DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and abc3

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_595055.1	Gene:	abc3 / 2540937	PomBaseID:	SPBC359.05	Length:	1465	Species:	Schizosaccharomyces pombe

Alignment Length:	1430	Identity:	461/1430 - (32%)
Similarity:	696/1430 - (48%)	Gaps:	199/1430 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KPTRKNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELER 70
            |..|.:..::|||.|:|.|:|....:..|....|...|:.....::||..|....||.|   :..
pombe   167 KGIRPSEVRYANIFSKLSFSWISSFIKFGYTNYLKESDVWLLPPDERSGNLIIGFEDWW---IYH 228

  Fly    71 SHRKKQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQ---FQKTPVAQLRNID 132
            |..|::...|...||        .|.......|.|..||..|||  .:|   .|||
pombe   229 SKNKRRSLFLWKLLF--------FNHWKLVALITITKLIQDVLA--FVQPTLIQKT--------- 274

  Fly   133 VNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNATAV 197
                                               .||..|.....|..|
pombe   275 -----------------------------------ILFISSYTSPNPESP--------------- 289

  Fly   198 RSILDQTVEHMWNDMNSLGAVLVLSTLFCCF----LLHHVDLRQRLMGARMRIACCSLIYRKTLR 258
                            |.|.::.:..|...|    ||...:....|:|.|.:....:.||||:|.
pombe   290 ----------------SRGFIIAILVLVANFLQTLLLQQYNQLIMLLGMRWKTELLASIYRKSLL 338

  Fly   259 LSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLL 323
            ||.........|.:||.::.|..::....|::..|...|.|..|....::..:|..|..||...:
pombe   339 LSSSARQNRSIGDIINYMAVDTQKISDLPIYLFIIVSGPFQIALALSNLYHLMGYSAFTGVAASV 403

  Fly   324 LKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARR----S 384
            : ..|....::.|....:..:.:..|:|..:|.|::..|:.||:||||.||...:...|.    |
pombe   404 I-LFPCNIIVANVYKKFQSILMKNKDSRSKLMTEIINNIRSIKLYAWETPFLQKLLHIRNTKELS 467

  Fly   385 EIKQIRYASYLRGFYLSTMVFTERSTLYITLAAAALM-----GQTITADFVFSAASYYNILQLVA 444
            .:|:|.:.:.:..|   ..:||  :.:..|:|..|.:     .|.:|||.||.|.|.:|:||...
pombe   468 MLKKIGFITAIGDF---AWIFT--TIIVTTVAFGAFIIFHGKTQALTADIVFPAVSLFNLLQFPL 527

  Fly   445 AIWYPLAVSFGAEALVSLRRIQDFLMLEGREERTQGLTHKRDQEGGDSRAVTIKDINASWDIEKP 509
            |: .|..:|...||.||:.||.:||:  .:|....|:......|......:.||....||. :|.
pombe   528 AM-LPTVISSLLEASVSVSRIYEFLI--AQELDYNGVQRFPATEIPHEICLEIKSGTFSWS-KKT 588

  Fly   510 QK-----TLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGDLSYAAQEPWL 569
            .|     ||:.||...:.|:|..:.|.|||||||:|:..:|.:....|.||..|.|:||||:||:
pombe   589 LKQQVTPTLRQINFVAKNGELTCIFGKVGAGKSSLLEACMGNMYKNSGSVFQCGSLAYAAQQPWI 653

  Fly   570 FTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAV 634
            |..::|.|||||.|||.:.|::....|.|..||:....||:|.||::||||||||::|||||||:
pombe   654 FDATIRENILFGSEFDPELYEKTIHACCLKRDFEIFTEGDQTEVGQKGASLSGGQKSRISLARAI 718

  Fly   635 YKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATR--ILVTHQVHFLSEADVIVIVDQ 697
            |..|.|||:||.||:||.||.|.|...:.||.|.|    .|.  :|.|:.::.|.|||.|.|:..
pombe   719 YSQADIYLLDDVLSSVDQHVSRDLIKNLFGPEGFL----RTHCVVLTTNSLNVLKEADSIYILSN 779

  Fly   698 GRILRQGTYQELI---NSDLDFARLLERPKEEEEGENSRNQTSPLSVNSLESDDEDIPF-----I 754
            |:|:.:|.|:.|.   ||:|         |::....|....|.||..::.......|..     :
pombe   780 GKIVEKGNYEHLFVSTNSEL---------KQQLSEFNDEKDTQPLPEHTTSYPSTQISLAPSIHV 835

  Fly   755 DGVKDGYQQLRKQSSSVHGSKSLDSTQLDDNVDEDDLAEAQAS-------GGISPRVWYEYFHA- 811
            :|::......||.||:.:  ||.....:...|.|||..:..|.       |.:...|::.||.:
pombe   836 EGLETYSSSERKDSSNKY--KSRKRNPIRQKVTEDDKGKCVAQTDELVQRGKVKWHVYWMYFKSC 898

  Fly   812 --GSTLLSFSFMVFVMVMSQVVCSSSDFFANIWTQ---QEHQRSQGEATFSTFECMYIY---GAL 868
              |..||.|.|::..::|:..        .|:|.:   :|:.:|..|...|.:..:.||   |.|
pombe   899 SIGLILLYFFFIISGIMMNVA--------TNVWLKHWSEENGKSSSELNPSPYFYLGIYLFFGFL 955

  Fly   869 IIAVV-----IMTTFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGA 928
            ..|.:     .||...|       :.:.:.|||.|...||.|.|.||:||.|||||||||.|:..
pombe   956 SCAFISSSSLTMTVLCG-------IRSGRYLHDSMLKTILRAPMGFFETTSSGRILNRFSNDVYK 1013

  Fly   929 IDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLVVAVVDVLILKL-----YLRPSQDLKR 988
            :||::....|.|.:.::   .:|.::|::  ...|.:.::.:|.:..|.|     |:|.|::|||
pombe  1014 VDEVVSLTFMFFFRNSI---QVLFILGVI--CYSAPLSLLLIVPLFFLYLYNRAYYVRTSRELKR 1073

  Fly   989 LEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCVS 1053
            |:.:.|||:::|:..||:||:.||:..:|:...:|.||..|.:..||.:..:.:....:.::|:.
pombe  1074 LDNVTRSPLYAHVQESLSGLSTIRAYGMQETFVEENDLRIDTNHRVWFMFFSSSRWQAIRVECIG 1138

  Fly  1054 CIFLTSVTFSFIISS--ETTYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTEL 1116
            .:.:....|..|:|:  .:...|.||.:::.|:.:|..:.:.|:|..::.....||||:|:|..:
pombe  1139 DLIIFCTAFYGILSAIKGSPNPGLVGFSLSYAIQITQGLSFIVQQSVDAENNTVSVERILEYINV 1203

  Fly  1117 EQE--PALGEKTPPQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSS 1179
            :.|  ..:.|..||.:|||.|.|.|.:.|.:|..:.|..|.|:|:.|....|:|||||||||||:
pombe  1204 KSEAPEIIPENRPPCEWPTDGAVSFNHYSAKYREDLSFALNNINIEISPREKIGIVGRTGAGKST 1268

  Fly  1180 LIGALFRLAH-IEGEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELW 1243
            |..||||:.. .||:|.||..:.....|..||:|:|||||:..:|...||.||||..|.||.::|
pombe  1269 LAMALFRIIEPTEGKIEIDNEDITKFGLYDLRSRLSIIPQESQIFEGNIRENLDPNHRLTDKKIW 1333

  Fly  1244 SALEDVELRKAI----PGLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTD 1304
            ..||...|:..|    .||...|.|.|.|||.|||||:||||.:|.:.::|:||||||:|..:||
pombe  1334 EVLEIASLKNCISQLEDGLYSRVAEGGANFSSGQRQLICLARVLLTSTRILLLDEATASVHAETD 1398

  Fly  1305 ALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEATG 1369
            |::|:|||.:||..|:||||||::||||||||:|:|.|..||||....||:........:.:.:|
pombe  1399 AIVQQTIRKRFKDRTILTVAHRINTVMDSDRILVLDHGKVVEFDATKKLLENKDSMFYSLAKESG 1463

Fly 1370 1369
pombe 1464 1463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	459/1423 (32%)
		ABC_membrane	214..441	CDD:294371	63/239 (26%)
		ABCC_MRP_domain1	495..699	CDD:213217	96/210 (46%)
		ABC_membrane	863..1088	CDD:294371	72/239 (30%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	113/219 (52%)
abc3	NP_595055.1	MRP_assoc_pro	101..1464	CDD:188098	461/1430 (32%)
		ABC_membrane	254..527	CDD:294371	80/355 (23%)
		ABCC_MRP_domain1	575..781	CDD:213217	96/210 (46%)
		ABC_membrane	907..1177	CDD:279056	82/289 (28%)
		ABCC_MRP_domain2	1224..1443	CDD:213211	112/218 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720