DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and Abcc5

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_446376.1	Gene:	Abcc5 / 116721	RGDID:	70913	Length:	1436	Species:	Rattus norvegicus

Alignment Length:	1481	Identity:	476/1481 - (32%)
Similarity:	723/1481 - (48%)	Gaps:	255/1481 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SSAKPTR-----KNPRQHANIISQLIFAWAIPLLYRGSRRG-LNTDDLTQCLKEDRSEQLGDRLE 61
            |:.||.|     ::|..:|.:.|.:.|:|..||.....::| |..:|:....|.:.|:....|||
  Rat    86 SALKPFRTTTKHQHPVDNAGLFSYMTFSWLSPLAQVVHKKGELLMEDVWPLSKYESSDVNCRRLE 150

  Fly    62 DQWFKELERSHRKKQKPHLRNALFRCFLGPTIINGLICFIYIVIKT-LIPAVLAQLLIQFQKTPV 125
            ..|.:||..                  :||...: |...::|..:| ||.:::..::.|.
  Rat   151 RLWQEELNE------------------VGPDAAS-LRRVVWIFCRTRLILSIVCLMITQL----- 191

  Fly   126 AQLRNIDVNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEV 190
                                                :|..|.|...|.|     ||..|.....:
  Rat   192 ------------------------------------AGFSGPAFVVKHL-----LEYTQATESNL 215

  Fly   191 DHNATAVRSILDQTVEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRLMGARMRIACCSLIYRK 255
            .::...|..:|...|...|    ||.....|:               ...|.|:|.|..::.::|
  Rat   216 QYSLLLVLGLLLTEVVRSW----SLALTWALN---------------YRTGVRLRGAVLTMAFKK 261

  Fly   256 TLRLSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVV 320
            .|:|  |...:...|.|||:.|||..|:.........:...|:.|:|.  :|: |:   .|:|..
  Rat   262 ILKL--KNIKEKSLGELINICSNDGQRMFEAAAVGSLLAGGPVVAILG--MIY-NV---IILGPT 318

  Fly   321 GLLLKTV-----PVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAE 380
            |.|...|     |....:|::|:..|.:....||.||..|||::..|:.||||||.|.|...|.:
  Rat   319 GFLGSAVFILFYPAMMFVSRLTAYFRRKCVAATDDRVQKMNEVLTYIKFIKMYAWVKAFSQCVQK 383

  Fly   381 ARRSEIKQIRYASYLRGFYLSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNILQLVAA 445
            .|..|.:.:..|.|.:...:............:|.:....:|..:||...|:..:.:|.:.....
  Rat   384 IREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMTFALK 448

  Fly   446 IWYPLAVSFGAEALVSLRRIQDFLMLE-------------------------------------- 472
            : .|.:|...:||.|::.|.:...::|
  Rat   449 V-TPFSVKSLSEASVAVDRFKSLFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSTQSSPKL 512

  Fly   473 ------------GREERTQGLTHKR------DQEG-----GDSRAVTI----KDINASWDIEKPQ 510
                        |::|:::.|.|..      :|:|     .|.|....    |.|:|.  ..:.|
  Rat   513 TPKVKKDKRAPKGKKEKSRQLQHTEHQAVLAEQKGHLLLDSDERPSPEEEEGKQIHAG--SMRLQ 575

  Fly   511 KTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGDLSYAAQEPWLFTGSVR 575
            :||.:|:|:||:|:|..:.|.||:||:|::..:||::.:::|.:.:.|..:|.||:.|:...::|
  Rat   576 RTLYNIDLEIEEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAVSGTFAYVAQQAWILNATLR 640

  Fly   576 NNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQI 640
            :|||||:|||.:||..|...|.|..|...|||.|.|.:|||||:||||||.|||||||:|....|
  Rat   641 DNILFGKEFDEERYNSVLNSCCLRPDLAILPNSDLTEIGERGANLSGGQRQRISLARALYSDRSI 705

  Fly   641 YLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRIL-VTHQVHFLSEADVIVIVDQGRILRQG 704
            |::||||||:|||||.|:|:..|..|     ||:..:| ||||:.:|.:.|.::.:.:|.|..:|
  Rat   706 YILDDPLSALDAHVGNHIFNSAIRKR-----LKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERG 765

  Fly   705 TYQELINSDLDFARLL------ERPKEEEEGENSRNQTSPLSVNSLESDDEDIPFIDGVKDGYQQ 763
            |::||:|.:.|:|.:.      |.|..|   .||:.:.|    .|.:|.|:      |.|.|
  Rat   766 THEELMNLNGDYATIFNNLLLGETPPVE---INSKKEAS----GSQKSQDK------GPKPG--- 814

  Fly   764 LRKQSSSVHGSKSLDSTQLDDNVDEDDL--AEAQASGGISPRVWYEYFHAGSTLLSFSFMVFVMV 826
                  ||...|::.|       :|..|  .|.:..|.:...|::.|..|....|:| .::.|:.
  Rat   815 ------SVKKEKAVKS-------EEGQLVQVEEKGQGSVPWSVYWVYIQAAGGPLAF-LVIMVLF 865

  Fly   827 MSQVVCSSSDFFANIWTQQEHQRSQGEATFSTFE---------------CMY---IYGALIIAVV 873
            |..|   .|..|:..|.  .:...||....:.||               ..|   ||...:..::
  Rat   866 MLNV---GSTAFSTWWL--SYWIKQGSGNSTVFEGNRSSVSDSMRDNPFLQYYASIYALSMAVML 925

  Fly   874 IMTTFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMM 938
            |:...||.:|.|..:.||..|||.:|..||.:.|:||||||:|||||||||||..:|..||....
  Rat   926 ILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAE 990

  Fly   939 DFIQ-IALVMFGILIVIGILNPVLVAA--MLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSH 1000
            .||| :.||.|.:.::.|:....|||.  :|::..|..::.::.:|   :||||:.|.:||..||
  Rat   991 MFIQNVILVFFCVGMIAGVFPWFLVAVGPLLILFSVLHIVSRVLIR---ELKRLDNITQSPFLSH 1052

  Fly  1001 LSASLTGLAIIRS-RQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCVSCIFLTSVTFSF 1064
            :::|:.|||.|.: .:.|:.:.:..:||.|..:..:..|.|:. .|.:.||.:|...:|:.....
  Rat  1053 ITSSIQGLATIHAYNKRQEFLHRYQELLDDNQAPFFLFTCAMR-WLAVRLDLISIALITTTGLMI 1116

  Fly  1065 IISSETTYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTE---LEQEPALGEKT 1126
            ::......|...||||:.|:.|||:.|:.||..:|:..:.|||||:..|.:   ||....:..|.
  Rat  1117 VLMHGQIPSAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKA 1181

  Fly  1127 PPQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAHIE 1191
            ||..||..|::.|.|...||..|...||:.::.||:...|:|||||||:|||||..|||||..:.
  Rat  1182 PPHDWPQEGEITFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELS 1246

  Fly  1192 GE-IFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDVELRKAI 1255
            |. |.|||:....|.|..||::::||||:|||||.|:|.|||||.:||:.::|.|||...:::.|
  Rat  1247 GGCIKIDGVRISDIGLADLRSKLTIIPQEPVLFSGTVRSNLDPFNQYTEEQIWDALERTHMKECI 1311

  Fly  1256 P----GLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFK 1316
            .    .|:..|.|.|.|||||:|||||:|||:||:.|:|:||||||.:|.:||.|||.|||..|.
  Rat  1312 AQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFA 1376

  Fly  1317 QCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEA 1367
            .||:||:|||||||:.||||:|:..|..||||.|.:||.........|..|
  Rat  1377 DCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMCAA 1427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	472/1473 (32%)
		ABC_membrane	214..441	CDD:294371	60/231 (26%)
		ABCC_MRP_domain1	495..699	CDD:213217	91/208 (44%)
		ABC_membrane	863..1088	CDD:294371	82/231 (35%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	118/219 (54%)
Abcc5	NP_446376.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	12..38
		PLN03130	100..1424	CDD:215595	470/1462 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	499..569		10/69 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	795..822		12/45 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.730