DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and CFTR

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_000483.3	Gene:	CFTR / 1080	HGNCID:	1884	Length:	1480	Species:	Homo sapiens

Alignment Length:	1550	Identity:	432/1550 - (27%)
Similarity:	723/1550 - (46%)	Gaps:	317/1550 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RKNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSHR 73
            :::|.:.|:::|:|.|:|..|:|.:|.|:.|...|:.|....|.::.|.::||.:|.:||    .
Human     2 QRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDREL----A 62

  Fly    74 KKQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNIDVNDISI 138
            .|:.|.|.|||.|||....:..|:..::..|.|.:.|.:|.:::..:
Human    63 SKKNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASY------------------ 109

  Fly   139 SDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNATAVRSILDQ 203
             |..|:..|:|..|:
Human   110 -DPDNKEERSIAIYL-------------------------------------------------- 123

  Fly   204 TVEHMWNDMNSLGAVL--VLSTLF---CCFLLHHVDLRQRLMGARMRIACCSLIYRKTLRLSMKT 263
                      .:|..|  ::.||.   ..|.|||:       |.:||||..||||:|||:||.:.
Human   124 ----------GIGLCLLFIVRTLLLHPAIFGLHHI-------GMQMRIAMFSLIYKKTLKLSSRV 171

  Fly   264 AGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVP 328
            ..:...|.|::||||::|:.|.|....|::||.|||..|...|||..:...|..| :|.|:....
Human   172 LDKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCG-LGFLIVLAL 235

  Fly   329 VQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIRYAS 393
            .|..|.::....|.:.|.:...|:.|.:|:::.||.:|.|.||:..:.::...|::|:|..|.|:
Human   236 FQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAA 300

  Fly   394 YLRGFYLSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNILQLVAAIWYPLAVSFGAEA 458
            |:|.|..|...|:....:::::...||: :.|....:|:..|:..:|::.....:|.||....::
Human   301 YVRYFNSSAFFFSGFFVVFLSVLPYALI-KGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDS 364

  Fly   459 LVSLRRIQDFLMLEGREERTQGLTHKRDQEGGDSRAVTIKDINASWD------IEKPQK------ 511
            |.::.:|||||..:..:.....||         :..|.::::.|.|:      .||.::
Human   365 LGAINKIQDFLQKQEYKTLEYNLT---------TTEVVMENVTAFWEEGFGELFEKAKQNNNNRK 420

  Fly   512 -------------------TLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQ 557
                               .|:.||.:||:|||.||.|..||||:|:|.:::|||...:|.:...
Human   421 TSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHS 485

  Fly   558 GDLSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSG 622
            |.:|:.:|..|:..|:::.||:||..:|..||:.|.:.|.|..|..:....|..::||.|.:|||
Human   486 GRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSG 550

  Fly   623 GQRARISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKA--TRILVTHQVHF 685
            ||||||||||||||.|.:||:|.|...:|....:.:|:..:      .:|.|  ||||||.::..
Human   551 GQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCV------CKLMANKTRILVTSKMEH 609

  Fly   686 LSEADVIVIVDQGRILRQGTYQELINSDLDFARLL------------------------------ 720
            |.:||.|:|:.:|.....||:.||.|...||:..|
Human   610 LKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSILTETLHRFSLEGD 674

  Fly   721 ------ERPKEE-----EEGENSRN---------------QTSPLSVNSLESDDED--------- 750
                  |..|:.     |.||..:|               |.:||.:|.:|.|.::
Human   675 APVSWTETKKQSFKQTGEFGEKRKNSILNPINSIRKFSIVQKTPLQMNGIEEDSDEPLERRLSLV 739

  Fly   751 ---------IPFIDGVKDG--YQQLRKQS------------SSVHGSKSLDS-----------TQ 781
                     :|.|..:..|  .|..|:||            .::|...:..:           |:
Human   740 PDSEQGEAILPRISVISTGPTLQARRRQSVLNLMTHSVNQGQNIHRKTTASTRKVSLAPQANLTE 804

  Fly   782 LD---------------DNVDEDDLAEAQASGGIS-PRV--WYEYFHAGSTLLSFSFMVFVMVMS 828
            ||               :.::|:||.|.......| |.|  |..|..   .:.....::||::..
Human   805 LDIYSRRLSQETGLEISEEINEEDLKECFFDDMESIPAVTTWNTYLR---YITVHKSLIFVLIWC 866

  Fly   829 QVVCSSSDFFANI-------WT----------QQEHQRSQGEATF----STFECMYIYGALIIAV 872
            .|:     |.|.:       |.          ...|.|:...|..    |::...|||..:...:
Human   867 LVI-----FLAEVAASLVVLWLLGNTPLQDKGNSTHSRNNSYAVIITSTSSYYVFYIYVGVADTL 926

  Fly   873 VIMTTFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAM 937
            :.|..|||.......:..||:||.:|...:|.|.|...:|..:|.||||||||:..:|:|||..:
Human   927 LAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTI 991

  Fly   938 MDFIQIALVMFGILIVIGILNPVLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLS 1002
            .||||:.|::.|.:.|:.:|.|.:..|.:.|.|..:::...:|:.||.||:||...|||:|:||.
Human   992 FDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLV 1056

  Fly  1003 ASLTGLAIIRSRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCVSCIFLTSVTFSFIIS 1067
            .||.||..:|:...|......|....::|::.|.|.::......:.::.:..||..:|||..|::
Human  1057 TSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILT 1121

  Fly  1068 SETTYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTELEQEPALGEKTPPQQ-- 1130
            :... .|.||:.:..||.:...:|:.|....:....|.||.||.::.::..|....:.|.|.:
Human  1122 TGEG-EGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNG 1185

  Fly  1131 ------------------WPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGK 1177
                              ||:.||:..::::.:|...|:.:|.|::.:|..|.:||::||||:||
Human  1186 QLSKVMIIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGK 1250

  Fly  1178 SSLIGALFRLAHIEGEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAEL 1242
            |:|:.|..||.:.||||.|||:...:|:|:..|....:|||...:||.|.|.||||:|:::|.|:
Human  1251 STLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEI 1315

  Fly  1243 WSALEDVELRKAI---PG-LDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQT 1303
            |...::|.||..|   || ||:::.:.|...|.|.:||:||||::|...|:|:|||.:|::||.|
Human  1316 WKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVT 1380

  Fly  1304 DALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFD-VPYLLLKKS 1357
            ..:|:||::..|..|||:...||:..:::..:.:|::.....::| :..||.::|
Human  1381 YQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERS 1435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	431/1549 (28%)
		ABC_membrane	214..441	CDD:294371	73/231 (32%)
		ABCC_MRP_domain1	495..699	CDD:213217	83/236 (35%)
		ABC_membrane	863..1088	CDD:294371	75/224 (33%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	84/219 (38%)
CFTR	NP_000483.3	CFTR_protein	1..1480	CDD:273530	431/1549 (28%)
		ABC_membrane	85..303	CDD:279056	74/304 (24%)
		ABCC_CFTR1	389..670	CDD:213258	92/286 (32%)
		CFTR_R	639..849	CDD:291094	34/209 (16%)
		Disordered R region. /evidence=ECO:0000269\|PubMed:10792060	654..831		26/176 (15%)
		ABC_membrane	866..1147	CDD:279056	84/286 (29%)
		ABCC_CFTR2	1208..1480	CDD:213256	86/227 (38%)
		Interaction with GORASP2. /evidence=ECO:0000269\|PubMed:21884936	1386..1480		12/49 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1452..1480
		PDZ-binding. /evidence=ECO:0000269\|PubMed:11707463, ECO:0000269\|PubMed:16331976	1478..1480
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920