DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and Abcc8

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_037171.2	Gene:	Abcc8 / 25559	RGDID:	3786	Length:	1582	Species:	Rattus norvegicus

Alignment Length:	1284	Identity:	403/1284 - (31%)
Similarity:	647/1284 - (50%)	Gaps:	186/1284 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   215 LGAVLVLST-LFCCFLLHHVDLRQRL-----MGARMRIACCSLIYRKTLRLSMK--TAGQTPAGY 271
            ||...||:. ||...||....|:...     .|..:|.|..:.||.|.:.||..  :.|:..||.
  Rat   352 LGNAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQ 416

  Fly   272 LINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVPVQTALSKV 336
            :.||::.|.|:|.:.|.....:|.||:|.::...|::..:|:.|::|...::| ..|||..::..
  Rat   417 ICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIIL-LAPVQYFVATK 480

  Fly   337 TSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIRYASYLRGF--Y 399
            .|..:....|.::.|:...||:::||:::|:||||..|.:.|.:.||.|:      :.||.|  |
  Rat   481 LSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFCSRVEKTRRKEM------TSLRAFAVY 539

  Fly   400 LSTMVFTERSTLYITLAAAAL--MGQTI---TADF----VFSAASYYNILQ----LVAAIWYPLA 451
            .|..:|...:   |.:||..:  :|...   .:||    .|::.|.::||.    |::::
  Rat   540 TSISIFMNTA---IPIAAVLITFVGHVSFFKESDFSPSVAFASLSLFHILVTPLFLLSSV----- 596

  Fly   452 VSFGAEALVSLRRIQDFL-MLEGREERTQGLTHKRDQEGGDSRAVTIKDINASWDIEKPQK---- 511
            |....:||||::::.:|| ..|.|||:..........:.|..:||.:|.:|.    ::|.:
  Rat   597 VRSTVKALVSVQKLSEFLSSAEIREEQCAPREPAPQGQAGKYQAVPLKVVNR----KRPAREEVR 657

  Fly   512 -------------------------------------TLQSINLQIEKGQLCAVIGPVGAGKSSI 539
                                                 ||.:|.::|.:|||..::|.||.||||:
  Rat   658 DLLGPLQRLTPSTDGDADNFCVQIIGGFFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSL 722

  Fly   540 LQLLLGELPVIDGGVF---------------------------IQGDLSYAAQEPWLFTGSVRNN 577
            |...|||:..:.|.||                           .:|.::||:|:|||...:|..|
  Rat   723 LLATLGEMQKVSGAVFWNSSLPDSEGEDPSNPERETAADSDARSRGPVAYASQKPWLLNATVEEN 787

  Fly   578 ILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQIYL 642
            |.|...|:::||:.|...|:|..|...||:||:|.:||||.:||||||.|||:|||:|:...:..
  Rat   788 ITFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHTNVVF 852

  Fly   643 MDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRILVTHQVHFLSEADVIVIVDQGRILRQGTYQ 707
            :|||.||:|.|:..||..  .|....|...|.|.:||||::.:|..||.|:.:..|.|.|:||.:
  Rat   853 LDDPFSALDVHLSDHLMQ--AGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLK 915

  Fly   708 ELINSDLD----FARLLERPKEEEEGENSRNQTSPLSVNSLESDDEDIPFIDGVKDGYQQLRKQS 768
            :...|:..    :..|:.|..:|.|.|....:.:|       ...:.:|            |..|
  Rat   916 DFQRSECQLFEHWKTLMNRQDQELEKETVMERKAP-------EPSQGLP------------RAMS 961

  Fly   769 SSVHGSKSLDSTQLDDNVDEDDLAEAQASGGISP----------RVWYEYFHAGSTLLSFSFMVF 823
            |.       |...||::.:|::.||::....:|.          |...:|..:...|| .|.:||
  Rat   962 SR-------DGLLLDEDEEEEEAAESEEDDNLSSVLHQRAKIPWRACTKYLSSAGILL-LSLLVF 1018

  Fly   824 VMVMSQVVCSSSDFFANIWTQQEHQRSQGEATFS-TFEC---MYIYG-------ALIIAVVIMTT 877
            ..::..:|..:.|::...||......|......| :.||   ..:|.       :|.||:.::|:
  Rat  1019 SQLLKHMVLVAIDYWLAKWTDSALVLSPAARNCSLSQECALDQSVYAMVFTVLCSLGIALCLVTS 1083

  Fly   878 ----FRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMM 938
                :.|       :..:|.||..:...|:.|.||||:|||.|.||||||.|...||:.:|..:.
  Rat  1084 VTVEWTG-------LKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLE 1141

  Fly   939 DFIQIALVMFGILIVIGILNPVLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSA 1003
            ...:..|:....|.||..:.||.:.|:|.:|||...|.|.:...|:||::|:...:.|:.||.:.
  Rat  1142 CLSRSTLLCVSALAVISYVTPVFLVALLPLAVVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAE 1206

  Fly  1004 SLTGLAIIRSRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCV-SCIFLTSVTFSFIIS 1067
            ::.||..||:.:.:....::.....|.::.......|.|..|.:.::.: :|:.|.:...|...|
  Rat  1207 TVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAATSISNS 1271

  Fly  1068 SETTYS-GNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERV--LQYTELEQ-EPALGEKTPP 1128
            .....| |.|||.:..|::::..:.:.||.:|:...|:.:|:|:  |..||.|. |..|.....|
  Rat  1272 LHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMEIQLGAVKRIHTLLKTEAESYEGLLAPSLIP 1336

  Fly  1129 QQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAHI-EG 1192
            :.||.:|:::.:|:|.|||.:..|||:::|..|..|.|:||.||||:||||...|.||:..: ||
  Rat  1337 KNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDMFEG 1401

  Fly  1193 EIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDVELR---KA 1254
            .|.||||:...:.|..||:|:|||.|||||||.|||:||||.::.:|:.||.|||..:|:   ||
  Rat  1402 RIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCSDSTLWEALEIAQLKLVVKA 1466

  Fly  1255 IP-GLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQC 1318
            :| |||.::||.|.|||.|||||.|||||.:|...:.::|||||::|..|:.::|:.:...|...
  Rat  1467 LPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADR 1531

  Fly  1319 TVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEA 1367
            ||:|:|||:||::.:|.::|:..|..:|||.|..||.:........|.|
  Rat  1532 TVVTIAHRVHTILSADLVMVLKRGAILEFDKPEKLLSQKDSVFASFVRA 1580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	402/1282 (31%)
		ABC_membrane	214..441	CDD:294371	70/244 (29%)
		ABCC_MRP_domain1	495..699	CDD:213217	86/271 (32%)
		ABC_membrane	863..1088	CDD:294371	67/237 (28%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	107/219 (49%)
Abcc8	NP_037171.2	CFTR_protein	223..1582	CDD:273530	403/1284 (31%)
		ABC_membrane	<375..590	CDD:279056	62/224 (28%)
		P-loop_NTPase	679..907	CDD:304359	82/229 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	741..768		0/26 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	939..962		5/41 (12%)
		ABC_membrane	1017..1295	CDD:279056	77/284 (27%)
		ABCC_SUR2	1343..1582	CDD:213255	112/238 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810