534 AGKSSILQLLLGELPVIDGGVFIQGDLSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCAL 598
            :||||::..|||::.:..|.|.:.|.|:|.:|:.|:|.|:||.||||||:::.:|||.....|.|
  Rat   518 SGKSSLISALLGQMQLQKGVVAVSGPLAYVSQQAWIFHGNVRENILFGEKYNHQRYQHTVHVCGL 582

  Fly   599 STDFQQLPNGDKT-------LVGERGASLSGGQRARISLARAVYKPAQIYLMDDPLSAVDAHVGR 656
            ..|...||.||.|       .:||||.:||||||.|||||||||...|:||:||||||||||||:
  Rat   583 QKDLNSLPYGDLTECHYPHLQIGERGVNLSGGQRQRISLARAVYANRQLYLLDDPLSAVDAHVGK 647

  Fly   657 HLFDEVIGP--RGRLAQLKATRILVTHQVHFLSEADVIVIVDQGRILRQGTYQELINSDLDFARL 719
            |:|:|.|..  :|:      |.:|||||:.||...|.:::::.|.|..:||::||:.....:|:|
  Rat   648 HVFEECIKKTLKGK------TVVLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKL 706

  Fly   720 LE-----RPKEEE------------EGENSRNQTSPLSVNSLESDDEDIPFIDGVKDGYQQLRKQ 767
            :.     :.|:.|            |.:..|::.:.|:    ..|:.|    :|.:...::....
  Rat   707 IHNLRGLQFKDPEHIYNVAMVETLKESQAQRDEDAVLA----SGDERD----EGKEPETEEFVDI 763

  Fly   768 SSSVHGSKSLDSTQLDDNVDEDDLAEAQASGGISPRVWYEYFHA-GSTLLSFSFM-VFVMVM--- 827
            .:.||....::|.|               .|.::.:.::.|..| |..|:||..: :|.::|   
  Rat   764 KAPVHQLIQIESPQ---------------EGIVTWKTYHTYIKASGGYLVSFLVLCLFFLMMGSS 813

  Fly   828 --------------SQVVCS--SSDFFANIWTQQEHQRSQGEATFSTFECMY--IYGALIIAVVI 874
                          |||:|:  |::...|:     :|..|     .|...||  :|.|.:::|:.
  Rat   814 AFSTWWLGLWLDSGSQVICAPQSNETACNV-----NQTLQ-----DTKHHMYQLVYIASMMSVLT 868

  Fly   875 MTTFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMD 939
            ....:||.|....:.||..||:|:|..|:.:.|.||||||:||::|||||||..:|..||....:
  Rat   869 FGIIKGFTFTNTTLMASSSLHNRVFNKIVSSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAEN 933

  Fly   940 FI-QIALVMFGILIVIGILNPVLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSA 1003
            |: |.::|:| ||:::....||::..:..:|::..::|:::.|..|:||::|.|.|||.|||:::
  Rat   934 FLQQFSMVVF-ILVIMAASFPVVLVVLAGLAILFFILLRIFHRGVQELKQVENISRSPWFSHITS 997

  Fly  1004 SLTGLAIIRSRQLQDVVAKEFDLLQDVHSS-VWQLTMAVN---TTLGLWLDCVSCIFLTSVTFSF 1064
            |:.||.:|.:...:|....:|..|.|.:|| :.....|:.   ..:.:.::.|:.:....||.||
  Rat   998 SMQGLGVIHAYDKKDDCISKFKALNDENSSHLLYFNCALRWFALRMDILMNIVTFVVALLVTLSF 1062

  Fly  1065 IISSETTYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTEL---EQEPALGEKT 1126
                .:..:.:.||:::..:.|:|::|..||...|:..:.||.|.:.:|...   |...:....|
  Rat  1063 ----SSISASSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSAELMREYISTCVPEHTQSFKVGT 1123

  Fly  1127 PPQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAH-I 1190
            .|:.||:||::.|::...||..|...||..|||.|::|..||||||||:|||||..|||||.. .
  Rat  1124 CPKDWPSRGEITFKDYRMRYRDNTPLVLDGLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPA 1188

  Fly  1191 EGEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDVELRKAI 1255
            .|.||||.::..|:.||.|||::::||||||||..|:||||||...:||..||..||...:|..|
  Rat  1189 SGTIFIDEVDICTVGLEELRTKLTMIPQDPVLFVGTVRYNLDPLGSHTDEMLWHVLERTFMRDTI 1253

  Fly  1256 ----PGLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFK 1316
                ..|...|||.|.|||||:|||||:|||:|||:|:::||||||::|.:||.|:|.||:..||
  Rat  1254 MKLPEKLQAEVTENGENFSVGERQLLCMARALLRNSKIILLDEATASMDSKTDTLVQSTIKEAFK 1318

  Fly  1317 QCTVLTVAHRLHTVMDSDRIIVMDAG-----VAVEFDVPYLLLKKSQGHLRQMVEATGG 1370
            .|||||:||||:||::.|.::||:.|     :.:|||.|.:|.:|.......::.|..|
  Rat  1319 SCTVLTIAHRLNTVLNCDLVLVMENGKVQEVLVIEFDKPEVLAEKPDSAFAMLLAAEVG 1377

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5789NP_001247286.1 CFTR_protein 9..1367 CDD:273530 473/1484 (32%)
ABC_membrane 214..441 CDD:294371 71/250 (28%)
ABCC_MRP_domain1 495..699 CDD:213217 94/228 (41%)
ABC_membrane 863..1088 CDD:294371 74/231 (32%)
ABCC_MRP_domain2 1135..1350 CDD:213211 119/224 (53%)
Abcc12XP_008770597.1 CFTR_protein 44..1348 CDD:273530 467/1458 (32%)
ABC_membrane 127..388 CDD:294371 81/307 (26%)
ABCC_MRP_domain1 487..686 CDD:213217 91/204 (45%)
ABC_membrane 802..1084 CDD:294371 87/296 (29%)
ABCC_MRP_domain2 1132..1357 CDD:213211 119/224 (53%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.730

Return to query results.
Submit another query.