DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG5789 and Cftr

DIOPT Version :9

Sequence 1:NP_001247286.1 Gene:CG5789 / 42928 FlyBaseID:FBgn0039207 Length:1402 Species:Drosophila melanogaster
Sequence 2:XP_006236159.1 Gene:Cftr / 24255 RGDID:2332 Length:1530 Species:Rattus norvegicus


Alignment Length:1593 Identity:439/1593 - (27%)
Similarity:735/1593 - (46%) Gaps:320/1593 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 RKNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSHR 73
            :|:|.:.|:.||:|.|:|..|:|.:|.|..|...|:.|....|.::.|.::||.:|    :|...
  Rat    56 QKSPLEKASFISKLFFSWTTPILRKGYRHHLELSDIYQAPSSDSADHLSEKLEREW----DREQA 116

  Fly    74 KKQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNIDVNDISI 138
            .|:||.|.:||.|||:...:..|::.::..|.|.:.|.:|.:::..:                  
  Rat   117 SKKKPQLIHALRRCFVWRFVFYGVLLYLGEVTKAVQPVLLGRIIASY------------------ 163

  Fly   139 SDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNATAVRSILDQ 203
             |..|...|:|..|:                                                  
  Rat   164 -DPDNTEERSIAIYL-------------------------------------------------- 177

  Fly   204 TVEHMWNDMNSLGAVL--VLSTLF---CCFLLHHVDLRQRLMGARMRIACCSLIYRKTLRLSMKT 263
                      .:|..|  ::.||.   ..|.|||:       |.:||||..||||:|||:||.:.
  Rat   178 ----------GIGLCLLFIVRTLLLHPAIFGLHHI-------GMQMRIAMFSLIYKKTLKLSSRV 225

  Fly   264 AGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVP 328
            ..:...|.||:||||::|:.|.|....|:|||.|||.:|...|:|..:...|..| :|||:..|.
  Rat   226 LDKISIGQLISLLSNNLNKFDEGLALAHFIWIAPLQVVLLMGLLWDLLQFSAFCG-LGLLIVLVI 289

  Fly   329 VQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIRYAS 393
            .|..|.|:....|.:.|.:.:.|:.|.:|::..|..:|.|.||...:.::...|..|:|..|.::
  Rat   290 FQAILGKMMVKYRDKRAAKINERLVITSEVIDNIYSVKAYCWESAMEKIIESLREEELKMTRRSA 354

  Fly   394 YLRGFYLSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNILQLVAAIWYPLAVSFGAEA 458
            |:|.|..|...|:....:::::....::...:... :|:..|:..:|::.....:|.||....::
  Rat   355 YMRFFTSSAFFFSGFFVVFLSVLPYTVINGIVLRK-IFTTISFCIVLRMSVTRQFPTAVQIWYDS 418

  Fly   459 LVSLRRIQDFLMLEGREERTQGLTHKRDQEGGDSRAVTIKDINASWD------IEKPQ------K 511
            |..:|:|||||..:..:.....|..         ..:.::::.|.|:      :||.|      |
  Rat   419 LGMIRKIQDFLQTQEYKVLEYNLMF---------TGLVMENVTAFWEEGFQELLEKVQLNNDDRK 474

  Fly   512 T-------------------LQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQ 557
            |                   |::|||.|:||::.|:.|..||||:|:|.|:||||...:|.:...
  Rat   475 TSNGENHLSFSHLCLVGNPVLKNINLNIKKGEMLAITGSTGAGKTSLLMLILGELEASEGIIKHS 539

  Fly   558 GDLSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSG 622
            |.:|:::|..|:..|:::.||:||..:|..||:.|.:.|.|..|..:....|.|::||.|.:|||
  Rat   540 GRVSFSSQISWIMPGTIKENIIFGVSYDEYRYKSVVKACQLQEDITKFAEQDNTVLGEGGVTLSG 604

  Fly   623 GQRARISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKA--TRILVTHQVHF 685
            ||||||||||||||.|.:||:|.|...:|......:|:..:      .:|.|  ||||||.::..
  Rat   605 GQRARISLARAVYKDADLYLLDSPFGYLDVLTEEQIFESCV------CKLMASKTRILVTSKMEQ 663

  Fly   686 LSEADVIVIVDQGRILRQGTYQELINSDLDFARLL------------------------------ 720
            |.:||.|:|:.:|.....||:.||.:...||:..|                              
  Rat   664 LKKADKILILHEGSSYFYGTFSELQSLRPDFSSKLMGYDTFDQFTEERRSSILTETLRRFSVDDA 728

  Fly   721 ----ERPKEE-----EEGENSRN---------------QTSPLSVNSLESDD---EDIPFIDGVK 758
                .:.|:.     |.||..:|               |.:|||:.. ||||   ..:..:...:
  Rat   729 STTWNKAKQSFRQTGEFGEKRKNSILSSFSSVKKISIVQKTPLSIEG-ESDDLQERRLSLVPDSE 792

  Fly   759 DGYQQL---------------RKQS---------SSVHGS------------------------- 774
            .|...|               |:||         |||..|                         
  Rat   793 HGEAALPRSNMITAGPTFPGRRRQSVLDLMTFTPSSVSSSLQRTRASIRKISLAPRISLKEEDIY 857

  Fly   775 ---KSLDST-QLDDNVDEDDLAEAQASGGIS-PRV--WYEY-----FHAGSTLLSFSFMVFVMVM 827
               .|.||| .:.:.::|:||.|......:. |.|  |..|     .|.|    .|:.:::.:::
  Rat   858 SRRLSQDSTLNITEEINEEDLKECFFDDMVKIPTVTTWNTYLRYFTLHRG----LFAVLIWCVLV 918

  Fly   828 SQVVCSSSDFFANIWTQQEHQRSQGE--------------ATFSTFECMYIYGALIIAVVIMTTF 878
            ..|..::|.|.  :|..:.:..:.|.              .:.|.:...|||..:...::.::.|
  Rat   919 FLVEVAASLFV--LWLLKNNPVNGGNNGTKIANTSYVVVITSSSFYYIFYIYVGVADTLLALSLF 981

  Fly   879 RGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQI 943
            ||.......:.|||:||.:|...||||.|..|:...:|.||||||||:..:|:.||..:.||||:
  Rat   982 RGLPLVHTLITASKILHRKMLHSILHAPMSTFNKLKAGGILNRFSKDIAILDDFLPLTIFDFIQL 1046

  Fly   944 ALVMFGILIVIGILNPVLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGL 1008
            ..::.|.:||:..|.|.:..|.:....|.:|:...:|..||.||:||...|||:|:||..||.||
  Rat  1047 LFIVVGAIIVVSALQPYIFLATVPGLAVFILLRAYFLHTSQQLKQLESEGRSPIFTHLVTSLKGL 1111

  Fly  1009 AIIRSRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCVSCIFLTSVTFSFIISSETTYS 1073
            ..:|:.:.|......|....::|::.|.:.:|......:.:|.:..:|...|||..|:::... .
  Rat  1112 WTLRAFRRQTYFETLFHKALNLHTANWFMYLATLRWFQMRIDMIFVLFFIVVTFISILTTGEG-E 1175

  Fly  1074 GNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTELEQEPAL---------GEKTPP- 1128
            |..|:.:..||.:...:|:.|....::...|.||.||.::.:::.|.::         .|.:|. 
  Rat  1176 GTTGIILTLAMNIMSTLQWAVNSSIDTDSLMRSVSRVFKFIDIQTEESICTKIMKELHSEDSPNA 1240

  Fly  1129 -----------QQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIG 1182
                       ..||:.|::..::::.:|..:|:.:|.|::.:|..|.:||::||||:|||:|:.
  Rat  1241 LVIKNEHVKKCDTWPSGGEMVVKDLTVKYVDDGNAILENISFSISPGQRVGLLGRTGSGKSTLLS 1305

  Fly  1183 ALFRLAHIEGEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALE 1247
            |..|:.:|:|||.|||:...:::|:..|....:|.|...:||.|.|.||||..::.|.|:|...:
  Rat  1306 AFLRMLNIKGEIQIDGVSWNSMTLQEWRKAFGVITQKVFIFSGTFRQNLDPNGKWRDEEIWKVAD 1370

  Fly  1248 DVELRKAI---PG-LDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQ 1308
            .|.|:..|   || |::.:.:.|...|.|.:||:||||::|...|:::|||.:||:||.|..:|:
  Rat  1371 QVGLKSVIEQFPGQLNFTLVDGGYVLSHGHKQLMCLARSVLSKAKIILLDEPSANLDPITYQVIR 1435

  Fly  1309 RTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEATGGESE 1373
            |.:|..|..|||:...||:..::|..|.:|::.|...:::....||.:.....|.:     ..||
  Rat  1436 RVLRQAFAGCTVVLCEHRIEAMLDCQRFLVIEQGNVWQYESLQALLSEKSVFQRAL-----SSSE 1495

  Fly  1374 ALKKTASDSHKRMQRERDE----RDRDQDESQE 1402
            .: |.....|...|:.|.:    ::..::|.||
  Rat  1496 KM-KLFHGRHSSKQKPRTQITAVKEETEEEVQE 1527

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5789NP_001247286.1 CFTR_protein 9..1367 CDD:273530 430/1552 (28%)
ABC_membrane 214..441 CDD:294371 72/231 (31%)
ABCC_MRP_domain1 495..699 CDD:213217 86/236 (36%)
ABC_membrane 863..1088 CDD:294371 75/224 (33%)
ABCC_MRP_domain2 1135..1350 CDD:213211 79/218 (36%)
CftrXP_006236159.1 CFTR_protein 55..1518 CDD:273530 436/1582 (28%)
ABC_membrane 139..357 CDD:294371 76/304 (25%)
ABCC_CFTR1 444..724 CDD:213258 94/285 (33%)
CFTR_R 693..898 CDD:291094 36/205 (18%)
ABC_membrane 915..1196 CDD:279056 82/283 (29%)
P-loop_NTPase 1258..1518 CDD:304359 88/265 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24223
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
44.020

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