DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and haf-4

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_001021666.1	Gene:	haf-4 / 171639	WormBaseID:	WBGene00001814	Length:	787	Species:	Caenorhabditis elegans

Alignment Length:	665	Identity:	158/665 - (23%)
Similarity:	278/665 - (41%)	Gaps:	170/665 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   803 RVWYEYFHAGSTLLSFSF-MVFV-----MVMSQVVCSSSDFFANIWTQQEHQRSQGEATFSTFEC 861
            |.|..:....|.|..:|. .:||     .|::.||.:.|
Worm   177 REWLWHISGFSWLFIYSITRIFVPYYTGQVIATVVATKS-------------------------- 215

  Fly   862 MYIYGALIIAVVIMTT----------FRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSG 916
               |.||..||.|||.          |||..|........:.:...:|..::...:.|:|...:|
Worm   216 ---YPALSNAVYIMTIISLVSAVAAGFRGGSFEYAYARIQRAIRYDLFHGLVKQDVAFYDAHKTG 277

  Fly   917 RILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILI-----------VIGILNPVL-VAAMLVVA 969
            .:.:|.:.|...:.:.:...:..|::..:::.|.:|           |..||.|:: ||:.:...
Worm   278 EVTSRLAADCQTMSDTVALNVNVFLRNCVMLLGSMIFMMKLSWRLSLVTFILVPIIFVASKIFGT 342

  Fly   970 VVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFDLLQDVHSSV 1034
            ..|:|                                      |.:.||.:|:..|:.::|.|::
Worm   343 YYDLL--------------------------------------SERTQDTIAESNDVAEEVLSTM 369

  Fly  1035 -----------------WQLTMAVNTTLGLWLDCVSCIFLTSVTFSFIISSETTYSGNVGLAIAQ 1082
                             .:||..::.|....:..:..::::.:..||||.|...|.|:  |.:.|
Worm   370 RTVRSFSCENVEADRFYGKLTHTLDVTRTKAIAYIGFLWVSELFQSFIIVSVLWYGGH--LVLTQ 432

  Fly  1083 AM---ILTGMVQYGVRQVAESLQQMTSV-----------ERVLQYTELEQEPAL---GEKTPPQQ 1130
            .|   :|...:.|.: |:.::|:||..|           .:|.:|  :::||.:   ||..|..
Worm   433 KMKGDLLVSFLLYQM-QLGDNLRQMGEVWTGLMQSVGASRKVFEY--IDREPQIQHNGEYMPEN- 493

  Fly  1131 WPTRGQVEFRNMSCRYDPNGS--PVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGAL--FRLAHIE 1191
              ..|::||||:...| |..|  |:|::|:.|:|.|..|.:||.:|:||||.|..|  |.:.: .
Worm   494 --VVGKIEFRNVHFSY-PTRSDQPILKDLSFTVEPGETVALVGPSGSGKSSCISLLENFYVPN-A 554

  Fly  1192 GEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDVELRKAI- 1255
            |::.:||:.........:..:|:::.|:||||:.::..|:.......|.|:..:.|.......|
Worm   555 GQVLVDGVPLEEFEHHYIHKKIALVGQEPVLFARSVMENVRYGVEVADTEIIRSCEMANAHGFIM 619

  Fly  1256 -PGLDY--MVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQ 1317
             ..|.|  .|.|:|...|.||:|.:.:|||::|...:|:|||||:.:|.:::.|:|..|......
Worm   620 QTTLKYETNVGEKGTQMSGGQKQRIAIARALVREPAILLLDEATSALDTESEHLVQEAIYKNLDG 684

  Fly  1318 CTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEATGGESEALKKTASDS 1382
            .:|:.:||||.||..:|:|:|::.|                     .||..|.....||.|....
Worm   685 KSVILIAHRLSTVEKADKIVVINKG---------------------RVEQIGNHETLLKDTNGTY 728

  Fly  1383 HKRMQRER--DERDR 1395
            .|.:||:.  |::.|
Worm   729 AKLVQRQMMGDQKPR 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	148/633 (23%)
		ABC_membrane	214..441	CDD:294371
		ABCC_MRP_domain1	495..699	CDD:213217
		ABC_membrane	863..1088	CDD:294371	50/266 (19%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	73/222 (33%)
haf-4	NP_001021666.1	3a01208	16..732	CDD:273363	154/652 (24%)
		ABC_membrane	189..449	CDD:279056	59/329 (18%)
		ABC_MTABC3_MDL1_MDL2	498..735	CDD:213216	80/259 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910