DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and pgp-4

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_001257142.1	Gene:	pgp-4 / 181327	WormBaseID:	WBGene00003998	Length:	1280	Species:	Caenorhabditis elegans

Alignment Length:	1267	Identity:	287/1267 - (22%)
Similarity:	534/1267 - (42%)	Gaps:	222/1267 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   215 LGAVLVLSTLF---CCFLLHHVDLRQRLMGARMRIACC-SLIYRKTLRLSMKTAGQTPAGYLINL 275
            ||.::...|.|   |.|.:           |..|:.|. ..:.:..||...|...:...|.|...
Worm   117 LGVLMFTCTYFSNACLFTM-----------AERRLYCIRKHLLQSVLRQDAKWFDENTVGGLTQK 170

  Fly   276 LSNDVNRLDYGF-----IFMHWIWIMPLQAMLTCYLIW-LNIGIPAIVGVVGLLLKTVPVQTALS 334
            :|:.:.::..|.     :.:..|........|..|:.| |.:          ::|.|||:|.. |
Worm   171 MSSGIEKIKDGIGDKIGVLVSGIATFISGVALGFYMCWQLTL----------VMLVTVPLQLG-S 224

  Fly   335 KVTSVLRMRIAERTDARV-----GIMNELVQGIQVIKMYAWEKPFQ-----AVVAEARRSEIKQI 389
            ...|...:..|.:.:...     |:.||::.||:.:..:. .:||:     |.:|:||:..|::.
Worm   225 MYLSAKHLNRATKNEMSAYSSAGGMANEVIAGIRTVIAFN-AQPFEIERYGAQLAKARKMGIRKA 288

  Fly   390 RYASYLRGFYLSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNILQLVAAIWYPLAVSF 454
            ...:......|..|        ::.:|.|...|..:|:..|.::.:.:.:      .|   ||..
Worm   289 IVLALCSAMPLFLM--------FVLMAGAFWYGAILTSYGVATSGTTFGV------FW---AVIL 336

  Fly   455 GAE----------ALVSLR-RIQDFLMLEGREER---TQGLTHKRDQEGGDSRAVTIKDINASWD 505
            |..          |:...| .:.|...:...|..   |:....:.|:..|   .:...:|..::.
Worm   337 GTRRLGEAAPHMGAITGARLAVNDIFKVIDHEPEINCTKQEGRRPDKVNG---KLVFDNIQFTYP 398

  Fly   506 IEKPQKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLL------------LGELPVIDGGV-FIQ 557
            .....|.|:.::.::..|:..|::|..|.|||:.:.||            |..:|:.|..: :::
Worm   399 TRPDVKILKGVSFEVNPGETIALVGHSGCGKSTSIGLLMRFYNQCAGSIKLDGIPIEDYNIQWLR 463

  Fly   558 GDLSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCC--ALSTDF-QQLPNGDKTLVGERGAS 619
            ..:....|||.:|..:|..|:..|:  |....:::...|  |.:.|| .:|..|..|::|.....
Worm   464 STIGIVQQEPIIFLATVAENVRMGD--DSITDKDIENACRQANAHDFIGKLSEGYNTVIGAGAVQ 526

  Fly   620 LSGGQRARISLARAVYKPAQIYLMDDPLSAVDAHVGRHL---FDEVIGPRGRLAQLKATRILVTH 681
            |||||:.|:::|||:.:..||.|:|:..||:|....|.:   .|:  ...||      |.:.:.|
Worm   527 LSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDK--ASEGR------TTLCIAH 583

  Fly   682 QVHFLSEADVIVIVDQGRILRQGTYQELINSDLDFARLLERPKEEEEGENSRNQTSPLSVNSLES 746
            ::..:..|..|::.|||.|..:|.:.:||..:..:|.::    ..:|.|.:::.|:       :.
Worm   584 RLSTIRNASKILVFDQGLIPERGIHDQLIRQNGIYANMV----RAQEIEKAKDDTT-------QD 637

  Fly   747 DDEDIPFIDGVKDGYQQLRKQSSS---VHGSKSL--DSTQLDDN-------VDEDDLAEAQASGG 799
            |||.:.     :|.|...|:.|:|   :..||||  |||:...:       |.:.::..|:.
Worm   638 DDELVE-----EDNYSISRRLSTSEEELRKSKSLLRDSTRFSQSMLSVTSQVPDWEMESARE--- 694

  Fly   800 ISPRVWYEYFHAGSTLLS----FSF-------MVFVMVMSQVVCSSSDFFANIWTQQEHQRSQG- 852
                   |....|:...|    |.|       :|..::.:.:...:...|:.::.|.....::|
Worm   695 -------EMIEEGAMEASMMDIFRFAKPEKMNIVIALIFTLIRGITWPAFSVVYGQLFKVFAEGG 752

  Fly   853 -----EATFSTFECMYIYGALIIAVVIMTTF-RGFLFFKICMHASKVLHDRMFACILHATMRFFD 911
                 .|..|:     ::..|:.....:||| .|.|..|.....|..|...:|..|:.....:||
Worm   753 EDLPVNALISS-----LWFVLLAVTSAVTTFISGSLLGKTGETMSSRLRMDVFKNIMQQDATYFD 812

  Fly   912 TTPS--GRILNRFSKD----MGAIDELLPRAMMDFIQIALVMFGILIVIGI---LNPV-LVAAML 966
            ....  |.:.:|.:.|    ..|||..|...:...:.:   ..||.:....   :.|: |:.|:|
Worm   813 DPKHNVGNLTSRLATDSQNVQAAIDHRLAEVLNGVVSL---FTGIAVAFWFGWSMAPIGLITALL 874

  Fly   967 VVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFDLL---- 1027
            :|.....:...|..|..:|::  ..|..|.:   ::.|::....:::...|:.:...|...
Worm   875 LVIAQSAVAQYLKYRGPKDME--SAIEASRI---VTESISNWKTVQALTKQEYMFHAFTAASKNP 934

  Fly  1028 --QDVHSSVWQ-LTMAVNTTLGLWLDCVSCIFLTSVTFSFIISSETTYSGNVGLAIAQAMILTGM 1089
              :.....:|| |:.|:..:..||...::.:|     ..::||:..|    ...|:.|.:....|
Worm   935 RKRAFTKGLWQSLSFALAGSFFLWNFAIAYMF-----GLWLISNNWT----TPFAVFQVIEALNM 990

  Fly  1090 VQYGVRQVAESLQQ--MTSVERVLQYTELEQEPALGEKTPPQQWP-TRGQVEFRNMSCRY-DPNG 1150
            ....|...|....:  ...:...:.:|.:.|:..:..:....:.| .||.:..:.:...| :.|.
Worm   991 ASMSVMMAASYFPEYVRARISAGIMFTMIRQKAKIDNRGLTGETPDIRGDISMKGVYFAYPNRNR 1055

  Fly  1151 SPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAH-IEGEIFIDGIETGTISLEILRTRIS 1214
            ..:|.|.|::.:.|..|.:||.:|.|||:.|..:.|... |.|.:.||..:...||::.||..|:
Worm  1056 QLILNNFNMSAQFGETVALVGPSGCGKSTSIQLIERYYDAICGAVKIDDHDIRDISVKHLRHNIA 1120

  Fly  1215 IIPQDPVLFSATIRYNL---------DPFER-YTDAELWSALEDVELRKAIPGLDYMVTERGGNF 1269
            ::.|:|.||:.|||.|:         :..|: .|.|.:.|.:|::.     .|.|..|...||..
Worm  1121 LVGQEPTLFNLTIRENITYGLENVSQEQVEKAATLANIHSFVENLP-----EGYDTSVGASGGRL 1180

  Fly  1270 SVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSD 1334
            |.||:|.:.:||||:||.|:|:|||||:.:|.:::.::|..:.......|.:.:||||.|:.::|
Worm  1181 SGGQKQRIAIARAIVRNPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLSTIQNAD 1245

  Fly  1335 RIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVE 1366
            :|||...|.|:|......||.: :|...::||
Worm  1246 KIIVCRNGKAIEEGTHQTLLAR-RGLYYRLVE 1276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	287/1267 (23%)
		ABC_membrane	214..441	CDD:294371	48/245 (20%)
		ABCC_MRP_domain1	495..699	CDD:213217	57/222 (26%)
		ABC_membrane	863..1088	CDD:294371	47/242 (19%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	75/226 (33%)
pgp-4	NP_001257142.1	ABC_membrane	65..338	CDD:279056	51/260 (20%)
		PTZ00265	68..1276	CDD:240339	285/1265 (23%)
		ABC_MTABC3_MDL1_MDL2	389..625	CDD:213216	63/249 (25%)
		ABC_membrane	724..993	CDD:279056	53/290 (18%)
		ABC_MTABC3_MDL1_MDL2	1041..1278	CDD:213216	79/242 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910