DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and mrp-1

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_001024719.2	Gene:	mrp-1 / 180409	WormBaseID:	WBGene00003407	Length:	1534	Species:	Caenorhabditis elegans

Alignment Length:	1444	Identity:	454/1444 - (31%)
Similarity:	711/1444 - (49%)	Gaps:	205/1444 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KN--PRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSH 72
            ||  |...|:.::||.|.|...|.|.|:::.|..:||....:.|::|.:.....:....|:|...
Worm   204 KNSCPEYTASFLNQLTFQWFSGLAYLGNKKSLEKEDLWDLNERDKAENIIPSFIENLIPEVEGYR 268

  Fly    73 RK----------KQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQ 127
            ||          |..|.:...:|:.:....:..|....::.:::.:.|.:|.||:
Worm   269 RKIKKNPEAAIPKNHPSILIPIFKTYKFTLLAGGCYKLMFDLLQFVAPELLRQLI---------- 323

  Fly   128 LRNIDVNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDH 192

Worm   324 ----------------------------------------------------------------- 323

  Fly   193 NATAVRSILDQTVEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRLMGARMRIACCSLIYRKTL 257
                  |.::...:.||..: |:..::.||:|....:||........:|..:|....|.:|.|||
Worm   324 ------SFIEDKNQPMWIGV-SIALLMFLSSLLQSMILHQYFHEMFRLGMNIRSVLTSAVYTKTL 381

  Fly   258 RLSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGL 322
            .||.:.......|.::||:|.|:.|:.....|:...|..|||.:|:.|.:|..:|:..:.|.| :
Worm   382 NLSNEARKGKTTGAIVNLMSVDIQRIQDMTTFIMLFWSAPLQILLSLYFLWKLLGVSVLAGFV-I 445

  Fly   323 LLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIK 387
            |:..:|..:.:|......:|...:..|.|:.:|:|::.|::|:|:|:|||..:.:|.|.|..||:
Worm   446 LILLIPFNSFISVKMRNCQMEQMKFKDERIKMMSEILNGMKVLKLYSWEKSMEKMVLEVREKEIR 510

  Fly   388 QIRYASYLRG----------FYLSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNILQL 442
            .::..|||..          |.::.:.|    .||:.....   ...:|....|.|.:.:|||:
Worm   511 VLKKLSYLNAATTLSWACAPFLVAVLTF----GLYVLWDPE---NNVLTPQITFVALALFNILR- 567

  Fly   443 VAAIWYPLAV-----SFGAEALVSLRRIQDFLMLEGREERTQGLTHKRDQEGGDSRAVTIKDINA 502
                 :||||     |...:...|..|:::|...|....:| .:.:     ||...|:.:...:.
Worm   568 -----FPLAVFAMVFSQAVQCSASNTRLKEFFAAEEMSPQT-SIAY-----GGTDSAIKMDGGSF 621

  Fly   503 SWDIEKPQKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGDLSYAAQEP 567
            :|..::..:.|..|...|::|||.|::|.||:||||:|..||||:..:.|.|.:.|.::|..|..
Worm   622 AWGSKEEDRKLHDITFNIKRGQLVAIVGRVGSGKSSLLHALLGEMNKLSGSVQVNGSVAYVPQLA 686

  Fly   568 WLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLAR 632
            |:...|:||||||...:|.|.||.|...|||..|.:.||..|:|.:||:|.:|||||:.|:||||
Worm   687 WIQNLSLRNNILFNRPYDAKLYQNVIENCALVQDLESLPAEDRTEIGEKGINLSGGQKQRVSLAR 751

  Fly   633 AVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRILVTHQVHFLSEADVIVIVDQ 697
            |||:.|:|.|:||||||||:|||:|:|:.||.........| ||:|:||.:.:|...|.::::..
Worm   752 AVYQNAEIVLLDDPLSAVDSHVGKHIFENVISTATGCLGTK-TRVLLTHGLTYLKHCDQVIVLKD 815

  Fly   698 GRILRQGTYQELINSDLDFARLLERPKEEEE---------GENSR---------NQTSP------ 738
            ..|...||||||:||:..|:..||....||.         ||:|:         :|.||
Worm   816 ETISEMGTYQELMNSNGAFSEFLEEFLLEESKHKGRSVSFGEDSKEVNELLRDLDQVSPAIRQRI 880

  Fly   739 ---LSVNSLESDDEDIPFIDGVKDGYQQLRKQSSSVHGS--KSLDSTQLDDNVDEDDLA------ 792
               :|....::||::...|   ::|   |.|...:.|.|  ||.:...|...:...:..
Worm   881 QSQMSQEIEKTDDKNAEII---RNG---LHKDEQTAHSSIGKSEEKESLLGAISPKEKTPEPPKQ 939

  Fly   793 --------EAQASGGISPRVWYEYFHAGSTLLSFSFMVFVMVMSQVVCSSSDFFANIWTQ--QEH 847
                    ||..:|.:...|:..||.|....::..|.: |.|.|.::...|:.:...|:.  :|.
Worm   940 TKTQLIEKEAVETGKVKFEVYMSYFRAIGIKIALVFFL-VYVASSMLGVFSNLYLARWSDDAKEI 1003

  Fly   848 QRSQGEATFSTFECMYIYGAL--------IIAVVIMTTFRGFLFFKICMHASKVLHDRMFACILH 904
            ..|...::..|...:.||..|        ..|.:||.      ...:|  ||::||..:...|:.
Worm  1004 ALSGNGSSSETQIRLGIYAVLGMGQATSVCAASIIMA------LGMVC--ASRLLHATLLENIMR 1060

  Fly   905 ATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLVVA 969
            :.|.|||.||.|||||||.||:..:|..:||.|..||:.|:....|:.:|....|:.::.:|.:.
Worm  1061 SPMAFFDVTPLGRILNRFGKDVDGVDTDIPRTMSMFIRTAVSSIEIIAIILWATPLAISLLLPLF 1125

  Fly   970 VVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFDLLQDVHSSV 1034
            :|..::|:.|:..|:.|||||...|||::||...|:.|.:.||:..:.|...:|.....|.:.:.
Worm  1126 IVYFVVLRFYVSTSRQLKRLESASRSPIYSHFQESIQGASSIRAYGVVDKFIRESQHRVDENLAT 1190

  Fly  1035 WQLTMAVNTTLGLWLDCV-SCIFLTSVTFS-FIISSETTYSGNVGLAIAQAMILTGMVQYGVRQV 1097
            :..::..|..|.:.|:.| :.|.|:|...: :...|....:|.|||:::.|:.:|..:.:.||..
Worm  1191 YYPSIVANRWLAVRLEMVGNLIVLSSAGAAVYFRDSPGLSAGLVGLSVSYALNITQTLNWAVRMT 1255

  Fly  1098 AESLQQMTSVERVLQYTELEQEPALGEKTPPQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIE 1162
            :|....:.:|||:.:||....|....:...|:.||..|::..:|.|.||.|....||..:...|.
Worm  1256 SELETNIVAVERINEYTITPTEGNNSQSLAPKSWPENGEISIKNFSVRYRPGLDLVLHGVTAHIS 1320

  Fly  1163 AGWKVGIVGRTGAGKSSLIGALFRLAHIEGE-IFIDGIETGTISLEILRTRISIIPQDPVLFSAT 1226
            ...|:|||||||||||||..||||:...:|. |.|||.....:.||.||:|::|:||||||||.|
Worm  1321 PCEKIGIVGRTGAGKSSLTLALFRIIEADGGCIEIDGTNIADLLLEQLRSRLTIVPQDPVLFSGT 1385

  Fly  1227 IRYNLDPFERYTDAELWSALEDVELRKAI----PGLDYMVTERGGNFSVGQRQLLCLARAILRNN 1287
            :|.|||||..::|.::|.||.:..|...:    .||.:.::|.|.|.|||||||:|||||:||..
Worm  1386 MRMNLDPFFAFSDDQIWEALRNAHLDSFVKSLQEGLHHHISEGGENLSVGQRQLICLARALLRKT 1450

  Fly  1288 KVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYL 1352
            ||||||||.|.||.:||:|:|:|||.:||.|||||:||||:|||||||::|:|.|...|||.|..
Worm  1451 KVLVLDEAAAAVDVETDSLLQKTIREQFKDCTVLTIAHRLNTVMDSDRLLVLDKGCVAEFDTPKK 1515

  Fly  1353 LLKKSQGHLRQMVE 1366
            ||....|....|.:
Worm  1516 LLSNPDGIFYSMAK 1529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	454/1444 (31%)
		ABC_membrane	214..441	CDD:294371	64/236 (27%)
		ABCC_MRP_domain1	495..699	CDD:213217	88/203 (43%)
		ABC_membrane	863..1088	CDD:294371	72/234 (31%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	119/219 (54%)
mrp-1	NP_001024719.2	MRP_assoc_pro	23..1531	CDD:188098	454/1444 (31%)
		ABC_membrane	309..570	CDD:294371	72/356 (20%)
		ABCC_MRP_domain1	614..815	CDD:213217	88/201 (44%)
		ABC_membrane	976..1248	CDD:279056	81/280 (29%)
		ABCC_MRP_domain2	1293..1513	CDD:213211	119/219 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.830