DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and Abcc1

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_032602.1	Gene:	Abcc1 / 17250	MGIID:	102676	Length:	1528	Species:	Mus musculus

Alignment Length:	1438	Identity:	473/1438 - (32%)
Similarity:	739/1438 - (51%)	Gaps:	200/1438 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSHR--- 73
            |...|:.:|::.|.|...::..|.|:.|.:.||....|||.||::...|.:.|.||.::|.:
Mouse   209 PESSASFLSRITFWWITGMMVHGYRQPLESSDLWSLNKEDTSEEVVPVLVNNWKKECDKSRKQPV 273

  Fly    74 ----------------------------------KKQKPHLRNALFRCFLGPTIINGLICFIYIV 104
                                              |.::|.|...|::.| ||..   |:.|:|..
Mouse   274 RIVYAPPKDPSKPKGSSQLDVNEEVEALIVKSPHKDREPSLFKVLYKTF-GPYF---LMSFLYKA 334

  Fly   105 IKTLI----PAVLAQLLIQFQKTPVAQLRNIDVNDISISDSLNRTARAIPNYVLSQAVANSSGSP 165
            :..|:    |.:| :|:|.|            |||           |..|::
Mouse   335 LHDLMMFAGPKIL-ELIINF------------VND-----------REAPDW------------- 362

  Fly   166 GDALFPKSLDKAGPLEPIQPPVEEVDHNATAVRSILDQTVEHMWNDMNSLGAVLVLSTLFCCFLL 230
             ...|..:|                    ..|.:.|.....|.:              ...||
Mouse   363 -QGYFYTAL--------------------LFVSACLQTLALHQY--------------FHICF-- 390

  Fly   231 HHVDLRQRLMGARMRIACCSLIYRKTLRLSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWI 295
                    :.|.|::.|....:|||.|.::......:..|.::||:|.|..|......:::.||.
Mouse   391 --------VSGMRIKTAVVGAVYRKALLITNAARKSSTVGEIVNLMSVDAQRFMDLATYINMIWS 447

  Fly   296 MPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQ 360
            .|||.:|..|.:||::| |:::..|.:::..||:...::..|...::...:..|.|:.:|||::.
Mouse   448 APLQVILALYFLWLSLG-PSVLAGVAVMILMVPLNAVMAMKTKTYQVAHMKSKDNRIKLMNEILN 511

  Fly   361 GIQVIKMYAWEKPFQAVVAEARRSEIKQIRYASYLRGFYLSTMVFTERSTLYITLAAAALMGQ-- 423
            ||:|:|:||||..||..|...|:.|:|.::.::||......|.|.|.......|.|....:.:
Mouse   512 GIKVLKLYAWELAFQDKVMSIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVFVTVDERN 576

  Fly   424 TITADFVFSAASYYNILQLVAAIWYPLAVSFGAEALVSLRRIQDFLMLEGREERTQGLTHKRDQE 488
            .:.|...|.:.:.:|||:....| .|:.:|...:|.|||:|::.||   ..||.......:|..:
Mouse   577 ILDAKKAFVSLALFNILRFPLNI-LPMVISSIVQASVSLKRLRIFL---SHEELEPDSIERRSIK 637

  Fly   489 GGDSRAVTIKDINASWDIEKPQKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGG 553
            .|:..::|:|:...:|...:| .||..|...|.:|.|.||:|.||.||||:|..||.|:..::|.
Mouse   638 SGEGNSITVKNATFTWARGEP-PTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGH 701

  Fly   554 VFIQGDLSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGA 618
            |.::|.::|..|:.|:...|:|.|||||.......|:.|...|||..|.:.||:||:|.:||:|.
Mouse   702 VTLKGSVAYVPQQAWIQNDSLRENILFGHPLQENYYKAVMEACALLPDLEILPSGDRTEIGEKGV 766

  Fly   619 SLSGGQRARISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRILVTHQV 683
            :|||||:.|:|||||||..:.|||.||||||||||||:|:|::|:||.|.|.  ..|||||||.:
Mouse   767 NLSGGQKQRVSLARAVYSNSDIYLFDDPLSAVDAHVGKHIFEKVVGPMGLLK--NKTRILVTHGI 829

  Fly   684 HFLSEADVIVIVDQGRILRQGTYQELINSDLDFARLL--------ERPKEEEEGENSRNQTSPLS 740
            .:|.:.|||:::..|:|...|:||||::.|..||..|        :...|::....|..::.|:.
Mouse   830 SYLPQVDVIIVMSGGKISEMGSYQELLDRDGAFAEFLRTYANAEQDLASEDDSVSGSGKESKPVE 894

  Fly   741 VNSLESDDEDIPFIDGVKDGYQQLRKQSSSVHGSKSLDSTQLDDNVDEDDLAEAQ---------- 795
            ...|.:|.        |....|:....|||..|    |::|...::.|...|.|:
Mouse   895 NGMLVTDT--------VGKHLQRHLSNSSSHSG----DTSQQHSSIAELQKAGAKEETWKLMEAD 947

  Fly   796 --ASGGISPRVWYEYFHAGSTLLSFSFMVFVMVMSQVVCSSSDFFANIWTQQEH--QRSQGEATF 856
              .:|.:...|::.|..|....::| ..:|:.:.:.|...:|:::.::||....  ..:|....|
Mouse   948 KAQTGQVQLSVYWNYMKAIGLFITF-LSIFLFLCNHVSALASNYWLSLWTDDPPVVNGTQANRNF 1011

  Fly   857 STFECMYIYGALIIAVVIMTTFRGFLFFKICM-------HASKVLHDRMFACILHATMRFFDTTP 914
            .    :.:||||.|       .:|...|...|       .||:.||..:...:|.:.|.||:.||
Mouse  1012 R----LSVYGALGI-------LQGAAIFGYSMAVSIGGIFASRRLHLDLLYNVLRSPMSFFERTP 1065

  Fly   915 SGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLVVAVVDVLILKLY 979
            ||.::|||||::..:|.::|:.:..|:.....:.|.:|:|.:..|:....:..:.:|...:.:.|
Mouse  1066 SGNLVNRFSKELDTVDSMIPQVIKMFMGSLFSVIGAVIIILLATPIAAVIIPPLGLVYFFVQRFY 1130

  Fly   980 LRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTT 1044
            :..|:.|||||.:.||||:||.:.:|.|:::||:.:.|:....:.||..|.:...:..::..|..
Mouse  1131 VASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRW 1195

  Fly  1045 LGLWLDCV-SCIFLTSVTFSFIISSETTYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVE 1108
            |.:.|:|| :||.|.:..|: :||..:..:|.|||:::.::.:|..:.:.||..:|....:.:||
Mouse  1196 LAVRLECVGNCIVLFAALFA-VISRHSLSAGLVGLSVSYSLQITAYLNWLVRMSSEMETNIVAVE 1259

  Fly  1109 RVLQYTELEQEP--ALGEKTPPQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVG 1171
            |:.:|:|.|:|.  .:.|..||..||..|:||||:...||..:...||:::|:|||.|.||||||
Mouse  1260 RLKEYSETEKEAPWQIQETAPPSTWPHSGRVEFRDYCLRYREDLDLVLKHINVTIEGGEKVGIVG 1324

  Fly  1172 RTGAGKSSLIGALFRL-AHIEGEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFE 1235
            |||||||||...|||: ...||||.|||:....|.|..||.:|:||||||||||.::|.|||||.
Mouse  1325 RTGAGKSSLTLGLFRINESAEGEIIIDGVNIAKIGLHNLRFKITIIPQDPVLFSGSLRMNLDPFS 1389

  Fly  1236 RYTDAELWSALEDVELR---KAIPG-LDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEAT 1296
            :|:|.|:|.|||...|:   .|:|. |::...|.|.|.|||||||:|||||:||..|:|||||||
Mouse  1390 QYSDEEVWMALELAHLKGFVSALPDKLNHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEAT 1454

  Fly  1297 ANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHL 1361
            |.||.:||.|||.|||.:|:.|||||:||||:|:||..|:||:|.|...|...|..||:: :|..
Mouse  1455 AAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEVRECGAPSELLQQ-RGIF 1518

  Fly  1362 RQMVEATG 1369
            ..|.:..|
Mouse  1519 YSMAKDAG 1526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	472/1434 (33%)
		ABC_membrane	214..441	CDD:294371	60/228 (26%)
		ABCC_MRP_domain1	495..699	CDD:213217	96/203 (47%)
		ABC_membrane	863..1088	CDD:294371	69/232 (30%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	126/219 (58%)
Abcc1	NP_032602.1	MRP_assoc_pro	7..1527	CDD:188098	473/1438 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	876..895		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	909..929		6/23 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.730