Protein Alignment CG5789 and pgp-5

DIOPT Version :9

• Sequence 1: NP_001247286.1
• Gene: CG5789 / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Sequence 2: NP_001257116.1
• Gene: pgp-5 / 181276
• WormBaseID: WBGene00003999
• Length: 1252
• Species: Caenorhabditis elegans
• Alignment Length: 1060
• Identity: 252/1060 - (23%)
• Similarity: 455/1060 - (42%)
• Gaps: 221/1060 - (20%)

  Fly   411 LYITLAAAALMGQTITADFVFSAASYYNILQLVAAIWYPLAVSFGAEALVSLRRIQDFLMLEGRE 475
            ||..|..:..:|:.|           .:|.:|.:||  ||.|.. |:.|:......|....|..:
 Worm   317 LYYILFGSYCLGEAI-----------LHISRLASAI--PLTVPI-ADILLDSDATADEFFSEEIK 367

  Fly   476 ERTQGLTHKRDQEGGDSRAVTIKDINASWDIEKPQKTLQSINLQIEKGQLCAVIGPVGAGKSSIL 540
            :..||:             ::.|::..|:........|:.|:..::.|:..|::|..|:|||:::
 Worm   368 DTFQGI-------------ISFKNVLFSYPTRPDVPVLKEISFNVQGGECIALVGASGSGKSTVI 419

  Fly   541 QLLLGELPVIDGGVFIQGD-------------LSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEV 592
            ||||....:..|.:.|.|:             :....|||.||..|:..||.||:....:  ||:
 Worm   420 QLLLHYYNIDSGRISIDGNDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATE--QEI 482

  Fly   593 TRCCALSTDFQ---QLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQIYLMDDPLSAVDAHV 654
            ......:..|.   ..|:|.||:||||||.|||||:.||::||.:.:..:|.|:|:..||:| :.
 Worm   483 IDALKNANAFDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALD-NE 546

  Fly   655 GRHLFDEVIGPRGRLAQLKATRILVTHQVHFLSEADVIVIVDQGRILRQGTYQELINSDLDFARL 719
            ...:..|.:    :.|.:..|.|:|.|::..:..|:.|:::::|.|:..|.:::||..:..:..|
 Worm   547 SEFIVQEAL----QKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNL 607

  Fly   720 LERPKEEEEGENSRNQTSPLSVN--SLESDDEDIPFIDGVKDGYQQLRKQSSSVHGSKSLDSTQL 782
            :              ||..:|.|  .:..::|.:            .|:.|.|...|..:...::
 Worm   608 V--------------QTQLMSTNYEKMNENEERV------------TRQSSHSDFPSNEISHQKI 646

  Fly   783 DDNVDEDD-----LAEAQASGGISPRVW--YEYFHAGSTLLSFSFM------VFVMVMSQVVCSS 834
            |   .|||     :||.:..|.....:.  .:|..:...:|..:.:      ::..:.||::..|
 Worm   647 D---QEDDYVKKLIAEIKEEGAKKSNICEIIKYCRSEYCILFIAVLGSAIQGIYYPLSSQLMIKS 708

  Fly   835 SDFFANIWTQQEHQRSQGEATFSTFECMYIYGALIIAVVIMTT-----FRGFLFFKICMHASKVL 894
            .:.:|   ..::...|:..           :.||.|..:..|.     |:.:.|.|.....|..|
 Worm   709 YEAYA---FDKDEMLSKSH-----------FWALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKL 759

  Fly   895 HDRMFACILHATMRFFDTT--PSGRILNRFSKD----MGAIDELLPRAMMDFIQIALVMFGILIV 953
            ....|..::.....|:|..  .:.|:.||.:.|    ..|:|:.|...:|..:.|.|.     ::
 Worm   760 RSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLA-----VI 819

  Fly   954 IGI-------LNPVLVAAMLVVA------VVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASL 1005
            :..       |..::...:|.:|      .||..:       .:|....|...|:.:     .:|
 Worm   820 MSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAV-------EEDSIAFEKSNRAAI-----EAL 872

  Fly  1006 TGLAIIRSRQLQD-VVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCVSCIFLTSVTFSF----- 1064
            ..:..:|:..::: |:......||.:.:|.::..:...|..|....|.  .|:.:|:|.|
 Worm   873 ENVRTVRALNMENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCY--FFIYAVSFKFGTWLV 935

  Fly  1065 ---------------IISSETTYSGNV-------GLAIAQAMILTGMVQYGVRQVAESLQQMTSV 1107
                           .:|...:|:|:.       ..||..|.::..:..|......:|.|...::
 Worm   936 LREEILPMDTYLVLMTLSMTASYAGSAVAYLPDHRKAIHAAGLIFHLFTYPAIMPYDSSQGKRNI 1000

  Fly  1108 ERVLQYTELEQEPALGEKTPPQQWPTRGQVEFRNMSCRY-DPNGSPVLRNLNLTIEAGWKVGIVG 1171
            :                         .|::|.:|:|..| ..:...:|..::|.:.||..:.:||
 Worm  1001 K-------------------------NGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVG 1040

  Fly  1172 RTGAGKSSLIGALFRLAH-IEGEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFE 1235
            .:|:|||::|..|.|..| ::||:.||......::|..||..:|::.|:||||:.:|:.|.
 Worm  1041 PSGSGKSTIISLLERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENF---- 1101

  Fly  1236 RYTDAELWSALE-DVELRKA--------IP-GLDYMVTERGGNFSVGQRQLLCLARAILRNNKVL 1290
            .:..:...|.|| |..|:.|        .| |||.:|.|||...|.||:|.:.:|||||||.|||
 Worm  1102 LFGISHNASQLEIDQALKVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVL 1166

  Fly  1291 VLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLK 1355
            :|||||:.:|..::.::|..:....::.:.:.|||||.||:::|.|.|:..|...|......||:
 Worm  1167 LLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLR 1231

  Fly  1356 KSQGHLRQMVEATGGESEAL 1375
            |...:.| :|:..|.:.|.|
 Worm  1232 KRSIYWR-LVQKQGIQVETL 1250

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	249/1050 (24%)
		ABC_membrane	214..441	CDD:294371	6/29 (21%)
		ABCC_MRP_domain1	495..699	CDD:213217	64/219 (29%)
		ABC_membrane	863..1088	CDD:294371	49/276 (18%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	81/226 (36%)
pgp-5	NP_001257116.1	PTZ00265	27..1241	CDD:240339	248/1049 (24%)
		ABC_membrane	41..322	CDD:294371	2/4 (50%)
		ABC_MTABC3_MDL1_MDL2	374..611	CDD:213216	71/257 (28%)
		ABC_membrane	688..955	CDD:294371	49/299 (16%)
		ABC_MTABC3_MDL1_MDL2	1005..1243	CDD:213216	85/242 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000