DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and Abcc12

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_766500.3	Gene:	Abcc12 / 244562	MGIID:	2441679	Length:	1366	Species:	Mus musculus

Alignment Length:	1485	Identity:	472/1485 - (31%)
Similarity:	734/1485 - (49%)	Gaps:	261/1485 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DSSAK---PTR------KNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLG 57
            |.|.|   |.|      .||...|.::|...|:|..|::.|..:..|..|.|......|.|:...
Mouse    26 DPSLKTMIPVRPRARLAPNPVDDAGLLSFATFSWLTPVMIRSYKHTLTVDTLPPLSPYDSSDINA 90

  Fly    58 DRLEDQWFKELERSHRKKQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQK 122
            .|.:..|.:|::|                  :||.                 .|.|.:::.:||:
Mouse    91 KRFQILWEEEIKR------------------VGPE-----------------KASLGRVVWKFQR 120

  Fly   123 TPVAQLRNIDVNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPV 187
            |                            .||...|||.......||.|..|            :
Mouse   121 T----------------------------RVLMDVVANILCIVMAALGPTVL------------I 145

  Fly   188 EEVDHNATAVRSILDQTVEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRLMGA---------- 242
            .::..:.|::.|             ..:|..:.|     |..|...:..:.|..|
Mouse   146 HQILQHITSISS-------------GHIGIGICL-----CLALFTTEFTKVLFWALAWAINYRTA 192

  Fly   243 -RMRIACCSLIYRKTLRLSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQA-----M 301
             |:::|..:||:...  ||.||.....||.::|:||:|...|....:|      .||.|     |
Mouse   193 IRLKVALSTLIFENL--LSFKTLTHISAGEVLNILSSDSYSLFEAALF------CPLPATIPILM 249

  Fly   302 LTC--YLIWLNIGIPAIVGVVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQV 364
            :.|  |..:: :|..|:|| :.:.|..:|:|..::|:.|..|......||.||..|||.:..|::
Mouse   250 VVCAVYAFFI-LGSTALVG-ISVYLIFIPIQMFMAKLNSTFRRSAISVTDKRVQTMNEFLTCIKL 312

  Fly   365 IKMYAWEKPFQAVVAEARRSEIKQIRYASYLRGF------YLSTMVFTERSTLYITLAAAALMGQ 423
            |||||||:.|...:.:.|:.|.|.:..|.|::..      .:||:......|.:|.|.      :
Mouse   313 IKMYAWEESFINTIHDIRKREKKLLEKAGYVQSGNSALAPIVSTIAIVSTFTCHIFLK------R 371

  Fly   424 TITADFVFSAASYYNILQLVAAIWYPLAVSFGAEALVSLRRIQ------------------DFLM 470
            .:||...||..:.:|:::...|| .|.:|...|||.|||||::                  |.::
Mouse   372 KLTAPVAFSVIAMFNVMKFSIAI-LPFSVKAVAEASVSLRRMKKILIAKSPPSYITQPEDPDTIL 435

  Fly   471 LEGREERT--QGLTHKRD---------------------QEGGDSRAVTIKDINASWDIEKPQKT 512
            |......|  |.:..|.|                     ::....:.|.    :..|....|:..
Mouse   436 LLANATLTWEQEINRKSDPPKAQIQKRHVFKKQRPELYSEQSRSDQGVA----SPEWQSGSPKSV 496

  Fly   513 LQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGDLSYAAQEPWLFTGSVRNN 577
            |.:|:..:.||::..:.|.||:||||::..|||::.:..|.|.:.|.|:|.:|:.|:|.|:||.|
Mouse   497 LHNISFVVRKGKVLGICGNVGSGKSSLISALLGQMQLQKGVVAVNGPLAYVSQQAWIFHGNVREN 561

  Fly   578 ILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQIYL 642
            |||||:::.:|||.....|.|..|...||.||.|.:||||.:||||||.|||||||||...|:||
Mouse   562 ILFGEKYNHQRYQHTVHVCGLQKDLNSLPYGDLTEIGERGVNLSGGQRQRISLARAVYANRQLYL 626

  Fly   643 MDDPLSAVDAHVGRHLFDEVIGP--RGRLAQLKATRILVTHQVHFLSEADVIVIVDQGRILRQGT 705
            :||||||||||||:|:|:|.|..  :|:      |.:|||||:.||...|.:::::.|.|..:||
Mouse   627 LDDPLSAVDAHVGKHVFEECIKKTLKGK------TVVLVTHQLQFLESCDEVILLEDGEICEKGT 685

  Fly   706 YQELINSDLDFARLLE--RPKEEEEGENSRNQTSPLSVNSLESD----DEDIPFIDG-VKDGYQQ 763
            ::||:.....:|:|:.  |..:.::.|:..|..   .|.:|:..    |||.....| .||
Mouse   686 HKELMEERGRYAKLIHNLRGLQFKDPEHIYNVA---MVETLKESPAQRDEDAVLASGDEKD---- 743

  Fly   764 LRKQSSSVHGSKSLDSTQLDDNVDEDDL--AEAQASGGISPRVWYEYFHA-GSTLLSFSFM-VFV 824
                    .|.:......:|.|.....|  .|:...|.::.:.::.|..| |..|:||..: :|.
Mouse   744 --------EGKEPETEEFVDTNAPAHQLIQTESPQEGIVTWKTYHTYIKASGGYLVSFLVLCLFF 800

  Fly   825 MVM-----------------SQVVCSSSDFFANIWTQQEHQRSQGEATFSTFECMYIYGALIIAV 872
            ::|                 |||||:|.    |..|.....::..:.....::.:||  |.:::|
Mouse   801 LMMGSSAFSTWWLGIWLDRGSQVVCASQ----NNKTACNVDQTLQDTKHHMYQLVYI--ASMVSV 859

  Fly   873 VIMTTFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAM 937
            ::....:||.|....:.||..||:|:|..|:.:.|.||||||:||::|||||||..:|..||...
Mouse   860 LMFGIIKGFTFTNTTLMASSSLHNRVFNKIVRSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHA 924

  Fly   938 MDFIQIALVMFGILIVIGILNPVLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLS 1002
            .:|:|...::..||:::..:.||::..:..:||:.:::|:::.|..|:||::|.|.|||.|||::
Mouse   925 ENFLQQFFMVVFILVIMAAVFPVVLVVLAGLAVIFLILLRIFHRGVQELKQVENISRSPWFSHIT 989

  Fly  1003 ASLTGLAIIRSRQLQDVVAKEFDLLQDVHSS-VWQLTMAVN---TTLGLWLDCVSCIFLTSVTFS 1063
            :|:.||.:|.:...:|....:|..|.|.:|| :.....|:.   ..:.:.::.|:.:....||.|
Mouse   990 SSIQGLGVIHAYDKKDDCISKFKTLNDENSSHLLYFNCALRWFALRMDILMNIVTFVVALLVTLS 1054

  Fly  1064 FIISSETTYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTEL---EQEPALGEK 1125
            |    .:..:.:.||:::..:.|:|::|..||...|:..:.||.|.:.:|...   |........
Mouse  1055 F----SSISASSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSAELLREYILTCVPEHTHPFKVG 1115

  Fly  1126 TPPQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAH- 1189
            |.|:.||:||::.|::...||..|...||..|||.|::|..||||||||:|||||..|||||..
Mouse  1116 TCPKDWPSRGEITFKDYRMRYRDNTPLVLDGLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEP 1180

  Fly  1190 IEGEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDVELRKA 1254
            ..|.|.||.::..|:.||.|||::::||||||||..|:||||||...:||..||..||...:|..
Mouse  1181 ASGTIIIDEVDICTVGLEDLRTKLTMIPQDPVLFVGTVRYNLDPLGSHTDEMLWHVLERTFMRDT 1245

  Fly  1255 I----PGLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKF 1315
            |    ..|...|||.|.|||||:|||||:|||:|||:|:::||||||::|.:||.|:|.||:..|
Mouse  1246 IMKLPEKLQAEVTENGENFSVGERQLLCMARALLRNSKIILLDEATASMDSKTDTLVQSTIKEAF 1310

  Fly  1316 KQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEATGG 1370
            |.|||||:||||:||::.|.::||:.|..:|||.|.:|.:|.......::.|..|
Mouse  1311 KSCTVLTIAHRLNTVLNCDLVLVMENGKVIEFDKPEVLAEKPDSAFAMLLAAEVG 1365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	466/1470 (32%)
		ABC_membrane	214..441	CDD:294371	69/250 (28%)
		ABCC_MRP_domain1	495..699	CDD:213217	93/205 (45%)
		ABC_membrane	863..1088	CDD:294371	73/228 (32%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	118/219 (54%)
Abcc12	NP_766500.3	MRP_assoc_pro	43..1366	CDD:188098	467/1468 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	470..492		2/25 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	726..749		7/34 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.730