Protein Alignment Cftr and abcc2

DIOPT Version :10

• Sequence 1: NP_651269.1
• Gene: Cftr / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Sequence 2: XP_004915926.1
• Gene: abcc2 / 100485020
• XenbaseID: XB-GENE-1012796
• Length: 1552
• Species: Xenopus tropicalis
• Alignment Length: 1442
• Identity: 473/1442 - (32%)
• Similarity: 772/1442 - (53%)
• Gaps: 171/1442 - (11%)

  Fly     8 TRKNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQW-------F 65
            |::||...|:.:|::.|.|...::.:|.::.|..:||.:..:||:::.:.:..|...       .
 Frog   199 TKENPELTASFLSRITFNWYNSIVVKGYKKPLEMEDLWELNEEDKTKNMYEIFEKHMKHDVRKAK 263

  Fly    66 KELE-RSHRKKQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLR 129
            |:|| |.:::|||.                :|      |.:..:..|....:|:..:|....:.:
 Frog   264 KDLEKRKNKRKQKE----------------SG------IEMNGISKAQSQDILVMEEKKKEKKKK 306

  Fly   130 NIDVNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAG-------PLEPIQPPV 187
                     ..|::.||:..|...|.:.:..:        ||.:|..:.       .|..:.|.:
 Frog   307 ---------EKSIDGTAKDYPKRWLIKTLIKT--------FPSTLLTSAIFKLLHDLLAFVSPQI 354

  Fly   188 EEVDHNATAVRSILDQTVEHMWNDMNSLGAVLVLST-LFCCFLLHHVDLRQRLMGARMRIACCSL 251
            .:|....||..|      :|.|...  ..|||:|.| |...|||........::|.|:|....:.
 Frog   355 LKVMVTFTADPS------QHQWQGF--FYAVLLLVTALLQSFLLQQYFHGCFVLGMRVRSLLMAA 411

  Fly   252 IYRKTLRLSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAI 316
            :|:|.|.:|.....::..|..:||:|.|..|......|:|.:|..|||..::...:|..:| |::
 Frog   412 VYKKALTVSNAIRKESTVGETVNLMSADAQRFMDLTNFIHLLWSSPLQIAISIVFLWEELG-PSV 475

  Fly   317 VGVVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEA 381
            :..:|:::..:|:...|:.|:..|:|:..:..|.|:.||||::.||:::|:||||..|:..|.|.
 Frog   476 LAGLGVMILLIPINAVLATVSRKLQMKNMKNKDKRMKIMNEILNGIKILKLYAWEPSFENQVQEI 540

  Fly   382 RRSEIKQIRYASYLRGFYLSTMVFTERSTLYITLAAAALM-----GQTITADFVFSAASYYNILQ 441
            |..|:|.:.:.:||..  :|..||| .:...:::|..|:.     ...:.|:..|::.|.:|||:
 Frog   541 REKELKDMLHFTYLHS--VSLFVFT-CAPFLVSVATFAVYVAVDPSNVLNAEKAFTSISLFNILR 602

  Fly   442 LVAAIWYPLAVSFGAEALVSLRRIQDFLMLEGREERTQGLTHKRDQEGGDS-------------R 493
            ...|: .|:.:|...:..||..|::.:|                   |||:             .
 Frog   603 FPLAM-LPMLISSMVQTSVSSARLEKYL-------------------GGDNLDTSAIRCDPNIDA 647

  Fly   494 AVTIKDINASWDIEKPQKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQG 558
            ||...|...||: |.....:.::||.|::|.|.||:|.||:||||::..:|||:..:.|.:.|:|
 Frog   648 AVQFSDATFSWE-EDANPAVNNVNLDIKEGNLVAVVGGVGSGKSSLVSAMLGEMDHVGGYINIKG 711

  Fly   559 DLSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGG 623
            .::|..|:.|:...:::||||||.:.|.:|||:|...|||..|.:.||..|::.:||:|.:||||
 Frog   712 SIAYVPQQAWIQNATLKNNILFGSKMDEERYQKVLEACALLPDLEMLPGHDESEIGEKGINLSGG 776

  Fly   624 QRARISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRILVTHQVHFLSE 688
            |:.|:|||||||..|.||::||||||||||||:|:|::|:||.|.|.  ..|||||||.|.||..
 Frog   777 QKQRVSLARAVYNDADIYILDDPLSAVDAHVGKHIFEKVVGPNGLLK--NKTRILVTHGVSFLKH 839

  Fly   689 ADVIVIVDQGRILRQGTYQELINSDLDFARLLERPKEEEEGENSRNQTSPLSVNSLESDDEDIPF 753
            ||.||::...|:...|:|:.|..::..||..|.  ...::.:.:.|:.:..:....|.|.:.:..
 Frog   840 ADDIVVLVNSRVTETGSYKTLQANNGAFAEFLR--LYAKQNDQTDNEATVFTGEDDEDDGDQVET 902

  Fly   754 IDGVKD----------GYQQLRKQSSSVHGS--KSL-DSTQLDDNVDEDDL-------AEAQASG 798
            .:.::|          ..:|.::.|.|::|:  :|: |.|:....:..:|.       .|...:|
 Frog   903 AEVIEDIVASTVKRENSMRQRKRSSVSMNGTLRRSVKDVTKKKTGIGSNDTKGQKLIEKETVETG 967

  Fly   799 GISPRVWYEYFHAGSTLLSFSFMVFVMVMSQVVCSSSDFFANIW--------------TQQEHQR 849
            .:..:::.:|..|..  ..|||.:||   |.::.:::....|||              |....||
 Frog   968 KVKFKLYLKYLRAVG--WGFSFWIFV---SYILQNAAFVGQNIWLSDWTGDAEKYYNITYPASQR 1027

  Fly   850 SQGEATFSTFECMYIYGALIIAVVIMTTFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTP 914
            ...         :.::|||.:|..:......||.....:.||::||.::...||...||||||||
 Frog  1028 DMR---------VGVFGALGVAQALFVLLGAFLVSGGAVRASRMLHTQLLHNILRVPMRFFDTTP 1083

  Fly   915 SGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLVVAVVDVLILKLY 979
            :|||:|||:||:..:||.:|.:...:|...|.:.|.|.:|.:..|:..|.::.:|:....:.:.|
 Frog  1084 TGRIVNRFAKDILTVDETIPMSFRSWIACFLGVIGTLFIICLATPIFAAVIVPLAIFYYFVQRFY 1148

  Fly   980 LRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQD-VVAKEFDLLQDVHSSVWQLTMAVNT 1043
            :..|:.|:||:.:.|||::||...:::||::||:...|| .:....|.:.:...||:...:: |.
 Frog  1149 VTTSRQLRRLDSVTRSPIYSHFGETVSGLSVIRAYGHQDRFLQHNEDTIDNNQKSVYSWIVS-NR 1212

  Fly  1044 TLGLWLDCVSCIFLTSVTFSFIISSETTYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVE 1108
            .|.:.|:.|..:.:.......::...|..||.|||:|:.|:.:|..:.:.||..:|....:.:||
 Frog  1213 WLAIRLEFVGNLTVFFAALFAVLGRGTVDSGTVGLSISSALNITQTLNWLVRMTSELETNIVAVE 1277

  Fly  1109 RVLQYTELEQEPA-LGEKTPPQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGR 1172
            ||.:|.::|:|.. :.:..||:.||.:|.|:|.:...||.|....||:.::.||.:..|||||||
 Frog  1278 RVDEYIKVEREAQWVEDHRPPKDWPEKGVVQFVDYKVRYRPELDLVLQGISCTINSMEKVGIVGR 1342

  Fly  1173 TGAGKSSLIGALFRLAHIE---GEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPF 1234
            ||||||||...:||:  ||   |:|.|||::..:|.|..||.:::||||||||||..:|.|||||
 Frog  1343 TGAGKSSLTNCIFRI--IESAGGKIMIDGLDIASIGLHDLRQKLTIIPQDPVLFSGNLRMNLDPF 1405

  Fly  1235 ERYTDAELWSALEDVELRKAIPGLD----YMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEA 1295
            .:|||.::|.|||...|:..:.||.    :.|:|.|.|.|||||||:|||||:||.:|:|:||||
 Frog  1406 NQYTDEDIWKALELSHLKPFVEGLQEKLFHEVSEGGENLSVGQRQLVCLARALLRKSKILILDEA 1470

  Fly  1296 TANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGH 1360
            ||.||.:||.|||||||.:|..|||||:||||||:|||.|::|:|||..:||..|..||:: |||
 Frog  1471 TAAVDLETDNLIQRTIRSEFADCTVLTIAHRLHTIMDSSRLMVLDAGKIIEFGSPDELLQR-QGH 1534

  Fly  1361 LRQMVEATGGES 1372
            ...|.:..|.:|
 Frog  1535 FFSMAKDAGIDS 1546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cftr	NP_651269.1	MRP_assoc_pro	12..1356	CDD:188098	465/1420 (33%)
abcc2	XP_004915926.1	MRP_assoc_pro	10..1544	CDD:188098	471/1438 (33%)