DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5789 and mrp-5

DIOPT Version :9

Sequence 1:NP_001247286.1 Gene:CG5789 / 42928 FlyBaseID:FBgn0039207 Length:1402 Species:Drosophila melanogaster
Sequence 2:NP_510479.1 Gene:mrp-5 / 181587 WormBaseID:WBGene00003411 Length:1427 Species:Caenorhabditis elegans


Alignment Length:1497 Identity:433/1497 - (28%)
Similarity:688/1497 - (45%) Gaps:263/1497 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 ANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSHRKKQKPHL 80
            |.:.|.:.::|..|.||:..|..|:.:.:..|...|.......|||..|  |.|:....| .|.|
 Worm    73 AGLFSFVTYSWVFPYLYQAVRGKLDRNQVWGCSFYDSCGLNMARLEVLW--EDEKKANAK-SPSL 134

  Fly    81 RNALFR---------------C----FLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVA 126
            ...::|               |    |:|||      |||             :.||.|.:.|  
 Worm   135 FKVIYRFISTRLWFSCAVFFFCLIFGFIGPT------CFI-------------RRLIAFAENP-- 178

  Fly   127 QLRNIDVNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVD 191
                          ..:..:|.:.:|             |.||                      
 Worm   179 --------------ERDEQSRIVYSY-------------GIAL---------------------- 194

  Fly   192 HNATAVRSILDQTVEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRLMGARMRIACCSLIYRKT 256
               .|..|:::      :..:.|.||...:|               ...|.|:|.|..:|:|:..
 Worm   195 ---VAAISVVE------FARVLSYGATWAVS---------------YRTGIRVRGAVLALLYKNV 235

  Fly   257 LRLSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVG 321
            |. |....|:|.:. :||:.:||..||.....|...:.:.||..:.....:.:.||..:::|::.
 Worm   236 LN-SKDLCGKTESD-VINIFANDGQRLFDAVTFAPLVLVGPLVLVGGIGYLLMVIGRWSLLGILV 298

  Fly   322 LLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEI 386
            ..:..| :|..|.|.....|.....:|:.|:.:|.|:::.|:::||..||:.|.|.:.:.|:.|.
 Worm   299 FFVFDV-IQFGLGKSMVACRNLAIVKTEKRISMMAEIIKYIRIVKMNGWEQIFSAKIDQFRKEEK 362

  Fly   387 KQIRYASYLRGFYLSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNILQLVAAIWYPLA 451
            .|||.:.|.:...::...........:|.....|.|..:.|...|||.:.|.:: |......|..
 Worm   363 VQIRKSGYAQSLAIACGPVVPVVAAILTFVGVVLAGNDLLASDAFSAITVYFVM-LFGIRMIPYG 426

  Fly   452 VSFGAEALVSLRRIQDFLMLE--------GREE---RTQGLTHKRDQEGGDSRAVTIKD--INAS 503
            ..:.|||:|::||||::|:||        ..|:   ..||.|:....:...:.....|:  .|..
 Worm   427 SRYLAEAVVAMRRIQEYLLLEQYAPYPVTNAEDVVLDCQGATYTYQPKAAKAPVDETKEPTENEV 491

  Fly   504 WDIEKPQKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFI-QGDLSYAAQEP 567
            ..:|.|..|.....|.|::|:..||||.||.|||:||:.:.|.:...|..:.: :....|..|:.
 Worm   492 IVVETPVFTCSFDKLSIKRGEHIAVIGAVGCGKSAILKAISGHMFTTDDALSVDRSQTVYVPQKA 556

  Fly   568 WLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLAR 632
            |:|.|:|::|||||::.:.:||.:....|.|:.|...|..||:|.||||||:|||||:||::|||
 Worm   557 WIFNGTVQDNILFGDKMNSERYYKAVNGCQLTEDLTTLSVGDRTEVGERGATLSGGQKARVALAR 621

  Fly   633 AVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRILVTHQVHFLSEADVIVIVDQ 697
            ||::...:||.||..:::|..|...:.:|:|   .:|.:.||. ::||:.:..|...|.::.|:.
 Worm   622 AVFQTKNLYLFDDIFASLDKKVANKIHEEII---QKLLKKKAL-MMVTNNMELLHHFDRVLFVEG 682

  Fly   698 GRILRQGTYQELINSDLDFARLLERPKEEEEGENSRNQTSPLSVNSLESDDEDIPFIDGVKDGYQ 762
            |.|:..|.:..|...:..:...::..   |..:.:...|||..                  ||..
 Worm   683 GNIVADGNHDILYEKNDAYKTFVDAC---ETYQATSGATSPCG------------------DGPA 726

  Fly   763 Q--------LRKQSSSVHGSKSLDSTQLDDNVDEDDLAEAQASGGISPRVWYEYFHAGS-----T 814
            |        ||..|..:.|    |:.:|..  ||:|:..:.    |:.|::.:|.||..     |
 Worm   727 QPAPLDAEILRNSSEDLKG----DADKLIS--DEEDMGNST----IAWRIYKQYIHAAGGWPIWT 781

  Fly   815 LLSFSFMVFVMVMSQVVCSSSDFFANIWTQQEHQRSQGEATFSTFECMYI--------------Y 865
            .|...|:|.|:         |:.|:..|..:..::...|.|..|....::              |
 Worm   782 CLVIGFIVNVV---------SNIFSTYWLSRWLKKGHDETTTITNGTEFLEMKTSLADSPVTGFY 837

  Fly   866 GAL-IIAVVIMT---TFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDM 926
            .|: ::|:|::|   .|:..:|.|:.:.|:..||||||..::|....|||:||:|||||||||||
 Worm   838 AAVYLVALVVLTISGLFKACVFVKVSLTAATRLHDRMFQAVIHGATSFFDSTPTGRILNRFSKDM 902

  Fly   927 GAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLVVAVVDVLILKLYLRPSQDLKRLEG 991
            ..||..||.....|:|..:...|.|:||..:.|..:...:.:.||.|:.:..:....::|||.|.
 Worm   903 DEIDVKLPFTAEVFLQNMITCLGFLVVITSVFPYFLLFAIPLFVVFVVFVSCFRAGIRNLKRSEH 967

  Fly   992 ICRSPVFSHLSASLTGLAII----RSRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCV 1052
            |.|||::.|:||||.|:..|    :|.:..:|:.|..    |.:|....:..:....|.:|||.:
 Worm   968 ISRSPLYDHVSASLEGITTIHTFQQSNRFLEVLKKHL----DCNSGAIFMFQSAMRWLAVWLDLL 1028

  Fly  1053 SCIFLTSVTFSFIISSETTYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTELE 1117
            ..:....|....::.:.|....:.|:|||.|:.::|:.|:.||...|...:|||||||..|.  :
 Worm  1029 VVVMTAIVALLTVMLTGTVSPADAGMAIAFAVQMSGIFQFAVRTQTELEAKMTSVERVSYYA--D 1091

  Fly  1118 QEPALGEKTPPQ------QWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAG 1176
            ..|..||....|      .||..||:.|..::.||..:....|.::...|:.|.||||:||||:|
 Worm  1092 NIPEDGEWNTRQGLDIESSWPANGQINFSEVNLRYRKSHPLALNDITFEIKGGEKVGIIGRTGSG 1156

  Fly  1177 KSSLIGALFRLAHI-EGEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDA 1240
            ||||...:|||..: .|.|:|||::..|:.|..||..||.|.|||.|||.|:|:||||...|:|:
 Worm  1157 KSSLANLIFRLYPVTNGTIYIDGVDIRTVGLVKLRRGISAIAQDPSLFSGTVRFNLDPSLEYSDS 1221

  Fly  1241 ELWSALEDVELRKAIPGLDYM----VTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDP 1301
            .:|.|||...|:..:..||..    |:..|.|||||:|||.|||||:|..:::::||||||:||.
 Worm  1222 MIWEALEKCHLKTLVQSLDKKLEADVSHGGNNFSVGERQLFCLARALLMKSRIVILDEATASVDA 1286

  Fly  1302 QTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVP---------------- 1350
            .||.|||..|:..|...||:.:||||..|.:.|||:.:..|..:.|..|                
 Worm  1287 GTDKLIQEVIKTVFADATVIIIAHRLDNVRNMDRIMHLKNGKLINFTTPQEMFKDDWSVYKLEDK 1351

  Fly  1351 ---------------YLLLKKSQGHLRQMVEATGGESEALKKTASDSHKRMQRERDERDRDQDES 1400
                           :.:.|.|||..::..:....|:|  :|.:||....::...|:...|..|.
 Worm  1352 DDDQHSAVVVGENSEHSMEKSSQGSSQESDDIVKVENE--QKDSSDDVVHIESGDDDVKADSSEV 1414

  Fly  1401 QE 1402
            :|
 Worm  1415 KE 1416

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5789NP_001247286.1 CFTR_protein 9..1367 CDD:273530 424/1460 (29%)
ABC_membrane 214..441 CDD:294371 56/226 (25%)
ABCC_MRP_domain1 495..699 CDD:213217 75/206 (36%)
ABC_membrane 863..1088 CDD:294371 77/246 (31%)
ABCC_MRP_domain2 1135..1350 CDD:213211 100/219 (46%)
mrp-5NP_510479.1 MRP_assoc_pro 90..1340 CDD:188098 414/1400 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 142 1.000 Domainoid score I2904
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.830

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