Protein Alignment CG5789 and Abcc10

DIOPT Version :9

• Sequence 1: NP_001247286.1
• Gene: CG5789 / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Sequence 2: NP_001334325.1
• Gene: Abcc10 / 224814
• MGIID: 2386976
• Length: 1526
• Species: Mus musculus
• Alignment Length: 1441
• Identity: 443/1441 - (30%)
• Similarity: 693/1441 - (48%)
• Gaps: 238/1441 - (16%)

  Fly    19 ISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSHRKKQKPHLRNA 83
            :|:..:||..|||.||.|..|.....| |       :|..||...:...:.::| .|:...|..|
Mouse   222 LSRFSYAWLAPLLARGVRGELQQPRDT-C-------RLPRRLHPAFLARVFQAH-WKEGAQLWRA 277

  Fly    84 LFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNIDVNDISISDSLNRTARA 148
            |:|.|....:..||:..:..::....|.:|: ||:.|
Mouse   278 LYRAFGCCYLALGLLKMVGTMLGFSGPLLLS-LLVGF---------------------------- 313

  Fly   149 IPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNATAVRSILDQTVEHMWNDMN 213
                                           ||..|.|:
Mouse   314 -------------------------------LEEGQEPL-------------------------- 321

  Fly   214 SLGAVLVL----STLFCCFLLHHVDLRQRLMGARMRIACCSLIYRKTLRLSMKTAGQTPAGYLIN 274
            |.|.:.||    .|:....|.:......|.:..:.|:|..|.:|||.|:|.   ..:.|.|.::|
Mouse   322 SHGLLYVLGLAGGTVISAVLQNQYGYEVRKVTLQARVAVLSTLYRKALKLG---PSRPPTGEVLN 383

  Fly   275 LLSNDVNR-LDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVPVQTALSKVTS 338
            ||..|..| |::...| |..|.:|||..:|.||::..:|:..:.|:| |.|..|||...::....
Mouse   384 LLGTDSERLLNFAGSF-HEAWGLPLQLAITLYLLYQQVGMAFLAGLV-LALLLVPVNKVIATRIM 446

  Fly   339 VLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIRYASYLRG--FYL- 400
            .....:....||||.:|.||:.||:|||.:.||:.....|...|..|:.::|...||..  .||
Mouse   447 ASNQEMLRHKDARVKLMTELLSGIRVIKFFRWEQALGDRVKACRTKELGRLRVIKYLDAACVYLW 511

  Fly   401 STMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNILQLVAAIWYPLAVSFGAEALVSLRRI 465
            :.:......|::||.   .|||..:||..||:|.:...:| ::....:|..::...|:.|||.||
Mouse   512 AALPVVICITIFITY---VLMGHQLTATKVFTALALVRML-ILPLNNFPWVINGLLESKVSLDRI 572

  Fly   466 QDFLMLEGREERTQGLTHKRDQEGGDSRAVTIKDINASWD-IEKPQKTLQSINLQIEKGQLCAVI 529
            |.||.|........   :..|.....|.|:.:.:...||| |...|||..| :||::||.|..::
Mouse   573 QRFLDLPSYSPEAY---YSPDPPAEPSTALELHEALFSWDPIGASQKTFIS-HLQVKKGMLVGIV 633

  Fly   530 GPVGAGKSSILQLLLGELPVIDGGVFIQGDLS----YAAQEPWLFTGSVRNNILFGEEFDRKRYQ 590
            |.||.||||:|..:.|||..:.|.|.: .:||    .|.||||:...::|:|||||:.||.:.|:
Mouse   634 GKVGCGKSSLLAAITGELHRLCGWVAV-SELSKGFGLATQEPWIQCATIRDNILFGKTFDAQLYR 697

  Fly   591 EVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQIYLMDDPLSAVDAHVG 655
            ||...|||:.|...||.||:|.|||:|.:|||||||||:||||||:...:||:||||:||||.|.
Mouse   698 EVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKALYLLDDPLAAVDADVA 762

  Fly   656 RHLFDEVIGPRGRLAQLKATRILVTHQVHFLSEADVIVIVDQGRILRQGTYQELINSDLDFARLL 720
            .||....|  .|.|:.  .||:|.||:..:|..|||:::::.|:::|.|...|:    |...:.:
Mouse   763 NHLLHRCI--LGVLSH--TTRLLCTHRTEYLERADVVLLMEAGQLVRTGPPSEI----LPLVQAV 819

  Fly   721 ERPKEEEEGENSRNQTSPLSVNSLESDDEDIPFIDGVKDGYQQLRKQSSSVHGSKSLDSTQLDDN 785
            .....|:|...:..| || ||..||...|            ::|..:.|:. |..
Mouse   820 PTAWAEKEQVATSGQ-SP-SVCDLERTTE------------EELEVEQSTC-GCL---------- 859

  Fly   786 VDEDDLAEAQASGGISPRVWYEYFHAGSTLLSFSFMVFVMVMSQVVCSSSDFFANIWTQQEHQRS 850
            |.|    |:::.|.::..|:..|:.|..:.|:.:.:|.:::| |...:.:|::...|..|.....
Mouse   860 VQE----ESKSEGAVALHVYRAYWRAMGSGLAAAILVSLLLM-QATRNGADWWLAHWLSQLKAGR 919

  Fly   851 QGE------------ATFSTFECMYIYGAL-------------------------IIAVV----- 873
            .|.            |.||....::..|.|                         :.|.:
Mouse   920 NGSREDPASCSPGSTALFSPRLLLFSPGNLYTPLLSTPLHKAASNGTADVHFYLIVYATIAGVNS 984

  Fly   874 IMTTFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMM 938
            :.|..|..||....:.|:..||.|:...:|.|.:.|:|:|||||:|||||.|:..:|:.||..:.
Mouse   985 LCTLLRAVLFAAGALQAAASLHHRLLHRLLMAPVTFYDSTPSGRVLNRFSSDVACVDDSLPFLLN 1049

  Fly   939 DFIQIALVMFGILIVIGILNPVLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSA 1003
            ..:..::.:.|:|.|:|...|.|:..:..::.|...:...|....::|:||..:..||::|||:.
Mouse  1050 ILLANSVGLLGLLAVLGSGLPWLLLLLPPLSFVYYSVQGYYRASFRELRRLGSLTWSPLYSHLAD 1114

  Fly  1004 SLTGLAIIRSRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCVSCIFLTSVTFSFIISS 1068
            :|.||.::|:........:|...|.:::......:.|....|.:.|..:....::::....::..
Mouse  1115 TLAGLPVLRAAGATYRFEEENQRLLELNQRCQFASYATMQWLDIRLQLMGAAVVSAIAGIALVQH 1179

  Fly  1069 ETTYS--GNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYT-ELEQEP-ALGEKTPPQ 1129
            :...:  |.|||.::.|:.|||::...|....::...|.||||:.:|: ::.||| :...::|.|
Mouse  1180 QQGLANPGLVGLVLSYALSLTGLLSGLVSSFTQTEAMMVSVERLEEYSCDVPQEPHSQPLQSPHQ 1244

  Fly  1130 Q---WPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAHIE 1191
            |   |.|:|.|||:::...|.|.....|..:...:|.|.|:|||||||:|||||...||||....
Mouse  1245 QRISWLTQGSVEFQDVVLVYRPGLPNALDGVTFRVEPGEKLGIVGRTGSGKSSLFLVLFRLLEPN 1309

  Fly  1192 -GEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDVEL---- 1251
             |.:.:|.::|..:.|..||:::::|||:|.|||.|||.||||...:.|..||.|||...|
Mouse  1310 AGRVLLDNVDTSQLELAELRSQLAVIPQEPFLFSGTIRENLDPQGLHEDRALWQALEQCHLSEVA 1374

  Fly  1252 -------------RKA-----------IPGLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVL 1292
                         |:|           ..|||..:.|||.|.|:|||||||||||:|.:.|:|.:
Mouse  1375 VAMGESQACQRSQREAKNGHWQCSALLTGGLDGELGERGQNLSLGQRQLLCLARALLTDAKILCI 1439

  Fly  1293 DEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKS 1357
            |||||:||.:||.|:|:||..:|...||||:||||:|:::|||::|:.||..||.|.|..|..:.
Mouse  1440 DEATASVDQKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPSALRNQP 1504

  Fly  1358 QGHLRQMVEAT 1368
            ....:|:::::
Mouse  1505 HSLFQQLLQSS 1515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	443/1438 (31%)
		ABC_membrane	214..441	CDD:294371	73/234 (31%)
		ABCC_MRP_domain1	495..699	CDD:213217	97/208 (47%)
		ABC_membrane	863..1088	CDD:294371	60/256 (23%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	109/243 (45%)
Abcc10	NP_001334325.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810