DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and abcb4

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_001303643.1	Gene:	abcb4 / 100136865	ZFINID:	ZDB-GENE-080204-52	Length:	1275	Species:	Danio rerio

Alignment Length:	1466	Identity:	314/1466 - (21%)
Similarity:	578/1466 - (39%)	Gaps:	355/1466 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 LKEDRSEQLGDRLEDQWFKELERSHRKKQKPHLRNALFRCFLGP-------TIINGLICFIYIVI 105
            :..|:.|:.||...::..||     .|::|..|.      .:||       ..|:.|:..:.:::
Zfish     9 VSSDKKEENGDVSGEKNGKE-----EKEEKEKLE------MVGPIELFRYADSIDILLMMLGLIM 62

  Fly   106 KTLIPAVLAQLLIQFQKTPVAQLRNIDVNDISISDSLNRTARAI---PNYVLSQAVANSSGSPGD 167
            .....|||..::|.|.          |:.|..:.|:|....:.|   ||:.
Zfish    63 SMANGAVLPLMVIVFG----------DMTDSFVDDTLLDNLKNITLPPNFT-------------- 103

  Fly   168 ALFPKSLDKAGPLEPIQPPVEEVDHNATAVRSILDQTVEHMWNDMNSLGAVLVLSTLFCCFLLHH 232
              ||::                  .|.|....:....:.:     :.:|.|:
Zfish   104 --FPET------------------SNITLGEKMTTHAIYY-----SIMGFVV------------- 130

  Fly   233 VDLRQRLMGARMRIACCSL------------IYRKTLRLSMKTAGQTPAGYLINLLSNDVNRLDY 285
                  |:.|.|::|..:|            .:...::..:........|.|...|::||.:::.
Zfish   131 ------LVAAYMQVAFWTLAAGRQVKKLRKIFFHSIMKQEIGWFDVNETGQLNTRLTDDVYKINE 189

  Fly   286 GF---IFMHWIWIMPLQAMLTCYLIWLNIG-------------IPAIVG----VVGLLLKTV--P 328
            |.   :.|       |...||.:::.:.||             :..::|    |:|.::.|.  .
Zfish   190 GIGDKLGM-------LIQNLTTFIVGIIIGFAKGWKLTLVILAVSPLLGISAAVIGKVMTTFTSK 247

  Fly   329 VQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKP----FQAVVAEARRSEIKQ- 388
            .|||.:|..:|     ||          |::..|:.:..:..:|.    :...:.:|:...:::
Zfish   248 EQTAYAKAGAV-----AE----------EVLSSIRTVFAFGGQKKEIKRYHKNLEDAKNVGVRKA 297

  Fly   389 ------------IRYASYLRGF-YLSTMVFTERSTL-------YITLAAAALMGQTITADFVFSA 433
                        :.|.||...| |.||::.....|:       :..|..|..:|||......||:
Zfish   298 ITVNIAMGFTFFMIYMSYALAFWYGSTLILGGEYTIGMLLTIFFAVLIGAFGLGQTSPNIQTFSS 362

  Fly   434 A--SYYNILQLVAAIWYPLAVSFGAEALVSLRRIQDFLMLEGREERTQGLTHKRDQEGGDSRAVT 496
            |  :.:.:.|::.  ..|...||..|.                        :|.|...|:   :.
Zfish   363 ARGAAHKVFQIID--HEPKINSFSEEG------------------------YKLDVVKGN---IE 398

  Fly   497 IKDINASWDIEKPQKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGD-- 559
            .|:|:..:......|.|..:||::..||..|::|..|.|||:.:|||.......:|.|.|.|.
Zfish   399 FKNIHFRYPSRDDVKVLNGMNLKVMSGQTIALVGSSGCGKSTTIQLLQRFYDPQEGSVSIDGHDI 463

  Fly   560 -----------LSYAAQEPWLFTGSVRNNILFG-EEFDRKRYQEVTRCCALSTDFQQLPNGDKTL 612
                       :...:|||.||..::..||.:| ::..:...::..|.........:||:..:||
Zfish   464 RSLNVRGLRELIGVVSQEPVLFATTIAENIRYGRQDVTQDEIEQAAREANAYNFIMKLPDKFETL 528

  Fly   613 VGERGASLSGGQRARISLARAVYKPAQIYLMDDPLSAVDAH---VGRHLFDEVIGPRGRLAQLKA 674
            ||:||..:||||:.||::|||:.:..:|.|:|:..||:||.   :.:...|:|        :|..
Zfish   529 VGDRGTQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESETIVQAALDKV--------RLGR 585

  Fly   675 TRILVTHQVHFLSEADVIVIVDQGRILRQGTYQELINSDLDFARLLE-------RPKEEEEGENS 732
            |.|:|.|::..:..||||.....|.|:..||:.||:.....:..|:.       ...||:..|.:
Zfish   586 TTIVVAHRLSTIRNADVIAGFQNGEIVELGTHDELMERKGIYHSLVNMQMFKSTEVAEEDSEEMT 650

  Fly   733 RNQTSPLSVNSLESDDEDIPFIDGVKDGYQQLRKQSSSVHGSKSLDS----TQLDDNVDE----- 788
            .::.||    |:.|.:|...|....:.|.::..|:.......:.:.:    |.|..|..|
Zfish   651 MDEKSP----SVSSMNERTLFRQKSRSGSEKELKEEEKPTEEEKVPNVSFLTVLKLNYPEWPYMV 711

  Fly   789 DDLAEAQASGGISPRVWYEYFHAGSTLLSFSFMVFVMVMSQVVCSSSDFFANIWTQQEHQRSQGE 853
            ..:..|..:||:.|                   .|.::.|:::...::...|:..|:
Zfish   712 VGILCATINGGMQP-------------------AFAVIFSKIIAVFAEPDQNLVRQR-------- 749

  Fly   854 ATFSTFECMYIYGALIIAVVIMTTF----RGFLFFKICMHASKVLHDRMFACILHATMRFFDTTP 914
                   | .:|..|...:.:::.|    :||.|.|.....:..|..:.|..::...:.::|.|.
Zfish   750 -------C-DLYSLLFAGIGVLSFFTLFLQGFCFGKAGELLTMRLRFKAFNAMMRQDLAWYDDTK 806

  Fly   915 S--GRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVIGI-----LNPVLVAAMLVVAVVD 972
            :  |.:..|.:.|...:.......:....| .:...|..|||..     |..::::.:.::||..
Zfish   807 NSVGALTTRLAADTAQVQGATGVRLATLAQ-NVANLGTAIVISFVYGWQLTLLILSIVPIMAVAG 870

  Fly   973 VLILKLY----LRPSQDLKRLEGICRSPVFS-HLSASLTGLAIIRSRQLQDVVAKEFDLLQDVHS 1032
            .:.:||.    |:..::|::...|....:.: ....|||..:...|...::::....:..:..|
Zfish   871 AIQMKLLAGHALKDKKELEQAGKIATEAIENVRTVVSLTRESKFESLYEENLIVPYKNAKKKAH- 934

  Fly  1033 SVWQLTMAVNTTL-----------GLWLDCVSCIFLTSVTFS--FIISSETTYSGNVGLAIAQAM 1084
             |:.||.:.:..:           |.||     |....:||.  |::.|...|.   .:|:.:|.
Zfish   935 -VFGLTFSFSQAMIYFAYAGCFKFGSWL-----IEQKLMTFEGVFLVISAVVYG---AMAVGEAN 990

  Fly  1085 ILTGMVQYGVRQVAESLQQMTSVERVLQYTELEQEPALGEKTPPQQWPTR--GQVEFRNMSCRYD 1147
            ..|  ..|...::        |...||..  :.:.||:...:.....|.:  |.|.|.::..:|.
Zfish   991 SFT--PNYAKAKM--------SASHVLML--INRAPAIDNSSEDGDKPDKFEGNVGFEHVYFKYP 1043

  Fly  1148 PNGS-PVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAH-IEGEIFIDGIETGTISLEILR 1210
            .... |||:.|.|.::.|..:.:||.:|.|||:.|..|.|... .:|.:.:|..:...:::..||
Zfish  1044 SRPDVPVLQGLKLRVKKGQTLALVGSSGCGKSTTIQLLERFYDPQQGRVMLDDNDAKQLNIHWLR 1108

  Fly  1211 TRISIIPQDPVLFSATIRYNL---DPFERYTDAELWSALEDVELRKAIPGL----DYMVTERGGN 1268
            ::|.|:.|:||||..::..|:   |........|:..|.:...:...|..|    .....::|..
Zfish  1109 SQIGIVSQEPVLFDCSLAENIAYGDNSREVDQEEIVEAAKAANIHSFIENLPQRYQTQAGDKGTQ 1173

  Fly  1269 FSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDS 1333
            .|.||:|.:.:|||||||.|||:|||||:.:|.:::.::|..:....|..|.:.|||||.|:.::
Zfish  1174 LSGGQKQRIAIARAILRNPKVLLLDEATSALDTESEKIVQDALDKASKGRTCIIVAHRLSTIQNA 1238

  Fly  1334 DRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEATG 1369
            |.|.|:..||.||           ||..:|::...|
Zfish  1239 DCIAVVQNGVVVE-----------QGTHQQLLSQQG 1263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	313/1462 (21%)
		ABC_membrane	214..441	CDD:294371	50/287 (17%)
		ABCC_MRP_domain1	495..699	CDD:213217	65/220 (30%)
		ABC_membrane	863..1088	CDD:294371	46/253 (18%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	73/223 (33%)
abcb4	NP_001303643.1	PTZ00265	55..1266	CDD:240339	301/1409 (21%)
		ABC_membrane	60..348	CDD:279056	59/377 (16%)
		ABC_MTABC3_MDL1_MDL2	397..634	CDD:213216	72/244 (30%)
		ABC_membrane	714..984	CDD:279056	53/315 (17%)
		ABC_MTABC3_MDL1_MDL2	1035..1272	CDD:213216	75/240 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000