DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and Abcc2

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_036965.1	Gene:	Abcc2 / 25303	RGDID:	2366	Length:	1541	Species:	Rattus norvegicus

Alignment Length:	1452	Identity:	468/1452 - (32%)
Similarity:	753/1452 - (51%)	Gaps:	182/1452 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SSAKPTRKNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKE 67
            |....:.:.|...|:.:|.:.|:|....:.:|.:..|..:|:....:..::..:..:.|....|:
  Rat   184 SGPSDSTQTPSVTASFLSSITFSWYDRTVLKGYKHPLTLEDVWDIDEGFKTRSVTSKFEAAMTKD 248

  Fly    68 LERSHRKKQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNID 132
            |:::.:..|:                                      .|.:.|:.|.|.|..::
  Rat   249 LQKARQAFQR--------------------------------------RLQKSQRKPEATLHGLN 275

  Fly   133 VNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFP-----KSLDKAGPLEPIQPPVEEVDH 192
            .......|.|          ||.:|...|..:..|  :|     |||.|...:..::..:.::.|
  Rat   276 KKQSQSQDVL----------VLEEAKKKSEKTTKD--YPKSWLIKSLFKTFHVVILKSFILKLIH 328

  Fly   193 ------NATAVRSIL---DQTVEHMWNDMNSLGAVLVLS-TL---FC-------CFLLHHVDLRQ 237
                  |...::.::   ..:..::|  ...:.|:|:.: ||   ||       ||:|
  Rat   329 DLLVFLNPQLLKLLIGFVKSSNSYVW--FGYICAILMFAVTLIQSFCLQSYFQHCFVL------- 384

  Fly   238 RLMGARMRIACCSLIYRKTLRLSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAML 302
               |..:|....|.||:|.|.||.....|...|..:||:|.|..:|.....:|..:|...:|..|
  Rat   385 ---GMCVRTTVMSSIYKKALTLSNLARKQYTIGETVNLMSVDSQKLMDATNYMQLVWSSVIQITL 446

  Fly   303 TCYLIWLNIGIPAIVGVVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKM 367
            :.:.:|..:| |:|:..||:::..:||...|:.....::::..:..|.|:.||||::.||:::|.
  Rat   447 SIFFLWRELG-PSILAGVGVMVLLIPVNGVLATKIRNIQVQNMKNKDKRLKIMNEILSGIKILKY 510

  Fly   368 YAWEKPFQAVVAEARRSEIKQIRYASYLRGFYLSTMVFTERSTLYITLAAAALM--GQTITADFV 430
            :|||..||..|...|:.|:|.:.....|:...:..:..|......:|.:...|:  ...:.|:..
  Rat   511 FAWEPSFQEQVQGIRKKELKNLLRFGQLQSLLIFILQITPILVSVVTFSVYVLVDSANVLNAEKA 575

  Fly   431 FSAASYYNILQLVAAIWYPLAVSFGAEALVSLRRIQDFLMLEGREERTQGLTHKRDQEGGD---- 491
            |::.:.:|||:...:: .|:..|...:|.||:.|::.:|                   |||
  Rat   576 FTSITLFNILRFPLSM-LPMVTSSILQASVSVDRLERYL-------------------GGDDLDT 620

  Fly   492 ---------SRAVTIKDINASWDIEKPQKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGEL 547
                     .:||...:.:.:||.:. :.|:|.:||.|:.|||.||:|.||:||||::..:|||:
  Rat   621 SAIRRVSNFDKAVKFSEASFTWDPDL-EATIQDVNLDIKPGQLVAVVGTVGSGKSSLVSAMLGEM 684

  Fly   548 PVIDGGVFIQGDLSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTL 612
            ..:.|.:.|||..:|..|:.|:..|::::|||||.|::.|:||:|.:.|||..|.:.||.||...
  Rat   685 ENVHGHITIQGSTAYVPQQSWIQNGTIKDNILFGSEYNEKKYQQVLKACALLPDLEILPGGDMAE 749

  Fly   613 VGERGASLSGGQRARISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRI 677
            :||:|.:|||||:.|:|||||.|:.|.||::||||||||||||:|:|::|:||.|.||  ..|||
  Rat   750 IGEKGINLSGGQKQRVSLARAAYQDADIYILDDPLSAVDAHVGKHIFNKVVGPNGLLA--GKTRI 812

  Fly   678 LVTHQVHFLSEADVIVIVDQGRILRQGTYQELINSDLDFARLLERPKEEE--EGENSRNQTSPLS 740
            .|||.:|||.:.|.||::.:|.||.:|:|::|::....|||..:...:..  |||.:.|
  Rat   813 FVTHGIHFLPQVDEIVVLGKGTILEKGSYRDLLDKKGVFARNWKTFMKHSGPEGEATVN------ 871

  Fly   741 VNSLESDDED---IPFIDGVKDGYQQL-------------RKQSSSVHGSKSLDSTQLDDNV--- 786
             |..|::|:|   ||.::.:.:....|             |...||....|||.::....||
  Rat   872 -NDSEAEDDDDGLIPTMEEIPEDAASLAMRRENSLRRTLSRSSRSSSRRGKSLKNSLKIKNVNVL 935

  Fly   787 -DEDDLAEAQ--------ASGGISPRVWYEYFHAGSTLLSFSFMVFVMVMSQVVCSSSDFFANIW 842
             :::...|.|        .:|.:...::.:|..|.. ..|..|::....::.|....|:.:.:.|
  Rat   936 KEKEKEVEGQKLIKKEFVETGKVKFSIYLKYLQAVG-WWSILFIILFYGLNNVAFIGSNLWLSAW 999

  Fly   843 TQQEHQRSQGEATFSTFECMYI--YGALIIAVVIMTTFRGFLFFKICMHASKVLHDRMFACILHA 905
            | .:.....|....|:...|.|  :|||.:|..|............|.:|||.||.::...||.|
  Rat  1000 T-SDSDNLNGTNNSSSHRDMRIGVFGALGLAQGICLLISTLWSIYACRNASKALHGQLLTNILRA 1063

  Fly   906 TMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLVVAV 970
            .||||||||:|||:||||.|:..:|:|||:.:..::.....:.|.|::|.:..||....::.:::
  Rat  1064 PMRFFDTTPTGRIVNRFSGDISTVDDLLPQTLRSWMMCFFGIAGTLVMICMATPVFAIIIIPLSI 1128

  Fly   971 VDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQDVV----AKEFDLLQDVH 1031
            :.:.:...|:..|:.|:||:.:.:||::||.|.::|||.|||:.:.|...    .|:.|:.|...
  Rat  1129 LYISVQVFYVATSRQLRRLDSVTKSPIYSHFSETVTGLPIIRAFEHQQRFLAWNEKQIDINQKCV 1193

  Fly  1032 SSVWQLTMAVNTTLGLWLDCVSCIFLTSVTFSFIISSETTYSGNVGLAIAQAMILTGMVQYGVRQ 1096
            .| |   :..|..|.:.|:.|..:.:.......:|..:|.....||..::.|:.:|..:.:.||.
  Rat  1194 FS-W---ITSNRWLAIRLELVGNLVVFCSALLLVIYRKTLTGDVVGFVLSNALNITQTLNWLVRM 1254

  Fly  1097 VAESLQQMTSVERVLQYTELEQE-PALGEKTPPQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLT 1160
            .:|:...:.:|||:.:|..:|.| |.:.:|.||..||..|:::|.|...||.|....||:.:...
  Rat  1255 TSEAETNIVAVERISEYINVENEAPWVTDKRPPADWPRHGEIQFNNYQVRYRPELDLVLKGITCN 1319

  Fly  1161 IEAGWKVGIVGRTGAGKSSLIGALFR-LAHIEGEIFIDGIETGTISLEILRTRISIIPQDPVLFS 1224
            |::|.|||:|||||||||||...||| |....|:|.||||:..:|.|..||.|::||||||:|||
  Rat  1320 IKSGEKVGVVGRTGAGKSSLTNCLFRILESAGGQIIIDGIDVASIGLHDLRERLTIIPQDPILFS 1384

  Fly  1225 ATIRYNLDPFERYTDAELWSALEDVELRKAIPGLDY----MVTERGGNFSVGQRQLLCLARAILR 1285
            .::|.|||||.:|:|.|:|.|||...||..:.||..    .|||.|.|.|:||||||||.||:||
  Rat  1385 GSLRMNLDPFNKYSDEEVWRALELAHLRSFVSGLQLGLLSEVTEGGDNLSIGQRQLLCLGRAVLR 1449

  Fly  1286 NNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVP 1350
            .:|:||||||||.||.:||:|||.|||.:|.||||:|:||||||:||||:|:|:|.|..||:..|
  Rat  1450 KSKILVLDEATAAVDLETDSLIQTTIRKEFSQCTVITIAHRLHTIMDSDKIMVLDNGKIVEYGSP 1514

  Fly  1351 YLLLKKSQGHLRQMVEATGGES 1372
            ..|| .::|....|.:..|.|:
  Rat  1515 EELL-SNRGSFYLMAKEAGIEN 1535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	465/1439 (32%)
		ABC_membrane	214..441	CDD:294371	64/239 (27%)
		ABCC_MRP_domain1	495..699	CDD:213217	99/203 (49%)
		ABC_membrane	863..1088	CDD:294371	71/230 (31%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	124/219 (57%)
Abcc2	NP_036965.1	MRP_assoc_pro	7..1533	CDD:188098	466/1448 (32%)
		ABC_membrane	322..589	CDD:279056	68/279 (24%)
		ABCC_MRP_domain1	633..834	CDD:213217	99/203 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	862..881		7/25 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	901..923		4/21 (19%)
		ABC_membrane	979..1245	CDD:279056	78/270 (29%)
		ABCC_MRP_domain2	1294..1514	CDD:213211	124/219 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.730