DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG5789 and Abcb4

DIOPT Version :9

Sequence 1:NP_001247286.1 Gene:CG5789 / 42928 FlyBaseID:FBgn0039207 Length:1402 Species:Drosophila melanogaster
Sequence 2:NP_036822.1 Gene:Abcb4 / 24891 RGDID:620248 Length:1278 Species:Rattus norvegicus


Alignment Length:1357 Identity:305/1357 - (22%)
Similarity:567/1357 - (41%) Gaps:282/1357 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   155 SQAVANSSGSP------GDALFPKSLDKAGPLE-PIQPPVEEVDHNATAVRSILDQTVEHMWNDM 212
            :.|:|:.||.|      |: :..|.:|.||... |:...:..::..     .||::.:.......
  Rat    59 AMAIAHGSGLPLMMIVFGE-MTDKFVDNAGNFSLPVNFSLSMLNPG-----RILEEEMTRYAYYY 117

  Fly   213 NSLGAVLVLS--------TLFCCFLLHHVDLRQRLMGARMRIACCSLIYRKTLRLSMKTAGQTPA 269
            :.||..::|:        ||.....:..:  ||:...|.:|........:.|..|:.:       
  Rat   118 SGLGGGVLLAAYIQVSFWTLAAGRQIRKI--RQKFFHAILRQEMGWFDIKGTTELNTR------- 173

  Fly   270 GYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLI-----W-LNIGIPAIVGVVGLLLKTVP 328
                  |::|::::..|......::...:......:::     | |.:.|.||..::||      
  Rat   174 ------LTDDISKISEGIGDKVGMFFQAIATFFAGFIVGFIRGWKLTLVIMAITAILGL------ 226

  Fly   329 VQTAL-SKVTSVLRMRIAERTD------ARVG-IMNELVQGIQVIKMYAWE----KPFQAVVAEA 381
             .||: :|:.|..       :|      |:.| :..|.:..|:.:..:..:    :.:|..:..|
  Rat   227 -STAVWAKILSTF-------SDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENA 283

  Fly   382 RRSEIKQ-------------IRYASYLRGF-YLSTMVFTERSTLYITLAAAALMGQTITADFVFS 432
            ::..||:             :.||||...| |.||:|.::..|:          |..:|..|...
  Rat   284 KKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTI----------GNAMTVFFSIL 338

  Fly   433 AASYYNILQLVAAI-WYPLAVSFGAEALVSLRRIQDFLMLEGREERTQGLTHKRDQEGGDSRAVT 496
            ..: :::.|....| .:|.|  .|| |.|....|.:...::...||    .||.|...|:   :.
  Rat   339 IGA-FSVGQAAPCIDAFPNA--RGA-AYVIFDIIDNNPKIDSFSER----GHKPDSIKGN---LE 392

  Fly   497 IKDINASWDIEKPQKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGD-- 559
            ..|::.|:......|.|:.:||:::.||..|::|..|.|||:.:|||.......:|.:.|.|.  
  Rat   393 FSDVHFSYPSRANIKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGTISIDGQDI 457

  Fly   560 -----------LSYAAQEPWLFTGSVRNNILFG------EEFDRKRYQEVTRCCALSTDF-QQLP 606
                       :...:|||.||:.::..||.:|      :|. :|..:|     |.:.|| .:||
  Rat   458 RNFNVRCLREFIGVVSQEPVLFSTTIAENIRYGRGNVTMDEI-KKAVKE-----ANAYDFIMKLP 516

  Fly   607 NGDKTLVGERGASLSGGQRARISLARAVYKPAQIYLMDDPLSAVD----AHVGRHLFDEVIGPRG 667
            ....||||:|||.|||||:.||::|||:.:..:|.|:|:..||:|    |.|...| |:  ...|
  Rat   517 QKFDTLVGDRGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAAL-DK--AREG 578

  Fly   668 RLAQLKATRILVTHQVHFLSEADVIVIVDQGRILRQGTYQELINSDLDFARLLERPKEEEEGENS 732
            |      |.|::.|::..:..||||...:.|.|:.||::.|||..:..:.||:          |.
  Rat   579 R------TTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELIKKEGIYFRLV----------NM 627

  Fly   733 RNQTSPLSVNSLESDDEDIPFIDGVKDGYQQLR---------KQSSSVHGSK-SLDSTQLDDNVD 787
            :...|.:.....|.:..|.....||.....:.|         .:||..|.:: .:::.:||.||.
  Rat   628 QTSGSQILSEEFEVELSDEKAAGGVAPNGWKARIFRNSTKKSLKSSRAHQNRLDVETNELDANVP 692

  Fly   788 EDDLAE------------------AQASGGISPRVWYEYFHAGSTLLSFSFMVFVMVMSQVVCSS 834
            .....:                  |.|:|.:.|        |.|.:||....:|           
  Rat   693 PVSFLKVLRLNKTEWPYFVVGTLCAIANGALQP--------AFSIILSEMIAIF----------- 738

  Fly   835 SDFFANIWTQQEHQRSQGEATFSTFEC-MYIYGALIIAVVIMTTF--RGFLFFKICMHASKVLHD 896
                           ..|:.|....:| |:....|.:.|....||  :||.|.|    |.::|..
  Rat   739 ---------------GPGDDTVKQQKCNMFSLVFLGLGVHSFFTFFLQGFTFGK----AGEILTT 784

  Fly   897 RM----FACILHATMRFFD--TTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVM-----FGI 950
            |:    |..:|...|.:||  ...:|.:..|.:.|...:.....      .::||:.     .|.
  Rat   785 RLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATG------TRLALIAQNTANLGT 843

  Fly   951 LIVIGI-----LNPVLVAAMLVVAVVDVLILKLYL-RPSQDLKRLE--GICRSPVFSHLSASLTG 1007
            .|:|..     |..:|::.:..:||..::.:|:.. ...:|.|.:|  |...:....::.   |.
  Rat   844 GIIISFIYGWQLTLLLLSVVPFIAVAGIVEMKMLAGNAKRDKKEMEAAGKIATEAIENIR---TV 905

  Fly  1008 LAIIRSRQLQDVVAKEF-----DLLQDVHSSVWQLTMAVNTTLGLWLDCVSCIFLTSVTFSFIIS 1067
            :::.:.|:.:.:..::.     :.::..|  ::.:|.:::... ::.....|         |...
  Rat   906 VSLTQERKFESMYVEKLHGPYRNSVRKAH--IYGITFSISQAF-MYFSYAGC---------FRFG 958

  Fly  1068 SETTYSGNV---GLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTELEQEPALGEKTPPQ 1129
            |....:|::   .:.:..:.|:.|.|..|.............:.....::..|::|.:...:...
  Rat   959 SYLIVNGHMRFKDVILVFSAIVLGAVALGHASSFAPDYAKAKLSAAYLFSLFERQPLIDSYSREG 1023

  Fly  1130 QWPTR--GQVEFRNMSCRYDPNGS-PVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAH-I 1190
            .||.:  |.|.|..:...|....: |||:.|:|.::.|..:.:||.:|.|||:::..|.|... :
  Rat  1024 MWPDKFEGSVTFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPM 1088

  Fly  1191 EGEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNL---DPFERYTDAELWSALEDVELR 1252
            .|.:.:||.|...::::.||.::.|:.|:|:||..:|..|:   |.....:..|:..|.::..:.
  Rat  1089 AGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAKNIAYGDNSRVVSQDEIVRAAKEANIH 1153

  Fly  1253 KAIPGL----DYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRI 1313
            ..|..|    :..|.::|...|.||:|.:.:|||::|..:||:|||||:.:|.:::.::|..:..
  Rat  1154 PFIETLPQKYETRVGDKGTQLSGGQKQRIAIARALIRQPRVLLLDEATSALDTESEKVVQEALDK 1218

  Fly  1314 KFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEATGG 1370
            ..:..|.:.:||||.|:.::|.|:|:|.|...|......||.: :|....||....|
  Rat  1219 AREGRTCIVIAHRLSTIQNADLIVVIDNGKVKEHGTHQQLLAQ-KGIYFSMVNIQAG 1274

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5789NP_001247286.1 CFTR_protein 9..1367 CDD:273530 304/1352 (22%)
ABC_membrane 214..441 CDD:294371 47/266 (18%)
ABCC_MRP_domain1 495..699 CDD:213217 72/227 (32%)
ABC_membrane 863..1088 CDD:294371 42/253 (17%)
ABCC_MRP_domain2 1135..1350 CDD:213211 67/223 (30%)
Abcb4NP_036822.1 PTZ00265 29..1271 CDD:240339 304/1352 (22%)
ABC_membrane 58..342 CDD:279056 60/328 (18%)
ABC_MTABC3_MDL1_MDL2 392..628 CDD:213216 82/260 (32%)
Interaction with HAX1. /evidence=ECO:0000269|PubMed:15159385 622..646 5/33 (15%)
ABC_membrane 714..984 CDD:279056 56/328 (17%)
ABC_MTABC3_MDL1_MDL2 1033..1272 CDD:213216 71/239 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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