DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5789 and tap1

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	XP_002665053.1	Gene:	tap1 / 100333043	ZFINID:	ZDB-GENE-050517-43	Length:	731	Species:	Danio rerio

Alignment Length:	658	Identity:	140/658 - (21%)
Similarity:	288/658 - (43%)	Gaps:	126/658 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   799 GISPRVWYEYFHAGSTLLS---------------------------FSFMVFVMVMSQVVCSSSD 836
            |:|..:|..  |..:.||:                           |:.:.|.:|:|.:...:..
Zfish   118 GLSLLIWKR--HVPTILLTAKKERTEKKGKASLQRLLGYMKPFSGRFAAVFFFVVISSLGEMAIP 180

  Fly   837 FFANIWTQQEHQRSQGEATFSTFECMYIYGALIIAVVIMTTFRGF------LFFKICM---HASK 892
            .:....|.......:.||          :...|..:.:||.....      |.:.|.|   |.|
Zfish   181 HYTGKMTDWIMNEDEPEA----------FNHAITVMTLMTIMSAVCEFVCDLIYNITMSRIHTS- 234

  Fly   893 VLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVIGIL 957
             :...:|..:|...:.|||...:|.|::|.:.|...:.|.|..      :::|:|:..:.||.:.
Zfish   235 -IQGLVFQAVLKQDIAFFDKATTGDIVSRITTDTNTMSESLSE------KLSLLMWYFMRVIFLF 292

  Fly   958 NPVLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAK 1022
            ..:|:.:..:.....:.:..:::.|.             :|......|       |.|:||.:||
Zfish   293 GSMLMLSTRLCCFTLLGLPVIWIIPE-------------IFGRFYQKL-------SAQVQDSLAK 337

  Fly  1023 EFDLLQDVHSSVWQL-------------------TMAVNT------TLGLWLDCVSCIFL-TSVT 1061
            ..::..:..||:..:                   |.|:|.      .:..|.:.:|.:.| .|:.
Zfish   338 ANEVATETFSSMKTVRSFANEDGETERYRKCLEDTFALNKVEAAAYAVSTWTNSMSSLALKVSIL 402

  Fly  1062 F--SFIISSETTYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTELEQE-PALG 1123
            :  ..:::.....||::...:...:..|..|:..:.......:.:.:.|::.:|.:.:.: |..|
Zfish   403 YYGGRLVTGSDVSSGDLVSFVLYELQFTSAVEVLMSYWPHVKKAVGASEKIFEYVDRKPDVPPDG 467

  Fly  1124 EKTPPQQWPTRGQVEFRNMSCRYDPN-GSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRL 1187
            ...|.   ..:|.|:|||::..|... .:.||:|::|.::||....:||.:|:||::::..|.|.
Zfish   468 SLAPK---TLKGHVQFRNVTFAYPKRPDTDVLKNVSLELKAGKITALVGPSGSGKTTVVSLLERF 529

  Fly  1188 AHIE-GEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLD-PFERYTDAELWSALEDV- 1249
            ...: |||.:|.....:...:.|..:||::.|:||||:.::|.|:. ..|..|:.|:::|....
Zfish   530 YQPQNGEILLDQKPLLSYKDQYLHEKISVVSQEPVLFARSVRENIKYGKENATNEEIYAAARLAN 594

  Fly  1250 --ELRKAIP-GLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTI 1311
              :...::| |.|....|:||..|.||:|.:.:|||:::..::||||:||:::|.:::..:...:
Zfish   595 AHDFISSLPKGYDTDAGEKGGQVSGGQKQRIAIARALIQKPQILVLDDATSSLDTESEHRVYSAL 659

  Fly  1312 RIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEATGGESEALK 1376
            :.:.:.||||.::|||..|.::|.|:.:..|..||           :|:.:|:::..|..:|.:|
Zfish   660 KKELQSCTVLLISHRLSGVENADHILFLREGELVE-----------EGNHQQLLDKQGFYAEFVK 713

  Fly  1377 KTASDSHK 1384
            :..:..|:
Zfish   714 QQNTAIHR 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	136/639 (21%)
		ABC_membrane	214..441	CDD:294371
		ABCC_MRP_domain1	495..699	CDD:213217
		ABC_membrane	863..1088	CDD:294371	44/261 (17%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	70/221 (32%)
tap1	XP_002665053.1	3a01208	42..712	CDD:273363	138/647 (21%)
		ABC_membrane	166..433	CDD:279056	51/304 (17%)
		P-loop_NTPase	467..692	CDD:304359	70/227 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000