Protein Alignment CG5789 and Abcc2

DIOPT Version :9

• Sequence 1: NP_001247286.1
• Gene: CG5789 / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Sequence 2: NP_038834.2
• Gene: Abcc2 / 12780
• MGIID: 1352447
• Length: 1543
• Species: Mus musculus
• Alignment Length: 1454
• Identity: 462/1454 - (31%)
• Similarity: 754/1454 - (51%)
• Gaps: 184/1454 - (12%)

  Fly     3 SSAKPTRKNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKE 67
            |.:..:...|...|:.:|.:.|:|....:.:|.:..|..:|:....:..:::.|..:.:....|:
Mouse   184 SESSDSTHAPSATASFLSSVTFSWYDSTVLKGYKHPLTIEDVWDIEENLKAKSLTSKFKTIMTKD 248

  Fly    68 LERSHRKKQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNID 132
            |:::         |.||.|                             .|.:.|::|......:.
Mouse   249 LQKA---------RQALQR-----------------------------RLKKSQQSPEGTSHGLT 275

  Fly   133 VNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKS-----LDKAGPLEPIQPPVEEVDH 192
            .......|.|          ||..:......|.....||||     |.|...:..::..:.::.|
Mouse   276 KKQSQSQDVL----------VLEDSKKKKKKSEATKDFPKSWLVKALFKTFYVVILKSFILKLAH 330

  Fly   193 ------NATAVRSILDQTVE---HMWNDMNSLGAVLVLST-------LFC----CFLLHHVDLRQ 237
                  |...::.::....:   :.|  :..:.|:|:.|.       |.|    ||:|
Mouse   331 DILLFLNPQLLKFLIGFVKDPDSYPW--VGYIYAILMFSVTLIQSFFLQCYFQFCFVL------- 386

  Fly   238 RLMGARMRIACCSLIYRKTLRLSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAML 302
               |..:|....:.:|:|.|.||.....|...|..:||:|.|..:|.....::|.:|...||..|
Mouse   387 ---GMTVRTTIIASVYKKALTLSNLARRQYTIGETVNLMSVDSQKLMDVTNYIHLLWSSVLQIAL 448

  Fly   303 TCYLIWLNIGIPAIVGVVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKM 367
            :.:.:|..:| |:|:..|||::..|||...|:.....::::..:..|.|:.||||::.||:::|.
Mouse   449 SIFFLWRELG-PSILAGVGLMVLLVPVNGVLATKIRKIQVQNMKNKDKRLKIMNEILSGIKILKY 512

  Fly   368 YAWEKPFQAVVAEARRSEIKQIRYASYLRGFYLSTMVFTERSTLYITLAAAALMG--QTITADFV 430
            :|||..|:..|...|:.|::.:...|.|:...:..:..|......||.:...|:.  ..:.|:..
Mouse   513 FAWEPSFKEQVNSIRKKELRNLLRFSQLQTILIFILHLTPTLVSVITFSVYVLVDSQNVLNAEKA 577

  Fly   431 FSAASYYNILQLVAAIWYPLAVSFGAEALVSLRRIQDFLMLEGREERTQGLTHKRDQEGGD---- 491
            |::.:.:|||:...|: .|:.:|...:|.||:.|::.:|                   |.|
Mouse   578 FTSITLFNILRFPLAM-LPMVISSVIQASVSVDRLEQYL-------------------GSDDLDL 622

  Fly   492 ---------SRAVTIKDINASWDIEKPQKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGEL 547
                     .:||...:.:.:||.:. :.|:|.:||.|:.|||.||:|.||:||||::..:|||:
Mouse   623 SAIRHVCHFDKAVQFSEASFTWDRDL-EATIQDVNLDIKPGQLVAVVGTVGSGKSSLISAMLGEM 686

  Fly   548 PVIDGGVFIQGDLSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTL 612
            ..:.|.:.|:|.::|..|:.|:..|::::|||||.|:|.|:||.|...|||..|.:.||.||...
Mouse   687 ENVHGHITIKGSIAYVPQQAWIQNGTIKDNILFGSEYDEKKYQRVIEACALLPDLEMLPGGDMAE 751

  Fly   613 VGERGASLSGGQRARISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRI 677
            :||:|.:|||||:.|:|||||.|:.|.||::||||||||.|||:|:|::|:||.|.|:  ..|||
Mouse   752 IGEKGINLSGGQKHRVSLARATYQDADIYILDDPLSAVDTHVGKHIFNKVVGPNGLLS--GKTRI 814

  Fly   678 LVTHQVHFLSEADVIVIVDQGRILRQGTYQELINSDLDFARLLERPKEEE--EGENSRNQTSPLS 740
            ||||.:|||.:.|.||::.:|.||.:|:|.:|::....||:..:...:..  |||.:.:
Mouse   815 LVTHGIHFLPQVDEIVVLGKGTILEKGSYSDLMDKKGVFAKNWKTFMKHSGPEGEATVD------ 873

  Fly   741 VNSLESDDED---IPFIDGVKDGYQQL---RKQS-------SSVHGS---KSLDSTQLDDNVD-- 787
             |..|.:|.|   ||.::.:.|....|   |:.|       ||..||   |||.|:....:|:
Mouse   874 -NDSEEEDGDCGLIPTVEEIPDDAASLTMRRENSLRRTLSRSSRSGSRRGKSLKSSLKIKSVNAL 937

  Fly   788 --EDDLAEAQ--------ASGGISPRVWYEYFHAGSTLLSFSFMVFVMVMSQVVCSSSDFFANIW 842
              ::::.:.|        .:|.:...::.:|..|.. ..|..|:|...|::.|....::.:.:.|
Mouse   938 NKKEEVVKGQKLIKKEFVETGKVKFSIYLKYLQAVG-WWSLLFIVIFYVLNYVAFIGTNLWLSAW 1001

  Fly   843 TQQEHQRSQGEATFSTFEC-MYIYGALIIAVVIMTTFRGFLFFKICMHASKVLHDRMFACILHAT 906
            |....:::..:.:.|..:. :.::|||.||..|............|.:|||.||.::...||.|.
Mouse  1002 TSDSEKQNGTDNSPSQRDMRIGVFGALGIAQGIFLLSSSLWSIYACRNASKTLHRQLLTNILRAP 1066

  Fly   907 MRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGI---LIVIGILNPVLVAAMLVV 968
            |.||||||:|||:|||:.|:..:|:.||:.:..::   |..|||   |::|.:..|:.:..::.:
Mouse  1067 MSFFDTTPTGRIVNRFAGDISTVDDTLPQTLRSWL---LCFFGIVSTLVMICMATPIFIIIIIPL 1128

  Fly   969 AVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQDVV----AKEFDLLQD 1029
            :::.|.:...|:..|:.|:||:.:.:||::||.|.:::||.:||:.:.|...    .|:.|..|.
Mouse  1129 SILYVSVQVFYVATSRQLRRLDSVTKSPIYSHFSETVSGLPVIRAFEHQQRFLANSEKQIDTNQK 1193

  Fly  1030 VHSSVWQLTMAVNTTLGLWLDCVSCIFLTSVTFSFIISSETTYSGNVGLAIAQAMILTGMVQYGV 1094
            ...| |   :..|..|.:.|:.|..:.:.......:|...:.....||..::.|:.:|..:.:.|
Mouse  1194 CVFS-W---ITSNRWLAIRLELVGNLIVFCSALLLVIYKNSLTGDTVGFVLSNALNITQTLNWLV 1254

  Fly  1095 RQVAESLQQMTSVERVLQYTELEQE-PALGEKTPPQQWPTRGQVEFRNMSCRYDPNGSPVLRNLN 1158
            |..:|....:.:|||:.:|..::.| |.:.:|.||..||.:|:::|.|...||.|....||:.:.
Mouse  1255 RMTSEVETNIVAVERINEYINVDNEAPWVTDKKPPADWPKKGEIQFNNYQVRYRPELDLVLKGIT 1319

  Fly  1159 LTIEAGWKVGIVGRTGAGKSSLIGALFR-LAHIEGEIFIDGIETGTISLEILRTRISIIPQDPVL 1222
            ..|::..|||:|||||||||||...||| |....|:|.||||:..:|.|..||.|::||||||:|
Mouse  1320 CNIKSTEKVGVVGRTGAGKSSLTNCLFRILESAGGQIIIDGIDIASIGLHDLRGRLTIIPQDPIL 1384

  Fly  1223 FSATIRYNLDPFERYTDAELWSALEDVELRKAIPGLD----YMVTERGGNFSVGQRQLLCLARAI 1283
            ||..:|.|||||.:|:|.|:|.|||...|:..:.||.    :.|||.|.|.|:||||||||.||:
Mouse  1385 FSGNLRMNLDPFNKYSDEEIWRALELAHLKSFVAGLQLGLLHEVTEGGDNLSIGQRQLLCLGRAV 1449

  Fly  1284 LRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFD 1348
            ||.:|:||||||||.||.:||:|||.|||.:|.||||:|:||||||:||||:|:|:|:|..||:.
Mouse  1450 LRKSKILVLDEATAAVDLETDSLIQTTIRNEFSQCTVITIAHRLHTIMDSDKIMVLDSGKIVEYG 1514

  Fly  1349 VPYLLLKKSQGHLRQMVEATGGES 1372
            .|..|| .:.|....|.:..|.||
Mouse  1515 SPEELL-SNMGPFYLMAKEAGIES 1537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	458/1441 (32%)
		ABC_membrane	214..441	CDD:294371	64/239 (27%)
		ABCC_MRP_domain1	495..699	CDD:213217	98/203 (48%)
		ABC_membrane	863..1088	CDD:294371	68/231 (29%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	122/219 (56%)
Abcc2	NP_038834.2	MRP_assoc_pro	10..1535	CDD:188098	459/1450 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	260..285		4/24 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	903..927		9/23 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.830