Protein Alignment CG5789 and abc2

DIOPT Version :9

• Sequence 1: NP_001247286.1
• Gene: CG5789 / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Sequence 2: NP_593943.3
• Gene: abc2 / 2543193
• PomBaseID: SPAC3F10.11c
• Length: 1478
• Species: Schizosaccharomyces pombe
• Alignment Length: 1417
• Identity: 455/1417 - (32%)
• Similarity: 695/1417 - (49%)
• Gaps: 173/1417 - (12%)

  Fly     2 DSSAKPTRKNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFK 66
            ::..:|:|..   :|||.|::.|.|..||:..|.|..|...|.......:||..|....|..|.
pombe   184 ETGLRPSRFT---YANIFSRISFGWLSPLMKFGYRNYLTESDAWSLPPAERSSNLTIVFEKNWI- 244

  Fly    67 ELERSHRKKQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNI 131
                ||.||:|..|      ...|...:|.....:.|::..|:..|:|  .||
pombe   245 ----SHAKKKKSSL------YMWGVLFLNHWKLTVVIIVLKLVQDVVA--FIQ------------ 285

  Fly   132 DVNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNATA 196
                              ||.:....:..||.|.               |..|||  :|..
pombe   286 ------------------PNLIRKIVIFVSSYSS---------------EHPQPP--QVGF---- 311

  Fly   197 VRSILDQTVEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRLMGARMRIACCSLIYRKTLRLSM 261
                             ||...:.|:.:....||........::|.|.|....:.||||:||||.
pombe   312 -----------------SLAIAMFLTNVVQTALLQQYFQLGMVLGMRWRSELITAIYRKSLRLSS 359

  Fly   262 KTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGV-VGLLLK 325
            ........|.::|.:|.|..::....:|:..|...|.|.:|....::..:|..|:.|. |..||
pombe   360 AARQSRSVGDIVNYMSVDTQKVCDLTMFLFVIVSGPFQIVLALTNLYHLVGYGALSGAFVTFLL- 423

  Fly   326 TVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSE----I 386
             .|....::.:....:.|..:..|||...|.|::..|:.||:||||..|...:.:.|.:.    :
pombe   424 -FPCNVVIASIFKRFQNRQMKNKDARSQFMTEIINNIRSIKLYAWENIFLQKLLQLRNTRELRML 487

  Fly   387 KQIRYASYLRGFYLSTMVFTERSTLYITLAAA------ALMGQT--ITADFVFSAASYYNILQLV 443
            |:|...:.:..|   |.:|..     |.::||      .|.|:|  ::.|.||:..|.:|:||..
pombe   488 KKIGIVNTIGNF---TWLFAP-----ILVSAATFGTFIVLYGKTRVLSVDIVFACLSLFNLLQFP 544

  Fly   444 AAIWYPLAVSFGAEALVSLRRIQDFLML-EGREERTQGLTHKRDQEGGDSRAVTIKDINASWD-- 505
            ..: .|:.||...||.|::.||..||.. |......|.....::..|   ..:.||....||.
pombe   545 LTM-LPIVVSSVLEASVAISRIYGFLTAGELDSNAVQRYPANKEPSG---VCLEIKKGTFSWSGP 605

  Fly   506 -IEKPQKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGDLSYAAQEPWL 569
             ....:.||:.|:....:|:||.::|.||.||||:|:..||.:....|.||..|.::||||:||:
pombe   606 GQNAAEPTLRDIDFVARRGELCCIVGKVGMGKSSLLEACLGNMQKHSGSVFRCGSIAYAAQQPWI 670

  Fly   570 FTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAV 634
            ...:::.|||||.|.|.:.|::..|.|.|..||:.|.:||:|.|||:|.||||||:|||||||||
pombe   671 LNATIQENILFGLELDPEFYEKTIRACCLLRDFEILADGDQTEVGEKGISLSGGQKARISLARAV 735

  Fly   635 YKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRILVTHQVHFLSEADVIVIVDQGR 699
            |..:.|||:||.|||||.||.|.|...::|.:|.|.  ....||.|:.:..|.||.:|.::..|:
pombe   736 YSRSDIYLLDDILSAVDQHVNRDLVRNLLGSKGLLR--SRCVILSTNSLTVLKEASMIYMLRNGK 798

  Fly   700 ILRQGTYQELINS-DLDFARLLERPKEEEEGEN-------SRNQ---TSPLSVNSLESDDEDI-- 751
            |:..|::.:|.:| |....:||....:::...:       ||:|   ||...|.|..|...|.
pombe   799 IIESGSFTQLSSSPDSQLFQLLSEFSKKDTASSTGADTPLSRSQSVITSSTDVTSSASRSSDTVS 863

  Fly   752 PFIDGVKDGYQQLRKQSSSVHGSKSLDSTQLDDNVD-EDDLAEAQASGGISPRVWYEYFHAGSTL 815
            .:......|..::||:.:.            :|||. ....||....|.:..:|::.||.|.|..
pombe   864 NYPKATIKGTGRIRKRLTD------------EDNVKATGQAAEKMERGKVKWKVYWTYFKACSLF 916

  Fly   816 LSFSFMVFVM--VMSQVVCSSSDFFANIWTQQEHQRSQGEATFSTFECMYIYGALIIAVVIMT-- 876
            |.|.:.:|::  :...|   .::.:...|::...|.......:.......::|.|..|::.::
pombe   917 LIFLYFLFIIGGIGMNV---GTNVWLKHWSEVNTQLGYNPKPYFYLGIYTLFGLLSCALISLSSL 978

  Fly   877 TFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFI 941
            |...|...|.|    :.|||.|...:|.|.|.||:|||:||||||||.|:..:||::.|..|.|.
pombe   979 TITVFCAIKSC----RYLHDSMVKAVLRAPMSFFETTPTGRILNRFSSDVYRVDEVISRVFMFFF 1039

  Fly   942 QIALVMFGILIVIGILNPVLVAAMLVVAVVDVLIL-----KLYLRPSQDLKRLEGICRSPVFSHL 1001
            :....:..:|.||...:|     |.::.:|.:..|     ..|.:.|::||||:.:.|||:::|.
pombe  1040 RNLFQIVFVLAVICYSSP-----MFMILIVPLFFLYRYNQVYYTQTSRELKRLDSVTRSPLYAHF 1099

  Fly  1002 SASLTGLAIIRSRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCVSCIFLTSVTFSFII 1066
            ..||.||:.||:..::|....|.|:..|.:..:|.|..:.|....:.::.:..:.:.|..|..::
pombe  1100 QESLGGLSTIRAYDMEDTFISENDIRVDTNHRIWFLYFSSNRWQAIRVEAIGALVVFSSAFFGVL 1164

  Fly  1067 SS--ETTYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTELEQE-PA-LGEKTP 1127
            |:  ....||.|||:::.|:.:|..:.:.|||..:....:.||||:|:|..|..| |: :.:..|
pombe  1165 SAVRGNPNSGLVGLSLSYAVQITQSLTFVVRQSVDVETNIVSVERMLEYIGLPSEAPSIIPDHRP 1229

  Fly  1128 PQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAH-IE 1191
            |:.||:.|.::|.:.|.||..|...||.::::.|:...|:|||||||||||:|..|||||.. ..
pombe  1230 PEGWPSHGAIKFDHYSVRYRENLPLVLNDISVNIKPQEKIGIVGRTGAGKSTLTLALFRLIEPTS 1294

  Fly  1192 GEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDVELRKAIP 1256
            |:|.:|.|...:|.|..||:|::||||:...|..|||.||||....||.|:|.|||...|::.|.
pombe  1295 GDIQLDDINITSIGLHDLRSRLAIIPQENQAFEGTIRENLDPNANATDEEIWHALEAASLKQFIQ 1359

  Fly  1257 GLD----YMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQ 1317
            .||    ..|||.|.|.|.|||||:||.||:|...:||:||||||.||.:|||::|||||.:|..
pombe  1360 TLDGGLYSRVTEGGANLSSGQRQLMCLTRALLTPTRVLLLDEATAAVDVETDAIVQRTIRERFND 1424

  Fly  1318 CTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEATG 1369
            .|:||:|||::|||||:||:|:|.|..||||....||:........:.:.:|
pombe  1425 RTILTIAHRINTVMDSNRILVLDHGKVVEFDSTKKLLENKASLFYSLAKESG 1476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	453/1406 (32%)
		ABC_membrane	214..441	CDD:294371	63/239 (26%)
		ABCC_MRP_domain1	495..699	CDD:213217	91/206 (44%)
		ABC_membrane	863..1088	CDD:294371	72/233 (31%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	114/219 (52%)
abc2	NP_593943.3	MRP_assoc_pro	96..1477	CDD:188098	455/1417 (32%)
		ABC_membrane	272..545	CDD:279056	80/352 (23%)
		ABCC_MRP_domain1	593..798	CDD:213217	91/206 (44%)
		ABC_membrane	928..1190	CDD:279056	76/273 (28%)
		ABCC_MRP_domain2	1237..1456	CDD:213211	113/218 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720