DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and Abcc8

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	XP_036008753.1	Gene:	Abcc8 / 20927	MGIID:	1352629	Length:	1597	Species:	Mus musculus

Alignment Length:	1303	Identity:	405/1303 - (31%)
Similarity:	646/1303 - (49%)	Gaps:	209/1303 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   215 LGAVLVLST-LFCCFLLHHVDLRQRL-----MGARMRIACCSLIYRKTLRLSMK--TAGQTPAGY 271
            ||...||:. ||...||....|:...     .|..:|.|..:.||.|.:.||..  :.|:..||.
Mouse   352 LGNAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQ 416

  Fly   272 LINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVPVQTALSKV 336
            :.||::.|.|:|.:.|.....:|.||:|.::...|::..:|:.|::|...::| ..|||..::..
Mouse   417 ICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIIL-LAPVQYFVATK 480

  Fly   337 TSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIRYASYLRGF--Y 399
            .|..:....|.::.|:...||:::||:::|:||||..|.:.|...||.|:      :.||.|  |
Mouse   481 LSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFCSRVEMTRRKEM------TSLRAFAVY 539

  Fly   400 LSTMVFTERSTLYITLAAAAL--MGQTI---TADF----VFSAASYYNILQ----LVAAIWYPLA 451
            .|..:|...:   |.:||..:  :|...   .:||    .|::.|.::||.    |::::
Mouse   540 TSISIFMNTA---IPIAAVLITFVGHVSFFKESDFSPSVAFASLSLFHILVTPLFLLSSV----- 596

  Fly   452 VSFGAEALVSLRRIQDFL-MLEGREERTQGLTHKRDQEGGDSRAVTIKDINASWDIEKPQK---- 511
            |....:||||::::.:|| ..|.|||:..........:.|..:||.:|.:|.    ::|.:
Mouse   597 VRSTVKALVSVQKLSEFLSSAEIREEQCAPREPAPQGQAGKYQAVPLKVVNR----KRPAREEVR 657

  Fly   512 -------------------------------------TLQSINLQIEKGQLCAVIGPVGAGKSSI 539
                                                 ||.:|.::|.:|||..::|.||.||||:
Mouse   658 DLLGPLQRLTPSMDGDADNFCVQIIGGFFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSL 722

  Fly   540 LQLLLGELPVIDGGVF---------------------------------IQGDLSYAAQEPWLFT 571
            |...|||:..:.|.||                                 .:|.::||:|:|||..
Mouse   723 LLATLGEMQRVSGAVFWNSSLPDSEGEDPRYCLRTSNPERETAADSDARSRGPVAYASQKPWLLN 787

  Fly   572 GSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYK 636
            .:|..||.|...|:::||:.|...|:|..|...||:||:|.:||||.:||||||.|||:|||:|:
Mouse   788 ATVEENITFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQ 852

  Fly   637 PAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRILVTHQVHFLSEADVIVIVDQGRIL 701
            ...:..:|||.||:|.|:..||..  .|....|...|.|.:||||::.:|..||.|:.:..|.|.
Mouse   853 HTNVVFLDDPFSALDVHLSDHLMQ--AGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQ 915

  Fly   702 RQGTYQELINSDLD----FARLLERPKEEEEGENSRNQTSPLSVNSLESDDEDIPFIDGVKDGYQ 762
            |:||.::...|:..    :..|:.|..:|.|.|....:.:|       ...:.:|
Mouse   916 REGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVMERKAP-------EPSQGLP---------- 963

  Fly   763 QLRKQSSSVHGSKSLDSTQLDDNVDEDDLAEAQASGGISP----------RVWYEYFHAGSTLLS 817
              |..||.       |...||::.:|::.||::....:|.          |...:|..:...||
Mouse   964 --RAMSSR-------DGLLLDEDEEEEEAAESEEDDNLSSVLHQRAKIPWRACTKYLSSAGVLL- 1018

  Fly   818 FSFMVFVMVMSQVVCSSSDFFANIWTQQEHQRSQGEATFS-TFEC---MYIYG-------ALIIA 871
            .|.:||..::..:|..:.|::...||......|......| :.||   ..:|.       :|.||
Mouse  1019 LSLLVFSQLLKHMVLVAIDYWLAKWTDSALVLSPAARNCSLSQECALDQSVYAMVFTVLCSLGIA 1083

  Fly   872 VVIMTT----FRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDEL 932
            :.::|:    :.|       :..:|.||..:...|:.|.||||:|||.|.||||||.|...||:.
Mouse  1084 LCLVTSVTVEWTG-------LKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQH 1141

  Fly   933 LPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPV 997
            :|..:....:..|:....|.||..:.||.:.|:|.:|||...|.|.:...|:||::|:...:.|:
Mouse  1142 IPSTLECLSRSTLLCVSALTVISYVTPVFLVALLPLAVVCYFIQKYFRVASRDLQQLDDTTQLPL 1206

  Fly   998 FSHLSASLTGLAIIRSRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLD------------ 1050
            .||.:.::.||..||:.:.:....::  ||:...|:  .:.....|....||:
Mouse  1207 LSHFAETVEGLTTIRAFRYEARFQQK--LLEYTDSN--NIASLFLTAANRWLEVRMPGPAAVLPQ 1267

  Fly  1051 --CVSCIFLTSVTFSFIISSETTYS-GNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERV-- 1110
              ..:|:.|.:...|...|.....| |.|||.:..|::::..:.:.||.:|:...|:.:|:|:
Mouse  1268 EYIGACVVLIAAATSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMEIQLGAVKRIHT 1332

  Fly  1111 LQYTELEQ-EPALGEKTPPQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTG 1174
            |..||.|. |..|.....|:.||.:|:::.:|:|.|||.:..|||:::|..|..|.|:||.||||
Mouse  1333 LLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTG 1397

  Fly  1175 AGKSSLIGALFRLAHI-EGEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYT 1238
            :||||...|.||:..: ||.|.||||:...:.|..||:|:|||.|||||||.|||:||||.::.:
Mouse  1398 SGKSSFSLAFFRMVDMFEGRIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCS 1462

  Fly  1239 DAELWSALEDVELR---KAIP-GLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANV 1299
            |:.||.|||..:|:   ||:| |||.::||.|.|||.|||||.|||||.:|...:.::|||||::
Mouse  1463 DSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASI 1527

  Fly  1300 DPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQM 1364
            |..|:.::|:.:...|...||:|:|||:||::.:|.::|:..|..:|||.|..||.:........
Mouse  1528 DMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVMVLKRGAILEFDKPEKLLSQKDSVFASF 1592

  Fly  1365 VEA 1367
            |.|
Mouse  1593 VRA 1595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	404/1301 (31%)
		ABC_membrane	214..441	CDD:294371	70/244 (29%)
		ABCC_MRP_domain1	495..699	CDD:213217	86/277 (31%)
		ABC_membrane	863..1088	CDD:294371	69/250 (28%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	107/219 (49%)
Abcc8	XP_036008753.1	MRP_assoc_pro	224..1594	CDD:188098	403/1300 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810