DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and abc4

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_594558.1	Gene:	abc4 / 2543059	PomBaseID:	SPAC30.04c	Length:	1469	Species:	Schizosaccharomyces pombe

Alignment Length:	1401	Identity:	415/1401 - (29%)
Similarity:	635/1401 - (45%)	Gaps:	240/1401 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 FAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSHRKKQKPHLRNALFRCF 88
            :.:..||:....||.:..||.......|:::        .|....||    .:.|.|...:.:.|
pombe   240 YGYLNPLVLTAKRRVVEVDDTPVIPDYDKNK--------AWTYRFER----MKTPSLFITIHKIF 292

  Fly    89 LGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNIDVNDISISDSLNRTARAIPNYV 153
            ....:..|:..|:..|.:.|.|..|.:||...:
pombe   293 WRQILGMGVSSFMVSVCQFLSPIALNRLLKHLE-------------------------------- 325

  Fly   154 LSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNATAVRSILDQTVEHMWNDMNSLGAV 218
                      ||       |.....||                           :|..:...|.
pombe   326 ----------SP-------SSSSVNPL---------------------------VWIVLLLTGP- 345

  Fly   219 LVLSTLFCCFLLHHVDLRQRLMGARMRIACCSLIYRKTL--RLSMKTAGQTPAGYLINLLSNDVN 281
             .|::||..|.|.   :..|.: ||........||.|.:  |.....:|.:..|...||:|.||:
pombe   346 -FLTSLFTQFYLF---MSTRYL-ARSYTTLVQQIYNKVIRSRFVQNKSGDSKVGRSNNLISTDVD 405

  Fly   282 RLDYGFI--FMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVPVQTALSKVTSVLRMRI 344
              |.|.|  |:|.|...|::...:.||:...:|..|.|| :.|.:.|..|...|..:.:.|.:|.
pombe   406 --DIGEIREFIHIIVRAPVEIAGSIYLLQKLLGWSAYVG-LALTVLTCSVPIVLGPLVAKLTLRA 467

  Fly   345 AERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEI----KQIRYASYLRGFYLSTMVF 405
            ...||:|:.:|:||:|.|::.|.:.||.|....|.:.|:.|:    |.:.....::....|..||
pombe   468 NRATDSRIELMSELLQSIRITKFFGWELPMLDRVKQRRQVELNRTWKLLLMEICIQVLVESLPVF 532

  Fly   406 TERSTLYITLAAAALMGQTITADFVFSAASYYNILQLVAAIWYPLAVSFGAEALVSLRRIQDFLM 470
            :..:|..:   ...:||||||....|::.|.::.::...: |....:....:..||:.|:.|||
pombe   533 SMFATFVV---FTTIMGQTITPSIAFTSISLFSFIRTQFS-WIAYLMRQIVQIFVSIGRVSDFL- 592

  Fly   471 LEGREERTQGLTHKRDQEGGDSRAVTIKD-------INAS--WDIEKPQK---TLQSINLQIEKG 523
                          .|.:..|. ..||:|       .|||  | :..|..   .|:.:|:...:.
pombe   593 --------------NDPDEVDP-VNTIEDTSQEIGFFNASLTW-VSNPSPGDFCLRDLNIVFPRN 641

  Fly   524 QLCAVIGPVGAGKSSILQLLLGELPVIDGGVFI--QGDLSYAAQEPWLFTGSVRNNILFGEEFDR 586
            :|..||||.|:||||::..|||||.:..|...:  ...:||.:|.|||...::|:||||...:..
pombe   642 KLSIVIGPTGSGKSSLISALLGELSLNKGSYNLPRSKGVSYVSQVPWLRNATIRDNILFDYPYIE 706

  Fly   587 KRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQIYLMDDPLSAVD 651
            :||::|.:.|.|.||.|.....|.|.:||:|.:|||||:.||:||||||.|..|.||||..||:|
pombe   707 ERYKKVIQACGLLTDLQSFVASDLTEIGEKGVTLSGGQKQRIALARAVYSPTSIVLMDDVFSALD 771

  Fly   652 AH----VGRHLFDEVIGPRGRLAQLKATRILVTHQVH-FLSEADVIVIVDQGRILRQGTYQELIN 711
            .|    :.:|.|...:       ....|.|||||.|| |:..|..||.|      :.|:...:.:
pombe   772 IHTSNWIYKHCFQSSL-------MENRTVILVTHNVHLFMDSAAFIVTV------KNGSAFPVTD 823

  Fly   712 SDLDFARLLERPKEEEEGENSRNQTSPL--SVNSLESDDEDIPFIDGVKDGYQQLRKQSSSVHGS 774
            .......|.|:.....|.........|:  .|:..|:.||        |||
pombe   824 KSSPLLFLAEQAASASEAAAPDLAAIPIPNEVDDAEAADE--------KDG-------------- 866

  Fly   775 KSLDSTQLDDNVDEDDLAEAQASGGISPRVWYEYF----HAGSTLLSFSFMVFVMVMSQVVCSSS 835
                     ..|:|    |.:.:|.:   |:.|.|    |.||.....:.::| .|.:|......
pombe   867 ---------KLVEE----EQRVTGDV---VFSEIFSYMKHFGSGFYVAAVLLF-FVTTQATSILI 914

  Fly   836 DFFANIWTQQEHQRSQGEATFSTFECMYIYGALIIAVVIMTTFRGFLFFKICMHASKVLHDRMFA 900
            |.:...||..    |......:..:.:::||.:::|..::...|...:.:....||:.|||.|..
pombe   915 DLWVAFWTNS----SVNSPDVNNNKFLFVYGTMLLAYSLLDFLRTVSYDRGAWWASRKLHDSMLE 975

  Fly   901 CILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAM 965
            .:......:||.||:|||:|||:||:.:||..|...:...|...|.:.|.::.:....|:.:...
pombe   976 SVFGTFASWFDKTPTGRIVNRFAKDIRSIDMNLSGWLFFSINCFLSVAGGILSVSSAMPIFMIPA 1040

  Fly   966 LVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEF----DL 1026
            ::|.:.......||.|....:|||..|..||:||.|..|:.|:::||:...|.:..:.|    |.
pombe  1041 VIVCLAGYYFGLLYTRAQVGVKRLISIYTSPIFSLLGESIVGVSVIRAFNRQTIFKQMFSERLDN 1105

  Fly  1027 LQDVHSSVWQLT--MAVNTTLGLWLDCVSCIFLTSVTFSFIISSETTYSGNVGLAIAQAMILTGM 1089
            |..:.|:.:.|.  :||.|      |.:|.: :.::.....:..:....|.||.::.||:|.:..
pombe  1106 LVRLQSTSYNLNRWVAVRT------DGISGL-VGAIAGLIALLQKDLSPGVVGFSLNQAVIFSSS 1163

  Fly  1090 VQYGVRQVAESLQ-QMTSVERVLQYTELEQEPA---LGEKTPPQQWPTRGQVEFRNMSCRYDPNG 1150
            |...||. ..||| :|.|.||||:|::|.||||   .|:  .|..||..|.:.|.::|..|...|
pombe  1164 VLLFVRS-CNSLQAEMNSYERVLEYSKLPQEPAPTIAGQ--VPATWPKEGDIVFNHVSVSYSAAG 1225

  Fly  1151 SPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAH-IEGEIFIDGIETGTISLEILRTRIS 1214
            ..:|:::||.|....||.:|||||:|||:|...|.|..| |.|||:|:|.||.:::|..||.|||
pombe  1226 PTILKDVNLHINPSEKVAVVGRTGSGKSTLGLTLLRFTHRISGEIYINGRETQSVNLNALRQRIS 1290

  Fly  1215 IIPQDPVLFSATIRYNLDPFERYTDAELWSALEDVELRKAIPG-----------LDYMVTERGGN 1268
            .|||||:|||.|:|.|||||:...|..|..||:.......|..           ||..|...|.|
pombe  1291 FIPQDPILFSGTVRSNLDPFDELEDNFLNEALKTSGASSMIMAHTDDQKPIHITLDTHVASEGSN 1355

  Fly  1269 FSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDS 1333
            ||.||:|:|.|||||:|.:|:::|||.||:||...|..||:|:|..|...|:|.:||||.|::|.
pombe  1356 FSQGQKQVLALARAIVRRSKIIILDECTASVDDAMDQKIQKTLREAFGDATMLCIAHRLKTIVDY 1420

  Fly  1334 DRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEATG 1369
            |:::|:|.||.||:..| .:|..:.||.|:|.:.:|
pombe  1421 DKVMVLDKGVLVEYGPP-AVLYHNNGHFRRMCDGSG 1455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	414/1397 (30%)
		ABC_membrane	214..441	CDD:294371	67/234 (29%)
		ABCC_MRP_domain1	495..699	CDD:213217	88/222 (40%)
		ABC_membrane	863..1088	CDD:294371	63/230 (27%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	103/226 (46%)
abc4	NP_594558.1	CFTR_protein	240..1449	CDD:273530	412/1393 (30%)
		ABC_membrane	300..568	CDD:294371	81/355 (23%)
		ABCC_MRP_domain1	611..817	CDD:213217	85/219 (39%)
		ABC_membrane	901..1164	CDD:294371	70/274 (26%)
		ABCC_MRP_domain2	1210..1437	CDD:213211	103/226 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.900