DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cftr and LOC1281393

DIOPT Version :10

Sequence 1:NP_651269.1 Gene:Cftr / 42928 FlyBaseID:FBgn0039207 Length:1402 Species:Drosophila melanogaster
Sequence 2:XP_061496997.1 Gene:LOC1281393 / 1281393 VectorBaseID:AGAMI1_011022 Length:1371 Species:Anopheles gambiae


Alignment Length:1479 Identity:630/1479 - (42%)
Similarity:867/1479 - (58%) Gaps:220/1479 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 TRK---NPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELE 69
            |||   ||||:|:|:|.|.|.|.|.|..:|..:.|...||.:.|..|||:.||||||.:||::..
Mosquito     5 TRKLPPNPRQNASILSALTFWWTIDLFRKGYSKVLELQDLFRPLDVDRSDVLGDRLEKKWFEQQA 69

  Fly    70 RSHRKKQKPHLRNALFRCF------LG-PTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQ 127
            ...|    |.|..|:|:.|      || .||||.      |||:...|..|..||:.|:|     
Mosquito    70 GPGR----PSLVKAIFKTFWREYGVLGFITIIND------IVIRLAQPIFLGWLLMYFRK----- 119

  Fly   128 LRNIDVNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDH 192
                                                                           |.
Mosquito   120 ---------------------------------------------------------------DT 121

  Fly   193 NATAVRSILDQTVEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRLMGA-----RMRIACCSLI 252
            ..|...:.|            ..||:::|:.|..      :.:.|.::|:     ::|||.||:|
Mosquito   122 EVTRESAFL------------YAGAIVLLNALSV------ITINQYVLGSFQNGMKVRIAVCSVI 168

  Fly   253 YRKTLRLSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIV 317
            |||.||||....|.|..|.::|||||||||.|...:|:|.:|..||.|::...|::|.||:..::
Mosquito   169 YRKALRLSRTALGDTAPGKVVNLLSNDVNRFDIVSVFLHSMWSAPLLAIIIGVLLYLEIGVAGLI 233

  Fly   318 GVVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEAR 382
            |::.:.:.| |:|:...|:||..|::.|.|||.|:.:|:|::.|||||||||||:||..::..||
Mosquito   234 GMIVIFIVT-PIQSYTGKLTSRFRLQTALRTDERIRLMDEIISGIQVIKMYAWERPFAKLIRHAR 297

  Fly   383 RSEIKQIRYASYLRGFYLSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNILQLVAAIW 447
            :.|:|.:|.::|:||.|::.::||.|:.|:.|:.|.||:|..:||..||..|:|::||....:..
Mosquito   298 QMELKIVRKSAYVRGLYMTFLLFTTRTALFCTMMAMALLGDELTAARVFVVATYFHILANTMSAM 362

  Fly   448 YPLAVSFGAEALVSLRRIQDFLMLEGREERTQGLTHKRDQ------EGGDSR------------- 493
            :...::..|||:|::||::.||..|.||  |:.|...:.:      ..||:.             
Mosquito   363 FVRGIAEIAEAMVAMRRLERFLEFEERE--TEALPDGKSRLLAEFGLNGDATEKQRLIESETQLP 425

  Fly   494 ---AVTIKDINASWDI-----------------------------EKPQKTLQSINLQIEKGQLC 526
               ||::|.:.|.|..                             |.|..||.::|:...||.|.
Mosquito   426 PTIAVSLKGVTARWGAVRRQEDFPRKAGAKQANGKLQQDGQGAPDELPPVTLSNLNIDFRKGLLI 490

  Fly   527 AVIGPVGAGKSSILQLLLGELPVIDGGVFIQGDLSYAAQEPWLFTGSVRNNILFGEEFDRKRYQE 591
            .||||||:||||:||.:|.|||:..|.|..||..:|.:||||:|:|:||.|||||:..:::||:.
Mosquito   491 GVIGPVGSGKSSLLQAILRELPLESGSVVAQGRFAYVSQEPWVFSGTVRQNILFGQPMEKERYEA 555

  Fly   592 VTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQIYLMDDPLSAVDAHVGR 656
            |.|.|||.|||:|||:||:|::|||||:|||||:||||||||||:.|.:||:|||||||||||||
Mosquito   556 VVRACALVTDFEQLPDGDRTMIGERGAALSGGQKARISLARAVYRRADVYLLDDPLSAVDAHVGR 620

  Fly   657 HLFDEVIGPRGRLAQLKATRILVTHQVHFLSEADVIVIVDQGRILRQGTYQELINSDLDFARLLE 721
            ||||..:||:|||..|:|||||||||||||.|||.:|::::||:..|||..:|:.|.:||..|:|
Mosquito   621 HLFDLCLGPQGRLGTLRATRILVTHQVHFLKEADWVVVLNEGRVQAQGTPHDLVQSGIDFVELVE 685

  Fly   722 RPKEEEEGENSRNQTSPLSVNSLESDDEDIPFIDGVKDGYQQLRKQSSSVHGSKSLDSTQLDDNV 786
            |  :|.||.............|:...|.     ...:|.....|...||||...|        :.
Mosquito   686 R--KEVEGSELEGGGGGDGDGSVGGGDR-----RSRRDSRASARSGGSSVHADVS--------DE 735

  Fly   787 DEDDLA---------EAQASGGISPRVWYEYFHAGSTLLSFSFMVFVMVMSQVVCSSSDFFANIW 842
            :|.|||         |..:.|.:...:...|..:|:..|....::.:.:.:|:..|.:|::...|
Mosquito   736 EERDLAADAPVQSNMEGTSRGKVQGSLLLSYLGSGANGLIMCGLLALFLATQLAASGADYWVAFW 800

  Fly   843 TQQEHQR--------SQG-EAT-------FSTFECMYIYGALIIAVVIMTTFRGFLFFKICMHAS 891
            |.||.||        |.| ||.       .||..||.|:|||:.::.::...|...|::..:.||
Mosquito   801 TSQEEQRLFRAAHNLSAGPEAATDELPPLLSTETCMAIHGALVGSIFLIAITRSISFYQTSVRAS 865

  Fly   892 KVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVIGI 956
            :.|||.|||..:..||||:||.||||||||||||||::|||||:||:|..||.|.:.|.|:|..:
Mosquito   866 QNLHDAMFAGCVSTTMRFYDTNPSGRILNRFSKDMGSVDELLPKAMLDASQIILSLCGTLVVTVL 930

  Fly   957 LNPVLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVA 1021
            :||:.:..:.::.||...:.::||:.|:::||||||.||||||||||||.||..||:...|..:.
Mosquito   931 VNPLFLVPLALLGVVFWFVRRIYLKTSKNIKRLEGITRSPVFSHLSASLAGLPTIRAFGAQGELI 995

  Fly  1022 KEFDLLQDVHSSVWQLTMAVNTTLGLWLDCVSCIFLTSVTFSFIISSETTYSGNVGLAIAQAMIL 1086
            :|||..||:|::.:.:.:..:|..|..||.:..||:..|.|||::..:.|:...|||||.|||.|
Mosquito   996 REFDAHQDIHTASFYMFITASTAFGFALDLLCLIFVFIVVFSFLLVEQDTFGDRVGLAITQAMAL 1060

  Fly  1087 TGMVQYGVRQVAESLQQMTSVERVLQYTEL--EQEP----ALGEKTPPQQWPTRGQVEFRNMSCR 1145
            |||:|:|:||.||....|.||||:|:|.:|  |::|    ||.     ..||..|::|||:::.|
Mosquito  1061 TGMMQWGIRQSAEVANFMMSVERLLEYRDLAPERQPERPRALN-----AGWPAEGRIEFRSVTYR 1120

  Fly  1146 YDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAHIEGEIFIDGIETGTISLEILR 1210
            |......|||:|:..|....|||||||||||||||||||||||.:||||.:|||:|..|:||.||
Mosquito  1121 YFEGAQAVLRDLSFEIRPREKVGIVGRTGAGKSSLIGALFRLAQVEGEIRLDGIDTADITLEQLR 1185

  Fly  1211 TRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDVELRKAI---PGLDYMVTERGGNFSVG 1272
            :::|||||||||||.|:|.||||||.|.|||||.|||.|||::..   .||...|...|.|||||
Mosquito  1186 SKVSIIPQDPVLFSGTLRRNLDPFEDYPDAELWGALEQVELKELANTPAGLQMAVAAGGSNFSVG 1250

  Fly  1273 QRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRII 1337
            ||||:||||||||||::||||||||||||.||.|||.|||.||..|||||:||||:|:|||||::
Mosquito  1251 QRQLICLARAILRNNRILVLDEATANVDPNTDRLIQETIRHKFADCTVLTIAHRLNTIMDSDRVL 1315

  Fly  1338 VMDAGVAVEFDVPYLLLKKSQGHLRQMVEATG-GESEALKKTASDSHKR 1385
            |||||.|||...|:.||:......|.||.||| .|||.|::.|...|::
Mosquito  1316 VMDAGQAVELGTPHELLQLPISIFRDMVLATGPAESERLQQIALHKHEQ 1364

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CftrNP_651269.1 MRP_assoc_pro 12..1356 CDD:188098 614/1440 (43%)
LOC1281393XP_061496997.1 None

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