DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and pgp-7

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_001361833.1	Gene:	pgp-7 / 188697	WormBaseID:	WBGene00004001	Length:	1152	Species:	Caenorhabditis elegans

Alignment Length:	1265	Identity:	270/1265 - (21%)
Similarity:	487/1265 - (38%)	Gaps:	342/1265 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 ISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNATAVRSILD 202
            :|.:|..||:.:  ..::.|:.|.:..|.|      |.||                       .:
Worm    60 VSYTLGETAQVL--VTITNAINNKTIDPAD------LKKA-----------------------YE 93

  Fly   203 QTVEHMWNDMNSLGAVLVLSTLFC-CFLLHHVDLRQRLMGARMRIACCSLIYR-------KTLRL 259
            |....|:.        :||....| |.......::.    |.|:....:..||       :.||.
Worm    94 QYERGMYQ--------VVLYFFLCGCAYFTFASIQH----AIMKYVGDNTTYRVRKQYISRLLRK 146

  Fly   260 SMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLI---------W------- 308
            ..:.......|:|..:|::::.|  :..:|...|.:  :.|:||.:::         |
Worm   147 DAEYFDNVSTGHLSTVLNDNLER--FREVFNEKIAL--IFALLTDFVVGTALAFYTDWRLASYGI 207

  Fly   309 ---LNIGIPAIVGVVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAW 370
               |.|.....:...|::..|....|..:...|:                     ..|.:..|
Worm   208 FFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSI---------------------AFQTLGAY-- 249

  Fly   371 EKPFQAVVA-EARRSEIKQIRYASYLR-----GFYLSTMVFTERSTLYITLAAAALMGQTITADF 429
                :.|.: ..:.:||:  ||...|:     |.:.:.|....|...|....:...:...:.|:.
Worm   250 ----KTVCSLNGQNTEIE--RYTEELKAGEKYGIHRALMYSISRGFTYFFCNSLNTVILYVGANM 308

  Fly   430 VFSAASYYNILQ--LVAAIWYPLAVSFGA----EALVSLRR----------IQDFLMLEGREERT 478
            ::|.:     |:  :|..|::  .:.|||    |||..:.|          |.:.|:.|..
Worm   309 IYSGS-----LEPAVVVRIFH--YMMFGAFCLSEALPHISRLAGAISSTAPIAEMLIKEDN---- 362

  Fly   479 QGLTHKRDQEGGDSRA-----VTIKDINASWDIEKPQKTLQSINLQIEKGQLCAVIGPVGAGKSS 538
               ..::|:...|...     ::.|::..|:......:.|:.|:..::.|:..|::|..|:|||:
Worm   363 ---VIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKST 424

  Fly   539 ILQLLLGELPVIDGGVFIQG-DLS------------YAAQEPWLFTGSVRNNILFG-------EE 583
            ::||||....:..|.:||.| ||:            ..:|||.||..::..||.||       |.
Worm   425 VVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEI 489

  Fly   584 FDRKRYQEVTRCCALSTDFQ-QLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQIYLMDDPL 647
            :...|.       |.:.||. ..|.|.||:|||||..|||||:.||::||.:.:..:|.|:|:..
Worm   490 YGALRK-------ANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEAT 547

  Fly   648 SAVDAHVGRHLFDEVIGPRGRLAQLKATRILVTHQVHFLSEADVIVIVDQGRILRQGTYQELI-- 710
            ||:|     :..::|:......|....|.|:|.|::..:..|..|:::.:|.|:..|.:.|||
Worm   548 SALD-----NESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAK 607

  Fly   711 ---NSDLDFARLLERPKEEEEGENSRNQTSPLSVNSLESDDEDIPFIDGVKDGYQQLRKQSSSVH 772
               .:||..|:|||...:.||       ..||:.                    :||.::.|.:|
Worm   608 RGVYNDLVQAQLLESHDDHEE-------LPPLAA--------------------RQLSQELSPLH 645

  Fly   773 GSKSLDSTQLDDNVDEDD----LAEAQASGG-------ISPRVWYEY---FHA--GSTLLSFSFM 821
            ......||..|..|.:||    |.|....|.       |..:...:|   |.|  ||.:...|:
Worm   646 SYAIQRSTSNDAGVHDDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSY- 709

  Fly   822 VFVMVMSQVVCSSSDFFANIWTQQEHQRSQGEATFSTFECMYIYGALIIAVVIMTTFRG------ 880
               .:::|::..:.:.||.|          ||      :.:|......::.:.:..||.
Worm   710 ---PILAQLIVRTYEGFAMI----------GE------DMLYYSHLWALSFMFLAVFRPLTLYCQ 755

  Fly   881 -FLFFKICMHASKVLHDRMFACILHATMRFFD--TTPSGRILNRFSKD----MGAIDELLPRAMM 938
             :.|.|:....|..|..:.|:.:|.....|:|  ...:.|:.||.:.|    ..|:|:.|...:|
Worm   756 YYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIM 820

  Fly   939 DFIQIALVM-------FGILIVIGILNPVL-VAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRS 995
            ..:.|::.:       :.:.:.:.|..|:| :|.....|..:..|       .:|....|...|:
Worm   821 TVVAISIAITTASLYCWKMTLEVLIFFPLLYLAEYCYDAATETSI-------QEDTIAFENSNRT 878

  Fly   996 PVFSHLSASLTGLAIIRSRQLQD-VVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCVSCIFLTS 1059
            .:     .:|..:..:|:..|:| :::...:.||.:|.|.::..:......||.|.|.  :|:.|
Worm   879 AI-----EALENMRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCY--LFVYS 936

  Fly  1060 VTFSF---------------------------IISSETTYSGNVGLAIAQAMILTGMVQYGVRQV 1097
            |:|.|                           :..|...|..:...|:..|.::..:..|.....
Worm   937 VSFKFGTYLALRKEVAPMDTYLILETLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMP 1001

  Fly  1098 AESLQQMTSVERVLQYTELEQEPALGEKTPPQQWPTRGQVEFRNMSCRYDPN-GSPVLRNLNLTI 1161
            ..|.....::|                         :|::...|:...||.. ...:|..:||.:
Worm  1002 FSSSDGKKNIE-------------------------KGEIIGENVQFHYDQRPDRMILNGVNLKV 1041

  Fly  1162 EAGWKVGIVGRTGAGKSSLIGALFRLAH-IEGEIFIDGIETGTISLEILRTRISIIPQDPVLFSA 1225
            :.|..:.:||.:|.|||::|..|.|..| ::||:.||......|:|..||:.::::.|:|.||:.
Worm  1042 DPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNC 1106

  Fly  1226 TIRYNLDPFERYTDAELWSALEDVELRKAI 1255
            :||.||    .|   .|..::..:||.||:
Worm  1107 SIRENL----LY---GLTRSVPQLELEKAL 1129

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	270/1265 (21%)
		ABC_membrane	214..441	CDD:294371	40/259 (15%)
		ABCC_MRP_domain1	495..699	CDD:213217	67/224 (30%)
		ABC_membrane	863..1088	CDD:294371	50/273 (18%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	40/123 (33%)
pgp-7	NP_001361833.1	MdlB	42..621	CDD:224055	145/662 (22%)
		ABC_MTABC3_MDL1_MDL2	381..618	CDD:213216	75/248 (30%)
		ABC_6TM_Pgp_ABCB1_D2_like	686..994	CDD:350022	62/341 (18%)
		TM helix 1	695..718	CDD:350022	6/26 (23%)
		TM helix 2	733..781	CDD:350022	8/47 (17%)
		TM helix 3	790..835	CDD:350022	9/44 (20%)
		TM helix 4	836..885	CDD:350022	10/60 (17%)
		TM helix 5	897..947	CDD:350022	13/51 (25%)
		TM helix 6	956..989	CDD:350022	4/32 (13%)
		P-loop_NTPase	1019..>1143	CDD:393306	39/118 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000