DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and mrp-4

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_509658.1	Gene:	mrp-4 / 181202	WormBaseID:	WBGene00003410	Length:	1573	Species:	Caenorhabditis elegans

Alignment Length:	1456	Identity:	482/1456 - (33%)
Similarity:	733/1456 - (50%)	Gaps:	198/1456 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 NPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSHRKK 75
            :|...::.::::...|...|...|.::.|...||....:.|.|..|..:..:.|.|:.::.....
Worm   217 SPETTSSFLNRITMWWFNSLCSLGVKKPLEVSDLYSLNEADTSNLLVPKWYNLWDKQSKKFEETA 281

  Fly    76 QKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNIDVNDISISD 140
            .:..:.:...|.....|..|                         ..||:       :||.|..|
Worm   282 ARRRIGSNASRTNRRRTSSN-------------------------DTTPL-------LNDQSTDD 314

  Fly   141 ----SLNRTARAIPNYVLS-------QAVANSSGSPGDALFPKSLDK----AGPLEPIQPPVEEV 190
                ...::.:.:|:.:.:       ..:.        |:|.|.|..    ..||
Worm   315 YGSVPAGQSTQKMPSIIWTLFLMFKWDVIT--------AMFVKLLSDVLLFCNPL---------- 361

  Fly   191 DHNATAVRSILDQTVE---HMWNDMNSLGAVLVLSTLFCC-----FLLHHVDLRQRLMGARMRIA 247
                 .::|::..|.|   .||.     |.||..:..|..     .|.|:..|..| :|.|::..
Worm   362 -----LLKSLIRFTEELERPMWQ-----GVVLAFTMFFSAELSSILLSHYFYLMYR-VGTRVQTC 415

  Fly   248 CCSLIYRKTLRLSMKTAGQTPAGYLINLLSNDVNR--------LDYGFIFMHWIWIMPLQAMLTC 304
            ..:.:||||||||.....:...|.::||::.||:|        :.|        |..|.|..|..
Worm   416 LTAAVYRKTLRLSNAARREKTVGEIVNLMAIDVDRFQQITPQTMQY--------WSNPFQIGLAL 472

  Fly   305 YLIWLNIGIPAIVGVVGLLLKTVPVQTALSKVTSVLRMRIAER--TDARVGIMNELVQGIQVIKM 367
            :|::..:|:....||..::| ..|:...::.:  :.:.:||:.  .|.|..::||::.||:|||:
Worm   473 FLLFQQLGVSVFSGVAVMVL-LFPINFVITMI--IRKWQIAQMYYKDERTKMVNEVLNGIKVIKL 534

  Fly   368 YAWEKPFQAVVAEARRSEIKQIRYASYLRGFYLSTMVFTERSTLYITLAAAALM-----GQTITA 427
            ||||.|.:.|:.:.|..|:..|:.|::||.|  |.|:.| .|...:.|:..|..     ...:|.
Worm   535 YAWEPPMEQVIEDLREQELGLIKKAAFLRTF--SDMLNT-ASPFLVALSTFATFIYIDPKNVLTP 596

  Fly   428 DFVFSAASYYNILQ----LVAAIWYPLAVSFGAEALVSLRRIQDFLMLEGREERTQGLTHK-RDQ 487
            :..|.:.:.:|.|:    .||.:     ::...:.:||.||:::||:.|  |...:.:.|: ||
Worm   597 EIAFVSLTLFNQLRSPMSQVAEL-----ITQTVQVVVSNRRLKEFLVSE--ELNVEAIDHRARD- 653

  Fly   488 EGGDSRAVTIKDINASWDI--EKPQKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVI 550
               ::..:.:|:...||:.  .:|..||.:|:..:.:|||..::|.|||||||:||.|:||:..:
Worm   654 ---NNDVICLKEACLSWESAEHQPVPTLTNISFSVNRGQLVTIVGRVGAGKSSMLQALMGEMEKL 715

  Fly   551 DGGVFIQGDLSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGE 615
            .|.:.:.|.|.|..|:||:...::|.||.||::||...|..|...|||..|.|.||.||.|.:||
Worm   716 SGSISMHGRLCYVPQQPWMQNNTLRQNITFGKQFDEYFYSRVLDACALYRDLQILPLGDNTEIGE 780

  Fly   616 RGASLSGGQRARISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRILVT 680
            :|.:|||||:||||||||||:...|||:|||:||||||||..||..||||.|.|.  ..||||||
Worm   781 KGINLSGGQKARISLARAVYQNHDIYLLDDPMSAVDAHVGSQLFGSVIGPEGMLR--NKTRILVT 843

  Fly   681 HQVHFLSEADVIVIVDQGRILRQGTYQELINSDLDFARLLERPKEE-----------EEGENSRN 734
            :::.||.::|:|:::::|:|...|.|.:|:........|:|..|||           |:.|||..
Worm   844 NELSFLEKSDLIIVMNEGKIEYSGKYDDLMQQGAFEQLLIECEKEERERREAEASADEDDENSEP 908

  Fly   735 QTSPLSVNSLESDDEDI---PFIDGV--------KDGYQQLRKQSSSVH---------------- 772
            ....:..:|....|:|:   |.||.|        ..|....|:.|:|.|
Worm   909 GGIMIGGDSDFEYDDDVMASPIIDHVLGTSHMSTVSGIINRRRISTSTHKQRRRLSTTKSHTHSI 973

  Fly   773 GSKSLDSTQLDDNVDEDDLAEAQASGGISPRVWYEYFHAGSTLLSFSFMVFVMVMSQVVCSSSDF 837
            .|.|..:.||..       .|...:|.:....:|:||.|....::..| |..|..|.:.....:.
Worm   974 TSASTQTRQLTG-------TERVETGRVKMDTYYKYFGAMGMSIAVLF-VLGMTTSTIFSMGRNL 1030

  Fly   838 FANIWTQQEHQRSQGEATFSTFEC-MYIYGALIIAVVIMTTFRGFLFFKI-CMHASKVLHDRMFA 900
            :...|:.....||....|...... :.:|..|..:.:|: .|.|.|.... .:.||:.||..:..
Worm  1031 WLTDWSNDNAARSGSNTTGQPIAIRLGVYAGLGFSEIIL-LFIGMLSLLYGGVSASRNLHAPLMR 1094

  Fly   901 CILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAM 965
            .:....|.|:||||.||||||..||:..:|.|||..:..|.|..|.:...||:|.|..||....:
Worm  1095 NLFRVPMAFYDTTPFGRILNRIGKDIETVDVLLPFNVQFFAQCLLQVVSTLIIIMISTPVFGIVI 1159

  Fly   966 LVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFDLLQDV 1030
            :.::|:.:::::.|:..|:.|||||.|.|||::||||.|:.|.|.||:..|.|...|..:...|.
Worm  1160 IPLSVMYLMVMRYYIATSRQLKRLESITRSPIYSHLSESIQGSATIRAYHLVDRFCKLSETKVDS 1224

  Fly  1031 HSSVWQLTMAVNTTLGLWLDCV-SCIFLTSVTFSFIISSETTYSGNVGLAIAQAMILTGMVQYGV 1094
            |.....|....|..|.:.|:.: :||.|.|..|: .::..||.||.:||:::.|:.:|.::.:.|
Worm  1225 HVQCRYLNYVANRWLSVRLEFIGNCIVLFSALFA-ALTRTTTTSGVIGLSVSYALNITTVLNFAV 1288

  Fly  1095 RQVAESLQQMTSVERVLQYTELE------QEPALGEKTPPQQWPTRGQVEFRNMSCRYDPNGSPV 1153
            ||:.:....:.|||||.:|.|.|      .||.   |.|||.||:.|::...|.|.||.|..:.|
Worm  1289 RQITKLETNIVSVERVKEYAETETEAEWKSEPG---KEPPQNWPSEGRIVMNNYSARYRPGLNLV 1350

  Fly  1154 LRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAH-IEGEIFIDGIETGTISLEILRTRISIIP 1217
            ::.||:.|:...||||||||||||||:..:|||:.. .||:|.:|||....|.|..||:.::|||
Worm  1351 VKQLNVEIKPHEKVGIVGRTGAGKSSVTLSLFRIIEAAEGQIVVDGINLAEIGLHDLRSNLTIIP 1415

  Fly  1218 QDPVLFSATIRYNLDPFERYTDAELWSALEDVELRKAIPG----LDYMVTERGGNFSVGQRQLLC 1278
            |||||||.|:|:|||||..|:|.::|..||...|::....    |:|::||.|.|.|||||||:|
Worm  1416 QDPVLFSGTLRFNLDPFNHYSDGDIWKTLEMANLKEFATAHNEQLNYIITEGGDNISVGQRQLVC 1480

  Fly  1279 LARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGV 1343
            ||||:||..:||:||||||.||..||||||:|||.:|...||||:||||:|:||.|||||::.|.
Worm  1481 LARALLRKTRVLILDEATAAVDVSTDALIQKTIREEFANATVLTIAHRLNTIMDYDRIIVLNDGK 1545

  Fly  1344 AVEFDVPYLLLKKSQGHLRQMVEATG 1369
            ..|||.|..||.........|.:..|
Worm  1546 VGEFDSPANLLSNRNSEFYSMAKRAG 1571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	481/1452 (33%)
		ABC_membrane	214..441	CDD:294371	68/246 (28%)
		ABCC_MRP_domain1	495..699	CDD:213217	99/205 (48%)
		ABC_membrane	863..1088	CDD:294371	79/226 (35%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	120/219 (55%)
mrp-4	NP_509658.1	MRP_assoc_pro	17..1572	CDD:188098	482/1456 (33%)
		ABC_membrane	346..613	CDD:294371	79/301 (26%)
		ABCC_MRP_domain1	658..862	CDD:213217	99/205 (48%)
		ABC_membrane	1012..1259	CDD:294371	80/249 (32%)
		ABCC_MRP_domain2	1332..1552	CDD:213211	120/219 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.730