DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and pgp-11

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_001364583.1	Gene:	pgp-11 / 183971	WormBaseID:	WBGene00004005	Length:	1241	Species:	Caenorhabditis elegans

Alignment Length:	1253	Identity:	274/1253 - (21%)
Similarity:	499/1253 - (39%)	Gaps:	289/1253 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 WNDMNSLGAVLVLSTLFCCFLLHHVDLRQRLMGARMRIACCSLIYRKTLRLSMKTAGQTPAGYLI 273
            |.|.:|.|::       .|.|..::::....:|.:    ||.|:                .|:.
Worm   141 WLDKHSSGSI-------TCQLNENIEVISDGLGNK----CCMLV----------------RGFA- 177

  Fly   274 NLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVPVQT----ALS 334
             :.::.:    ....|::|        .||  .|...:| |....|:.||.|...|..    :||
Worm   178 -MFTSSI----IACAFINW--------QLT--FITFTMG-PVSAFVLHLLTKVNEVSNEELMSLS 226

  Fly   335 KVT------SVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIRYAS 393
            ..:      |:|.:|..:..:.:..::.:|.|..:.||.:..:..|                :|.
Worm   227 AQSHAIIEESILNVRTVQSCNGQNFMITKLNQVNEKIKKFYNKSTF----------------WAG 275

  Fly   394 YLRGFYLSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYN-----------ILQLVAAIW 447
            :..|..|..:.|....:|:                  |....|:|           |:..:....
Worm   276 FFDGLALFVIYFITGISLF------------------FGCRLYFNQEIGKAGDVILIVNTICVTG 322

  Fly   448 YPL-------------AVSFGAEALVSLRRIQDFLMLEGRE-----ERTQGLTHKRDQEGGDSRA 494
            |.|             |.||    |:..:.|:.....||:|     ..|:|             .
Worm   323 YFLGLLGPHMSSLQQAATSF----LLLYKTIESAPKSEGKEGEIKISSTRG-------------N 370

  Fly   495 VTIKDINASWDIEKPQKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQG- 558
            :..:|:...: ..:..:.||.::||:..||..|::|..|.|||:.:.||.......:|.:.|.|
Worm   371 IEFRDVRFKY-FTRDNEVLQGLSLQVLPGQTVALVGTSGCGKSTSIGLLTKLYRASEGEILIDGK 434

  Fly   559 ------------DLSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKT 611
                        .:....|||.||.|::..||..|...|.:..:........|:..::|.||.:|
Worm   435 NIDMLDAKSLRQQIGIVQQEPKLFDGTIMENIKLGRNVDEETIKTAADIANASSFIEKLENGYET 499

  Fly   612 LVGERGASLSGGQRARISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVI--GPRGRLAQLKA 674
            .:|..|..|||||:.||.:|||:.....|.|:|:..||:|:| ..|:.::.:  ...||
Worm   500 RLGPGGVQLSGGQKQRICIARALVTSPSILLLDEATSALDSH-NEHIVNKALTKASEGR------ 557

  Fly   675 TRILVTHQVHFLSEADVIVIVDQGRILRQGTYQELINSDLDFARLLERPKEEEEGENSRNQTSPL 739
            |.|::.|::..|...|.|.::|||:....||:.|||.....:|||   .|.:|..::|:......
Worm   558 TTIIIAHRLSSLKSVDRIYVLDQGKTKEIGTHDELILLGGIYARL---AKSQEVEQSSKKDWERE 619

  Fly   740 SVNSLESDDEDIPFIDGVKDGYQQLRKQSSSVHGSKSLDSTQLDDNVDEDDLAEAQASGGISPRV 804
            .:...|...:....::.::.....|::...:..||.          :.|::..:...| |||...
Worm   620 ELRRAEKMKKKGRTVEIIEPNSTILQEHEHNFVGSV----------ITENEEQKISFS-GISKLF 673

  Fly   805 WYEYFHAGSTLLSFSFMV--FVMVMSQVVCSSSDFFANIWTQQEHQRSQGEATFSTFECMYIYGA 867
            .|...|..:.:|..:.::  .:.:.|..:..|..|       :..|||:.:  :.|:.  ||
Worm   674 NYLPKHRKTLILIIALLIPRAIELCSYGIGMSFAF-------KTLQRSKDD--YMTWN--YI--- 724

  Fly   868 LIIAVVIMTTFRGFLFFKICMH----------ASKVLHD---RMFACILHATMRFFD---TTPS- 915
                .:...|..|..|:  .:|          |::|:::   .|.:.:|:..:.:||   |:||
Worm   725 ----TLAQQTLAGITFW--ILHTSLMYLCGWLANEVMNEVKQEMLSEVLNKPIPYFDNPETSPSA 783

  Fly   916 --GRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIV------IGILNPVLVAAMLVVAVVD 972
              .||::........:|.   ||:.....||..:|.:|:.      :|:|.   :...:::.:..
Worm   784 CVSRIISHAHNCYACLDH---RAIRFVWFIAGTIFSLLLAFPFVWELGVLG---LGITILLTIFS 842

  Fly   973 VLILKLYLRPSQDLKRLE--GICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEF-------DLLQ 1028
            :..:.:..|...:...::  |.....:..|:.|       |:...::.....:|       ::.:
Worm   843 LHFVSVAHRAHSEKSVMDKSGEFAVEIVEHIRA-------IKLLAVEGYFENKFSEYLKTSEIYE 900

  Fly  1029 DVHSSVWQLTMAVNTTLGLWLDCVSCIFLTSVTFSFIISSETTYSG-----NVGLAIAQAMILTG 1088
            :....|..|..|:..         |.:|...:.. |.:.:...|.|     .|.||...|.:...
Worm   901 NKIGFVSSLNFAITQ---------SYVFACDMLL-FFVGTLLIYHGRYSPDKVFLAFNGAQMSAW 955

  Fly  1089 MVQYGVRQVAESLQQMTSVERVLQYTELEQEPALGEKTPPQQWPTRGQVEFRNMSCRY--DPNGS 1151
            .|.|......|.::...|..::..:.:..:..:....:.|:   ..|:||..:::..|  .|:.:
Worm   956 GVMYFSPWFPEIVRGSASANQIFSFFDKNRTNSTSGLSKPE---INGKVEVSDVTFAYPSTPHRN 1017

  Fly  1152 PVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAHIE-GEIFIDGIETGTISLEILRTRISI 1215
             |....:|.|..|..:.:||.:|.|||::|..|.|....: |.|.:|..:...|.:..||..||:
Worm  1018 -VCEGFSLNIPKGHSIALVGASGCGKSTIISMLERFYSAKAGRISVDDNDIDGIDVNHLRNNISV 1081

  Fly  1216 IPQDPVLFSATIRYNLDPFERYTDAELWSALEDV---ELRKAIP-------------GLDYMVTE 1264
            :.|:||||:||||.|:.           ..:::|   |::||..             |.|.:|.|
Worm  1082 VGQEPVLFNATIRENIT-----------IGIDEVSVEEVQKACKAANAAGFIESFPLGYDTIVGE 1135

  Fly  1265 RGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHT 1329
            .|.:.|.||:|.:.:||||:|..|:|:|||||:.:|.|::.::|:.:|......|.:.|||||.|
Worm  1136 GGASLSGGQKQRIAIARAIIRKPKILLLDEATSALDTQSEEIVQKALRSATTGRTSIIVAHRLST 1200

  Fly  1330 VMDSDRIIVMDAGVAVEF 1347
            |...|.|..:..|...|:
Worm  1201 VQHCDTIYYISRGAVAEY 1218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	274/1253 (22%)
		ABC_membrane	214..441	CDD:294371	40/247 (16%)
		ABCC_MRP_domain1	495..699	CDD:213217	63/218 (29%)
		ABC_membrane	863..1088	CDD:294371	44/263 (17%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	77/232 (33%)
pgp-11	NP_001364583.1	PTZ00265	38..1235	CDD:240339	274/1253 (22%)
pgp-11	NP_001364583.1	MdlB	46..607	CDD:224055	127/571 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910