DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and Abcc5

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_038818.2	Gene:	Abcc5 / 27416	MGIID:	1351644	Length:	1436	Species:	Mus musculus

Alignment Length:	1483	Identity:	473/1483 - (31%)
Similarity:	723/1483 - (48%)	Gaps:	259/1483 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SSAKPTR-----KNPRQHANIISQLIFAWAIPLLYRGSRRG-LNTDDLTQCLKEDRSEQLGDRLE 61
            |..||.|     ::|..:|.:.|.:.|:|..||.....::| |..:|:....|.:.|:....|||
Mouse    86 SVLKPFRTTTKHQHPVDNAGLFSYMTFSWLSPLARVVHKKGELLMEDVWPLSKYESSDVNSRRLE 150

  Fly    62 DQWFKELERSHRKKQKPHLRNALFRCFLGPTIINGLICFIYIVIKT-LIPAVLAQLLIQFQKTPV 125
            ..|.:||..                  :||...: |...::|..:| ||.:::..::.|.
Mouse   151 RLWQEELNE------------------VGPDAAS-LRRVVWIFCRTRLILSIVCLMITQL----- 191

  Fly   126 AQLRNIDVNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEV 190
                                                :|..|.|...|.|     ||..|.....:
Mouse   192 ------------------------------------AGFSGPAFVVKHL-----LEYTQATESNL 215

  Fly   191 DHNATAVRSILDQTVEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRLMGARMRIACCSLIYRK 255
            .::...|..:|...|...|    ||.....|:               ...|.|:|.|..::.::|
Mouse   216 QYSLLLVLGLLLTEVVRSW----SLALTWALN---------------YRTGVRLRGAILTMAFKK 261

  Fly   256 TLRLSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVV 320
            .|:|  |...:...|.|||:.|||..|:.........:...|:.|:|.  :|: |:   .|:|..
Mouse   262 ILKL--KNIKEKSLGELINICSNDGQRMFEAAAVGSLLAGGPVVAILG--MIY-NV---IILGPT 318

  Fly   321 GLLLKTV-----PVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAE 380
            |.|...|     |....:|::|:..|.:....||.||..|||::..|:.||||||.|.|...|.:
Mouse   319 GFLGSAVFILFYPAMMFVSRLTAYFRRKCVAATDDRVQKMNEVLTYIKFIKMYAWVKAFSQCVQK 383

  Fly   381 ARRSEIKQIRYASYLRGFYLSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNILQLVAA 445
            .|..|.:.:..|.|.:...:............:|.:....:|..:||...|:..:.:|.:.....
Mouse   384 IREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSVHMTLGFHLTAAQAFTVVTVFNSMTFALK 448

  Fly   446 IWYPLAVSFGAEALVSLRRIQDFLMLE-------------------------------------- 472
            : .|.:|...:||.|::.|.:...::|
Mouse   449 V-TPFSVKSLSEASVAVDRFKSLFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSIQNSPKL 512

  Fly   473 ------------GREERTQGLTHKRDQEG-GDSRAVTIKDINASWDIEKP--------------- 509
                        |::|:::.|.|...|.. .:.:...:.|.:     |:|
Mouse   513 TPKMKKDKRATRGKKEKSRQLQHTEHQAVLAEQKGHLLLDSD-----ERPSPEEEEGKQIHTGSL 572

  Fly   510 --QKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGDLSYAAQEPWLFTG 572
              |:||.:|:|:||:|:|..:.|.||:||:|::..:||::.:::|.:.:.|..:|.||:.|:...
Mouse   573 RLQRTLYNIDLEIEEGKLVGICGSVGSGKTSLVSAILGQMTLLEGSIAVSGTFAYVAQQAWILNA 637

  Fly   573 SVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKP 637
            ::|:|||||:|||.:||..|...|.|..|...|||.|.|.:|||||:||||||.|||||||:|..
Mouse   638 TLRDNILFGKEFDEERYNSVLNSCCLRPDLAILPNSDLTEIGERGANLSGGQRQRISLARALYSD 702

  Fly   638 AQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRIL-VTHQVHFLSEADVIVIVDQGRIL 701
            ..||::||||||:|||||.|:|:..|..|     ||:..:| ||||:.:|.:.|.::.:.:|.|.
Mouse   703 RSIYILDDPLSALDAHVGNHIFNSAIRKR-----LKSKTVLFVTHQLQYLVDCDEVIFMKEGCIT 762

  Fly   702 RQGTYQELINSDLDFARLL------ERPKEEEEGENSRNQTSPLSVNSLESDDEDIPFIDGVKDG 760
            .:||::||:|.:.|:|.:.      |.|..|   .||:.:    :..|.:|.|:      |.|.|
Mouse   763 ERGTHEELMNLNGDYATIFNNLLLGETPPVE---INSKKE----ATGSQKSQDK------GPKPG 814

  Fly   761 YQQLRKQSSSVHGSKSLDSTQLDDNVDEDDL--AEAQASGGISPRVWYEYFHAGSTLLSFSFMVF 823
                     ||...|::.|       :|..|  .|.:..|.:...|::.|..|....|:|..::.
Mouse   815 ---------SVKKEKAVKS-------EEGQLVQVEEKGQGSVPWSVYWVYIQAAGGPLAFLVIMV 863

  Fly   824 VMVMSQVVCSSSDFFANIWTQQEHQRS---QGEATF-------STFECMY--IYGALIIAVVIMT 876
            :.:::....:.|.::.:.|.:|....|   ||..:|       :.|...|  ||...:..::|:.
Mouse   864 LFMLNVGSTAFSTWWLSYWIKQGSGNSTVYQGNRSFVSDSMKDNPFMQYYASIYALSMAVMLILK 928

  Fly   877 TFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFI 941
            ..||.:|.|..:.||..|||.:|..||.:.|:||||||:|||||||||||..:|..||.....||
Mouse   929 AIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFI 993

  Fly   942 Q-IALVMFGILIVIGI-------LNPVLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVF 998
            | :.||.|.:.::.|:       :.|:|:...|:..|..|||        ::||||:.|.:||..
Mouse   994 QNVILVFFCVGMIAGVFPWFLVAVGPLLILFSLLHIVSRVLI--------RELKRLDNITQSPFL 1050

  Fly   999 SHLSASLTGLAIIRS-RQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCVSCIFLTSVTF 1062
            ||:::|:.|||.|.: .:.|:.:.:..:||.|..:..:..|.|:. .|.:.||.:|...:|:...
Mouse  1051 SHITSSIQGLATIHAYNKRQEFLHRYQELLDDNQAPFFLFTCAMR-WLAVRLDLISIALITTTGL 1114

  Fly  1063 SFIISSETTYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTE---LEQEPALGE 1124
            ..::......|...||||:.|:.|||:.|:.||..:|:..:.|||||:..|.:   ||....:..
Mouse  1115 MIVLMHGQIPSAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKN 1179

  Fly  1125 KTPPQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAH 1189
            |.||..||..|:|.|.|...||..|...||:.::.||:...|:|||||||:|||||..|||||..
Mouse  1180 KAPPHDWPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVE 1244

  Fly  1190 IEGE-IFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDVELRK 1253
            :.|. |.||||....|.|..||::::||||:|||||.|:|.|||||.:||:.::|.|||...:::
Mouse  1245 LSGGCIKIDGIRISDIGLADLRSKLAIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKE 1309

  Fly  1254 AIP----GLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIK 1314
            .|.    .|:..|.|.|.|||||:|||||:|||:||:.|:|:||||||.:|.:||.|||.|||..
Mouse  1310 CIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREA 1374

  Fly  1315 FKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEA 1367
            |..||:||:|||||||:.||||:|:..|..||||.|.:||.........|..|
Mouse  1375 FADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAA 1427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	469/1475 (32%)
		ABC_membrane	214..441	CDD:294371	60/231 (26%)
		ABCC_MRP_domain1	495..699	CDD:213217	91/221 (41%)
		ABC_membrane	863..1088	CDD:294371	83/235 (35%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	120/219 (55%)
Abcc5	NP_038818.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41
		PLN03130	100..1424	CDD:215595	467/1464 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	501..569		8/72 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	798..822		9/42 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.730