DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5789 and Abcc4

DIOPT Version :9

Sequence 1:NP_001247286.1 Gene:CG5789 / 42928 FlyBaseID:FBgn0039207 Length:1402 Species:Drosophila melanogaster
Sequence 2:XP_038948894.1 Gene:Abcc4 / 170924 RGDID:620266 Length:1382 Species:Rattus norvegicus


Alignment Length:1464 Identity:560/1464 - (38%)
Similarity:823/1464 - (56%) Gaps:199/1464 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 SSAKPTRKNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKE 67
            :..||   ||.|.||:.|:|.|.|..||...|.:|.|..||:...|.||||:.||:.|:..|.||
  Rat     6 TEVKP---NPLQDANLCSRLFFWWLNPLFKAGHKRRLEEDDMFSVLPEDRSKHLGEELQGYWDKE 67

  Fly    68 LERSHRKKQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNID 132
            :.|:.:..:||.|..|:.:|:....:|.|:...|....:.:.|..|.:::..|:|        .|
  Rat    68 VLRAKKDARKPSLTKAIVKCYWKSYLILGIFTLIEETTRVVQPIFLGKIIDYFEK--------YD 124

  Fly   133 VNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNATAV 197
            .:|                   |.|:..:.|                                  
  Rat   125 SDD-------------------SAALHTAYG---------------------------------- 136

  Fly   198 RSILDQTVEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRLMGARMRIACCSLIYRKTLRLSMK 262
                             ..|||.|.||....|.|......:..|.|:|:|.|.:||||.||||..
  Rat   137 -----------------YAAVLSLCTLILAILHHLYFYHVQCAGMRIRVAMCHMIYRKALRLSNS 184

  Fly   263 TAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTV 327
            ..|:|..|.::||||||||:.|...||:|::|..||||:....|:|:.|||..:.| :.:|:..:
  Rat   185 AMGKTTTGQIVNLLSNDVNKFDQVTIFLHFLWAGPLQAIGVTILLWVEIGISCLAG-LAILVILL 248

  Fly   328 PVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIRYA 392
            |:|:.:.|:.|.||.:.|..||||:..|||::.|:::||||||||.|..::...|:.||.:|..:
  Rat   249 PLQSCIGKLFSSLRSKTAAFTDARIRTMNEVITGMRIIKMYAWEKSFADLITNLRKKEISKILGS 313

  Fly   393 SYLRGFYLSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNILQLVAAIWYPLAVSFGAE 457
            |||||..:::.....:..|::|.....|:|..|||..||.|.:.|..::|...:::|.|:...:|
  Rat   314 SYLRGMNMASFFIANKVILFVTFTTYVLLGNKITASHVFVAMTLYGAVRLTVTLFFPSAIERVSE 378

  Fly   458 ALVSLRRIQDFLMLEGREERTQGLTHKRDQEGGDSRAVT-IKDINASWDIEKPQKTLQSINLQIE 521
            |:||:|||::||:|:...||       :.||..|.:|:. ::|..|.||......|||.::....
  Rat   379 AVVSVRRIKNFLLLDELPER-------KAQEPSDGKAIVHVQDFTAFWDKALDTPTLQGLSFTAR 436

  Fly   522 KGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGDLSYAAQEPWLFTGSVRNNILFGEEFDR 586
            .|:|.||:|||||||||:|..:|||||...|.|.:.|.::|.:|:||:|:|:||:|||||.::::
  Rat   437 PGELLAVVGPVGAGKSSLLSAVLGELPPTSGLVSVHGRIAYVSQQPWVFSGTVRSNILFGRKYEK 501

  Fly   587 KRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQIYLMDDPLSAVD 651
            :||::|.:.|||..|.|.|.:||.|::|:|||:|||||:||::||||||:.|.|||:||||||||
  Rat   502 ERYEKVIKACALKKDLQLLEDGDLTVIGDRGATLSGGQKARVNLARAVYQDADIYLLDDPLSAVD 566

  Fly   652 AHVGRHLFDEVIGPRGRLAQLKATRILVTHQVHFLSEADVIVIVDQGRILRQGTYQELINSDLDF 716
            |.||:|||...|   .:....|.| ||||||:.:|..|..|:|:..|.::::|||.|.:.|.:||
  Rat   567 AEVGKHLFQLCI---CQTLHEKIT-ILVTHQLQYLKAASHILILKDGEMVQKGTYTEFLKSGVDF 627

  Fly   717 ARLLERPKEEEEGENS--------RNQT-SPLSVNSLESDDEDIPFIDGVKDGYQQLRKQSSSVH 772
            ..||:  ||.||.|.|        ||:| |..|:.|.:|....:.  |||.|             
  Rat   628 GSLLK--KENEEAEPSPVPGTPTLRNRTFSEASIWSQQSSRPSLK--DGVPD------------- 675

  Fly   773 GSKSLDSTQLDDNVDEDDLAEAQASGGISPRVWYEYFHAGSTLLSFSFMVFVMVMSQVVCSSSDF 837
                   .|..:|.......|:::.|.|..:.:..||.||::.....|:|.:.:|.||.....|:
  Rat   676 -------AQDAENTQAAQPEESRSEGRIGFKAYKNYFSAGASWFFIIFLVLLNLMGQVFYVLQDW 733

  Fly   838 FANIWTQQ-----EHQRSQGEATFSTFECMY---IYGALIIAVVIMTTFRGFLFFKICMHASKVL 894
            :.:.|..:     :.:.:.|..| .|.:..:   ||..|....|:....|..|.|.:.::||:.|
  Rat   734 WLSHWANRQGALNDTKNANGNVT-GTLDLSWYLGIYTGLTAVTVLFGIARSLLVFYVLVNASQTL 797

  Fly   895 HDRMFACILHATMRFFDTTP--------------------------------------------- 914
            |:|||..||.|.:.|||..|                                             
  Rat   798 HNRMFESILKAPVLFFDRNPIELTQLEVFRVVDGALDSHRHLSHPHPWPQNGSLQASVTSVTGSD 862

  Fly   915 ------------SGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLV 967
                        .||||||||||:|.:|:|||...:||||..|::..::.|...:.|.::..::.
  Rat   863 VIRFPEVLLLALPGRILNRFSKDIGHMDDLLPLTFLDFIQTLLLVVSVIAVAAAVIPWILIPLVP 927

  Fly   968 VAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFDLLQDVHS 1032
            ::::.|::.:.:|..|:|:||||...|||||||||:||.||..||:.:.::...:.||..||:||
  Rat   928 LSIIFVVLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHS 992

  Fly  1033 SVWQLTMAVNTTLGLWLDCVSCIFLTSVTFSFIISSETTYSGNVGLAIAQAMILTGMVQYGVRQV 1097
            ..|.|.:..:....:.||.:..:|:..|.|..::.::|..:|.||||::.::.|.||.|:.|||.
  Rat   993 EAWFLFLTTSRWFAVRLDAICAVFVIVVAFGSLVLAKTLDAGQVGLALSYSLTLMGMFQWSVRQS 1057

  Fly  1098 AESLQQMTSVERVLQYTELEQE-PALGEKTPPQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTI 1161
            ||....|.|||||::||:||:| |....|.||..||..|.:.|.|::..|..:|..||::|...|
  Rat  1058 AEVENMMISVERVIEYTDLEKEAPWECRKRPPPGWPHEGVIVFDNVNFTYSLDGPLVLKHLTALI 1122

  Fly  1162 EAGWKVGIVGRTGAGKSSLIGALFRLAHIEGEIFIDGIETGTISLEILRTRISIIPQDPVLFSAT 1226
            ::..||||||||||||||||.|||||:..||:|:||.|.|..|.|..||.::|||||:||||:.|
  Rat  1123 KSREKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGT 1187

  Fly  1227 IRYNLDPFERYTDAELWSALEDVELRKAI---PG-LDYMVTERGGNFSVGQRQLLCLARAILRNN 1287
            :|.|||||..::|.|||.|||:|:|::||   || :|..:.|.|.|||||||||:|||||||:.|
  Rat  1188 MRKNLDPFNEHSDEELWKALEEVQLKEAIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILKKN 1252

  Fly  1288 KVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYL 1352
            ::|::|||||||||:||.|||:.||.||.||||||:||||:|::|||:|:|:|:|...|:|.||:
  Rat  1253 RILIIDEATANVDPRTDELIQQKIREKFAQCTVLTIAHRLNTIIDSDKIMVLDSGRLREYDEPYV 1317

  Fly  1353 LLKKSQGHLRQMVEATG-GESEALKKTASDSHKR 1385
            ||:..:....:||:..| ||:.||.:||...:.|
  Rat  1318 LLQNPESLFYKMVQQLGKGEAAALTETAKQVYFR 1351

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5789NP_001247286.1 CFTR_protein 9..1367 CDD:273530 550/1437 (38%)
ABC_membrane 214..441 CDD:294371 92/226 (41%)
ABCC_MRP_domain1 495..699 CDD:213217 102/204 (50%)
ABC_membrane 863..1088 CDD:294371 86/284 (30%)
ABCC_MRP_domain2 1135..1350 CDD:213211 129/218 (59%)
Abcc4XP_038948894.1 MRP_assoc_pro 6..1334 CDD:188098 552/1445 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 98 1.000 Domainoid score I6989
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 1 1.000 - - FOG0001028
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 1 1.100 - - O PTHR24223
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X771
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
109.830

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