DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and mrp-3

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_001359552.1	Gene:	mrp-3 / 181677	WormBaseID:	WBGene00003409	Length:	1505	Species:	Caenorhabditis elegans

Alignment Length:	1395	Identity:	437/1395 - (31%)
Similarity:	702/1395 - (50%)	Gaps:	147/1395 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSHRK 74
            |.|.::||.||:.:..|...::..|..|.|..||:.:...:...|.|..|.:.:|.|:.|::..|
Worm   192 KCPEENANFISRQLLLWFTQIISLGYERTLVADDVFEMDSQMDQEYLKARWKTEWLKQTEKAREK 256

  Fly    75 K-----QKPHLRNALFRCFLGPTIIN----------------GLICFIYIVIKTLIPAVLAQLLI 118
            :     ::...|....:..|..|..|                .:|..::.::|.   .:|....|
Worm   257 QVKLDDKRERARTGSEKAPLLGTFNNYGAVNLDDKDRVIVQPSVIVTLWQIMKW---EILGGSFI 318

  Fly   119 QFQKTPVAQLRNIDVNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPI 183
            :|                 :||.|........||::              ||            |
Worm   319 KF-----------------LSDLLQFANPTFLNYLI--------------LF------------I 340

  Fly   184 QPPVEEVDHNATAVRSILDQTVEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRLMGARMRIAC 248
            :.|      ||..:..|             .|...|.|:.......::...:....:||:::...
Worm   341 ETP------NAPLINGI-------------GLAVGLFLAGQIKSLFMNTYFIAMTRVGAKIQTML 386

  Fly   249 CSLIYRKTLRLSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGI 313
            ...:|.|:|.||.....:...|.::|:||.||:|.......:...|..|.|.::...|:...||:
Worm   387 SCAVYEKSLLLSNTARRERTVGEMVNILSIDVDRFRMITPQIQQYWSSPFQIIICMVLLSQTIGV 451

  Fly   314 PAIVGVVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVV 378
            ....|:| :::..||:...:|.:|...::|:.:..|.|:.::||::.||:|:|:.|||...:..:
Worm   452 AVWAGIV-VMISIVPINICVSMITKRWQLRLMKYKDERIRLINEVLNGIKVVKLSAWETAMEETI 515

  Fly   379 AEARRSEIKQIRYASYLRGF----YLSTMVFTERS--TLYITLAAAALMGQTITADFVFSAASYY 437
            ...|..|:|.|:.::.|:.|    .:...||...|  |:::.:...    ..:|.:..|.:.|.:
Worm   516 ERVRDKELKMIKQSALLKTFADCLNVGAPVFVALSSFTVFVLIDPK----NVLTPNIAFVSLSLF 576

  Fly   438 NILQ---LVAAIWYPLAVSFGAEALVSLRRIQDFLMLEGREERTQGLTHKRDQE-GGD--SRAVT 496
            |:|:   ::||    ..|:...:.:||.:|::.||.  .:|..|..:    |:| .|:  :..|.
Worm   577 NLLRGPLMMAA----ELVAQTVQLVVSNKRVRTFLC--EKEVDTAAI----DKEIRGELYTNTVE 631

  Fly   497 IKDINASWDIEKPQKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGDLS 561
            |...:.:|| ....:.|..|.......:|..|:|.||:||||:|...|||:..:.|.|.::|.::
Worm   632 IHSGSFAWD-SAEARILSDIEFLAGSKELVTVVGSVGSGKSSLLLAALGEMEKVCGYVGVRGSVA 695

  Fly   562 YAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRA 626
            |.:|:||:...|::.|:|...:.:...|::|...|||..|.:|||:||.|.:||:|.:|||||:|
Worm   696 YLSQQPWILNQSLKKNVLMQADLNDVLYKKVIESCALKEDLKQLPDGDDTEIGEKGINLSGGQKA 760

  Fly   627 RISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRILVTHQVHFLSEADV 691
            ||:||||||:...:|.:||||||||||||:|:||.||||.|.|:.  .||||||:...||.|:..
Worm   761 RIALARAVYQSKDVYFLDDPLSAVDAHVGKHIFDNVIGPNGMLSH--TTRILVTNCTSFLQESGK 823

  Fly   692 IVIVDQGRILRQGTYQELINSDLDFARLLERPKEEEEGENSRNQTSPLSVNSLESDDEDIPFIDG 756
            |:::..|||...|||.||: :|::....|    :|.:.|.::.|.|....:..|.:.:.:|  ..
Worm   824 IIVMKDGRIKHCGTYNELL-TDVEAREYL----QEVDNEYAQAQESSGEESGGEENSDILP--GS 881

  Fly   757 VKDGYQQLR-KQSSSVHGSKSLDSTQLDDNVDEDDLAEAQASGGISPRVWYEYFHAGSTLLSFSF 820
            :..|.:..| .:.|.:...||..|.......|.....|..|.|.::|.|:..||.|...:.....
Worm   882 IASGSRMSRLSRLSKISRKKSKSSIVEKKKPDALITKEEAAIGRVNPGVYLLYFKAMGIVTYVLP 946

  Fly   821 MVFVMVMSQVVCSSSDFFANIWTQQEHQRSQGEATFSTFECMYIYGALIIAVVIMTTFRGFLFFK 885
            ....:|::.........:...|:......:..: |.|....:.:|....|..||      ||||.
Worm   947 YAIAVVLNVSFALGRSLWLTAWSDANIDINHPD-TMSVGARLGVYAGFGITEVI------FLFFS 1004

  Fly   886 ICM------HASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIA 944
            :.:      .|||.||..:...:|...:.:||.||.|||:||.:|||..:|..|..:.. |:.:|
Worm  1005 LVLLLIGGVAASKNLHKPLLHNVLRNPLSYFDITPIGRIINRLAKDMEVVDLRLSSSFR-FLVMA 1068

  Fly   945 LV-MFGILIVIGILNPVLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGL 1008
            |: |...::::....|:.:|.::.|.::...:||..::.::.|:|:..:.|||:||:.|.:|.|:
Worm  1069 LINMVQTVLIVSYTTPLFIAIIIPVFIIYFFVLKYSIKSTRQLQRIASLTRSPIFSNFSETLQGI 1133

  Fly  1009 AIIRSRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCVSCIFLTSVTFSFIISSET-TY 1072
            :.:|:.|..|...:..|...:.|......:...|..|.:.|:.:..|.:.|.....||..|: ..
Worm  1134 STVRAFQWSDEFVRRNDEHLNTHVKCSYYSQMANRWLSIRLELLGNIVIFSAAILAIIGKESGIT 1198

  Fly  1073 SGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQY--TELEQEPALGEKTPPQQWPTRG 1135
            :|.:||:::.::.:|.|:...|||:.|....:.||||:.:|  |:.|.|..|.....|..|||.|
Worm  1199 AGMLGLSVSYSLNITFMLNMFVRQINEVETNVVSVERIDEYSKTKSEAEWRLDNNNLPSNWPTGG 1263

  Fly  1136 QVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAH-IEGEIFIDGI 1199
            .|...:.||||......||:.::|.|..|.|||:.||||||||||..||||:.. .:|.|.||..
Worm  1264 AVNIEDYSCRYRDELDLVLKQISLNILPGQKVGVCGRTGAGKSSLALALFRIVEAADGNISIDQT 1328

  Fly  1200 ETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDVELR---KAIP-GLDY 1260
            .|..|.|..||.:::||||:.|||:.|:|:|:||..::||.:||.|||:..|:   :.:| .|:.
Worm  1329 ITSHIGLHDLREKLTIIPQENVLFANTLRFNIDPKGQFTDQQLWLALENSNLKAHVELLPHKLES 1393

  Fly  1261 MVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAH 1325
            .|.|.|.||||||||||||.||:||.:||||||||||.:|.:||.::|.|||.||...|::|:||
Worm  1394 PVAEGGENFSVGQRQLLCLTRALLRKSKVLVLDEATAGIDNRTDTMVQATIREKFADSTIITIAH 1458

  Fly  1326 RLHTVMDSDRIIVMDAGVAVEFDVPYLLLK 1355
            ||||::|.|||||||||..||..:|..|||
Worm  1459 RLHTIIDYDRIIVMDAGRIVEDGIPGELLK 1488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	437/1395 (31%)
		ABC_membrane	214..441	CDD:294371	55/232 (24%)
		ABCC_MRP_domain1	495..699	CDD:213217	90/203 (44%)
		ABC_membrane	863..1088	CDD:294371	63/232 (27%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	117/219 (53%)
mrp-3	NP_001359552.1	MRP_assoc_pro	25..1501	CDD:188098	437/1395 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	1.000	Domainoid score	I5384
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720