Protein Alignment Cftr and Abcc2

DIOPT Version :10

• Sequence 1: NP_651269.1
• Gene: Cftr / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Sequence 2: NP_036965.1
• Gene: Abcc2 / 25303
• RGDID: 2366
• Length: 1541
• Species: Rattus norvegicus
• Alignment Length: 1452
• Identity: 468/1452 - (32%)
• Similarity: 753/1452 - (51%)
• Gaps: 182/1452 - (12%)

  Fly     3 SSAKPTRKNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKE 67
            |....:.:.|...|:.:|.:.|:|....:.:|.:..|..:|:....:..::..:..:.|....|:
  Rat   184 SGPSDSTQTPSVTASFLSSITFSWYDRTVLKGYKHPLTLEDVWDIDEGFKTRSVTSKFEAAMTKD 248

  Fly    68 LERSHRKKQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNID 132
            |:::.:..|:                                      .|.:.|:.|.|.|..::
  Rat   249 LQKARQAFQR--------------------------------------RLQKSQRKPEATLHGLN 275

  Fly   133 VNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFP-----KSLDKAGPLEPIQPPVEEVDH 192
            .......|.|          ||.:|...|..:..|  :|     |||.|...:..::..:.::.|
  Rat   276 KKQSQSQDVL----------VLEEAKKKSEKTTKD--YPKSWLIKSLFKTFHVVILKSFILKLIH 328

  Fly   193 ------NATAVRSIL---DQTVEHMWNDMNSLGAVLVLS-TL---FC-------CFLLHHVDLRQ 237
                  |...::.::   ..:..::|  ...:.|:|:.: ||   ||       ||:|
  Rat   329 DLLVFLNPQLLKLLIGFVKSSNSYVW--FGYICAILMFAVTLIQSFCLQSYFQHCFVL------- 384

  Fly   238 RLMGARMRIACCSLIYRKTLRLSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAML 302
               |..:|....|.||:|.|.||.....|...|..:||:|.|..:|.....:|..:|...:|..|
  Rat   385 ---GMCVRTTVMSSIYKKALTLSNLARKQYTIGETVNLMSVDSQKLMDATNYMQLVWSSVIQITL 446

  Fly   303 TCYLIWLNIGIPAIVGVVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKM 367
            :.:.:|..:| |:|:..||:::..:||...|:.....::::..:..|.|:.||||::.||:::|.
  Rat   447 SIFFLWRELG-PSILAGVGVMVLLIPVNGVLATKIRNIQVQNMKNKDKRLKIMNEILSGIKILKY 510

  Fly   368 YAWEKPFQAVVAEARRSEIKQIRYASYLRGFYLSTMVFTERSTLYITLAAAALM--GQTITADFV 430
            :|||..||..|...|:.|:|.:.....|:...:..:..|......:|.:...|:  ...:.|:..
  Rat   511 FAWEPSFQEQVQGIRKKELKNLLRFGQLQSLLIFILQITPILVSVVTFSVYVLVDSANVLNAEKA 575

  Fly   431 FSAASYYNILQLVAAIWYPLAVSFGAEALVSLRRIQDFLMLEGREERTQGLTHKRDQEGGD---- 491
            |::.:.:|||:...:: .|:..|...:|.||:.|::.:|                   |||
  Rat   576 FTSITLFNILRFPLSM-LPMVTSSILQASVSVDRLERYL-------------------GGDDLDT 620

  Fly   492 ---------SRAVTIKDINASWDIEKPQKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGEL 547
                     .:||...:.:.:||.:. :.|:|.:||.|:.|||.||:|.||:||||::..:|||:
  Rat   621 SAIRRVSNFDKAVKFSEASFTWDPDL-EATIQDVNLDIKPGQLVAVVGTVGSGKSSLVSAMLGEM 684

  Fly   548 PVIDGGVFIQGDLSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTL 612
            ..:.|.:.|||..:|..|:.|:..|::::|||||.|::.|:||:|.:.|||..|.:.||.||...
  Rat   685 ENVHGHITIQGSTAYVPQQSWIQNGTIKDNILFGSEYNEKKYQQVLKACALLPDLEILPGGDMAE 749

  Fly   613 VGERGASLSGGQRARISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRI 677
            :||:|.:|||||:.|:|||||.|:.|.||::||||||||||||:|:|::|:||.|.||  ..|||
  Rat   750 IGEKGINLSGGQKQRVSLARAAYQDADIYILDDPLSAVDAHVGKHIFNKVVGPNGLLA--GKTRI 812

  Fly   678 LVTHQVHFLSEADVIVIVDQGRILRQGTYQELINSDLDFARLLERPKEEE--EGENSRNQTSPLS 740
            .|||.:|||.:.|.||::.:|.||.:|:|::|::....|||..:...:..  |||.:.|
  Rat   813 FVTHGIHFLPQVDEIVVLGKGTILEKGSYRDLLDKKGVFARNWKTFMKHSGPEGEATVN------ 871

  Fly   741 VNSLESDDED---IPFIDGVKDGYQQL-------------RKQSSSVHGSKSLDSTQLDDNV--- 786
             |..|::|:|   ||.::.:.:....|             |...||....|||.::....||
  Rat   872 -NDSEAEDDDDGLIPTMEEIPEDAASLAMRRENSLRRTLSRSSRSSSRRGKSLKNSLKIKNVNVL 935

  Fly   787 -DEDDLAEAQ--------ASGGISPRVWYEYFHAGSTLLSFSFMVFVMVMSQVVCSSSDFFANIW 842
             :::...|.|        .:|.:...::.:|..|.. ..|..|::....::.|....|:.:.:.|
  Rat   936 KEKEKEVEGQKLIKKEFVETGKVKFSIYLKYLQAVG-WWSILFIILFYGLNNVAFIGSNLWLSAW 999

  Fly   843 TQQEHQRSQGEATFSTFECMYI--YGALIIAVVIMTTFRGFLFFKICMHASKVLHDRMFACILHA 905
            | .:.....|....|:...|.|  :|||.:|..|............|.:|||.||.::...||.|
  Rat  1000 T-SDSDNLNGTNNSSSHRDMRIGVFGALGLAQGICLLISTLWSIYACRNASKALHGQLLTNILRA 1063

  Fly   906 TMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLVVAV 970
            .||||||||:|||:||||.|:..:|:|||:.:..::.....:.|.|::|.:..||....::.:::
  Rat  1064 PMRFFDTTPTGRIVNRFSGDISTVDDLLPQTLRSWMMCFFGIAGTLVMICMATPVFAIIIIPLSI 1128

  Fly   971 VDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQDVV----AKEFDLLQDVH 1031
            :.:.:...|:..|:.|:||:.:.:||::||.|.::|||.|||:.:.|...    .|:.|:.|...
  Rat  1129 LYISVQVFYVATSRQLRRLDSVTKSPIYSHFSETVTGLPIIRAFEHQQRFLAWNEKQIDINQKCV 1193

  Fly  1032 SSVWQLTMAVNTTLGLWLDCVSCIFLTSVTFSFIISSETTYSGNVGLAIAQAMILTGMVQYGVRQ 1096
            .| |   :..|..|.:.|:.|..:.:.......:|..:|.....||..::.|:.:|..:.:.||.
  Rat  1194 FS-W---ITSNRWLAIRLELVGNLVVFCSALLLVIYRKTLTGDVVGFVLSNALNITQTLNWLVRM 1254

  Fly  1097 VAESLQQMTSVERVLQYTELEQE-PALGEKTPPQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLT 1160
            .:|:...:.:|||:.:|..:|.| |.:.:|.||..||..|:::|.|...||.|....||:.:...
  Rat  1255 TSEAETNIVAVERISEYINVENEAPWVTDKRPPADWPRHGEIQFNNYQVRYRPELDLVLKGITCN 1319

  Fly  1161 IEAGWKVGIVGRTGAGKSSLIGALFR-LAHIEGEIFIDGIETGTISLEILRTRISIIPQDPVLFS 1224
            |::|.|||:|||||||||||...||| |....|:|.||||:..:|.|..||.|::||||||:|||
  Rat  1320 IKSGEKVGVVGRTGAGKSSLTNCLFRILESAGGQIIIDGIDVASIGLHDLRERLTIIPQDPILFS 1384

  Fly  1225 ATIRYNLDPFERYTDAELWSALEDVELRKAIPGLDY----MVTERGGNFSVGQRQLLCLARAILR 1285
            .::|.|||||.:|:|.|:|.|||...||..:.||..    .|||.|.|.|:||||||||.||:||
  Rat  1385 GSLRMNLDPFNKYSDEEVWRALELAHLRSFVSGLQLGLLSEVTEGGDNLSIGQRQLLCLGRAVLR 1449

  Fly  1286 NNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVP 1350
            .:|:||||||||.||.:||:|||.|||.:|.||||:|:||||||:||||:|:|:|.|..||:..|
  Rat  1450 KSKILVLDEATAAVDLETDSLIQTTIRKEFSQCTVITIAHRLHTIMDSDKIMVLDNGKIVEYGSP 1514

  Fly  1351 YLLLKKSQGHLRQMVEATGGES 1372
            ..|| .::|....|.:..|.|:
  Rat  1515 EELL-SNRGSFYLMAKEAGIEN 1535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cftr	NP_651269.1	MRP_assoc_pro	12..1356	CDD:188098	463/1425 (32%)
Abcc2	NP_036965.1	MRP_assoc_pro	7..1533	CDD:188098	466/1448 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	862..881		7/25 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	901..923		4/21 (19%)