Protein Alignment Cftr and abcc3

DIOPT Version :10

• Sequence 1: NP_651269.1
• Gene: Cftr / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Sequence 2: NP_001107301.1
• Gene: abcc3 / 100135090
• XenbaseID: XB-GENE-1003737
• Length: 1531
• Species: Xenopus tropicalis
• Alignment Length: 1416
• Identity: 465/1416 - (32%)
• Similarity: 728/1416 - (51%)
• Gaps: 181/1416 - (12%)

  Fly    12 PRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSHRKKQ 76
            |...|..:|:|.|.|...:...|.:|.|...||....::|.|..:...|..:|  |.|:|:
 Frog   208 PESDAGFLSRLTFWWFTKMAILGYKRPLEDKDLWSLNEDDTSNVVVTNLIKEW--EKEKSN---- 266

  Fly    77 KPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNID----VNDIS 137
                                                |||:.:.:.|.|.|.|.:.|    .:|:.
 Frog   267 ------------------------------------LAQMQVSYSKKPEAVLNHTDEKAYESDVL 295

  Fly   138 ISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKA-GP--------------LEPIQPPV 187
            |.|                     :..|.:..|.|.|.:. ||              |..:.|.:
 Frog   296 IVD---------------------NKKPKEPSFLKVLLRTFGPYFLIGSFFKLFQDLLSFVNPQL 339

  Fly   188 EEVDHNATAVRSILDQTVEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRLMGARMRIACCSLI 252
            ..:     .:..|.::.....|.  ..:..::.|::|....:||.......:.|.|:|.|...:|
 Frog   340 LSI-----LITFIKNKDAPSWWG--FCIAVLMFLTSLVQTLILHQHFQYCFVTGMRLRSAITGII 397

  Fly   253 YRKTLRLSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIV 317
            |||:|.::......:..|.::||:|.|..|......|::.:|..|||..|..|.:|..:| |:::
 Frog   398 YRKSLVITNSAKRSSTVGEVVNLMSVDAQRFQDLTTFLNMLWSAPLQICLALYFLWQALG-PSVL 461

  Fly   318 GVVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEAR 382
            ..|.:::..:|:...::..|...::...:..|:|:.:|||::.||:|:|:||||..|...|.|.|
 Frog   462 AGVAVMVLLIPINAFIAMKTRAFQVEQMQYKDSRIKLMNEILNGIKVLKLYAWEPSFAQKVLEIR 526

  Fly   383 RSEIKQIRYASYLRGFYLSTMVFTERSTL--------YITLAAAALMGQTITADFVFSAASYYNI 439
            ..|:..::.|:||..  |||..:|....|        |:|:....:    :.|:..|.:.|.:||
 Frog   527 NKELNILKKAAYLNA--LSTFAWTSAPFLVALTTFAVYVTVDEKNI----LDAEKAFVSLSLFNI 585

  Fly   440 LQLVAAIWYPLAVSFGAEALVSLRRIQDFLMLEGREERTQGLTHKRDQEGGDSRAVTIKDINASW 504
            |:....: .|..:|..|:|.||::|||:||..:  |.....:|..:...|   .|:|:.:...||
 Frog   586 LRFPLNM-LPQVISNLAQASVSIKRIQNFLAND--ELDLNAVTKDKTLPG---NAITVHNGTFSW 644

  Fly   505 DIEKPQKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGDLSYAAQEPWL 569
             .:.....||:|||.:..|.|.||:|.||.||||::..||||:...:|.|.::|.::|..|:.|:
 Frog   645 -AKNGGAILQNINLLVPSGSLVAVVGQVGCGKSSLVSALLGEMEKEEGEVSVRGSVAYVPQQAWI 708

  Fly   570 FTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAV 634
            ...::::|||||...:.|.|::|...|||.||.:.||.||:|.:||:|.:|||||:.|:||||||
 Frog   709 QNCTLKDNILFGRAANEKNYKKVLEACALVTDLEVLPGGDQTEIGEKGINLSGGQKQRVSLARAV 773

  Fly   635 YKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRILVTHQVHFLSEADVIVIVDQGR 699
            :..|.:||:|||||||||||.:|:||.||||.|.|.  ..||:||||.:.||.:.|.||::..||
 Frog   774 FSNADVYLLDDPLSAVDAHVAKHIFDNVIGPDGLLR--GKTRVLVTHGISFLPQVDHIVVLVDGR 836

  Fly   700 ILRQGTYQELINSDLDFARLLER--------------PKEEEE--GENSRNQTSPLSVNSLESDD 748
            :...|:||||:..:..|:..|..              |.|||.  .|.:.:..:.|:.|...:::
 Frog   837 VTEMGSYQELLKQNGAFSEFLRNYAFDDEVEEEDITIPDEEEVLLAEETLSTHTDLADNEPVANE 901

  Fly   749 EDIPFI-------DGVKDGYQQLRKQSSSVHGSKSLDSTQLDDNVDEDDLAEAQASGGISPRVWY 806
            ....||       ||........|::.:....|::|.:.|  ...::....|...:|.:...|::
 Frog   902 ARKKFIRQISILSDGEPSHAMSTRRRFTEKKPSENLVAKQ--PPTEKLIQTETTETGRVKMTVFW 964

  Fly   807 EYFHAGSTLLSFSFMVFVMVMSQVVC-SSSDFFANIW------------TQQEHQRSQGEATFST 858
            :|..|    :..:..||:..:..  | :::...||:|            |||..|...|
 Frog   965 QYMKA----VGLAISVFICFLYS--CQNAAAIGANVWLSDWTNEPVINQTQQNTQMRVG------ 1017

  Fly   859 FECMYIYGALII--AVVIMTTFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNR 921
                 :|.||.|  .:::||:  .|......:.|::.||..:....:|....|:||||.|||:||
 Frog  1018 -----VYAALGILQGLLVMTS--SFSLAIAGIGAARKLHSALLDNKMHTPQSFYDTTPIGRIINR 1075

  Fly   922 FSKDMGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLVVAVVDVLILKLYLRPSQDL 986
            ||||:..|||::|..::.|:.........:|||....|:....::.:|:..:.:.:.|:..|:.|
 Frog  1076 FSKDIYVIDEVIPGTILMFLATFFTSLSTMIVIVASTPLFAVVIIPLAIAYIFVQRFYVATSRQL 1140

  Fly   987 KRLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDC 1051
            ||||.:.|||::||.|.::||.:|||:...|:......|...|.:...:...:..|..||:.::.
 Frog  1141 KRLESVSRSPIYSHFSETITGASIIRAYGRQNSFIVLSDNKVDENQKSYYPGIVSNRWLGVRVEF 1205

  Fly  1052 V-SCIFLTSVTFSFIISSETTYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTE 1115
            | :|:.|.:..|: ::..|....|.|||:::.|:.:|..:.:.||..::....:.:||||.:|.|
 Frog  1206 VGNCVVLFAALFA-VLGREHLSPGLVGLSVSYALQVTMSLNWMVRMTSDLETNIVAVERVKEYAE 1269

  Fly  1116 LEQEPA--LGEKTPPQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKS 1178
            .|.|..  :.:..||:.||::|:||..|.|.||......||:||||.:..|.|||||||||||||
 Frog  1270 NETEAPWHIEDTKPPEDWPSKGEVELSNYSVRYRAGLDLVLKNLNLKVNGGEKVGIVGRTGAGKS 1334

  Fly  1179 SLIGALFR-LAHIEGEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAEL 1242
            |:...||| |...||.:.||.:....|.|:.||:|::||||||||||.|:|.|||||.:|:|.|:
 Frog  1335 SMTLCLFRILEPAEGIVKIDNVNISEIGLQDLRSRLTIIPQDPVLFSGTLRMNLDPFNKYSDDEI 1399

  Fly  1243 WSALEDVELRKAIPG----LDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQT 1303
            |.|||...|:|.:.|    |:|..:|.|.|.|||||||:|||||:||..::|:||||||.:|.:|
 Frog  1400 WKALELSNLKKFVAGQPSQLEYECSEGGENLSVGQRQLVCLARALLRKTRILILDEATAAIDLET 1464

  Fly  1304 DALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLL 1354
            |.|||.|||.:|:.|||||:||||:|:||..|::|:|.|...|||.|..|:
 Frog  1465 DDLIQMTIRTQFEDCTVLTIAHRLNTIMDYTRVLVLDKGRIAEFDTPTNLI 1515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cftr	NP_651269.1	MRP_assoc_pro	12..1356	CDD:188098	465/1416 (33%)
abcc3	NP_001107301.1	MRP_assoc_pro	7..1530	CDD:188098	465/1416 (33%)