Protein Alignment CG5789 and mrp-7

DIOPT Version :9

• Sequence 1: NP_001247286.1
• Gene: CG5789 / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Sequence 2: NP_507812.3
• Gene: mrp-7 / 180289
• WormBaseID: WBGene00003413
• Length: 1525
• Species: Caenorhabditis elegans
• Alignment Length: 1451
• Identity: 460/1451 - (31%)
• Similarity: 733/1451 - (50%)
• Gaps: 220/1451 - (15%)

  Fly     2 DSSAKPTRKNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWF- 65
            :.::..:..:|...::.:::|...|...:.:.|:||.|..||:.:..:...:|.|.:..|..|.
 Worm   198 EKASSKSAASPELQSSFLNRLTLWWFNSIPWTGARRDLEIDDIFELNERSGTEFLSELWESFWEP 262

  Fly    66 KELERSH----------RKKQK-----PHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQ 115
            |.|:..|          .:::|     |.:.::||..|....::...:.|:...::...|.:|.:
 Worm   263 KRLKYIHDTSIWAKKDPSEQEKDPVVIPSVVSSLFMMFRWEFLLASTLKFVSDTMQFASPFLLHE 327

  Fly   116 LLIQFQKTPVAQLRNIDVNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPL 180
            ||                                 |::          |..:|.|.|.:
 Worm   328 LL---------------------------------NFI----------SAKNAPFWKGM------ 343

  Fly   181 EPIQPPVEEVDHNATAVRSILDQTVEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRLMGARMR 245
                            ..|||..:|..:.:        |:|:..|      ::..|   ||.:::
 Worm   344 ----------------ALSILMFSVSELRS--------LILNGYF------YIMFR---MGTKIQ 375

  Fly   246 IACCSLIYRKTLRLSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLN 310
            .:..:.:|:|||.:|.........|.::||::.||.|.......:...|..|.|.......:::.
 Worm   376 TSLTAAVYKKTLLISNSARRDRTVGEIVNLMAIDVERFQMITPQIQQFWSCPYQITFALVYLFIT 440

  Fly   311 IGIPAIVGVVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQ 375
            :|..|:.||| :::..||:....|.:....::...:..|.|..::||::.||:|:|:||||.|.:
 Worm   441 LGYSALPGVV-IMVIFVPMNIISSMIVRKWQIEQMKLKDERTKMVNEVLNGIKVVKLYAWEVPME 504

  Fly   376 AVVAEARRSEIKQIRYASYLRG---------------FYLSTMVFTERSTLYITLAAAALMGQTI 425
            |.:.|.|..|:..|:.::.:|.               |...|.|.:..|.|             :
 Worm   505 AYIDEIRTKELALIKKSAMVRNILDSFNTASPFLVALFSFGTFVLSNPSHL-------------L 556

  Fly   426 TADFVFSAASYYNILQ----LVAAIWYPLAVSFGAEALVSLRRIQDFLMLEGREER--TQGLTHK 484
            |....|.:.:.:|.|:    ::|     |.::...:|:||.:|:::||:.|..:|:  .:.:..:
 Worm   557 TPQIAFVSLALFNQLRSPMTMIA-----LLINQAVQAVVSNKRLKEFLVAEELDEKCVDRSVNIE 616

  Fly   485 RDQEGGDSRAVTIKDINASWDIEKP--QKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGEL 547
            |..     .||.::::.||||.|:.  :||||.::|...:..|.||:|.||:||||:||.||||:
 Worm   617 RSH-----NAVRVENLTASWDPEEAAGEKTLQDVDLTAPRNSLIAVVGKVGSGKSSLLQALLGEM 676

  Fly   548 PVIDGGVFIQGDLSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTL 612
            ..:.|.:.:.|.::|..|:||:...::|:||.||..||||||.:|...|||..|.:.||.||:|.
 Worm   677 GKLRGRIGVNGRVAYVPQQPWIQNMTLRDNITFGRPFDRKRYDQVLYACALKADIKILPAGDQTE 741

  Fly   613 VGERGASLSGGQRARISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRI 677
            :||:|.:|||||:||:|||||||:...:||:||||||||||||||:|::||||.|.|.:  .|||
 Worm   742 IGEKGINLSGGQKARVSLARAVYQNLDVYLLDDPLSAVDAHVGRHIFEKVIGPNGLLRE--KTRI 804

  Fly   678 LVTHQVHFLSEADVIVIVDQGRILRQGTYQELINSDLDFARLLERPKEEEEGENSRNQTSPLSVN 742
            ||||.:.:...||.|:::.:|:|...||::.||.....|...:|   |.:.|.::.::..
 Worm   805 LVTHGLTYTKMADEILVMLEGKIEESGTFEHLIKRRGLFFDFME---EYKSGSDNSSEAG----- 861

  Fly   743 SLESDDEDIPFIDGVKDGYQ--------------------QLRKQSSSVH-------GSKSLDST 780
              .|.|:|...|.|....|.                    :|..|.|::.       |:....:|
 Worm   862 --GSQDDDFEAIGGEIQDYMNPEDVVLTVTNDLDETIRTPELTTQISTMSSPEKPPTGTSPAAAT 924

  Fly   781 QLDDNVDEDDLAEAQASGGISPRVWYEYFHAGSTLLSFSFM-VFVMVMSQVVCSSSDFFANIWTQ 844
            :..:.:.:   .|..|.|.:....:..|..|...|||.:|: .|::.|:..:..|  |:.:.|:.
 Worm   925 ESQNKLIK---KEGIAQGKVEIATYQLYVKAAGYLLSIAFIGFFIVYMTLQILRS--FWLSAWSD 984

  Fly   845 QEHQRSQGEATFSTFECMYIYGAL-------IIAVVIMTTFRGFLFFKICMHASKVLHDRMFACI 902
            :....|......:....:.:||||       ....::...|.|       ..|||.||..:...:
 Worm   985 EYDPDSPSAHPMAKGWRLGVYGALGFSETACFFVALLALVFVG-------QRASKNLHGPLIHNL 1042

  Fly   903 LHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLV 967
            :.:.|.|:||||.||||||.:||:..||.:||......:...|.:...||||.|..|:....:|.
 Worm  1043 MRSPMSFYDTTPLGRILNRCAKDIETIDMMLPMNFRYLVMCVLQVAFTLIVIIISTPLFAVVILP 1107

  Fly   968 VAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFDLLQDVHS 1032
            :|::.::.|:.|:..|:.|||||.:.|||::||...::.|.|.||:....|...::...:.|...
 Worm  1108 LALIYLIFLRYYVPTSRQLKRLESVHRSPIYSHFGETIQGAASIRAFGKVDEFRQDSGRILDTFI 1172

  Fly  1033 SVWQLTMAVNTTLGLWLDCV-SCIFLTSVTFSFIISSE---TTYSGNVGLAIAQAMILTGMVQYG 1093
            .....::..|..|.:.|:.| :||...:..|: ::|.|   .|..|.:|::::.|:.:|.::.:.
 Worm  1173 RCRYSSLVSNRWLAVRLEFVGNCIIFFAALFA-VLSKEFGWITSPGVIGVSVSYALNITEVLNFA 1236

  Fly  1094 VRQVAESLQQMTSVERVLQYTELEQEP--ALGEKTPPQQWPTRGQVEFRNMSCRYDPNGSPVLRN 1156
            ||||:|....:.|||||.:||....|.  .:..:.|...||:||.|:|...|.||......||.:
 Worm  1237 VRQVSEIEANIVSVERVNEYTNTPNEAPWRIEGREPAPGWPSRGVVKFDGYSTRYREGLDLVLHD 1301

  Fly  1157 LNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAHIE---GEIFIDGIETGTISLEILRTRISIIPQ 1218
            ::..:.||.|:||||||||||||...||||:  ||   |.|.||.:|...|.|..||:.|:||||
 Worm  1302 ISADVAAGEKIGIVGRTGAGKSSFALALFRM--IEAAGGRIVIDDVEVSQIGLHDLRSNITIIPQ 1364

  Fly  1219 DPVLFSATIRYNLDPFERYTDAELWSALEDVELR---KAIP-GLDYMVTERGGNFSVGQRQLLCL 1279
            ||||||.|:|:|||||..|:|.::|.|||...|:   ..:| ||.|.::|.|.|.|||||||:.|
 Worm  1365 DPVLFSGTLRFNLDPFFTYSDDQIWRALELAHLKHFAAGLPDGLLYKISEAGENLSVGQRQLVAL 1429

  Fly  1280 ARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVA 1344
            |||:||:.:|||||||||.||..||||||.|||.:||:|||.|:||||:|:||.|||:|:|.|..
 Worm  1430 ARALLRHTRVLVLDEATAAVDVATDALIQETIREEFKECTVFTIAHRLNTIMDYDRIMVLDKGSI 1494

  Fly  1345 VEFDVPYLLLKKSQGHLRQMV 1365
            :|||.|..|:........:||
 Worm  1495 LEFDTPDALMADKNSAFAKMV 1515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	460/1444 (32%)
		ABC_membrane	214..441	CDD:294371	55/241 (23%)
		ABCC_MRP_domain1	495..699	CDD:213217	104/205 (51%)
		ABC_membrane	863..1088	CDD:294371	70/235 (30%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	125/221 (57%)
mrp-7	NP_507812.3	MRP_assoc_pro	14..1518	CDD:188098	460/1451 (32%)
		ABC_membrane	310..575	CDD:294371	70/360 (19%)
		ABCC_MRP_domain1	622..826	CDD:213217	104/205 (51%)
		ABC_membrane	976..1227	CDD:279056	73/260 (28%)
		ABCC_MRP_domain2	1280..1500	CDD:213211	125/221 (57%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.730