DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and cft-1

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_504463.1	Gene:	cft-1 / 178939	WormBaseID:	WBGene00000477	Length:	1247	Species:	Caenorhabditis elegans

Alignment Length:	1322	Identity:	307/1322 - (23%)
Similarity:	573/1322 - (43%)	Gaps:	193/1322 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 SISDSLNRTARAIPNYVLSQAVANSSGS-----PGDALFPKSLDKAGPLEPIQPPVEEVDHNATA 196
            |:|.:|::.||.|.|...::...:|..|     |...|..|.......::.:  |:.|....:..
Worm     4 SVSVNLSKNARQIQNETENEQAKSSFASKLLELPVSKLLQKCRSSTITVDDL--PILEEKQCSNR 66

  Fly   197 VRS-------ILDQTVEHMWND------------MNSLGAVLVL----------STLFCCF---- 228
            |.|       ::...:...|..            .....::|:|          :|||..|
Worm    67 VMSGFKWKKRVIFSILMKFWKSFAGAFAFRMCAIFADYASILLLKYLIDSAEISATLFNFFIIAV 131

  Fly   229 -LLHHVDLRQRLMG----------ARMRIACCSLIYRKTLRLSMKTAGQTPAGYLINLLSNDVNR 282
             :|..:.|:..|:|          ..|.....::|.:|.|.|:.:..... ...:..||:.....
Worm   132 LILFFMQLKSLLLGVHTYLVGEDSVEMVTVLNNIIVKKALHLTSENTDWN-RSKISKLLTTHSEA 195

  Fly   283 LDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVPVQTALSKVTSV-----LRM 342
            :..|..::|......::..:..:.||..:|...|:.|:.:.|    |....:.:.|.     |::
Worm   196 VSNGLAYVHHSCSALIELTIALFWIWETLGTRTIIVVLIVAL----VYAVFNIIDSYVYKKSLKV 256

  Fly   343 RIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIRYASYLRGFYLSTMVFTE 407
            ::..| |.||.....::..::.|||::||..|...:...|..|:...|....:..|..|..|
Worm   257 QLKCR-DERVEFEKTVLNSMETIKMFSWEPHFWKKLKSMRGKELSVFRKTLSINSFMHSLNV--- 317

  Fly   408 RSTLYITLAAAALMGQTITADFVFSAASYYNILQLVAAIWY---PLAVSFGA-----EALVSLRR 464
            .|...||..:.|:.|    ..:..||..:.:...|:|...|   ||.|...:     :||.|...
Worm   318 TSPFVITFVSFAVYG----LQYEISALRFEDAFVLIAIFNYMRRPLHVIIPSLEIVDKALHSATI 378

  Fly   465 IQDFLMLEGREERTQGLTHKRDQEGGDSRAVTIKDINASWDIEKPQKTLQSINLQIEKGQLCAVI 529
            |..||::    :::..:..|...:......:.||.:||::.......||..:.:.::||:..|.|
Worm   379 INQFLIV----KQSPKINTKTAPQPPVEPDLDIKILNANFSWNGKDDTLNDVCVHVKKGEKHAFI 439

  Fly   530 GPVGAGKSSILQLLLGELPVIDGGVFIQGDLSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTR 594
            |....||||:|..:.|||.:..|.:::...:|:|...|::|:.|::.|||||.::.:.:|.:|..
Worm   440 GFPLCGKSSLLFSITGELKMTKGNMWVSKGISFAPASPYIFSQSLKENILFGNDYVKSKYDKVIM 504

  Fly   595 CCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQIYLMDDPLSAVDAHVGRHLF 659
            .|.|..|...||..:.|::|::|..|:..|:|:|||||.:|:.|.||.:|.....:|......:|
Worm   505 ACDLKKDIFSLPRCEATVLGDKGYVLTSTQKAQISLARCLYEDADIYALDKAFGPMDRTTSNKIF 569

  Fly   660 DEVIGPRGRLAQLKATRILVTHQVHFLSEADVIVIVDQGRILRQGTYQELINSDLDFARLLERPK 724
            ..|:|..|.|..  .|.||.|:.:..:....::.::..|:|...|:|.:::......:.||.:.:
Worm   570 TRVLGENGYLRD--KTVILATNNIELIKTFTMVHVLKNGKIETSGSYDQILECSEIMSDLLNQSR 632

  Fly   725 EEEEGENSRNQTSPLSVNSLESDDEDIPFIDGVKDGYQQLRKQSSSVHGSKSLDSTQLDDNVDED 789
            .::..|...:...|        ..:.:.|.|.|    .:.||:..|:                 :
Worm   633 IDKIIEEKYSDEKP--------PRKTVMFDDKV----LKKRKKKQSM-----------------E 668

  Fly   790 DLAEAQASGGISPRVWYEYFHAGSTLLSFSFMVFVMVMSQVVCSSSDFFANIWTQQEHQRSQGEA 854
            |.|....:..:.|    .||.:||.:.: :|.:.:::...|..:.:.|:.:.|.         :.
Worm   669 DTAPVFENRSVYP----FYFRSGSFIFT-AFYIVLLICRFVFQALAFFWLSFWL---------DP 719

  Fly   855 TFSTFEC------MYIYGALIIAV-VIMTTFRGFLFFKIC-MHASKVLHDRMFACILHATMRFFD 911
            .:...||      ::|......|: .|::|...:.||.:. :..|:.|:..:.:.|....|.|..
Worm   720 VWKKVECENCPQYVFIQTMSFFAISAIISTMLSYTFFVLTNVQTSRKLYQHITSAIFAVPMIFLS 784

  Fly   912 TTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLVVAVVDVLI- 975
            .|....::|..:.|:..:|...|.......:..|.:..|..::.:..||.  |:.|||.:..|:
Worm   785 PTNKESLMNMITSDLDIVDTQFPLFFKFSFECTLHILMIFAIVCVNVPVF--AIFVVAFLIFLVG 847

  Fly   976 LKLYLRPS-------QDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFDLLQDVHSS 1033
            |..|..|:       ::.||...:|.|  .....|.:......::||.....:...|:|.
Worm   848 LLRYFLPALHKISSLEEQKRDLFLCGS--IEDFEARIMVRTFGKTRQTLAKTSVNADILT----- 905

  Fly  1034 VWQLTMAVNTTLGLWLD-----------CVSCIFLTSVTFSFIISSETTYSGNV--GLAIAQAMI 1085
              :..||..:|| .|:.           |: |.|:.|:..      :..|.||.  .|::|..:.
Worm   906 --RCRMARYSTL-RWISLRTEFISNLMICM-CFFIASICL------KVDYIGNAQFALSVASILC 960

  Fly  1086 LTGMVQYGVRQ--VAESLQQMTSVERVLQYTELEQEPALGEKTPPQQWPTRGQVEFRNMSC---R 1145
            ::.:|...:|.  :.|||  ...|:|:....|..:||.:.:.|....||..|::|.:|::.   :
Worm   961 ISELVSTFIRTTCILESL--TPHVQRISNVREYPKEPMIDKCTIRDSWPDDGKIEIKNLNVFANK 1023

  Fly  1146 YDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRL--AHIEGEIFIDGIETGTISLEI 1208
            |    ..|:::::|.||...|:||:|:.|:|||.|...|..:  |..|..|.:|.::...:|::.
Worm  1024 Y----RHVIKDVSLVIEEREKLGIIGKVGSGKSQLAKTLVMMSSADKESHIVVDDLDIFEMSVKT 1084

  Fly  1209 LRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDVELR---KAIP-GLDYMVTERGGNF 1269
            ||:||::|||...:||.|:|.|:||..::.|:::|.|:|..:||   |::| ||..||:..  ..
Worm  1085 LRSRITVIPQKAKIFSDTLRSNIDPCCQFADSDIWLAIEACQLREYVKSLPDGLHQMVSPE--KM 1147

  Fly  1270 SVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSD 1334
            |..|:..:.:.||:|:..::.|:|::|..:.....:|:...||...||.|.:.:......|...|
Worm  1148 SNEQKCQVNVCRALLKGGQIFVIDQSTKMMKEPIKSLVNEAIRNSLKQSTTIWIGEDFSDVEHCD 1212

  Fly  1335 RIIVMDAGVAVEFDVPYLLLKK 1356
            |::|::.||.:..|.|..|:.:
Worm  1213 RVVVIENGVILTTDTPQNLISE 1234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	307/1322 (23%)
		ABC_membrane	214..441	CDD:294371	51/256 (20%)
		ABCC_MRP_domain1	495..699	CDD:213217	63/203 (31%)
		ABC_membrane	863..1088	CDD:294371	51/247 (21%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	70/223 (31%)
cft-1	NP_504463.1	MdlB	76..631	CDD:224055	134/573 (23%)
		ABC_membrane	93..359	CDD:294371	54/278 (19%)
		P-loop_NTPase	407..607	CDD:304359	63/201 (31%)
		ABC_membrane	696..938	CDD:294371	50/263 (19%)
		P-loop_NTPase	1010..1228	CDD:304359	70/223 (31%)
		EcfA2	1012..1234	CDD:224047	71/227 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920