Protein Alignment Cftr and CFTR

DIOPT Version :10

• Sequence 1: NP_651269.1
• Gene: Cftr / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Sequence 2: NP_000483.3
• Gene: CFTR / 1080
• HGNCID: 1884
• Length: 1480
• Species: Homo sapiens
• Alignment Length: 1550
• Identity: 432/1550 - (27%)
• Similarity: 723/1550 - (46%)
• Gaps: 317/1550 - (20%)

  Fly     9 RKNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSHR 73
            :::|.:.|:::|:|.|:|..|:|.:|.|:.|...|:.|....|.::.|.::||.:|.:||    .
Human     2 QRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDREL----A 62

  Fly    74 KKQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNIDVNDISI 138
            .|:.|.|.|||.|||....:..|:..::..|.|.:.|.:|.:::..:
Human    63 SKKNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASY------------------ 109

  Fly   139 SDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNATAVRSILDQ 203
             |..|:..|:|..|:
Human   110 -DPDNKEERSIAIYL-------------------------------------------------- 123

  Fly   204 TVEHMWNDMNSLGAVL--VLSTLF---CCFLLHHVDLRQRLMGARMRIACCSLIYRKTLRLSMKT 263
                      .:|..|  ::.||.   ..|.|||:       |.:||||..||||:|||:||.:.
Human   124 ----------GIGLCLLFIVRTLLLHPAIFGLHHI-------GMQMRIAMFSLIYKKTLKLSSRV 171

  Fly   264 AGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVP 328
            ..:...|.|::||||::|:.|.|....|::||.|||..|...|||..:...|..| :|.|:....
Human   172 LDKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCG-LGFLIVLAL 235

  Fly   329 VQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIRYAS 393
            .|..|.::....|.:.|.:...|:.|.:|:::.||.:|.|.||:..:.::...|::|:|..|.|:
Human   236 FQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAA 300

  Fly   394 YLRGFYLSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNILQLVAAIWYPLAVSFGAEA 458
            |:|.|..|...|:....:::::...||: :.|....:|:..|:..:|::.....:|.||....::
Human   301 YVRYFNSSAFFFSGFFVVFLSVLPYALI-KGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDS 364

  Fly   459 LVSLRRIQDFLMLEGREERTQGLTHKRDQEGGDSRAVTIKDINASWD------IEKPQK------ 511
            |.::.:|||||..:..:.....||         :..|.::::.|.|:      .||.::
Human   365 LGAINKIQDFLQKQEYKTLEYNLT---------TTEVVMENVTAFWEEGFGELFEKAKQNNNNRK 420

  Fly   512 -------------------TLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQ 557
                               .|:.||.:||:|||.||.|..||||:|:|.:::|||...:|.:...
Human   421 TSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHS 485

  Fly   558 GDLSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSG 622
            |.:|:.:|..|:..|:::.||:||..:|..||:.|.:.|.|..|..:....|..::||.|.:|||
Human   486 GRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSG 550

  Fly   623 GQRARISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKA--TRILVTHQVHF 685
            ||||||||||||||.|.:||:|.|...:|....:.:|:..:      .:|.|  ||||||.::..
Human   551 GQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCV------CKLMANKTRILVTSKMEH 609

  Fly   686 LSEADVIVIVDQGRILRQGTYQELINSDLDFARLL------------------------------ 720
            |.:||.|:|:.:|.....||:.||.|...||:..|
Human   610 LKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSILTETLHRFSLEGD 674

  Fly   721 ------ERPKEE-----EEGENSRN---------------QTSPLSVNSLESDDED--------- 750
                  |..|:.     |.||..:|               |.:||.:|.:|.|.::
Human   675 APVSWTETKKQSFKQTGEFGEKRKNSILNPINSIRKFSIVQKTPLQMNGIEEDSDEPLERRLSLV 739

  Fly   751 ---------IPFIDGVKDG--YQQLRKQS------------SSVHGSKSLDS-----------TQ 781
                     :|.|..:..|  .|..|:||            .::|...:..:           |:
Human   740 PDSEQGEAILPRISVISTGPTLQARRRQSVLNLMTHSVNQGQNIHRKTTASTRKVSLAPQANLTE 804

  Fly   782 LD---------------DNVDEDDLAEAQASGGIS-PRV--WYEYFHAGSTLLSFSFMVFVMVMS 828
            ||               :.::|:||.|.......| |.|  |..|..   .:.....::||::..
Human   805 LDIYSRRLSQETGLEISEEINEEDLKECFFDDMESIPAVTTWNTYLR---YITVHKSLIFVLIWC 866

  Fly   829 QVVCSSSDFFANI-------WT----------QQEHQRSQGEATF----STFECMYIYGALIIAV 872
            .|:     |.|.:       |.          ...|.|:...|..    |::...|||..:...:
Human   867 LVI-----FLAEVAASLVVLWLLGNTPLQDKGNSTHSRNNSYAVIITSTSSYYVFYIYVGVADTL 926

  Fly   873 VIMTTFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAM 937
            :.|..|||.......:..||:||.:|...:|.|.|...:|..:|.||||||||:..:|:|||..:
Human   927 LAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTI 991

  Fly   938 MDFIQIALVMFGILIVIGILNPVLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLS 1002
            .||||:.|::.|.:.|:.:|.|.:..|.:.|.|..:::...:|:.||.||:||...|||:|:||.
Human   992 FDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLV 1056

  Fly  1003 ASLTGLAIIRSRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCVSCIFLTSVTFSFIIS 1067
            .||.||..:|:...|......|....::|::.|.|.::......:.::.:..||..:|||..|::
Human  1057 TSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILT 1121

  Fly  1068 SETTYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTELEQEPALGEKTPPQQ-- 1130
            :... .|.||:.:..||.:...:|:.|....:....|.||.||.::.::..|....:.|.|.:
Human  1122 TGEG-EGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNG 1185

  Fly  1131 ------------------WPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGK 1177
                              ||:.||:..::::.:|...|:.:|.|::.:|..|.:||::||||:||
Human  1186 QLSKVMIIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGK 1250

  Fly  1178 SSLIGALFRLAHIEGEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAEL 1242
            |:|:.|..||.:.||||.|||:...:|:|:..|....:|||...:||.|.|.||||:|:::|.|:
Human  1251 STLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEI 1315

  Fly  1243 WSALEDVELRKAI---PG-LDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQT 1303
            |...::|.||..|   || ||:::.:.|...|.|.:||:||||::|...|:|:|||.:|::||.|
Human  1316 WKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVT 1380

  Fly  1304 DALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFD-VPYLLLKKS 1357
            ..:|:||::..|..|||:...||:..:::..:.:|::.....::| :..||.::|
Human  1381 YQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERS 1435

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cftr	NP_651269.1	MRP_assoc_pro	12..1356	CDD:188098	431/1544 (28%)
CFTR	NP_000483.3	CFTR_protein	1..1480	CDD:273530	431/1549 (28%)
		Disordered R region. /evidence=ECO:0000269|PubMed:10792060	654..831		26/176 (15%)
		Interaction with GORASP2. /evidence=ECO:0000269|PubMed:21884936	1386..1480		12/49 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1452..1480
		PDZ-binding. /evidence=ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:16331976	1478..1480