Protein Alignment Cftr and Abcc6

DIOPT Version :10

• Sequence 1: NP_651269.1
• Gene: Cftr / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Sequence 2: XP_006541009.1
• Gene: Abcc6 / 27421
• MGIID: 1351634
• Length: 1500
• Species: Mus musculus
• Alignment Length: 1326
• Identity: 377/1326 - (28%)
• Similarity: 618/1326 - (46%)
• Gaps: 198/1326 - (14%)

  Fly     5 AKPTRKNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQW----- 64
            ::|....|...|:..|:.:|.||..||:||.::.|...||....:|:.||:|..:||.:|
Mouse   271 SQPLNPCPEAEASFPSKAMFWWASGLLWRGYKKLLGPKDLWSLGRENSSEELVSQLEREWRRSCN 335

  Fly    65 ------------------FKELERSHRKKQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPA 111
                              |.:.|||.|   .|.|| |::|.|....::..|...|....:..:|.
Mouse   336 GLPGHKGHSSVGAPETEAFLQPERSQR---GPLLR-AIWRVFRSTFLLGTLSLVISDAFRFAVPK 396

  Fly   112 VLAQLLIQFQKTPVAQLRNIDVNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDK 176
            :|: |.::|..                    :|.:.|...::|:..:
Mouse   397 LLS-LFLEFMG--------------------DRNSSAWTGWLLAVLM------------------ 422

  Fly   177 AGPLEPIQPPVEEVDHNATAVRSILDQTVEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRLMG 241
                           ..|..::::.:|  :||:                          |.:::.
Mouse   423 ---------------FAAACLQTLFEQ--QHMY--------------------------RAKVLQ 444

  Fly   242 ARMRIACCSLIYRKTLRLSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYL 306
            .|:|.|...|:|||.|.||..:...:.||.::||:|.|:.||....|:::.:|::.|...:....
Mouse   445 MRLRTAITGLVYRKVLVLSSGSRKSSAAGDVVNLVSVDIQRLAESIIYLNGLWLLFLWIFVCFVY 509

  Fly   307 IWLNIGIPAIVGVVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWE 371
            :|..:| |:.:..|.:.|..:|:...::|.....:.....:..:|..:.:.:::.::.||.:.||
Mouse   510 LWQLLG-PSALTAVAVFLSLLPLNFFITKKRGFHQEEQMRQKASRARLTSSMLRTVRTIKSHGWE 573

  Fly   372 KPFQAVVAEARRSEIKQIRYASYLRGFYLSTMVFTERSTLYITLAAAAL-----MGQTITADFVF 431
            ..|...:...|..|:..::.::.|  |.:|.:.| :.||..:.|...|:     ....:.|:..|
Mouse   574 HAFLERLLHIRGQELSALKTSTLL--FSVSLVSF-QVSTFLVALVVFAVHTLVAEDNAMDAEKAF 635

  Fly   432 SAASYYNILQLVAAIWYPLAVSFGAEALVSLRRIQDFLMLEGREERTQGLTHKRDQEGGDSRAVT 496
            ...:..:||....| :.|.:|....:|.||..|:..||.||  |....|:.....:.....| ::
Mouse   636 VTLTVLSILNKAQA-FLPFSVHCIVQARVSFDRLAAFLCLE--EVDPNGMIASNSRRSSKDR-IS 696

  Fly   497 IKDINASWDIEKPQKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGDLS 561
            :.:...:|..|.| ..|..|||.:.:|.|.||:|||||||||:|..|||||..::|.|.|:|.::
Mouse   697 VHNGTFAWSQESP-PCLHGINLTVPQGCLLAVVGPVGAGKSSLLSALLGELLKVEGSVSIEGSVA 760

  Fly   562 YAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRA 626
            |..||.|:...||..|:.|.:|.|....|:|...|||.:|....|.|..|.:||:|.:|||||:.
Mouse   761 YVPQEAWVQNTSVVENVCFRQELDLPWLQKVLDACALGSDVASFPAGVHTPIGEQGMNLSGGQKQ 825

  Fly   627 RISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRILVTHQVHFLSEADV 691
            |:||||||||.|.|||:||||:|:||||.:.:|.:||||.|.|.  ..|||||||.:|.|.:||.
Mouse   826 RLSLARAVYKKAAIYLLDDPLAALDAHVSQQVFKQVIGPSGLLQ--GTTRILVTHTLHVLPQADR 888

  Fly   692 IVIVDQGRILRQGTYQELINSDLDFARLLERPKEEEEGENSRNQTSPLSVNSLESDDEDIPFIDG 756
            |:::..|.|...|:||:|:..:.....||:..::            |...:...:.|:...|..|
Mouse   889 ILVLANGTIAEMGSYQDLLQRNGALVGLLDGARQ------------PAGTHDAATSDDLGGFPGG 941

  Fly   757 VKDGYQQLR---KQSSSVHGSKSLDSTQLDDNVDEDDLAEAQAS------GGISPRVWYEYFHAG 812
            .:...:..|   .:::.|.| :|....|::.::|:.:.....|.      |.:...::..|..|.
Mouse   942 GRPTCRPDRPRPTEAAPVKG-RSTSEVQMEASLDDPEATGLTAEEDSVRYGRVKTTIYLSYLRAV 1005

  Fly   813 STLLSFSFMVFVMVMSQVVCSSSDFFANIWT-------QQEHQRSQGEATFSTFECMYIYGALI- 869
            .|.|. ::.:|:.:..||...|..::.::|.       :|.|...:| ..|....|:...|...
Mouse  1006 GTPLC-TYTLFLFLCQQVASFSQGYWLSLWADDPVVDGRQMHAALRG-WVFGLLGCLQAIGLFAS 1068

  Fly   870 IAVVIMTTFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLP 934
            :|.|.:...|          ||.:|...:...:..:.:.||:.||.|.:||||||:...:|..:|
Mouse  1069 MAAVFLGGAR----------ASGLLFRSLLWDVARSPIGFFERTPVGNLLNRFSKETDTVDVDIP 1123

  Fly   935 RAMMDFIQIALVMFGILIVIGILNPVLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFS 999
            ..:...:..|..:..:.:.:.:..|:.:.|:|.:.|:......||:..|..|:|||....|.|.|
Mouse  1124 DKLRSLLTYAFGLLEVGLAVTMATPLAIVAILPLMVLYAGFQSLYVATSCQLRRLESARYSSVCS 1188

  Fly  1000 HLSASLTGLAIIRSRQLQDVVAKEFDLLQDVHSSV---------WQLTMAVNTTL---GLWLDCV 1052
            |::.:..|..::|:.:.|.....:.|.|.|.:..|         |   :|.|..|   ||.....
Mouse  1189 HMAETFQGSLVVRAFRAQASFTAQHDALMDENQRVSFPKLVADRW---LATNLELLGNGLVFVAA 1250

  Fly  1053 SCIFLTSVTFSFIISSETTYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTELE 1117
            :|..|:....|         :|.||.:::.|:.:|..:|:.||...:....|.:||||..|..:.
Mouse  1251 TCAVLSKAHLS---------AGLVGFSVSAALQVTQTLQWVVRSWTDLENSMVAVERVQDYARIP 1306

  Fly  1118 QEPALGEKTPPQQ--WPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSL 1180
            :|......|...|  ||..||:|||:...|:.|.....::.::|.|.||.|||||||||||||||
Mouse  1307 KEAPWRLPTCAAQPLWPCGGQIEFRDFGLRHRPELPLAVQGVSLKIHAGEKVGIVGRTGAGKSSL 1371

  Fly  1181 IGALFRLAH-IEGEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWS 1244
            ...|.||.. .||.|:|||:....:.|..||:||:|||||||||..::|.|||..:.:||..:|:
Mouse  1372 AWGLLRLQEAAEGNIWIDGVPITHVGLHTLRSRITIIPQDPVLFPGSLRMNLDLLQEHTDEGIWA 1436

  Fly  1245 ALEDVELR---KAIPG-LDYMVTERG 1266
            |||.|:|:   .::|| |.|....:|
Mouse  1437 ALETVQLKAFVTSLPGQLQYECAGQG 1462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cftr	NP_651269.1	MRP_assoc_pro	12..1356	CDD:188098	376/1319 (29%)
Abcc6	XP_006541009.1	MRP_assoc_pro	101..1465	CDD:188098	377/1326 (28%)