Protein Alignment CG5789 and mrp-6

DIOPT Version :9

• Sequence 1: NP_001247286.1
• Gene: CG5789 / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Sequence 2: NP_001362008.1
• Gene: mrp-6 / 180691
• WormBaseID: WBGene00003412
• Length: 1415
• Species: Caenorhabditis elegans
• Alignment Length: 1469
• Identity: 453/1469 - (30%)
• Similarity: 751/1469 - (51%)
• Gaps: 217/1469 - (14%)

  Fly    16 ANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSHRKKQKPHL 80
            |.:||.::|::.....:|......:||.|.:..|...::....:||.:|...      ..::.|.
 Worm    51 AGLISSILFSFVGFYWWRTRNAQTDTDLLEKPSKGISAKYAAQKLESKWISS------GPKRTHF 109

  Fly    81 RNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNIDVNDISISDSLNRT 145
            ...::.|.....:.:.:...:..:.:...|.:|.:|:..:           |:.:
 Worm   110 LVGVWHCTKVSVMAHAISLCLEELTRVAQPLLLRELMSYY-----------DIEE---------- 153

  Fly   146 ARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNATAVRSILDQTVEHMWN 210
                                            |...|..|.::
 Worm   154 --------------------------------GQEFPYWPAMQ---------------------- 164

  Fly   211 DMNSLGAVLVLSTL-FCCFLLHHVDLRQRL-MGARMRIACCSLIYRKTLRLSMKTAGQTPAGYLI 273
                  ..|::|.| |....:||......| :|...|:|...|:|||:||:|:.:..:|.:|.:|
 Worm   165 ------VALIISLLSFVTVCIHHPYFHGLLKVGNHARVATGVLLYRKSLRISLTSLFETNSGQII 223

  Fly   274 NLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVPVQTALSKVTS 338
            .||:.|..:|:..|:|.|::|:.||......|::|...|...::|.: :::..|..|...|....
 Worm   224 QLLNTDAAKLEQAFLFAHYVWLCPLLMFFYAYILWSMFGFCCLLGFL-VMMAIVSFQVHYSYQLG 287

  Fly   339 VLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIR----YASYLRGFY 399
            |.|..|.::.|:|:.:|:|::.||:||||:.||..|...:...|..|||.:.    |:|.:.|.|
 Worm   288 VNRRNIGDKMDSRLKVMSEIINGIKVIKMHGWENAFAEKIRILREDEIKAVGTSAFYSSMVMGIY 352

  Fly   400 LSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNILQLVAAIWYPLAVSFGAEALVSLRR 464
            .    .:.:..|::.:.|.....:.:|...||::::.:|.::|..|::.||.:.||.|...:.||
 Worm   353 F----ISAKIGLFVYIFACDYFDEILTTRGVFASSALFNSVRLPFALFLPLGLLFGRELFSTSRR 413

  Fly   465 IQDFLMLE----------------GREERTQGLTHKRDQE---------GGDSRAVTIKDINASW 504
            |..|..||                |.:...:|||.|:..|         ..:..:|.:..:.|.|
 Worm   414 IDLFFCLEEYSRITLELDSTDTEDGSKNEKEGLTLKKIGEKPSWTLKCDKAEKTSVFLNKVTAVW 478

  Fly   505 ------DIEKPQK--------------------------TLQSINLQIEKGQLCAVIGPVGAGKS 537
                  |.:|.:|                          .:|.::.:...|....:||.||:|||
 Worm   479 YDKDEHDQKKKKKNFKALSDNDATVIAGEKKDEPLHVVYAVQDLSFEFVAGTCYGIIGSVGSGKS 543

  Fly   538 SILQLLLGELPVIDGGVFIQGDLSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDF 602
            |:|..:|.|..:..|.:.:.|..:|.|||||:||||:::||:||.||:::||:.....|.|:.|.
 Worm   544 SLLLTILSESRMTRGNLSVNGSFAYCAQEPWIFTGSIQDNIVFGSEFNKERYENALELCLLTPDL 608

  Fly   603 QQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRG 667
            :|..|||.|:||:.|::||||||||::||||||..|.|||:||||||||||||:.|::.:|  ||
 Worm   609 RQFANGDMTIVGDNGSTLSGGQRARVALARAVYADADIYLLDDPLSAVDAHVGKKLYENLI--RG 671

  Fly   668 RLAQLKATRILVTHQVHFLSEADVIVIVDQGRILRQGTYQELINSDL-DFARL--LERPKEEEE- 728
            .|:....  ||||||:|||||.|.::::...:::..|:..||.::.. ||.:|  :|...:.:|
 Worm   672 FLSDKLV--ILVTHQIHFLSELDSVILMKNNKMVGNGSLDELKSTFTDDFIKLQAVETEVQSDEL 734

  Fly   729 ---GENSRNQTSPLSVNSLESDDEDIPFIDGVKDGYQQLRKQSSSVHGSKSLDSTQLDDNVDEDD 790
               |..|....||:::.|:|..:::..|           ::.:|.:.|||..::..:.:.|
 Worm   735 FVDGPPSSPPPSPVNIESMEKINKESIF-----------QRANSVLSGSKMSETEYVKEIV---- 784

  Fly   791 LAEAQASGGISPRVWYEYFHAGSTLLSFS-FMVFVMVMSQVVCSSSDFFANIW------------ 842
             .|::.||.||..|::||.......|.:. ::|..::::|::.:..|::.|.|
 Worm   785 -YESRKSGTISWSVYWEYTRGVINPLKYGIWLVVCVLITQLMNNFVDWWLNKWLVDLDMNNADNS 848

  Fly   843 -TQQEHQRSQG------EATFSTFECMYIYGALIIAVVIMTTFRGFLFFKICMHASKVLHDRMFA 900
             :::|..|:..      ..||.|:|..:|...:|::  |:...|...|....:.||::||:.||.
 Worm   849 TSKEEFNRNVDVLGYTFNVTFQTYELTFIISTVIMS--ILGVVRSVWFRNAQLMASRILHNSMFD 911

  Fly   901 CILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAM 965
            |:|.....|||....|.||||||||:|..|:||.....:|:...|...||:.::.::.|:::.|.
 Worm   912 CVLKTESEFFDKNSEGMILNRFSKDIGLTDDLLAFTYFEFVFGTLTFVGIVGLVSMVRPIVILAC 976

  Fly   966 LVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFDLLQDV 1030
            ..:........|:|:..|::|||:|...|||:.:.:::::.||:.||:.:.::.:.::|..|.||
 Worm   977 AFITAGFYFCRKMYVHRSRELKRIEAAARSPLNTTITSTVHGLSTIRAYRKENEMIEKFCALHDV 1041

  Fly  1031 HSSVWQLTMAVNTTLGLWLDCVSCIFLTSVTFSFIISSETTYSGNVGLAIAQAMILTGMVQYGVR 1095
            :.:.:.:.:......|:.:|.:..:|::.|....::..||...|.|||.:..|:.|:|...:.:|
 Worm  1042 YMAAYNMGLLSARWFGICIDFLVSVFVSIVAIVVVLQYETLTVGEVGLCLVCAVQLSGFFSWIMR 1106

  Fly  1096 QVAESLQQMTSVERVLQYTELEQE-------PALGEKTPPQQWPTRGQVEFRNMSCRYDPNGSPV 1153
            |.||....|.||||||:||:|:.|       .|..:|.....|||:|::||.|:|..|  ..:.|
 Worm  1107 QSAELENGMVSVERVLEYTKLKSEEEARRPHDAYLDKQLLNSWPTKGEIEFENVSVNY--GETKV 1169

  Fly  1154 LRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRL-AHIEGEIFIDGIETGTISLEILRTRISIIP 1217
            |:||:..:..|.|:|:|||||||||:||..:|.| .:..|.:.|||::...|||...|..:||||
 Worm  1170 LKNLSFVVLGGQKIGVVGRTGAGKSTLIKIIFGLKEYCSGRVTIDGVDLDHISLNFRRGGMSIIP 1234

  Fly  1218 QDPVLFSATIRYNLDPFERYTDAELWSALEDVELRKAI---PGLDYMVTERGGNFSVGQRQLLCL 1279
            |:||:||.|:|.|||||:.|.||.:|.|||..||:::|   .||:..:.:||.:.|||||||.||
 Worm  1235 QEPVIFSGTVRENLDPFDEYDDATIWFALEQCELKRSITKEKGLNVELGQRGVSLSVGQRQLFCL 1299

  Fly  1280 ARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVA 1344
            |||::..:|:||:||||||||..|||.||:|||..||..|::||||||||:|:||.::|.:.|..
 Worm  1300 ARAMIHRSKILVIDEATANVDGVTDACIQKTIRDFFKNATIITVAHRLHTIMNSDNVMVFEKGEL 1364

  Fly  1345 VEFDVPYLLLKKSQGHLRQMVEATGGESEALKKTASDSH 1383
            ||||.|..||........:|...:|.|:....:.|:.:|
 Worm  1365 VEFDKPITLLDDQSSLFSRMAAQSGAENFDSLRAAALAH 1403

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	449/1451 (31%)
		ABC_membrane	214..441	CDD:294371	67/232 (29%)
		ABCC_MRP_domain1	495..699	CDD:213217	97/235 (41%)
		ABC_membrane	863..1088	CDD:294371	65/224 (29%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	115/218 (53%)
mrp-6	NP_001362008.1	MRP_assoc_pro	<126..1389	CDD:188098	435/1372 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	148	1.000	Domainoid score	I2739
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	1	1.000	-	-		otm14754
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X771
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.830