Protein Alignment Cftr and Abcc9

DIOPT Version :10

• Sequence 1: NP_651269.1
• Gene: Cftr / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Sequence 2: NP_035641.1
• Gene: Abcc9 / 20928
• MGIID: 1352630
• Length: 1546
• Species: Mus musculus
• Alignment Length: 1472
• Identity: 436/1472 - (29%)
• Similarity: 702/1472 - (47%)
• Gaps: 221/1472 - (15%)

  Fly    44 LTQCLKEDRSEQLGDRLEDQWFKELERSHRKKQKPHLRNALFRCFLG-PTIINGLICFIYIVI-- 105
            :|:.:|..:..|||..:.|..|                     |..| ..|:|||:..:.|.:
Mouse   146 ITKTIKLVKYWQLGWGVSDLRF---------------------CITGVMVILNGLLMAVEINVIR 189

  Fly   106 -----------KTLIPAVLAQLLIQFQKTPV-----------------AQLRNIDVNDISISDSL 142
                       |...|..|..|.::|.:..|                 |..:.||:..|.   .|
Mouse   190 VRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHRKPIDLKAIG---KL 251

  Fly   143 NRTARAIPNYV-LSQAVANSSGSPGD----------ALF-----PKSLDK-----------AGPL 180
            ....||:.||| |.:|.........|          |::     |..|..           ||||
Mouse   252 PIAMRAVTNYVCLKEAYEEQKKKAADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPL 316

  Fly   181 EPIQPPVEEVDHNATAVRSILDQTV---EHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRL--- 239
             .|...|:.|:......|.:..:|:   |.:.|      |.::...||...:|....|:...
Mouse   317 -CISGIVQRVNEKTNTTREMFPETLSSKEFLEN------AHVLAVLLFLALILQRTFLQASYYVT 374

  Fly   240 --MGARMRIACCSLIYRKTLRLSMK--TAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQA 300
              .|..:|.|..::||.|.||||..  :.|:...|.:.||::.:.|:|.:.......:|.||:|.
Mouse   375 IETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQI 439

  Fly   301 MLTCYLIWLNIGIPAIVGVVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVI 365
            ::...|::..:|..|:||...::| ..|:|..::...:..:....:.:..|:...||:::||:::
Mouse   440 IMGVILLYNLLGSSALVGAAVIVL-LAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLL 503

  Fly   366 KMYAWEKPFQAVVAEARRSEIKQIRYASYLRGFYLSTMVFTERS-------TLYITLAAAALMGQ 423
            |:||||..|...|.|.|..|:..::..:    .|.|..:|...:       ..::|.|.|:  |.
Mouse   504 KLYAWEHIFCKSVEETRMKELSSLKTFA----LYTSLSIFMNAAIPIAAVLATFVTHAYAS--GN 562

  Fly   424 TITADFVFSAASYYNILQLVAAIWYPLAVSFGAEALVSLRRIQDFLMLE--GRE----------- 475
            .:.....|::.|.::|| :.........|.|..:|::|::::.:||:.:  |.:
Mouse   563 NLKPAEAFASLSLFHIL-VTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGEDSWRAGEGTLPF 626

  Fly   476 ---ERTQGLTHK---RDQEG---------------GDSRAVTIKDINASWDIEKPQKTLQSINLQ 519
               ::..|:..|   |.|.|               .::..:.||..|..:.......||.:|:::
Mouse   627 ESCKKHTGVQSKPINRKQPGRYHLDSYEQARRLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIR 691

  Fly   520 IEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQG-----------------DLSYAAQEP 567
            |..|||..::|.||.||||:|..:|||:..::|.|:...                 .::||||:|
Mouse   692 IPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVYWNNVNESEPSFEATRSRSRYSVAYAAQKP 756

  Fly   568 WLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLAR 632
            ||...:|..||.||..|:|:||:.||..|:|..|...||.||:|.:||||.:||||||.||.:||
Mouse   757 WLLNATVEENITFGSPFNRQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVAR 821

  Fly   633 AVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRILVTHQVHFLSEADVIVIVDQ 697
            |:|:...|..:|||.||:|.|:..||..|  |....|...|.|.:||||::.:|:.||.|:.:..
Mouse   822 ALYQNTNIVFLDDPFSALDIHLSDHLMQE--GILKFLQDDKRTVVLVTHKLQYLTHADWIIAMKD 884

  Fly   698 GRILRQGTYQELINSDLD----FARLLERPKEEEEGENSRNQTSPLSVNSLESDDEDIPFIDGVK 758
            |.:||:||.:::...|::    :..|:.|..:|.|.:...:||      :||.
Mouse   885 GSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQT------TLER------------ 931

  Fly   759 DGYQQLRKQSSSVHGSKSLDSTQLDDNVDEDDLAEAQASGGISPRV-------WYEYFHAGSTLL 816
               :.||:...|......::....::..:||:  |...|..:..|.       |: |..:|...|
Mouse   932 ---KTLRRAMYSREAKAQMEDEDEEEEEEEDE--EDNMSTVMRLRTKMPWKTCWW-YLTSGGFFL 990

  Fly   817 SFSFMVFVMVMSQVVCSSSDFFANIWTQQEHQRSQGEATFSTFECMYIYGALII--AVVIMTTFR 879
            .| .|:|..::...|..:.|::...||.:......|:|. .||   |:.|..|:  |.:.:....
Mouse   991 LF-LMIFSKLLKHSVIVAIDYWLATWTSEYSINHPGKAD-QTF---YVAGFSILCGAGIFLCLVT 1050

  Fly   880 GFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIA 944
            ......:.:.|:|.||..:...|:...:|||||||.|.||||||.|...||:.:|..:....:..
Mouse  1051 SLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRST 1115

  Fly   945 LVMFGILIVIGILNPVLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLA 1009
            |:....:.:|....||.:.|:..:.|....|.|.:...|:||:.|:...:.|:..|.|.:..||.
Mouse  1116 LLCLSAIGMISYATPVFLVALAPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLT 1180

  Fly  1010 IIRSRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCV-SCIFLTSVTFSFIISSETTYS 1073
            .||:.:.:....:....|.|.::..:....|.|..|.:..|.: :||.||:   |....|.::.|
Mouse  1181 TIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTA---SIASISGSSNS 1242

  Fly  1074 GNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTELEQEPALGEKTP---PQQWPTRG 1135
            |.|||.:..|:.:|..:.:.||.:|:...||.:|::|..:..:|.|...|...|   |:.||..|
Mouse  1243 GLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEG 1307

  Fly  1136 QVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAHI-EGEIFIDGI 1199
            :::..::..||:.|..|||:::...|:.|.||||.||||:|||||..|.||:..| :|:|.||||
Mouse  1308 EIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGI 1372

  Fly  1200 ETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDVELR---KAIP-GLDY 1260
            :...:.|..||:|:|||.|||:|||.:||:||||..:.||..||.|||..:|:   |::| |||.
Mouse  1373 DISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDA 1437

  Fly  1261 MVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAH 1325
            .|||.|.|||||||||.|||||.:|.:.:|::|||||::|..|:.::|:.:...|...||:|:||
Mouse  1438 TVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAH 1502

  Fly  1326 RLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEA 1367
            |:||::.:|.:|||..|..:|:|.|..||.:..|.....|.|
Mouse  1503 RVHTILTADLVIVMKRGNILEYDTPESLLAQEDGVFASFVRA 1544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cftr	NP_651269.1	MRP_assoc_pro	12..1356	CDD:188098	433/1459 (30%)
Abcc9	NP_035641.1	MRP_assoc_pro	23..1543	CDD:188098	434/1469 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	941..964		3/24 (13%)