DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and ABCC2

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_000383.2	Gene:	ABCC2 / 1244	HGNCID:	53	Length:	1545	Species:	Homo sapiens

Alignment Length:	1419	Identity:	456/1419 - (32%)
Similarity:	756/1419 - (53%)	Gaps:	146/1419 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SSAKPTRKNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKE 67
            |....:..||...|:.:|.:.::|...::.:|.:|.|..:|:.:..:|.:::.|..:.|....:|
Human   185 SENNESSNNPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLVSKFETHMKRE 249

  Fly    68 LERSHRKKQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNID 132
            |:::.|..|:...:::                                     |:...|:|..::
Human   250 LQKARRALQRRQEKSS-------------------------------------QQNSGARLPGLN 277

  Fly   133 VNDISISDSL-----------NRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPP 186
            .|.....|:|           :.|.:.:|...|.:|:..:        |...|.|:..|:.:...
Human   278 KNQSQSQDALVLEDVEKKKKKSGTKKDVPKSWLMKALFKT--------FYMVLLKSFLLKLVNDI 334

  Fly   187 VEEVDHNATAVR-SILDQTVEHMWNDMNSLGAVLVLSTL----FC-------CFLLHHVDLRQRL 239
            ...|......:. |.......::|  :..|.|:|:.:..    ||       ||.|
Human   335 FTFVSPQLLKLLISFASDRDTYLW--IGYLCAILLFTAALIQSFCLQCYFQLCFKL--------- 388

  Fly   240 MGARMRIACCSLIYRKTLRLSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTC 304
             |.::|.|..:.:|:|.|.||.....:...|..:||:|.|..:|.....|||.:|...||.:|:.
Human   389 -GVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSI 452

  Fly   305 YLIWLNIGIPAIVGVVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYA 369
            :.:|..:| |:::..||:::..:|:...||..:..::::..:..|.|:.||||::.||:::|.:|
Human   453 FFLWRELG-PSVLAGVGVMVLVIPINAILSTKSKTIQVKNMKNKDKRLKIMNEILSGIKILKYFA 516

  Fly   370 WEKPFQAVVAEARRSEIKQIRYASYLRGFYLSTMVFTERSTLYITLAAAALM--GQTITADFVFS 432
            ||..|:..|...|:.|:|.:...|.|:...:.....|......:|.:...|:  ...:.|...|:
Human   517 WEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVFQLTPVLVSVVTFSVYVLVDSNNILDAQKAFT 581

  Fly   433 AASYYNILQLVAAIWYPLAVSFGAEALVSLRRIQDFLMLEGREERTQGLTHKRDQEGGDSRAVTI 497
            :.:.:|||:...:: .|:.:|...:|.||..|::.:  |.|.:..|..:.|    :....:|:..
Human   582 SITLFNILRFPLSM-LPMMISSMLQASVSTERLEKY--LGGDDLDTSAIRH----DCNFDKAMQF 639

  Fly   498 KDINASWDIEKPQKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGDLSY 562
            .:.:.:|:.:. :.|::.:||.|..|||.|||||||:||||::..:|||:..:.|.:.|:|..:|
Human   640 SEASFTWEHDS-EATVRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAY 703

  Fly   563 AAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRAR 627
            ..|:.|:..|::::|||||.||:.||||:|...|||..|.:.||.||...:||:|.:|||||:.|
Human   704 VPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQR 768

  Fly   628 ISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRILVTHQVHFLSEADVI 692
            ||||||.|:...|||:||||||||||||:|:|::|:||.|.|.  ..||:||||.:|||.:.|.|
Human   769 ISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLK--GKTRLLVTHSMHFLPQVDEI 831

  Fly   693 VIVDQGRILRQGTYQELINSDLDFARLLER------PKEE---EEGENSRNQTSPLSVNSLESDD 748
            |::..|.|:.:|:|..|:....:||:.|:.      |:||   .:|....:....| ::|:|...
Human   832 VVLGNGTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSEEEDDDYGL-ISSVEEIP 895

  Fly   749 EDIPFIDGVKD-GYQQLRKQSSSVHGS--KSLDSTQLDDNV----DEDDLAEAQ--------ASG 798
            ||...|...:: .:::...:||..:|.  |||.::....||    ::::|.:.|        .:|
Human   896 EDAASITMRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSLKEDEELVKGQKLIKKEFIETG 960

  Fly   799 GISPRVWYEYFHAGSTLLSFSFMVFVMVMSQVVCSSSDFFANIWTQQ-------EHQRSQGEATF 856
            .:...::.||..| ..|.|..|::...||:.|....|:.:.:.||..       ::..||.:...
Human   961 KVKFSIYLEYLQA-IGLFSIFFIILAFVMNSVAFIGSNLWLSAWTSDSKIFNSTDYPASQRDMRV 1024

  Fly   857 STFECMYIYGALIIA----VVIMTTFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGR 917
            .      :||||.:|    |.|...:..|.|    :|||.:||.::...||.|.||||||||:||
Human  1025 G------VYGALGLAQGIFVFIAHFWSAFGF----VHASNILHKQLLNNILRAPMRFFDTTPTGR 1079

  Fly   918 ILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLVVAVVDVLILKLYLRP 982
            |:|||:.|:..:|:.||:::..:|...|.:...|::|.:..||....::.:.::.|.:...|:..
Human  1080 IVNRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFYVST 1144

  Fly   983 SQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGL 1047
            |:.|:||:.:.|||::||.|.:::||.:||:.:.|....|..::..|.:.......:..|..|.:
Human  1145 SRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSNRWLAI 1209

  Fly  1048 WLDCVSCIFLTSVTFSFIISSETTYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQ 1112
            .|:.|..:.:.......:|..:|.....||..::.|:.:|..:.:.||..:|....:.:|||:.:
Human  1210 RLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVRMTSEIETNIVAVERITE 1274

  Fly  1113 YTELEQE-PALGEKTPPQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAG 1176
            ||::|.| |.:.:|.||..||::|:::|.|...||.|....|||.:...|.:..|:|:|||||||
Human  1275 YTKVENEAPWVTDKRPPPDWPSKGKIQFNNYQVRYRPELDLVLRGITCDIGSMEKIGVVGRTGAG 1339

  Fly  1177 KSSLIGALFRLAHIE-GEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDA 1240
            ||||...|||:.... |:|.|||::..:|.|..||.:::||||||:|||.::|.|||||..|:|.
Human  1340 KSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFNNYSDE 1404

  Fly  1241 ELWSALEDVELRKAIP----GLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDP 1301
            |:|.|||...|:..:.    ||.:.|||.|||.|:||||||||.||:||.:|:||||||||.||.
Human  1405 EIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDL 1469

  Fly  1302 QTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLK 1355
            :||.|||.||:.:|..|||:|:||||||:||||:::|:|.|..:|...|..||:
Human  1470 ETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQ 1523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	455/1413 (32%)
		ABC_membrane	214..441	CDD:294371	63/239 (26%)
		ABCC_MRP_domain1	495..699	CDD:213217	99/203 (49%)
		ABC_membrane	863..1088	CDD:294371	69/228 (30%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	116/219 (53%)
ABCC2	NP_000383.2	SunT	8..1537	CDD:331423	456/1419 (32%)
ABCC2	NP_000383.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	253..284		6/67 (9%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.830