Protein Alignment Cftr and ABCC5

DIOPT Version :10

• Sequence 1: NP_651269.1
• Gene: Cftr / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Sequence 2: NP_005679.2
• Gene: ABCC5 / 10057
• HGNCID: 56
• Length: 1437
• Species: Homo sapiens
• Alignment Length: 1481
• Identity: 461/1481 - (31%)
• Similarity: 714/1481 - (48%)
• Gaps: 254/1481 - (17%)

  Fly     3 SSAKPTR-----KNPRQHANIISQLIFAWAIPLLYRGSRRG-LNTDDLTQCLKEDRSEQLGDRLE 61
            |:.||.|     ::|..:|.:.|.:.|:|...|.....::| |:.:|:....|.:.|:....|||
Human    86 SALKPIRTTSKHQHPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLE 150

  Fly    62 DQWFKELERSHRKKQKPHLRNALFRCFLGPTIINGLICFIYIVIKT-LIPAVLAQLLIQFQKTPV 125
            ..|.:||..                  :||...: |...::|..:| ||.:::..::.|.
Human   151 RLWQEELNE------------------VGPDAAS-LRRVVWIFCRTRLILSIVCLMITQL----- 191

  Fly   126 AQLRNIDVNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEV 190
                                                :|..|.|...|.|     ||..|.....:
Human   192 ------------------------------------AGFSGPAFMVKHL-----LEYTQATESNL 215

  Fly   191 DHNATAVRSILDQTVEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRLMGARMRIACCSLIYRK 255
            .::...|..:|...:...|    ||.....|:               ...|.|:|.|..::.::|
Human   216 QYSLLLVLGLLLTEIVRSW----SLALTWALN---------------YRTGVRLRGAILTMAFKK 261

  Fly   256 TLRLSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVV 320
            .|:|  |...:...|.|||:.|||..|:.........:...|:.|:|.  :|: |:   .|:|..
Human   262 ILKL--KNIKEKSLGELINICSNDGQRMFEAAAVGSLLAGGPVVAILG--MIY-NV---IILGPT 318

  Fly   321 GLLLKTV-----PVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAE 380
            |.|...|     |.....|::|:..|.:....||.||..|||::..|:.||||||.|.|...|.:
Human   319 GFLGSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQK 383

  Fly   381 ARRSEIKQIRYASYLRGFYLSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNILQLVAA 445
            .|..|.:.:..|.|.:...:............:|.:....:|..:||...|:..:.:|.:.....
Human   384 IREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMTFALK 448

  Fly   446 IWYPLAVSFGAEALVSLRRIQDFLMLEGREERTQGLTHK-RDQEGGDSRAVTIKDINASWDI--- 506
            : .|.:|...:||.|::.|.:...::|.        .|. :::.......:.:|:...:||.
Human   449 V-TPFSVKSLSEASVAVDRFKSLFLMEE--------VHMIKNKPASPHIKIEMKNATLAWDSSHS 504

  Fly   507 --------------------------------------------------EKP------------ 509
                                                              |:|
Human   505 SIQNSPKLTPKMKKDKRASRGKKEKVRQLQRTEHQAVLAEQKGHLLLDSDERPSPEEEEGKHIHL 569

  Fly   510 -----QKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGDLSYAAQEPWL 569
                 |:||.||:|:|::|:|..:.|.||:||:|::..:||::.:::|.:.|.|..:|.||:.|:
Human   570 GHLRLQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGTFAYVAQQAWI 634

  Fly   570 FTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAV 634
            ...::|:|||||:|:|.:||..|...|.|..|...||:.|.|.:|||||:||||||.|||||||:
Human   635 LNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLARAL 699

  Fly   635 YKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRIL-VTHQVHFLSEADVIVIVDQG 698
            |....||::||||||:|||||.|:|:..|     ...||:..:| ||||:.:|.:.|.::.:.:|
Human   700 YSDRSIYILDDPLSALDAHVGNHIFNSAI-----RKHLKSKTVLFVTHQLQYLVDCDEVIFMKEG 759

  Fly   699 RILRQGTYQELINSDLDFARLL------ERPKEEEEGENSRNQTSPLSVNSLESDDEDIPFIDGV 757
            .|..:||::||:|.:.|:|.:.      |.|..|   .||:.:||.   :..:|.|:      |.
Human   760 CITERGTHEELMNLNGDYATIFNNLLLGETPPVE---INSKKETSG---SQKKSQDK------GP 812

  Fly   758 KDGYQQLRKQSSSVHGSKSLDSTQLDDNVDEDDLA--EAQASGGISPRVWYEYFHAGSTLLSFSF 820
            |.|         ||...|::       ..:|..|.  |.:..|.:...|:..|..|....|:|..
Human   813 KTG---------SVKKEKAV-------KPEEGQLVQLEEKGQGSVPWSVYGVYIQAAGGPLAFLV 861

  Fly   821 MVFVMVMSQVVCSSSDFFANIWTQQ---------EHQRSQGEATFSTFECMY---IYGALIIAVV 873
            ::.:.:::....:.|.::.:.|.:|         .::.|..::........|   ||...:..::
Human   862 IMALFMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNETSVSDSMKDNPHMQYYASIYALSMAVML 926

  Fly   874 IMTTFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMM 938
            |:...||.:|.|..:.||..|||.:|..||.:.|:||||||:|||||||||||..:|..||....
Human   927 ILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAE 991

  Fly   939 DFIQ-IALVMFGILIVIGILNPVLVAAMLVVAVVDVL--ILKLYLRPSQDLKRLEGICRSPVFSH 1000
            .||| :.||.|.:.::.|:....|||...:|.:..||  :.::.:|   :||||:.|.:||..||
Human   992 MFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSRVLIR---ELKRLDNITQSPFLSH 1053

  Fly  1001 LSASLTGLAIIRS-RQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCVSCIFLTSVTFSF 1064
            :::|:.|||.|.: .:.|:.:.:..:||.|..:..:..|.|:. .|.:.||.:|...:|:.....
Human  1054 ITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFTCAMR-WLAVRLDLISIALITTTGLMI 1117

  Fly  1065 IISSETTYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTE---LEQEPALGEKT 1126
            ::..........||||:.|:.|||:.|:.||..:|:..:.|||||:..|.:   ||....:..|.
Human  1118 VLMHGQIPPAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKA 1182

  Fly  1127 PPQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAHIE 1191
            |...||..|:|.|.|...||..|...||:.::.||:...|:|||||||:|||||..|||||..:.
Human  1183 PSPDWPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELS 1247

  Fly  1192 GE-IFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDVELRKAI 1255
            |. |.|||:....|.|..||:::|||||:|||||.|:|.|||||.:||:.::|.|||...:::.|
Human  1248 GGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECI 1312

  Fly  1256 P----GLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFK 1316
            .    .|:..|.|.|.|||||:|||||:|||:||:.|:|:||||||.:|.:||.|||.|||..|.
Human  1313 AQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFA 1377

  Fly  1317 QCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEA 1367
            .||:||:|||||||:.||||:|:..|..||||.|.:||.........|..|
Human  1378 DCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAA 1428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cftr	NP_651269.1	MRP_assoc_pro	12..1356	CDD:188098	455/1454 (31%)
ABCC5	NP_005679.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	15..41
		PLN03130	100..1425	CDD:215595	455/1462 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	501..538		0/36 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	794..827		12/57 (21%)