DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cftr and MRP

DIOPT Version :10

Sequence 1:NP_651269.1 Gene:Cftr / 42928 FlyBaseID:FBgn0039207 Length:1402 Species:Drosophila melanogaster
Sequence 2:XP_061509603.1 Gene:MRP / 1279254 VectorBaseID:AGAMI1_005212 Length:1521 Species:Anopheles gambiae


Alignment Length:1432 Identity:487/1432 - (34%)
Similarity:740/1432 - (51%) Gaps:175/1432 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 KPTRKN---------PRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLE 61
            ||.|::         |...|:..|::.|||...|.:.|.|:.|..|||.:...||.|:::.....
Mosquito   192 KPPRQSKYEITDKDCPELAASFPSRIFFAWFDRLAWVGFRKPLEVDDLWKMKPEDSSKEVSPAFL 256

  Fly    62 DQWFKELERSHRKKQKPH------LRNALFRCFLGPTIINGLICFIYIVIKT-----LIPAV--L 113
            ..|.:.||::::.::..:      |.|:. |.....|....:...:..:|||     |:.:.  |
Mosquito   257 HHWNETLEKTYQSRETSNDVTFKKLGNSA-RVDFRTTKAKNIASILPALIKTFGGTFLLGSFLKL 320

  Fly   114 AQLLIQFQKTPVAQLRNIDVNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAG 178
            .|.|:.|....:.:|                    |..:|                        |
Mosquito   321 GQDLLTFASPQILKL--------------------IIGFV------------------------G 341

  Fly   179 PLEPIQPPVEEVDHNATAVRSILDQTVEHMWNDMNSLGAVLVLSTLFC-----CFLLHHVDLRQR 238
            ..||                         ||.      .::...|||.     ..||.....|..
Mosquito   342 GEEP-------------------------MWK------GLMYAITLFVVAGTQTLLLGQYFNRMF 375

  Fly   239 LMGARMRIACCSLIYRKTLRLSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLT 303
            .:|.|:|.|..|.||||.|.:|......:..|.::||::.|..|......:::.||..|||..|.
Mosquito   376 FVGLRIRTALISAIYRKALIISNSARKGSTVGEIVNLMAVDAQRFMDLTTYINMIWSAPLQIGLA 440

  Fly   304 CYLIWLNIGIPAIVGVVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMY 368
            .|.:|..:| |:::..:.:::..:||...::.:...|:::..:..|.||.:|||::.||:|:|:|
Mosquito   441 LYFLWQILG-PSVLAGLAVMIILIPVNGVIANMIKTLQIKQMKNKDERVKLMNEVLSGIKVLKLY 504

  Fly   369 AWEKPFQAVVAEARRSEIKQIRYASYLR---GFYLSTMVFTERSTLYITLAAAALMGQ--TITAD 428
            |||..|:..:.:.|..|:|.::.|:||.   .|..|...|.   ...:|.|...|:.:  .:.|.
Mosquito   505 AWEPSFEQQILKIRDKEVKVLKSAAYLNAGTSFIWSCAPFL---VSLVTFATYVLVDENNVLDAS 566

  Fly   429 FVFSAASYYNILQLVAAIWYPLAVSFGAEALVSLRRIQDFLMLEGREERTQGLTHKRDQEGGDSR 493
            ..|.:.|.:|||:...:: .|:.:|...:..||:.||..||..|  |.....:.|  |::  :|.
Mosquito   567 TAFVSLSLFNILRFPLSM-LPMLISNMVQTSVSVNRINTFLNQE--ELDPDNVQH--DEK--ESS 624

  Fly   494 AVTIKDINASWDIEKPQKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQG 558
            .:.|::...||..|  :.||::||:::||.|:.||:|.||:||||:|...|||:..|.|.|...|
Mosquito   625 PLLIENGVFSWGGE--ETTLKNINVRVEKNQIVAVVGTVGSGKSSLLSAFLGEMDKISGRVNTLG 687

  Fly   559 DLSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGG 623
            .::|.:|:.|:...::::|||||:..|::||..|...|||..|.:.||.||.|.:||:|.:||||
Mosquito   688 RIAYVSQQAWIQNATLKDNILFGKPMDQRRYARVIEACALKPDIEMLPGGDMTEIGEKGINLSGG 752

  Fly   624 QRARISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRILVTHQVHFLSE 688
            |:.|:|||||||..|.:|.:||||||||:|||:|:|::||||.|.||  |.||:||||.:.:|..
Mosquito   753 QKQRVSLARAVYNDADVYFLDDPLSAVDSHVGKHIFEQVIGPSGLLA--KKTRVLVTHGITYLPN 815

  Fly   689 ADVIVIVDQGRILRQGTYQELINSDLDFARL----LERPKEEEE--------------GENSRNQ 735
            .|.|.::.:|.|...||||||::....||..    |:...||||              ||...||
Mosquito   816 TDKIFVLREGEISESGTYQELMDKKGAFAEFLIQHLQEVSEEEEDLDEIKQQLENSVGGEELLNQ 880

  Fly   736 TSPLSVNSLESDDEDIPFIDGVKDGYQQLRKQSSSVHGSKSL--DSTQLDDNVDEDDLAEAQAS- 797
            ..  ..||..|..|.......|||    :.:|:|:...:.||  .:::....|.:..|.|.:.| 
Mosquito   881 LK--RSNSKRSRSESTSETGSVKD----ISRQNSTTDSNTSLRRRTSEKAPEVAKTKLIETEKSE 939

  Fly   798 -GGISPRVWYEYFHAGSTLLSFSFMVFVMVMSQVVCSSSDFFANIWTQQEHQRSQGEATFSTFEC 861
             |.:...|:..|..:....||.:.::..|:. |.....|:.:.:.|:..:   :.|..|......
Mosquito   940 TGSVKWEVYKHYLKSIGLTLSVATVILNMIF-QGFSIGSNLWLSRWSTDD---TAGNDTSRRDMY 1000

  Fly   862 MYIYGALIIAVVIMTTFRGFLFFKI-CMHASKVLHDRMFACILHATM-RFFDTTPSGRILNRFSK 924
            :.:||| ..|..:::||...||..| .:.||:.||..:...:|||.: .|||.||.||:||||||
Mosquito  1001 LGVYGA-FGAGQVLSTFLSTLFLYIGALEASRTLHKTLLRRVLHAPLTSFFDITPVGRVLNRFSK 1064

  Fly   925 DMGAIDELLPRAMMDFIQIALVMFGI---LIVIGILNPVLVAAMLVVAVVDVLILKLYLRPSQDL 986
            |:...|..||..:..:   :...||:   |:||.|..|:..|.::.:.::...:.:.|:..|:.|
Mosquito  1065 DIDTTDSDLPATLRAW---SACFFGVVATLVVISISTPIFAAVIVPIGILYYAVQRFYVATSRQL 1126

  Fly   987 KRLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDC 1051
            ||||.:.|||::||...::.|:..||:..:||....|.|...|.:...:..::..|..|.:.|:.
Mosquito  1127 KRLESVSRSPIYSHFGETIQGVQTIRAYSVQDRFILESDEKVDGNQLCYCPSIIANRWLAVRLEM 1191

  Fly  1052 VSCIFLTSVTFSFIISSETTYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTEL 1116
            |..:.:.......::..||..:|.|||:::.|:.:|..:.:.||..::....:.:|||:.:|.|.
Mosquito  1192 VGNLIILFAALFAVLGRETMNAGLVGLSVSYALQITQTLNWLVRMTSDVETNIVAVERIKEYGET 1256

  Fly  1117 EQEPA--LGEKTPPQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSS 1179
            :||.|  |...|.|:.||.:|.||||:...||......|||.::.|:..|.||||||||||||||
Mosquito  1257 KQEAAWELPNSTLPRDWPEQGMVEFRDFQVRYREGLELVLRGISFTVNGGEKVGIVGRTGAGKSS 1321

  Fly  1180 LIGALFRLAHIE---GEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAE 1241
            |..||||:  ||   |.|.|||.:...:.|..||:|::||||||||||.|:|.|||||...:|.:
Mosquito  1322 LTLALFRI--IESAGGSIVIDGQDISQLGLHALRSRLTIIPQDPVLFSGTLRINLDPFNAQSDDD 1384

  Fly  1242 LWSALEDVELRKAIPGL----DYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQ 1302
            :|.|||...|:..:.||    ::.|||.|.|.|||||||:|||||:||..|||:||||||.||.:
Mosquito  1385 IWKALEHAHLKTFVKGLTAGINHEVTEGGENLSVGQRQLICLARALLRKTKVLILDEATAAVDLE 1449

  Fly  1303 TDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEA 1367
            ||.|||||||.:||.|||||:||||:|:||||::||:|.|..|||..|..||:........|.:.
Mosquito  1450 TDDLIQRTIRTEFKDCTVLTIAHRLNTIMDSDKVIVLDKGQIVEFAPPAELLQSKNSAFYSMAKD 1514

  Fly  1368 TG 1369
            .|
Mosquito  1515 AG 1516

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CftrNP_651269.1 MRP_assoc_pro 12..1356 CDD:188098 482/1402 (34%)
MRPXP_061509603.1 None

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