DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and pgp-9

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_507487.1	Gene:	pgp-9 / 180165	WormBaseID:	WBGene00004003	Length:	1294	Species:	Caenorhabditis elegans

Alignment Length:	1370	Identity:	314/1370 - (22%)
Similarity:	569/1370 - (41%)	Gaps:	323/1370 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 LEPIQPPVEEVDHNATAVRSILDQTVEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRLMGARM 244
            |:|.....|:....|.....::...:::::.......|..:.::   ||::....|..|..
Worm    82 LDPNSTASEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQAS---CFMVICEKLSNRFR---- 139

  Fly   245 RIACCSLIYRKTLRLSMKTAGQTPAGYLINLLSNDVNRLDYG-------------------FIFM 290
                 ...:...:|..:....:..:|.|.|.|.:::.|:..|                   .:..
Worm   140 -----RQFFHSVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAF 199

  Fly   291 HWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIM 355
            .:.|::.|          :.:.:...:.:.||.         |:|:.:....:.|::.....||.
Worm   200 TYDWLLTL----------IMMSLSPFMMICGLF---------LAKLLATAATKEAKQYAVAGGIA 245

  Fly   356 NELVQGIQVIKMYAWE----KPFQAVVAEARRSEIKQ-------------IRYASYLRGFYLST- 402
            .|::..|:.:..:..:    |.::..:...:::.||:             |.||||...|::.|
Worm   246 EEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTN 310

  Fly   403 MVFTER--STLYITLAAAALMGQ-----------TI-TADFVFSAASYYNILQLVAAIWYPLAVS 453
            .|::.|  |...:|:..:.:||.           || ||  :.:|||.|.::..:..|
Worm   311 FVYSGRLESGTVLTVFFSVMMGSMALGQAGQQFATIGTA--LGAAASLYEVIDRIPEI------- 366

  Fly   454 FGAEALVSLRRIQDFLMLEGREERTQGLTHKRDQEGGDSRAVTIKDINASWDIEKPQKTLQSINL 518
               :|.                 .|:|.|..:     .|..:::..:..::......|.|:.::|
Worm   367 ---DAY-----------------STEGQTPSK-----ISGRISVNKVEFTYPTRADVKILKGVSL 406

  Fly   519 QIEKGQLCAVIGPVGAGKSSILQL------------LLGELPVIDGGV-FIQGDLSYAAQEPWLF 570
            ..:.||..|::|..|.|||:|:||            |:.::|:.|..: :::..:...:|||.||
Worm   407 DAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLF 471

  Fly   571 TGSVRNNILFG--EEFDRKRYQEVTRCC--ALSTDF-QQLPNGDKTLVGERGASLSGGQRARISL 630
            ..|:..||.:|  :..|    :::.|..  |.:.|| :..|.|..||||:||..:||||:.||::
Worm   472 NTSIEQNIRYGRSDVSD----EDIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAI 532

  Fly   631 ARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVI--GPRGRLAQLKATRILVTHQVHFLSEADVIV 693
            |||:.:..:|.|:|:..||:||. ...:....:  ..|||      |.|::.|::..:..||.|:
Worm   533 ARALVRNPKILLLDEATSALDAE-SESIVQSALENASRGR------TTIVIAHRLSTVRNADKII 590

  Fly   694 IVDQGRILRQGT----------YQELINSDLDFARLLERPKEEEEGENSRNQTSPL--SVN--SL 744
            ::..|:::..||          |.||:::.: ||.:.::||::|.......|||..  |||  :.
Worm   591 VMKAGQVMEVGTHETLIEQKGLYHELVHAQV-FADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQ 654

  Fly   745 ESDDEDIPFIDGVKDGYQQLRKQSSSVHGSKSLDSTQLDDNVDEDDLAEAQASGGI---SPRVWY 806
            ||..::.|   |.....:...|:..           :|...::|:...:|.....:   .|...|
Worm   655 ESQVDEKP---GAPPAPEAAEKEIK-----------RLKKELEEEGAVKANLFKILRYARPEWIY 705

  Fly   807 EYFHAGSTLLSFSFM-VFVMVMSQVVCSSSDFFANIWTQQEHQRSQGEATFSTFECMYIYGALII 870
            .:|...:.|:..:.| .|.:..||::        |:::..:..:.:.:..|  :..|:    |::
Worm   706 IFFAIIAALIQGAVMPAFSLFFSQII--------NVFSNPDRDQMKKDGHF--WALMF----LVL 756

  Fly   871 AVVIMTT--FRGFLFFKICMHASKVLHDRMFACILHATMRFFDT---TPSGRILNRFSKD----M 926
            |.|..|:  |:..||.......:..:..:::..:|.....:||.   :| |||..|.:.|    .
Worm   757 AAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSP-GRITTRLATDAPNIK 820

  Fly   927 GAIDELLPRAMMDFIQIALV--MFGILIVIGILNPVLVAAML-VVAVVDVLILKLY-LRPSQDLK 987
            .|||..|...   |..||.|  ..||....|.....||.|:. .:||...|::|.: ...:.|.|
Worm   821 SAIDYRLGSI---FNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKYHGGSATSDAK 882

  Fly   988 RLEGICRSP---------------------VF-SHLSASLTG---LAIIRSRQLQDVVAKEFDLL 1027
            .:|...::.                     :| |||.|...|   .||||.            |.
Worm   883 EMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRG------------LT 935

  Fly  1028 QDVHSSVWQLTMAVNTTLGLWLDCVSCIF--------------LTSVTFSFIISSETTYSGNVGL 1078
            ....:|:...|.|.....||:|     ||              |.:::|||         |.:|.
Worm   936 YGFANSIQFFTYAAAFRFGLFL-----IFDKNVLMEPENVLRVLFAISFSF---------GTIGF 986

  Fly  1079 AIA------QAMILTGMVQYGVRQVAESLQQMTSVERVLQYTELEQEPALGEKTPPQQWP-TRGQ 1136
            |.:      :|....|::                      :..||:||.:...|....:| ..|:
Worm   987 AASYFPEYIKATFAAGLI----------------------FNMLEEEPRIDGMTSSGTYPQLSGE 1029

  Fly  1137 VEFRNMSCRYDPNGS-PVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAH-IEGEIFIDGI 1199
            |:...:..||....: |:|:.||:.::.|..:.:||.:|.|||::|..|.||.. :||.:.:|..
Worm  1030 VKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNN 1094

  Fly  1200 ETGTISLEILRTRISIIPQDPVLFSATIR----YNLDPFERYTDAELWSALEDVELRKAI----P 1256
            :...::.:.||..|:::.|:|:||..:||    |.|.|.| ||..::.:|.....:.|.|    .
Worm  1095 DLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGE-YTHEQIETACSKANIHKFIDELPD 1158

  Fly  1257 GLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVL 1321
            |.:..|.|:|...|.||:|.:.:|||::||.|:|:|||||:.:|.:::..:|..:....|..|.:
Worm  1159 GYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCI 1223

  Fly  1322 TVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHL----RQMVEATGG---ESEALKKTA 1379
            .|||||.|::::..|:|:..|..||......|:.|...:.    :|....:||   .||||....
Worm  1224 VVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSSNQSGGAFDTSEALDDDD 1288

  Fly  1380 SDSHK 1384
            .|..|
Worm  1289 DDHVK 1293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	306/1348 (23%)
		ABC_membrane	214..441	CDD:294371	47/277 (17%)
		ABCC_MRP_domain1	495..699	CDD:213217	64/223 (29%)
		ABC_membrane	863..1088	CDD:294371	64/282 (23%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	75/224 (33%)
pgp-9	NP_507487.1	PTZ00265	28..1262	CDD:240339	305/1337 (23%)
		ABC_membrane	50..334	CDD:279056	43/282 (15%)
		ABC_MTABC3_MDL1_MDL2	383..620	CDD:213216	70/247 (28%)
		ABC_membrane	710..977	CDD:279056	65/301 (22%)
		ABC_MTABC3_MDL1_MDL2	1030..1269	CDD:213216	76/239 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000