Protein Alignment Cftr and Abcc12

DIOPT Version :10

• Sequence 1: NP_651269.1
• Gene: Cftr / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Sequence 2: NP_766500.3
• Gene: Abcc12 / 244562
• MGIID: 2441679
• Length: 1366
• Species: Mus musculus
• Alignment Length: 1485
• Identity: 472/1485 - (31%)
• Similarity: 734/1485 - (49%)
• Gaps: 261/1485 - (17%)

  Fly     2 DSSAK---PTR------KNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLG 57
            |.|.|   |.|      .||...|.::|...|:|..|::.|..:..|..|.|......|.|:...
Mouse    26 DPSLKTMIPVRPRARLAPNPVDDAGLLSFATFSWLTPVMIRSYKHTLTVDTLPPLSPYDSSDINA 90

  Fly    58 DRLEDQWFKELERSHRKKQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQK 122
            .|.:..|.:|::|                  :||.                 .|.|.:::.:||:
Mouse    91 KRFQILWEEEIKR------------------VGPE-----------------KASLGRVVWKFQR 120

  Fly   123 TPVAQLRNIDVNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPV 187
            |                            .||...|||.......||.|..|            :
Mouse   121 T----------------------------RVLMDVVANILCIVMAALGPTVL------------I 145

  Fly   188 EEVDHNATAVRSILDQTVEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRLMGA---------- 242
            .::..:.|::.|             ..:|..:.|     |..|...:..:.|..|
Mouse   146 HQILQHITSISS-------------GHIGIGICL-----CLALFTTEFTKVLFWALAWAINYRTA 192

  Fly   243 -RMRIACCSLIYRKTLRLSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQA-----M 301
             |:::|..:||:...  ||.||.....||.::|:||:|...|....:|      .||.|     |
Mouse   193 IRLKVALSTLIFENL--LSFKTLTHISAGEVLNILSSDSYSLFEAALF------CPLPATIPILM 249

  Fly   302 LTC--YLIWLNIGIPAIVGVVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQV 364
            :.|  |..:: :|..|:|| :.:.|..:|:|..::|:.|..|......||.||..|||.:..|::
Mouse   250 VVCAVYAFFI-LGSTALVG-ISVYLIFIPIQMFMAKLNSTFRRSAISVTDKRVQTMNEFLTCIKL 312

  Fly   365 IKMYAWEKPFQAVVAEARRSEIKQIRYASYLRGF------YLSTMVFTERSTLYITLAAAALMGQ 423
            |||||||:.|...:.:.|:.|.|.:..|.|::..      .:||:......|.:|.|.      :
Mouse   313 IKMYAWEESFINTIHDIRKREKKLLEKAGYVQSGNSALAPIVSTIAIVSTFTCHIFLK------R 371

  Fly   424 TITADFVFSAASYYNILQLVAAIWYPLAVSFGAEALVSLRRIQ------------------DFLM 470
            .:||...||..:.:|:::...|| .|.:|...|||.|||||::                  |.::
Mouse   372 KLTAPVAFSVIAMFNVMKFSIAI-LPFSVKAVAEASVSLRRMKKILIAKSPPSYITQPEDPDTIL 435

  Fly   471 LEGREERT--QGLTHKRD---------------------QEGGDSRAVTIKDINASWDIEKPQKT 512
            |......|  |.:..|.|                     ::....:.|.    :..|....|:..
Mouse   436 LLANATLTWEQEINRKSDPPKAQIQKRHVFKKQRPELYSEQSRSDQGVA----SPEWQSGSPKSV 496

  Fly   513 LQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGDLSYAAQEPWLFTGSVRNN 577
            |.:|:..:.||::..:.|.||:||||::..|||::.:..|.|.:.|.|:|.:|:.|:|.|:||.|
Mouse   497 LHNISFVVRKGKVLGICGNVGSGKSSLISALLGQMQLQKGVVAVNGPLAYVSQQAWIFHGNVREN 561

  Fly   578 ILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQIYL 642
            |||||:::.:|||.....|.|..|...||.||.|.:||||.:||||||.|||||||||...|:||
Mouse   562 ILFGEKYNHQRYQHTVHVCGLQKDLNSLPYGDLTEIGERGVNLSGGQRQRISLARAVYANRQLYL 626

  Fly   643 MDDPLSAVDAHVGRHLFDEVIGP--RGRLAQLKATRILVTHQVHFLSEADVIVIVDQGRILRQGT 705
            :||||||||||||:|:|:|.|..  :|:      |.:|||||:.||...|.:::::.|.|..:||
Mouse   627 LDDPLSAVDAHVGKHVFEECIKKTLKGK------TVVLVTHQLQFLESCDEVILLEDGEICEKGT 685

  Fly   706 YQELINSDLDFARLLE--RPKEEEEGENSRNQTSPLSVNSLESD----DEDIPFIDG-VKDGYQQ 763
            ::||:.....:|:|:.  |..:.::.|:..|..   .|.:|:..    |||.....| .||
Mouse   686 HKELMEERGRYAKLIHNLRGLQFKDPEHIYNVA---MVETLKESPAQRDEDAVLASGDEKD---- 743

  Fly   764 LRKQSSSVHGSKSLDSTQLDDNVDEDDL--AEAQASGGISPRVWYEYFHA-GSTLLSFSFM-VFV 824
                    .|.:......:|.|.....|  .|:...|.::.:.::.|..| |..|:||..: :|.
Mouse   744 --------EGKEPETEEFVDTNAPAHQLIQTESPQEGIVTWKTYHTYIKASGGYLVSFLVLCLFF 800

  Fly   825 MVM-----------------SQVVCSSSDFFANIWTQQEHQRSQGEATFSTFECMYIYGALIIAV 872
            ::|                 |||||:|.    |..|.....::..:.....::.:||  |.:::|
Mouse   801 LMMGSSAFSTWWLGIWLDRGSQVVCASQ----NNKTACNVDQTLQDTKHHMYQLVYI--ASMVSV 859

  Fly   873 VIMTTFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAM 937
            ::....:||.|....:.||..||:|:|..|:.:.|.||||||:||::|||||||..:|..||...
Mouse   860 LMFGIIKGFTFTNTTLMASSSLHNRVFNKIVRSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHA 924

  Fly   938 MDFIQIALVMFGILIVIGILNPVLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLS 1002
            .:|:|...::..||:::..:.||::..:..:||:.:::|:::.|..|:||::|.|.|||.|||::
Mouse   925 ENFLQQFFMVVFILVIMAAVFPVVLVVLAGLAVIFLILLRIFHRGVQELKQVENISRSPWFSHIT 989

  Fly  1003 ASLTGLAIIRSRQLQDVVAKEFDLLQDVHSS-VWQLTMAVN---TTLGLWLDCVSCIFLTSVTFS 1063
            :|:.||.:|.:...:|....:|..|.|.:|| :.....|:.   ..:.:.::.|:.:....||.|
Mouse   990 SSIQGLGVIHAYDKKDDCISKFKTLNDENSSHLLYFNCALRWFALRMDILMNIVTFVVALLVTLS 1054

  Fly  1064 FIISSETTYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTEL---EQEPALGEK 1125
            |    .:..:.:.||:::..:.|:|::|..||...|:..:.||.|.:.:|...   |........
Mouse  1055 F----SSISASSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSAELLREYILTCVPEHTHPFKVG 1115

  Fly  1126 TPPQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAH- 1189
            |.|:.||:||::.|::...||..|...||..|||.|::|..||||||||:|||||..|||||..
Mouse  1116 TCPKDWPSRGEITFKDYRMRYRDNTPLVLDGLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEP 1180

  Fly  1190 IEGEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDVELRKA 1254
            ..|.|.||.::..|:.||.|||::::||||||||..|:||||||...:||..||..||...:|..
Mouse  1181 ASGTIIIDEVDICTVGLEDLRTKLTMIPQDPVLFVGTVRYNLDPLGSHTDEMLWHVLERTFMRDT 1245

  Fly  1255 I----PGLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKF 1315
            |    ..|...|||.|.|||||:|||||:|||:|||:|:::||||||::|.:||.|:|.||:..|
Mouse  1246 IMKLPEKLQAEVTENGENFSVGERQLLCMARALLRNSKIILLDEATASMDSKTDTLVQSTIKEAF 1310

  Fly  1316 KQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEATGG 1370
            |.|||||:||||:||::.|.::||:.|..:|||.|.:|.:|.......::.|..|
Mouse  1311 KSCTVLTIAHRLNTVLNCDLVLVMENGKVIEFDKPEVLAEKPDSAFAMLLAAEVG 1365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cftr	NP_651269.1	MRP_assoc_pro	12..1356	CDD:188098	463/1450 (32%)
Abcc12	NP_766500.3	MRP_assoc_pro	43..1366	CDD:188098	467/1468 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	470..492		2/25 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	726..749		7/34 (21%)