DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and Abcc9

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_037172.2	Gene:	Abcc9 / 25560	RGDID:	3787	Length:	1545	Species:	Rattus norvegicus

Alignment Length:	1475	Identity:	439/1475 - (29%)
Similarity:	699/1475 - (47%)	Gaps:	228/1475 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 LTQCLKEDRSEQLGDRLEDQWFKELERSHRKKQKPHLRNALFRCFLG-PTIINGLICFIYIVI-- 105
            :|:.:|..:..|||..:.|..|                     |..| ..|:|||:..:.|.:
  Rat   146 ITKTIKLVKYWQLGWGMSDLRF---------------------CITGVMVILNGLLMAVEINVIR 189

  Fly   106 -----------KTLIPAVLAQLLIQFQKTPV-----------------AQLRNIDVNDISISDSL 142
                       |...|..|..|.::|.:..|                 |..:.||:..|.   .|
  Rat   190 VRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHRKPIDLKAIG---KL 251

  Fly   143 NRTARAIPNYV-LSQAVANSSGSPGD----------ALF-----PKSLDK-----------AGPL 180
            ....||:.||| |.:|.........|          |::     |..|..           ||||
  Rat   252 PIAMRAVTNYVCLKEAYEEQKKKAADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPL 316

  Fly   181 --EPIQPPVEEVDHNATAVRSILDQTVEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRL---- 239
              ..|...|.|..:|.|.....| .:.|.:.|      |.::...||...:|....|:...
  Rat   317 CISGIVQRVNEPKNNTTRFSETL-SSKEFLEN------AHVLAVLLFLALILQRTFLQASYYVTI 374

  Fly   240 -MGARMRIACCSLIYRKTLRLSMK--TAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAM 301
             .|..:|.|..::||.|.||||..  :.|:...|.:.||::.:.|:|.:.......:|.||:|.:
  Rat   375 ETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQII 439

  Fly   302 LTCYLIWLNIGIPAIVGVVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIK 366
            :...|::..:|..|:||...::| ..|:|..::...:..:....:.:..|:...||:::||:::|
  Rat   440 MGVILLYNLLGSSALVGAAVIVL-LAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLK 503

  Fly   367 MYAWEKPFQAVVAEARRSEIKQIRYASYLRGFYLSTMVFTERS-------TLYITLAAAALMGQT 424
            :||||..|...|.|.|..|:..::..:    .|.|..:|...:       ..::|.|.|:  |..
  Rat   504 LYAWEHIFCKSVEETRMKELSSLKTFA----LYTSLSIFMNAAIPIAAVLATFVTHAYAS--GNN 562

  Fly   425 ITADFVFSAASYYNILQLVAAIWYPLAVSFGAEALVSLRRIQDFLMLE--GRE------------ 475
            :.....|::.|.::|| :.........|.|..:|::|::::.:||:.:  |.:
  Rat   563 LKPAEAFASLSLFHIL-VTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGEDSWRTGEGTLPFE 626

  Fly   476 --ERTQGLTHK---RDQEG---------------GDSRAVTIKDINASWDIEKPQKTLQSINLQI 520
              ::..|:..|   |.|.|               .::..|.||..|..:.......||.:|:::|
  Rat   627 SCKKHTGVQSKPINRKQPGRYHLDNYEQARRLRPAETEDVAIKVTNGYFSWGSGLATLSNIDIRI 691

  Fly   521 EKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQG-----------------DLSYAAQEPW 568
            ..|||..::|.||.||||:|..:|||:..::|.|:...                 .::||||:||
  Rat   692 PTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVYWNNVNESEPSFEATRSRSRYSVAYAAQKPW 756

  Fly   569 LFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARA 633
            |...:|..||.||..|:|:||:.||..|:|..|...||.||:|.:||||.:||||||.||.:|||
  Rat   757 LLNATVEENITFGSSFNRQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARA 821

  Fly   634 VYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRILVTHQVHFLSEADVIVIVDQG 698
            :|:...|..:|||.||:|.|:..||..|  |....|...|.|.:||||::.:|:.||.|:.:..|
  Rat   822 LYQNTNIVFLDDPFSALDIHLSDHLMQE--GILKFLQDDKRTVVLVTHKLQYLTHADWIIAMKDG 884

  Fly   699 RILRQGTYQELINSDLD----FARLLERPKEEEEGENSRNQTSPLSVNSLESDDEDIPFIDGVKD 759
            .:||:||.:::...|::    :..|:.|..:|.|.:...:||      :||.
  Rat   885 SVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQT------TLER------------- 930

  Fly   760 GYQQLRKQSSSVHGSKSLDSTQLDDNVDEDDLAEAQASGGIS-----------PRVWYEYFHAGS 813
              :.||:...|...     ..|::|. ||::..|......:|           ...|: |..:|.
  Rat   931 --KTLRRAMYSREA-----KAQMEDE-DEEEEEEEDEDDNMSTVMRLRTKMPWKTCWW-YLTSGG 986

  Fly   814 TLLSFSFMVFVMVMSQVVCSSSDFFANIWTQQEHQRSQGEATFSTFECMYIYGALII--AVVIMT 876
            ..|.| .|:|..::...|..:.|::...||.:......|:|. .||   |:.|..|:  |.:.:.
  Rat   987 FFLLF-LMIFSKLLKHSVIVAIDYWLATWTSEYSINDPGKAD-QTF---YVAGFSILCGAGIFLC 1046

  Fly   877 TFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFI 941
            .........:.:.|:|.||..:...|:...:|||||||.|.||||||.|...||:.:|..:....
  Rat  1047 LVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLT 1111

  Fly   942 QIALVMFGILIVIGILNPVLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLT 1006
            :..|:....:.:|....||.:.|:..:.|....|.|.:...|:||:.|:...:.|:..|.|.:..
  Rat  1112 RSTLLCLSAIGMISYATPVFLIALAPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAE 1176

  Fly  1007 GLAIIRSRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCV-SCIFLTSVTFSFIISSET 1070
            ||..||:.:.:....:....|.|.::..:....|.|..|.:..|.: :||.||:   |....|.:
  Rat  1177 GLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTA---SIASISGS 1238

  Fly  1071 TYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTELEQEPALGEKTP---PQQWP 1132
            :.||.|||.:..|:.:|..:.:.||.:|:...||.:|::|..:..:|.|...|...|   |:.||
  Rat  1239 SNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWP 1303

  Fly  1133 TRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAHI-EGEIFI 1196
            ..|:::..::..||:.|..|||:::...|:.|.||||.||||:|||||..|.||:..| :|:|.|
  Rat  1304 QEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVI 1368

  Fly  1197 DGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDVELR---KAIP-G 1257
            |||:...:.|..||:|:|||.|||:|||.:||:||||..:.||..||.|||..:|:   |::| |
  Rat  1369 DGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGG 1433

  Fly  1258 LDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLT 1322
            ||..|||.|.|||||||||.|||||.:|.:.:|::|||||::|..|:.::|:.:...|...||:|
  Rat  1434 LDATVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVT 1498

  Fly  1323 VAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEA 1367
            :|||:||::.:|.:|||..|..:|:|.|..||.:..|.....|.|
  Rat  1499 IAHRVHTILTADLVIVMKRGNILEYDTPESLLAQEDGVFASFVRA 1543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	438/1473 (30%)
		ABC_membrane	214..441	CDD:294371	58/240 (24%)
		ABCC_MRP_domain1	495..699	CDD:213217	89/220 (40%)
		ABC_membrane	863..1088	CDD:294371	64/227 (28%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	108/219 (49%)
Abcc9	NP_037172.2	MRP_assoc_pro	222..1542	CDD:188098	417/1375 (30%)
Abcc9	NP_037172.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	940..963		5/28 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810