Protein Alignment Cftr and mrp-8

DIOPT Version :10

• Sequence 1: NP_651269.1
• Gene: Cftr / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Sequence 2: NP_499598.2
• Gene: mrp-8 / 190710
• WormBaseID: WBGene00003414
• Length: 1461
• Species: Caenorhabditis elegans
• Alignment Length: 1434
• Identity: 432/1434 - (30%)
• Similarity: 695/1434 - (48%)
• Gaps: 254/1434 - (17%)

  Fly    10 KNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSHRK 74
            :.|.:.::.:|::.|.|..||:..|:::.|..:.|         ..|.:....:|.....|:...
 Worm   175 QTPEEKSSFLSKIFFCWLNPLIRAGAKQPLTNESL---------HNLNENATSEWLYTRWRAEFD 230

  Fly    75 KQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNIDVNDISIS 139
            |:|...::       |.|.|  :..||.|...|:|...||:|...
 Worm   231 KEKAGRKS-------GETSI--VWPFIRIQRATIITLTLARLTAD-------------------- 266

  Fly   140 DSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNATAVRSILDQT 204
                     |.:|                           |.||                :|.|.
 Worm   267 ---------IVHY---------------------------LNPI----------------LLKQL 279

  Fly   205 VEHM-WNDMNSLGAVLVLSTLFCCFLLHHVDLRQRLMGARMRIACCSLIY----------RKTLR 258
            :::: .:|......:.:...:|.|     ...|..|...::...|...:|          .|.||
 Worm   280 IDYVSLHDQPLSFGIAIACIMFSC-----STTRSLLQNYQIAGMCRQAVYYQTVLSNAILHKILR 339

  Fly   259 LSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLL 323
            ||........||.::|..:.|:..:.:...::..:|.:|.|..|...::.:.:|..|:.||. ::
 Worm   340 LSPSARSNRTAGEILNHAAVDIEIIVHSVPYLQNMWSVPFQVTLAMTMLAITLGWAAMAGVC-IM 403

  Fly   324 LKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQ 388
            :..:|:....|:...:.:.:..:..|.|..:.||::.||:|:|:||||:.|:..:...|..|:|.
 Worm   404 ILFIPLNLCTSRFIKLSQQKQMKIKDERTKLSNEMLNGIKVVKLYAWEESFEDQINRLRAKEVKM 468

  Fly   389 IR----------YASYLRGFYLSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNIL--- 440
            :|          .|:....|.::...|    |.|:..:...   ..:|....|.|.:.:|.|
 Worm   469 LRNVCILSRIVDVANAASPFLVAIGSF----TCYVLWSPDE---NGLTPSVAFVALTIFNQLRQP 526

  Fly   441 -QLVAAIWYPLAVSFGAEALVSLRRIQDFLMLEGREERTQGLTHKRDQEGGDSRAVTIKDINASW 504
             ::||.:     ::...:|.||.:|::.||..|..|.:|         |.....|:..|:.:.:|
 Worm   527 MRMVANL-----INTLVQARVSNKRLRQFLNDEEMERKT---------EVALGNAIVFKNASLNW 577

  Fly   505 DIEKPQKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGDLSYAAQEPWL 569
            ...:....|:.::..|:.|||.|::|.||.||||:|..:|.|:.::||.|.:.|.::|..|..|:
 Worm   578 KGPQNPPVLKDLSATIKPGQLIAIVGSVGGGKSSLLSAVLDEMVLLDGRVKVGGSIAYVPQHSWI 642

  Fly   570 FTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAV 634
            |..:::.|||||.|.....|.:|...|.|.|||:....|:.|:|||.|.:|||||:|||||||||
 Worm   643 FNKTIKENILFGNELSNYFYDQVVGSCQLKTDFRHFQQGENTMVGENGITLSGGQKARISLARAV 707

  Fly   635 YKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRILVTHQVHFLSEADVIVIVDQGR 699
            |:...|||:|||||||||||||.|||:||||.|.|.  ..||:||||.:.:....|.|.:::.|:
 Worm   708 YQDKDIYLLDDPLSAVDAHVGRALFDKVIGPDGLLR--SKTRVLVTHNLQYTKYVDTIYVIEDGQ 770

  Fly   700 ILRQGTYQELINSDLDFARL---LERPKE---EEEGENSRNQTSPLSVNSLESDDEDIPFIDGVK 758
            |::.|:::::...|..|.||   .|...|   :||.|:|....:| .|..||:.|      :|..
 Worm   771 IVQHGSFEDIAYVDGPFGRLWSECENSDEDVADEEAESSEASVTP-PVPVLENGD------NGAI 828

  Fly   759 DGYQQLRKQSS--SVHGSKSLDSTQ-LDDNVDEDDLAEAQASGGISPRVWYEYFHAGSTLLSFSF 820
            :...|:.:.:|  |....||.:..| ::.||:...|      |.:...|:..|........|.:|
 Worm   829 EKSSQIDRTNSHFSEKSRKSEEKPQKVEKNVENVQL------GRVKKSVYQLYIKTMGIFNSSAF 887

  Fly   821 MVF------VMVMSQVVCSSSDFFANIWTQQEHQRSQGEATFSTFECMYIYGALIIAVVIMT--- 876
            ::|      ||:|..:..|.       |:.:  ..:..:||.|:.:.:....::...|.:.|
 Worm   888 LIFFIAHFTVMIMRSLWLSD-------WSNE--NAAIKKATLSSVDYLNSTSSVDGPVSVETRLI 943

  Fly   877 TFRGF---------LFFKI----CMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGA 928
            .:.||         |.|.:    .:.||..||..:...:|.|.:.||||||:|||:||.|:|:..
 Worm   944 VYAGFGGLEMLLLALAFTVLTIGSLRASYGLHSPLIHALLVAPISFFDTTPTGRIINRLSRDLDV 1008

  Fly   929 IDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGIC 993
            ||:|.....| ..|..|....||::|.|..|:.:.....:.::...::..|:..|:.|||||...
 Worm  1009 IDKLQDNIRM-CTQTLLNACMILVLISISTPIFLVCAAPLILIYYFVMIYYIPTSRQLKRLESAN 1072

  Fly   994 RSPVFSHLSASLTGLAIIRSRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDC------- 1051
            |||:.|.::.|:.|.:.||:          ||..:       :.|.|::|.:..:..|
 Worm  1073 RSPILSTIAESIHGASSIRA----------FDKTE-------RTTTALSTNVDKFAQCRYLSHMS 1120

  Fly  1052 ------------VSCIFLTSVTFSFIISSETTY----SGNVGLAIAQAMILTGMVQYGVRQVAES 1100
                        .:|:...|::.:.    .|.|    .|..||:::.|:.:|.::...||.|:|.
 Worm  1121 NRWLATRLELLGNTCVLFASLSATL----STKYFGLTPGMAGLSVSYALTITEVLNICVRSVSEI 1181

  Fly  1101 LQQMTSVERVLQYTELEQE-PALGEKT--PPQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIE 1162
            ...:.|||||.:|.:||.| |...||:  ..::||.:|::|....|.||..|...||:|::|.||
 Worm  1182 ESNIVSVERVNEYQKLEPEAPWRIEKSLENEEKWPVKGKIELDGFSMRYRKNLPLVLKNIDLKIE 1246

  Fly  1163 AGWKVGIVGRTGAGKSSLIGALFRLAHIEGE---IFIDGIETGTISLEILRTRISIIPQDPVLFS 1224
            .|.::|::||||:|||||..||:|:  ||||   |.||.:|..||.|..||:::.||||:||:||
 Worm  1247 GGERIGVIGRTGSGKSSLTMALYRM--IEGESGTIKIDDVEIDTIGLHQLRSKLIIIPQEPVVFS 1309

  Fly  1225 ATIRYNLDPFERYTDAELWSALEDVELRKAI----PGLDYMVTERGGNFSVGQRQLLCLARAILR 1285
            .|:|:|||||.:|:|.::|:.||..:|::..    ..||..:.|.|.|.|||:||||||.||:||
 Worm  1310 GTLRFNLDPFNQYSDDQIWNCLEICQLKQFAQEDDKTLDRYIAEGGKNMSVGERQLLCLCRALLR 1374

  Fly  1286 NNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVP 1350
            ..::::||||||:||..||.::||.||..|.|.|.:::||||.|::|||||:|:|||...|||.|
 Worm  1375 GARIVILDEATASVDTVTDGIVQRAIRQHFPQSTTISIAHRLDTIVDSDRIVVLDAGRVAEFDTP 1439

  Fly  1351 YLLL 1354
            ..||
 Worm  1440 SNLL 1443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cftr	NP_651269.1	MRP_assoc_pro	12..1356	CDD:188098	432/1432 (30%)
mrp-8	NP_499598.2	MRP_assoc_pro	177..1451	CDD:188098	432/1432 (30%)