DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and ABCC5

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_005679.2	Gene:	ABCC5 / 10057	HGNCID:	56	Length:	1437	Species:	Homo sapiens

Alignment Length:	1481	Identity:	461/1481 - (31%)
Similarity:	714/1481 - (48%)	Gaps:	254/1481 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SSAKPTR-----KNPRQHANIISQLIFAWAIPLLYRGSRRG-LNTDDLTQCLKEDRSEQLGDRLE 61
            |:.||.|     ::|..:|.:.|.:.|:|...|.....::| |:.:|:....|.:.|:....|||
Human    86 SALKPIRTTSKHQHPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLE 150

  Fly    62 DQWFKELERSHRKKQKPHLRNALFRCFLGPTIINGLICFIYIVIKT-LIPAVLAQLLIQFQKTPV 125
            ..|.:||..                  :||...: |...::|..:| ||.:::..::.|.
Human   151 RLWQEELNE------------------VGPDAAS-LRRVVWIFCRTRLILSIVCLMITQL----- 191

  Fly   126 AQLRNIDVNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEV 190
                                                :|..|.|...|.|     ||..|.....:
Human   192 ------------------------------------AGFSGPAFMVKHL-----LEYTQATESNL 215

  Fly   191 DHNATAVRSILDQTVEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRLMGARMRIACCSLIYRK 255
            .::...|..:|...:...|    ||.....|:               ...|.|:|.|..::.::|
Human   216 QYSLLLVLGLLLTEIVRSW----SLALTWALN---------------YRTGVRLRGAILTMAFKK 261

  Fly   256 TLRLSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVV 320
            .|:|  |...:...|.|||:.|||..|:.........:...|:.|:|.  :|: |:   .|:|..
Human   262 ILKL--KNIKEKSLGELINICSNDGQRMFEAAAVGSLLAGGPVVAILG--MIY-NV---IILGPT 318

  Fly   321 GLLLKTV-----PVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAE 380
            |.|...|     |.....|::|:..|.:....||.||..|||::..|:.||||||.|.|...|.:
Human   319 GFLGSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQK 383

  Fly   381 ARRSEIKQIRYASYLRGFYLSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNILQLVAA 445
            .|..|.:.:..|.|.:...:............:|.:....:|..:||...|:..:.:|.:.....
Human   384 IREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMTFALK 448

  Fly   446 IWYPLAVSFGAEALVSLRRIQDFLMLEGREERTQGLTHK-RDQEGGDSRAVTIKDINASWDI--- 506
            : .|.:|...:||.|::.|.:...::|.        .|. :::.......:.:|:...:||.
Human   449 V-TPFSVKSLSEASVAVDRFKSLFLMEE--------VHMIKNKPASPHIKIEMKNATLAWDSSHS 504

  Fly   507 --------------------------------------------------EKP------------ 509
                                                              |:|
Human   505 SIQNSPKLTPKMKKDKRASRGKKEKVRQLQRTEHQAVLAEQKGHLLLDSDERPSPEEEEGKHIHL 569

  Fly   510 -----QKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGDLSYAAQEPWL 569
                 |:||.||:|:|::|:|..:.|.||:||:|::..:||::.:::|.:.|.|..:|.||:.|:
Human   570 GHLRLQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGTFAYVAQQAWI 634

  Fly   570 FTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAV 634
            ...::|:|||||:|:|.:||..|...|.|..|...||:.|.|.:|||||:||||||.|||||||:
Human   635 LNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLARAL 699

  Fly   635 YKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRIL-VTHQVHFLSEADVIVIVDQG 698
            |....||::||||||:|||||.|:|:..|     ...||:..:| ||||:.:|.:.|.::.:.:|
Human   700 YSDRSIYILDDPLSALDAHVGNHIFNSAI-----RKHLKSKTVLFVTHQLQYLVDCDEVIFMKEG 759

  Fly   699 RILRQGTYQELINSDLDFARLL------ERPKEEEEGENSRNQTSPLSVNSLESDDEDIPFIDGV 757
            .|..:||::||:|.:.|:|.:.      |.|..|   .||:.:||.   :..:|.|:      |.
Human   760 CITERGTHEELMNLNGDYATIFNNLLLGETPPVE---INSKKETSG---SQKKSQDK------GP 812

  Fly   758 KDGYQQLRKQSSSVHGSKSLDSTQLDDNVDEDDLA--EAQASGGISPRVWYEYFHAGSTLLSFSF 820
            |.|         ||...|::       ..:|..|.  |.:..|.:...|:..|..|....|:|..
Human   813 KTG---------SVKKEKAV-------KPEEGQLVQLEEKGQGSVPWSVYGVYIQAAGGPLAFLV 861

  Fly   821 MVFVMVMSQVVCSSSDFFANIWTQQ---------EHQRSQGEATFSTFECMY---IYGALIIAVV 873
            ::.:.:::....:.|.::.:.|.:|         .::.|..::........|   ||...:..::
Human   862 IMALFMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNETSVSDSMKDNPHMQYYASIYALSMAVML 926

  Fly   874 IMTTFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMM 938
            |:...||.:|.|..:.||..|||.:|..||.:.|:||||||:|||||||||||..:|..||....
Human   927 ILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAE 991

  Fly   939 DFIQ-IALVMFGILIVIGILNPVLVAAMLVVAVVDVL--ILKLYLRPSQDLKRLEGICRSPVFSH 1000
            .||| :.||.|.:.::.|:....|||...:|.:..||  :.::.:|   :||||:.|.:||..||
Human   992 MFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSRVLIR---ELKRLDNITQSPFLSH 1053

  Fly  1001 LSASLTGLAIIRS-RQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCVSCIFLTSVTFSF 1064
            :::|:.|||.|.: .:.|:.:.:..:||.|..:..:..|.|:. .|.:.||.:|...:|:.....
Human  1054 ITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFTCAMR-WLAVRLDLISIALITTTGLMI 1117

  Fly  1065 IISSETTYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTE---LEQEPALGEKT 1126
            ::..........||||:.|:.|||:.|:.||..:|:..:.|||||:..|.:   ||....:..|.
Human  1118 VLMHGQIPPAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKA 1182

  Fly  1127 PPQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAHIE 1191
            |...||..|:|.|.|...||..|...||:.::.||:...|:|||||||:|||||..|||||..:.
Human  1183 PSPDWPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELS 1247

  Fly  1192 GE-IFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDVELRKAI 1255
            |. |.|||:....|.|..||:::|||||:|||||.|:|.|||||.:||:.::|.|||...:::.|
Human  1248 GGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECI 1312

  Fly  1256 P----GLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFK 1316
            .    .|:..|.|.|.|||||:|||||:|||:||:.|:|:||||||.:|.:||.|||.|||..|.
Human  1313 AQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFA 1377

  Fly  1317 QCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEA 1367
            .||:||:|||||||:.||||:|:..|..||||.|.:||.........|..|
Human  1378 DCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAA 1428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	457/1473 (31%)
		ABC_membrane	214..441	CDD:294371	60/231 (26%)
		ABCC_MRP_domain1	495..699	CDD:213217	91/274 (33%)
		ABC_membrane	863..1088	CDD:294371	82/231 (35%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	120/219 (55%)
ABCC5	NP_005679.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	15..41
		CFTR_protein	100..1430	CDD:273530	457/1467 (31%)
		ABC_membrane	<271..447	CDD:294371	49/181 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	501..538		0/36 (0%)
		ABCC_MRP_domain1	577..759	CDD:213217	85/186 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	794..827		12/57 (21%)
		ABC_membrane	863..1143	CDD:294371	88/283 (31%)
		ABCC_MRP_domain2	1191..1411	CDD:213211	120/219 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.730