DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and ABCC4

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_005836.2	Gene:	ABCC4 / 10257	HGNCID:	55	Length:	1325	Species:	Homo sapiens

Alignment Length:	1390	Identity:	548/1390 - (39%)
Similarity:	810/1390 - (58%)	Gaps:	129/1390 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RKNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSHR 73
            :.||.|.||:.|::.|.|..||...|.:|.|..||:...|.||||:.||:.|:..|.||:.|:..
Human     9 KPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAEN 73

  Fly    74 KKQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNIDVNDISI 138
            ..|||.|..|:.:|:....::.|:...|....|.:.|..|.:::..|:
Human    74 DAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFE----------------- 121

  Fly   139 SDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNATAVRSILDQ 203
                        ||                                .|::.|..| ||.
Human   122 ------------NY--------------------------------DPMDSVALN-TAY------ 135

  Fly   204 TVEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRLMGARMRIACCSLIYRKTLRLSMKTAGQTP 268
                      :...||...||....|.|......:..|.|:|:|.|.:||||.||||....|:|.
Human   136 ----------AYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTT 190

  Fly   269 AGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVPVQTAL 333
            .|.::||||||||:.|...:|:|::|..||||:....|:|:.|||..:.|:..|:: .:|:|:..
Human   191 TGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLII-LLPLQSCF 254

  Fly   334 SKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIRYASYLRGF 398
            .|:.|.||.:.|..||||:..|||::.||::||||||||.|..::...|:.||.:|..:|.|||.
Human   255 GKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGM 319

  Fly   399 YLSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNILQLVAAIWYPLAVSFGAEALVSLR 463
            .|::.....:..:::|.....|:|..|||..||.|.:.|..::|...:::|.|:...:||:||:|
Human   320 NLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIR 384

  Fly   464 RIQDFLMLEGREERTQGLTHKRDQEGGDSRAVTIKDINASWDIEKPQKTLQSINLQIEKGQLCAV 528
            |||.||:|:...:|.:.|    ..:|  .:.|.::|..|.||......|||.::..:..|:|.||
Human   385 RIQTFLLLDEISQRNRQL----PSDG--KKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAV 443

  Fly   529 IGPVGAGKSSILQLLLGELPVIDGGVFIQGDLSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVT 593
            :|||||||||:|..:||||....|.|.:.|.::|.:|:||:|:|::|:|||||::::::||::|.
Human   444 VGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVI 508

  Fly   594 RCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQIYLMDDPLSAVDAHVGRHL 658
            :.|||..|.|.|.:||.|::|:||.:|||||:||::||||||:.|.|||:|||||||||.|.|||
Human   509 KACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHL 573

  Fly   659 FDEVIGPRGRLAQLKATRILVTHQVHFLSEADVIVIVDQGRILRQGTYQELINSDLDFARLLERP 723
            |:..|   .::...|.| ||||||:.:|..|..|:|:..|:::::|||.|.:.|.:||..||::.
Human   574 FELCI---CQILHEKIT-ILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKD 634

  Fly   724 KEEEE------GENSRNQTSPLSVNSLESDDEDIPFIDGVKDGYQQLRKQSSSVHGSKSLDSTQL 782
            .||.|      ....||:|  .|.:|:.|.....|   .:|||               :|:| |.
Human   635 NEESEQPPVPGTPTLRNRT--FSESSVWSQQSSRP---SLKDG---------------ALES-QD 678

  Fly   783 DDNVDEDDLAEAQASGGISPRVWYEYFHAGSTLLSFSFMVFVMVMSQVVCSSSDFFANIWTQQEH 847
            .:||......|.::.|.:..:.:..||.||:..:.|.|::.:...:||.....|::.:.|..::.
Human   679 TENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYWANKQS 743

  Fly   848 Q-----RSQGEATFSTFECMY--IYGALIIAVVIMTTFRGFLFFKICMHASKVLHDRMFACILHA 905
            .     ...|..|.......|  ||..|.:|.|:....|..|.|.:.:::|:.||::||..||.|
Human   744 MLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKA 808

  Fly   906 TMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLVVAV 970
            .:.|||..|.||||||||||:|.:|:|||...:||||..|.:.|::.|...:.|.:...::.:.:
Human   809 PVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGI 873

  Fly   971 VDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFDLLQDVHSSVW 1035
            :.:.:.:.:|..|:|:||||...|||||||||:||.||..||:.:.::...:.||..||:||..|
Human   874 IFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAW 938

  Fly  1036 QLTMAVNTTLGLWLDCVSCIFLTSVTFSFIISSETTYSGNVGLAIAQAMILTGMVQYGVRQVAES 1100
            .|.:..:....:.||.:..:|:..|.|..:|.::|..:|.||||::.|:.|.||.|:.|||.||.
Human   939 FLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEV 1003

  Fly  1101 LQQMTSVERVLQYTELEQE-PALGEKTPPQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAG 1164
            ...|.|||||::||:||:| |...:|.||..||..|.:.|.|::..|.|.|..||::|...|::.
Human  1004 ENMMISVERVIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQ 1068

  Fly  1165 WKVGIVGRTGAGKSSLIGALFRLAHIEGEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRY 1229
            .||||||||||||||||.|||||:..||:|:||.|.|..|.|..||.::|||||:||||:.|:|.
Human  1069 EKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRK 1133

  Fly  1230 NLDPFERYTDAELWSALEDVELRKAI---PG-LDYMVTERGGNFSVGQRQLLCLARAILRNNKVL 1290
            |||||..:||.|||:||::|:|::.|   || :|..:.|.|.|||||||||:||||||||.|::|
Human  1134 NLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQIL 1198

  Fly  1291 VLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLK 1355
            ::|||||||||:||.|||:.||.||..|||||:||||:|::|||:|:|:|:|...|:|.||:||:
Human  1199 IIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQ 1263

  Fly  1356 KSQGHLRQMVEATG-GESEALKKTA 1379
            ..:....:||:..| .|:.||.:||
Human  1264 NKESLFYKMVQQLGKAEAAALTETA 1288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	542/1375 (39%)
		ABC_membrane	214..441	CDD:294371	89/226 (39%)
		ABCC_MRP_domain1	495..699	CDD:213217	100/203 (49%)
		ABC_membrane	863..1088	CDD:294371	88/226 (39%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	129/218 (59%)
ABCC4	NP_005836.2	CFTR_protein	11..1269	CDD:273530	540/1367 (40%)
		ABC_membrane	96..365	CDD:294371	103/347 (30%)
		ABCC_MRP_domain1	410..610	CDD:213217	100/203 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	657..688		11/49 (22%)
		ABC_membrane	718..991	CDD:279056	94/272 (35%)
		ABCC_MRP_domain2	1039..1258	CDD:213211	129/218 (59%)
		PDZ-binding	1322..1325
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X771
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.930