DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and pgp-6

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_001041287.2	Gene:	pgp-6 / 181278	WormBaseID:	WBGene00004000	Length:	1263	Species:	Caenorhabditis elegans

Alignment Length:	1357	Identity:	311/1357 - (22%)
Similarity:	543/1357 - (40%)	Gaps:	311/1357 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 GPLEPIQPPVEEVDHNATAVRSILDQTVEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRLMGA 242
            |.:..:...:....:|.|...:.|::..|.....||.     |:...|.|...:.:  ...|..|
Worm    65 GEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQ-----VVFHFFLCGCAYFI--FASLQHA 122

  Fly   243 RMRIACCSLIYR-------KTLRLSMKTAGQTPAGYLINLLSNDVNRLDYGF-----IFMHWIWI 295
            .|:....:..||       :.|:...:.......|:|..:|::::.|....|     :.:.::..
Worm   123 IMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTD 187

  Fly   296 MPLQAMLTCYLIW----------LNIGIPAIVGVVGLLLKTVPVQTALSKVTSVLRMRI-AERTD 349
            ..|...|..|..|          |.|.....:...|::..|....|..:...|:....: |.:|
Worm   188 FTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKT- 251

  Fly   350 ARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIRYA---SYLRG---FYLSTMVFTER 408
                          |..:...:...:....|.:..|...||.|   |..||   |:.:::
Worm   252 --------------VCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSL----- 297

  Fly   409 STLYITLAAAALMGQTITADFVFSAASYYNILQLVAAIWYPLAVSFGA----EALVSLRRIQDFL 469
            :|:.:.:.|..:...|:....|.....|               :.|||    |||..:.|
Worm   298 NTVVLYVGATMIYSGTLETAVVVRLFHY---------------MLFGAFCLSEALPHISR----- 342

  Fly   470 MLEGREERTQGLTH---------KRDQEGGDSRA-----VTIKDINASWDIEKPQKTLQSINLQI 520
             |.|....|..:..         ::|:...|...     ::.|::..|:......:.|:.|:..:
Worm   343 -LAGAISSTAPIAEMLIKDDNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDV 406

  Fly   521 EKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQG-DLS------------YAAQEPWLFTG 572
            :.|:..|::|..|:|||:::||||....:..|.:||.| ||:            ..:|||.||..
Worm   407 QNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNT 471

  Fly   573 SVRNNILFG-------EEFDRKRYQEVTRCCALSTDFQ-QLPNGDKTLVGERGASLSGGQRARIS 629
            ::..||.||       |.:...|.       |.:.||. ..|.|.||:|||||..|||||:.||:
Worm   472 TIEENIRFGNPNVSLPEIYGALRK-------ANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIA 529

  Fly   630 LARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRILVTHQVHFLSEADVIVI 694
            :||.:.:..:|.|:|:..||:|     :..::|:......|....|.|:|.|::..:..|..|::
Worm   530 IARTLVRNPKILLLDEATSALD-----NESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIV 589

  Fly   695 VDQGRILRQGTYQELI-----NSDLDFARLLERPKEEEEGENSRNQTSPLSVNSLESDDEDIPFI 754
            :.:|.|:..|.:.|||     .:||..|:|||...:.||       ..||:.
Worm   590 MQKGEIVEVGNHDELIAKRGVYNDLVQAQLLESHDDHEE-------LPPLAA------------- 634

  Fly   755 DGVKDGYQQLRKQSSSVHGSKSLDSTQLDDNVDEDD----LAEAQASGG-------ISPRVWYEY 808
                   :||.::.|.:|......||..|..|.:||    |.|....|.       |..:...:|
Worm   635 -------RQLSQELSPLHSYAIQRSTSNDAGVHDDDMERILDELSKEGAKKSNLREIVKQCRPDY 692

  Fly   809 ---FHA--GSTLLSFSFMVFVMVMSQVVCSSSDFFANIWTQQEHQRSQGEATFSTFECMYIYGAL 868
               |.|  ||.:...|:    .:::|::..:.:.||.|          ||      :.:|.....
Worm   693 CFLFIAVFGSAIQGVSY----PILAQLIVRTYEGFAMI----------GE------DMLYYSHLW 737

  Fly   869 IIAVVIMTTFRG-------FLFFKICMHASKVLHDRMFACILHATMRFFD--TTPSGRILNRFSK 924
            .::.:.:..||.       :.|.|:....|..|..:.|:.:|.....|:|  ...:.|:.||.:.
Worm   738 ALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNT 802

  Fly   925 D----MGAIDELLPRAMMDFIQIALVM-------FGILIVIGILNPVL-VAAMLVVAVVDVLILK 977
            |    ..|:|:.|...:|..:.|::.:       :.:.:.:.:..|:| :|.....|..:..|
Worm   803 DSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPLLYLAEYCYEAATETAI-- 865

  Fly   978 LYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQD-VVAKEFDLLQDVHSSVWQLTMAV 1041
                 .:|....|...|:.:     .:|..:..:|:..|:| :::...:.||.:|.|.::..:..
Worm   866 -----QEDTIAFENSNRTAI-----EALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQ 920

  Fly  1042 NTTLGLWLDCVSCIFLTSVTFSF---------------------------IISSETTYSGNVGLA 1079
            ....||.|.|.  :|:.||:|.|                           :..|...|..:...|
Worm   921 GAANGLSLSCF--LFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKA 983

  Fly  1080 IAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTELEQEPALGEKTPPQQWPTRGQVEFRNMSC 1144
            :..|.::..:..|.......|.....::|                         :|::...|:..
Worm   984 VHAAGLIFHLFTYPATMPFSSSDGKKNIE-------------------------KGEIIGENVQF 1023

  Fly  1145 RYDPN-GSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAH-IEGEIFIDGIETGTISLE 1207
            .||.. ...:|..:||.::.|..:.:||.:|.|||::|..|.|..| ::||:.||......|:|.
Worm  1024 HYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLN 1088

  Fly  1208 ILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDVELRKAI-------------PGLD 1259
            .||:.::::.|:|.||:.:||.||    .|   .|..::..:||.||:             .|||
Worm  1089 HLRSNLALVSQEPTLFNCSIRENL----LY---GLTRSVPQLELEKALQTANAFNFVFQFPQGLD 1146

  Fly  1260 YMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVA 1324
            .:|.|||...|.||:|.:.:|||||||.|||:|||||:.:|..::.::|..:....::.:.:.||
Worm  1147 TLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVA 1211

  Fly  1325 HRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEATGGESEALKKTASD 1381
            |||.||:::|.|.|:..|...|......||:|...:.| :|:..|.:.|    |.||
Worm  1212 HRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWR-LVQKQGIQVE----TPSD 1263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	306/1341 (23%)
		ABC_membrane	214..441	CDD:294371	41/255 (16%)
		ABCC_MRP_domain1	495..699	CDD:213217	67/224 (30%)
		ABC_membrane	863..1088	CDD:294371	49/273 (18%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	80/229 (35%)
pgp-6	NP_001041287.2	PTZ00265	32..1252	CDD:240339	305/1340 (23%)
		ABC_membrane	47..331	CDD:294371	50/307 (16%)
		ABC_MTABC3_MDL1_MDL2	381..618	CDD:213216	75/248 (30%)
		ABC_membrane	699..970	CDD:279056	54/304 (18%)
		ABC_MTABC3_MDL1_MDL2	1019..1254	CDD:213216	84/242 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910