DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5789 and mrp-2

DIOPT Version :9

Sequence 1:NP_001247286.1 Gene:CG5789 / 42928 FlyBaseID:FBgn0039207 Length:1402 Species:Drosophila melanogaster
Sequence 2:NP_508121.1 Gene:mrp-2 / 180408 WormBaseID:WBGene00003408 Length:1525 Species:Caenorhabditis elegans


Alignment Length:1442 Identity:467/1442 - (32%)
Similarity:733/1442 - (50%) Gaps:216/1442 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 PRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSHRK-- 74
            |...|:.|::|.|.|...|.|.|:::.|..:||....:.|::|.|...........::..|:.  
 Worm   208 PEYTASFINRLTFQWFTGLAYLGNKKSLENEDLWDLNEIDKAENLIPSFMQNLKPRIDEYHQNIK 272

  Fly    75 --------KQKPHLRNALFRCFLGPTIINGL---ICFIYIVIKTLIPAVLAQLLIQFQKTPVAQL 128
                    |..|.....:|:.: ..|::.|.   :||  .:::.|.|.:|.||:           
 Worm   273 KDPSAALPKNHPSFVIPIFKTY-KYTLLAGFFYKLCF--DMLQFLAPQLLKQLI----------- 323

  Fly   129 RNIDVNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHN 193
                                                             |.:|....||      
 Worm   324 -------------------------------------------------GFIEDKNQPV------ 333

  Fly   194 ATAVRSILDQTVEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRLMGARMRIACCSLIYRKTLR 258
                           |...:.:|.:...|.|...||..:.....|| |..:|....|.:|.|.|.
 Worm   334 ---------------WIGCSIVGIMFFSSFLQSMFLHQYYHSMFRL-GMHVRSVLTSAVYSKALN 382

  Fly   259 LSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLL 323
            ||.:.......|.::||:|.|:.::......:...|..|||..|:.|.:|..:|:.|:.|:|.|:
 Worm   383 LSNEARKGKTIGAIVNLMSVDIQKIQDMAPTIMLFWSAPLQIFLSIYFLWKFLGVAALAGLVVLI 447

  Fly   324 LKTVPVQTALSKVTSVLRMRIAER-----TDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARR 383
            | .:||...::     ::||..:.     .|.|:.:|:|::.|::|:|:|:||:..:.:|.:.|.
 Worm   448 L-ALPVNGLIA-----IQMRKCQTEQMKLKDERIKMMSEILNGMKVLKLYSWERSMENMVLKIRE 506

  Fly   384 SEIKQIRYASYLRGFYLSTMVFTERSTLYITLAAAALM-------GQTITADFVFSAASYYNILQ 441
            .|:..::..||    :::.:||:.....::....:.::       ...:|.:..|.|.|.::||:
 Worm   507 RELHILKKLSY----FMAAIVFSWICAPFLASVISFVVYVYLDPENNVLTPEITFVALSLFDILR 567

  Fly   442 LVAAIWYPLAVSFG--AEALVSLRRIQDFLMLEGREERTQGLTHKRDQEGGDSRAVTIKDINASW 504
            :..|:   :|:.:|  .:..||..|:::|...|....:| .::|     |....|:.:::...||
 Worm   568 MPLAM---VAMVYGEAVQCSVSNTRLKEFFAAEEMSPQT-SISH-----GETDSAIEVENGLFSW 623

  Fly   505 DIEKPQKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGDLSYAAQEPWL 569
            ..:: ..||:.|:.:|:||||.|::|.||:||||:|..||||:..:.|.|.|.|:::|..|:.|:
 Worm   624 SSDE-DPTLREISFKIQKGQLVAIVGKVGSGKSSLLHALLGEMNKLSGSVQINGNIAYVPQQAWI 687

  Fly   570 FTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAV 634
            ...|:||||||.:.:|.:.|::|.:.|||..|...||.||:|.:||:|.:|||||:.|:||||||
 Worm   688 QNMSLRNNILFNKPYDLENYEDVVKNCALKEDLANLPAGDRTEIGEKGINLSGGQKQRVSLARAV 752

  Fly   635 YKPAQIYLMDDPLSAVDAHVGRHLFDEVI-GPRGRLAQLKATRILVTHQVHFLSEADVIVIVDQG 698
            |:...|.|:||||||||:|||:|:|:.|| ...|.||  ..||:||||.:.:|...|.::::.:|
 Worm   753 YQNPDIILLDDPLSAVDSHVGKHIFENVISSSTGCLA--SKTRVLVTHGLTYLKHCDQLIVLKEG 815

  Fly   699 RILRQGTYQELINSDLDFARLLERPKEEEEGENSRNQTSPLSVNSLESDDEDIPFIDGVKDGY-- 761
            .|...||||||:|:...||..||....||  ..:|.:.:.:...|.|. ||.:..:..||.|.  
 Worm   816 TISELGTYQELLNNSGAFAEFLEEFLIEE--SKTRGRVASIGDGSGEV-DEILRDLGQVKPGILK 877

  Fly   762 -------QQLRKQSSSVHGSK-SLDS-----------TQLDDN------VDEDDLA--------- 792
                   |:..|:.:|....: |.||           :|.::|      :.||..|         
 Worm   878 RLESHLSQESDKEDTSARAIEYSRDSSRRSVLLHSPRSQHEENEALLGAISEDVPAQENTQLIEK 942

  Fly   793 EAQASGGISPRVWYEYFHAGS---TLLSFSFMVFVMVMSQVVCSSSDFFANIWTQQEHQRSQGEA 854
            |...:|.:...|:..||.|.|   |||.|    |:.|.|..:...|:|:  :....:|.:| |..
 Worm   943 ETVETGKVKFEVYIAYFQAISIPITLLFF----FLYVGSSGLGILSNFY--LAKLSDHAKS-GNR 1000

  Fly   855 TFSTFEC-MYIYGAL--------IIAVVIMTTFRGFLFFKICMHASKVLHDRMFACILHATMRFF 910
            |.|..:. :.||..|        :||.:|:|.  |.|      .||::||..:...|:.:.|.||
 Worm  1001 TSSDAKMELGIYAVLGMGQSFVVLIASIILTI--GVL------RASRILHAGLLGNIMRSPMAFF 1057

  Fly   911 DTTPSGRILNRFSKDMGAIDELLPRAMMDFIQ-IALVMFGI---LIVIGILNPVLVAAMLVVAVV 971
            |.||.||||||..||:.|||..||    |.|: :::.:|.:   |:||....|....|..:::|:
 Worm  1058 DVTPIGRILNRIGKDIEAIDRTLP----DVIRHMSMTIFNVVATLVVIMWATPWAGIAFAILSVI 1118

  Fly   972 DVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFDLLQDVHSSVWQ 1036
            ..::|:.|:..|:.|||||...|||::||...|:.|.:.||:..:.|...|:.....|.|...:.
 Worm  1119 YFIVLRFYISTSRQLKRLESASRSPIYSHFQESIQGASSIRAFGVVDNFIKQSQQRVDDHLIAYY 1183

  Fly  1037 LTMAVNTTLGLWLDCVSCIFLTSVTFS--FIISSETTYSGNVGLAIAQAMILTGMVQYGVRQVAE 1099
            .::..|..|.:.|:.|..:.:.|...:  :...|....:|.|||:::.|:.:|..:.:.||..:|
 Worm  1184 PSIVANRWLAVRLEMVGNLIVLSAAGAAVYFRDSPGLSAGLVGLSVSYALNITQTLNWAVRMTSE 1248

  Fly  1100 SLQQMTSVERVLQYTELEQEPALGEKTPPQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAG 1164
            ....:.||||:.:||....|.....:...:.||.:|::..:|.|.||.|....||..::..|...
 Worm  1249 LETNIVSVERIKEYTVTPTEGNNSRRLAAKSWPEKGEISIKNFSVRYRPGLDLVLHGISAHIAPS 1313

  Fly  1165 WKVGIVGRTGAGKSSLIGALFRLAHIE-GEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIR 1228
            .|||||||||||||||..||||:...: |.|.||||....:.||.||:.::|:||||||||.|::
 Worm  1314 EKVGIVGRTGAGKSSLTLALFRIIEADGGSIEIDGINIANLQLEQLRSCLTIVPQDPVLFSGTMK 1378

  Fly  1229 YNLDPFERYTDAELWSALEDVELRKAI----PGLDYMVTERGGNFSVGQRQLLCLARAILRNNKV 1289
            .|||||..|:|:::|.|||:..|:..:    .||::.::|.|.|.|||||||:|||||:||..||
 Worm  1379 MNLDPFSAYSDSQVWEALENAHLKPFVKSLQDGLEHKISEGGENLSVGQRQLICLARALLRKTKV 1443

  Fly  1290 LVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLL 1354
            ||||||.|.||.:||:|||:|||.:||:|||||:||||:|||||||::|:|.|...|||.|..||
 Worm  1444 LVLDEAAAAVDVETDSLIQKTIREQFKECTVLTIAHRLNTVMDSDRLLVLDKGRVAEFDSPKNLL 1508

  Fly  1355 KKSQGHLRQMVE 1366
            ....|....|.:
 Worm  1509 ANPDGIFYSMAK 1520

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5789NP_001247286.1 CFTR_protein 9..1367 CDD:273530 467/1442 (32%)
ABC_membrane 214..441 CDD:294371 59/238 (25%)
ABCC_MRP_domain1 495..699 CDD:213217 93/204 (46%)
ABC_membrane 863..1088 CDD:294371 74/238 (31%)
ABCC_MRP_domain2 1135..1350 CDD:213211 122/219 (56%)
mrp-2NP_508121.1 MRP_assoc_pro 25..1522 CDD:188098 467/1442 (32%)
ABC_membrane 309..570 CDD:294371 70/352 (20%)
ABCC_MRP_domain1 614..816 CDD:213217 93/204 (46%)
ABC_membrane 971..1239 CDD:279056 86/286 (30%)
ABCC_MRP_domain2 1284..1504 CDD:213211 122/219 (56%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.730

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